Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

• Xiaoyan Ma,
• Haoning Gong,
• Kenji Ogino,
• Xuehai Yan and
• Ruirui Xing

Beilstein J. Nanotechnol. 2022, 13, 284–291, doi:10.3762/bjnano.13.23

• antioxidant peptides by proteases. The combination of liposomes or polymers with different payload materials has been reported, for example, PEG-modified liposomes loaded with resveratrol, layer-by-layer-coated gelatin nanoparticles, or Gelucire-based solid lipid and polymeric micelles [14][15][16][17][18][19

Photothermal ablation of murine melanomas by Fe₃O₄ nanoparticle clusters

• Xue Wang,
• Lili Xuan and
• Ying Pan

Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20

• micelles and the formation of Fe3O4 nanoparticle clusters, which were then coated with polyvinylpyrrolidone (PVP) to improve stability, biocompatibility and chemical features of the nanoparticles. Further SEM measurements revealed the as-formed Fe3O4 NPCs to be spherical and uniformly sized with an average

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• nanosystems. According to previous evidence, the use of nanosystems is highly flexible since it can be tailored for numerous applications with highly specific goals. Polymeric micelles and theranostics (a strategy that combines treatment and diagnostics) are two examples of such applications that are based on

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• , and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes

• carrier. The imaging applications of these materials will also be discussed. These materials include nanocarrier formulations and nanostructured contrast agents, such as microbubbles (MBs), surfactant-based carriers (including micelles, NEs, and niosomes), polymer-based carriers (including gels

• less-discussed US-responsive nanomaterials in addition to the conventional nanomaterials (i.e., microbubbles, micelles, liposomes, and nanoemulsions) is another distinguishable feature of this review. Ultrasound-responsive nanomaterials are discussed in terms of their background, structure, preparation

Rapid controlled synthesis of gold–platinum nanorods with excellent photothermal properties under 808 nm excitation

• Jialin Wang,
• Qianqian Duan,
• Min Yang,
• Boye Zhang,
• Li Guo,
• Pengcui Li,
• Wendong Zhang and
• Shengbo Sang

Beilstein J. Nanotechnol. 2021, 12, 462–472, doi:10.3762/bjnano.12.37

• micelles were formed in the solution. PtCl42− is complexed with CTAB micelles and then gets reduced at the surface of AuNRs by ascorbic acid. During the reaction, a relatively obvious Pt shell formed gradually. In sharp contrast, in the presence of Ag+, it is apparent that Pt grows mainly at the tip of the

• , as shown in curve Au@Pt-3 and Au@Pt-4 in Figure 3a. We hypothesize that with the increase of K2PtCl4 content, the collision frequency between PtCl42−-CTAB micelles and AuNRs also increased, and eventually, Pt smoothly covers the surface of AuNRs and forms a thicker Pt coating. The absorption spectra

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• ]. Separation of AgNPs from Ag+: The cloud point extraction (CPE) technique was initiated by Goto et al. and it is based on the solubilization capacity and on the cloud point of nonionic surfactants [148]. At the cloud point, the instability observed in the micelles is promoted by the dehydration of the

• hydrophilic groups with consequent formation of giant micelles (cages) providing reduced water solubility (which defines the cloud point transition). It is exactly at this point that the AgNPs get surrounded by these non-ionic micelles and separated from the ionic silver (hydrophilic character) [149]. The

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• the improvement of the overall therapeutic efficacy. A targeted NDDS for the co-delivery of ponatinib and SAR302503 (selective JAK2 inhibitor) for efficient CML treatment was developed by Mu and co-workers [47]. The authors employed alendronate-decorated PLA–PEG micelles for BM targeting. Both

• ponatinib and SAR302503 are hydrophobic drugs and were co-encapsulated inside the hydrophobic core of PEG–PLA micelles by solvent displacement nanoprecipitation. The results demonstrated that the targeted NDDS enabled a high availability of the drugs inside the BM, which is a prerequisite for overcoming the

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

• Sina Kaabipour and
• Shohreh Hemmati

Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9

• humidity [233]. The sol–gel process is associated with costly precursors, process longevity, and difficulties regarding reproducibility [234]. 2.2.2 Reverse-micelle process. The reverse micelle is another approach for the synthesis of AgNPs. Reverse micelles are produced from surfactants such as sucrose

• AgNPs in sodium dioctyl sulfosuccinate (AOT) reverse micelles using ascorbic acid as the reductant and obtained particles with an average size of 6 nm. Yang et al. [154] used sodium borohydride as the reductant and octadecylamine (ODA) as the solvent and produced AgNPs with an average size of 3.38 nm

• concentration inside the reverse micelles [235]. AOT-microemulsions have been the most common microemulsions for the preparation of micelles [152]. However, this method may result in the synthesis of AgNPs with weak surface plasmon characteristics due to a broad surface plasmon band [152]. 2.2.3 Chemical vapor

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

• Matías Guerrero Correa,
• Fernanda B. Martínez,
• Cristian Patiño Vidal,
• Camilo Streitt,
• Juan Escrig and
• Carol Lopez de Dicastillo

Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129

• Cu NPs. The bioavailability of these antimicrobial NPs had lower MIC values against E. coli and B. subtilis than copper hydroxide particles in suspension [143]. Silver carbon complexes with different formulations, including micelles and NPs, have also shown an antimicrobial effect since they inhibit

Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy

• Gayathri Kandasamy,
• Elena N. Danilovtseva,
• Vadim V. Annenkov and
• Uma Maheswari Krishnan

Beilstein J. Nanotechnol. 2020, 11, 354–369, doi:10.3762/bjnano.11.26

• applications [18]. A folic acid-conjugated amine containing poly(1-vinylimidazole) was found to effectively complex DNA and transfect cancer cells [19]. PVI linked with the dipeptide Cys–Trp was demonstrated to self-assemble to micelles that could also complex RNA effectively. Very few studies have also

Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system for parenteral applications

• Eike Folker Busmann,
• Dailén García Martínez,
• Henrike Lucas and
• Karsten Mäder

Beilstein J. Nanotechnol. 2020, 11, 213–224, doi:10.3762/bjnano.11.16

• drug delivery systems such as solid lipid or polymeric nanoparticles, nanocapsules, liquid nanoemulsions, liposomes and micelles can be used to carry poorly water soluble ingredients of pharmaceuticals for parenteral applications [1][2][3]. Thereby, the physical entrapment of the active ingredients

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• the importance of intracellular targeting has been addressed. Keywords: intracellular targeting; micelles; photodynamic therapy (PDT); photochemistry; polymer; self-assembly; Review Introduction After Paul Ehrlich, in 1900, had the very first notion of a drug being delivered at will to a specific

• micelles or vesicles. The driving forces of this assembly are a loss of entropy during the self-assembly and different interactions acting on the monomer units of the polymer. Whereas polymer/polymer interactions are favored for the hydrophobic block, interactions between the hydrophobic block and water

• ). This strategy also revealed not to be always appropriate for ROS production and in the case of vinylpyridinium-based block copolymers (with both the pH-insensitive 4-vinilpyridinium and the positively charged N-methyl-2-vinylpyridinium iodide), the PIC micelles are even proposed as antioxidants due to

Molecular architectonics of DNA for functional nanoarchitectures

• Debasis Ghosh,
• Lakshmi P. Datta and
• Thimmaiah Govindaraju

Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11

• from DNA block copolymer micelles [100]. The block copolymer micelles were synthesized through ring-opening polymerization, followed by the integration of DNA oligonucleotides in a postpolymerization modification process. The DNA acted as a polar head group, while the whole polymer system acted as a

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• , direct translocation is regarded as a single-step process including mechanisms involving the formation of inverted micelles, pores and the ‘carpet’ model [21]. This process can be tested under specific experimental conditions – low temperature, energy depletion and the use of endocytic inhibitors for

• inverted micelles was initially reported for penetratin as a mechanism involved at the early stages of cellular uptake [24]. Penetratin is a protein transduction domain derived from the homeoprotein Antennapeadia. It is one of the first peptides described that was able to successfully carry active

• membrane curvature [26]. Such membrane curvatures or invaginations can lead to the formation of inverted micelles that entrap the peptide. The hydrophilic environment inside the inverted micelle allows accumulation of the peptide and is favorable for the transport of hydrophilic compounds conjugated to the

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• synthesize clusters, so-called colloidal molecules [21]. Nanospherical satellites were covalently bonded via amide groups within the dimples of valence-endowed patchy nanoparticles, allowing the tuning of their topology and self-assembling ability. Polyion complex micelles formed by complexation between poly

• (ethylene oxide)-b-poly(acrylic acid) (PEO-b-PAA) and an oligo-chitosan-type polyamine was used as a structure-directing agent to prepare ordered mesoporous silica materials in the work “pH-mediated control over the mesostructure of ordered mesoporous materials templated by polyion complex micelles” [22

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

• Cynthia Kembuan,
• Maysoon Saleh,
• Bastian Rühle,
• Ute Resch-Genger and
• Christina Graf

Beilstein J. Nanotechnol. 2019, 10, 2410–2421, doi:10.3762/bjnano.10.231

• remain constant. Hence, the number of micelles stays constant, and their size is increased to accommodate the growing core–shell particles. Consequently, the formation of core-free silica particles is suppressed. When the negative zeta potential of the particles, which continuously decreased during the

• , the size and the number of the aqueous domains, i.e., the water pools inside the micelles, are determined by the ratio of ammonia water to Igepal CO-520, often denoted as the R-value [30][36][51][52]. Several authors suggested that for an optimal growth process where particles with multiple cores as

• well as coreless particles are absent, the number of micelles has to ideally match the number of particles [36][47]. If in the course of this process the silica shell becomes thicker, ammonia water and surfactant must be added accordingly in order to balance the particle growth, while suppressing the

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• elucidated by incorporation kinetics and location studies. They revealed that the drug was quickly incorporated and located in the hydrophobic portion of nanometer-sized polymeric micelles. Moreover, the systems displayed plastic behavior with rheopexy characteristics at 37 °C, viscoelastic properties and a

• characteristics beneficial for pharmaceutical and biomedical use [1]. P407 is a non-ionic block copolymer with polypropylene oxide (PPO) and polyethylene oxide (PEO) segments, which can display thermoresponsive properties forming nanometer-sized micelles, hydrogels and lyotropic liquid crystals [2][3]. The

• increase of temperature can promote the self-assembly from unimers to micelles, with large endothermic heat. In this sense, PPO-groups dehydrate in a hydrophobic core with a surrounding hydrated shell. Higher concentrations of P407 are used (15% to 20%, w/w) as colloidal gelling systems in a cubic

Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials

• Stefania Ordanini,
• Wanda Celentano,
• Anna Bernardi and
• Francesco Cellesi

Beilstein J. Nanotechnol. 2019, 10, 2192–2206, doi:10.3762/bjnano.10.212

• aggregates (e.g., micelles and vesicles) above their critical aggregation concentration (CAC). The resulting self-assembled nanoparticles can act as drug carriers and delivery systems, being able to accommodate a hydrophobic drug within their hydrophobic core [22], or chemically bind bioactive agents [23][24

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• 33.9 ± 0.5%, respectively). These loading efficiencies are in the range of those described for similar preparations, although higher drug loads have been described when using alternative PLGA-based formulations such as nanoparticles or micelles with doxorubicin covalently bound to the polymer

• , nanoparticles produced by nanoprecipitation, micelles based on multi-arm star-shaped PLGA–PEG block copolymers, or nanopolymersomes [14][15][16][17][18]. In addition, PLGA nanoparticles prepared at pH 7 displayed a more controlled and sustained doxorubicin release than PLGA nanoparticles prepared without pH

• such as nanoparticles or micelles with doxorubicin covalently bound to the polymer, nanoparticles produced by nanoprecipitation, micelles based on multi-arm star-shaped PLGA–PEG block copolymers, or nanopolymersomes [14][15][16][17][18]. Nanoparticle efficacy in cell culture Finally, the effects of

Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• disadvantageous in the formation of host–guest complexes. However, the incorporation of guanidinium functionality into molecular assemblies such as aqueous micelles and lipid bilayers to place recognition sites at a mesoscopic interface increased the binding constants between guanidinium and phosphate to 102–104

Gold-coated plant virus as computed tomography imaging contrast agent

• Alaa A. A. Aljabali,
• Mazhar S. Al Zoubi,
• Khalid M. Al-Batanyeh,
• Ali Al-Radaideh,
• Mohammad A. Obeid,
• Abeer Al Sharabi,
• Walhan Alshaer,
• Bayan AbuFares,
• Tasnim Al-Zanati,
• Murtaza M. Tambuwala,
• Naveed Akbar and
• David J. Evans

Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195

• contrast agents including gold nanoparticles (AuNPs) [13], bromine [14], platinum [15], ytterbium [16], gadolinium [4], and tungsten [15]. Many of the systems are made up of a core that is coated with a polymeric material such as liposomes [17], micelles [13], lipoproteins or polymeric nanoparticles [18

• ]. One of the first examples of such NP-based systems was reported by Caride et al. using brominated phospholipids packaged into liposomes and administered to dogs. Contrast enhancement signals of 40 HU were observed in the liver of imaged animals [14]. Two hours after injection, micelles loaded with

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• -coated iron oxide nanoparticles to target tumor-associated macrophages [36] and D-AE-peptide-modified micelles as a multitarget drug delivery system [37], the benefits of the nanoprobe in this study are described as follows. First, the nanoprobe has a diameter of around 100 nm and can directly pass

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

• Mohammad A. Obeid,
• Ibrahim Khadra,
• Abdullah Albaloushi,
• Margaret Mullin,
• Hanin Alyamani and
• Valerie A. Ferro

Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177

• unwanted side effects [8][9]. Liposomes, solid lipid nanoparticles, dendrimers, micelles, polymeric nanoparticles, gold nanoparticles, and carbon nanotubes are among the most common types of nanoparticle delivery systems [10]. These efforts have been reported in several studies. For example, Guo et al

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

• guanidinium-functionalized aqueous micelles and lipid bilayers reaches values of 102 to 104 M−1. Surprisingly, the binding constant of the same recognition pair further increases to 106 to 107 M−1 when a macroscopic less dynamic interface, the air–water interface, is used as the recognition medium [157][158

Tailoring the stability/aggregation of one-dimensional TiO₂(B)/titanate nanowires using surfactants

• Atiđa Selmani,
• Johannes Lützenkirchen,
• Kristina Kučanda,
• Dario Dabić,
• Engelbert Redel,
• Ida Delač Marion,
• Damir Kralj,
• Darija Domazet Jurašin and
• Maja Dutour Sikirić

Beilstein J. Nanotechnol. 2019, 10, 1024–1037, doi:10.3762/bjnano.10.103

• in aqueous solutions. In order to fill this void, in this study, the effect of monomers and micelles of (a) monomeric dodecyltrimethylammonium bromide (DTAB), and (b) its corresponding gemini, bis(N,N-dimethyl-N-dodecyl)ethylene-1,2-diammonium dibromide (12-2-12) quaternary ammonium surfactant

• micelles) on the stability of TNWs was assessed in two media, water and aqueous electrolyte solution of sodium bromide, thus increasing the complexity of the investigated systems. The observed effects were quantified by surface complexation modeling (SCM) in order to describe the TNW behavior when

• tension with increase of surfactant concentration up to almost constant σ values, indicating the formation of micelles. As expected, 12-2-12 exhibited considerably lower σ values as well as a lower critical micelle concentration (cmc) than DTAB (Table S1 in Supporting Information) indicating its greater