Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• hybrid nanoparticles (PLHNPs) have emerged as a novel delivery system that combines the advantages of both polymeric and lipid-based nanoparticles to overcome these challenges. This review explores the potential of PLHNPs to enhance the delivery and efficacy of phytochemicals for biomedical applications

• challenges ahead and prospects of PLHNPs regarding their widespread use in clinical settings. Overall, PLHNPs hold strong potential for the effective delivery of phytochemicals for biomedical applications. As per the findings from pre-clinical studies, this may offer a promising strategy for managing various

• advantageous for chronic conditions requiring long-term treatment, such as cancer, cardiovascular diseases, and neurodegenerative disorders [22][23]. This review aims to discuss the ability of PLHNPs to improve the therapeutic delivery of phytochemicals for biomedical applications. In this review, we discuss

Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications

• The-Long Phan,
• Le Viet Cuong,
• Vu Dinh Lam and
• Ngoc Toan Dang

Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112

• results prove that ZnO exhibits many novel nanostructures that can foster the development of next-generation optoelectronic nanodevices and new applications in biological and biomedical fields. Keywords: chemical vapour deposition; electron microscopy; Raman and photoluminescent spectra; ZnO

• DMSs, these nanostructures will be beneficial to the development of new ZnO-based materials for photocatalytic [25], biomedical [26], gas sensing [27][28], and flexible electronic/optoelectronic applications [29][30]. They are usually fabricated by chemical vapour deposition (CVD) or solid-vapour phase

• nanodevices. They also have potential applications in biological, biomedical, and environmental fields. A representative EDX spectrum recorded from ZnO nanorods showing the presence of Zn and O in the product. SEM micrographs of some nanostructures: (a, b) rods (R1 and R2), (c) matches or drumsticks (M), (d

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• high strength to nanoparticles, the use of such nanoparticles is limited in sensing, catalysis, and biomedical applications because of post-synthesis functionalization, morphology, and toxicity [6][7][8]. CTAB is a resilient molecule on the nanoparticle surface because of its micellar structure and

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• is also possible to modify pristine fullerenes by adding polar functional groups (e.g., –COOH, –OH, or –NH2), to improve water solubility, antioxidant properties, and even biological activity [25]. For instance, polyhydroxy fullerenes (PHFs) exhibit properties suitable for biomedical applications

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• newly created MONPs, particularly those used in biomedical applications, necessitates the implementation of safety-by-design strategies for these materials. The potential to lower development timeframes, costs associated with experiments, and late-stage attrition, in addition to ethical, societal, and

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• targeting; hepatic fibrosis; nanocarriers; nanomedicine; passive targeting; Introduction Over the last three decades, we have witnessed tremendous progress in the field of nanomedicine through the preparation of a vast number of nanoscale (bio)materials. Nanomedicine itself is defined as the biomedical

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• . Current biomedical and pharmaceutical science has one focus on developing nanoparticle-based sensors, especially biopolymeric nanoparticles. Alginate is a widely used biopolymer in a variety of applications. The hydrogel-forming characteristic, the chemical structure with hydroxy and carboxylate moieties

• , biocompatibility, biodegradability, and water solubility of alginate have expanded opportunities in material and biomedical sciences. Recently, research on alginate-based nanoparticles and their applications has begun. These materials are gaining popularity because of their wide usage potential in the biomedical

• discussed, including drug delivery and environmental sensing applications for humidity, heavy metals, and hydrogen peroxide. Moreover, biomedical sensing applications of alginate-based nanoparticles regarding various analytes such as glucose, cancer cells, pharmaceutical drugs, and human motion will also be

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• thickness and some morphological properties of the deposited nanostructured film can be controlled by adjusting deposition time, substrate temperature, and deposition rate. The response of biological surfaces to non-biological materials The first challenge in developing biomedical implants is related to

Recent progress on field-effect transistor-based biosensors: device perspective

• Billel Smaani,
• Fares Nafa,
• Mohamed Salah Benlatrech,
• Ismahan Mahdi,
• Hamza Akroum,
• Mohamed walid Azizi,
• Khaled Harrar and
• Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

• currents, making this biosensor structure promising and an excellent candidate for various highly sensitive biomedical applications. 2.2.15 Negative-capacitance TFET-based biosensors. A Ge/GaAs negative-capacitance double-gate tunnel FET (NC DG) FET-based biosensor has been proposed by Paul et al. [119

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• Co. Ltd.)) [101]. The main polymeric nanofiber products on the market for bone regeneration are ReBOSSIS (Ortho Rebirth, Japan), a PLGA-based biomedical product for filling a synthetic bone cavity, poly-ʟ-lactic acid (PLLA) and collagen scaffolds (The Electrospinning Company, United Kingdom), and PCL

• ’ recovery, ReBOSSIS is gradually replaced with bone. ReBOSSIS was approved by the US Food and Drug Administration in April 2015, and it us available in the USA [102]. PLLA and collagen-containing scaffolds developed by The Electrospinning Company are used for biomedical applications in various bone defects

Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

• Indrasis Dasgupta,
• Totan Das,
• Biplab Das and
• Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

• advancement of nanotechnology has led to the widespread utilization of engineered nanostructured metal oxides (ENMOs) in various industrial and biomedical applications [1]. Nanoparticles (NPs) are described by the International Organization for Standardization as structures characterized by one, two, or three

• implications for the rational design of ENMOs with tailored properties for biomedical applications, ensuring their higher efficiency. Materials and Methods Preparation of datasets The current study was performed employing the experimental cellular uptake data of 109 chemically attached surface modifiers of

When nanomedicines meet tropical diseases

• Eder Lilia Romero,
• Katrien Van Bocxlaer and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 830–832, doi:10.3762/bjnano.15.69

• , York Biomedical Research Institute, University of York, York YO10 5DD, UK Aggeu Magalhães Institute, Oswaldo Cruz Foundation (FIOCRUZ), 50670-420, Recife, PE, Brazil Faculty of Medical Sciences, University of Pernambuco (UPE), 52171-011, Recife, PE, Brazil 10.3762/bjnano.15.69 Keywords: Aedes aegypti

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

• Veronika Pálos,
• Krisztina S. Nagy,
• Rita Pázmány,
• Krisztina Juriga-Tóth,
• Bálint Budavári,
• Judit Domokos,
• Dóra Szabó,
• Ákos Zsembery and
• Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

• containing antibacterial and tissue-regenerating salts of zinc acetate or strontium nitrate in different concentrations, whose structures may be suitable for developing biomedical wound dressing systems in the future. Several experiments have been conducted to optimize the physicochemical, mechanical, and

• )/hydroxyapatite in orthopedics [1][2]. Biocompatible polymers are widely used in biomedical fields, such as stents, drug delivery systems in cancer therapy, bone repair, dentistry, joint prostheses, and tissue engineering [2][3][4][5][6]. Polymers have several advantageous properties for these applications as

• created and used in numerous biomedical applications, such as tissue engineering, wound dressing, and drug delivery [11][12]. Electrospinning has many advantages: it is a simple technique, cost-effective, reproducible, scalable, and reliable. In addition, various polymers can be used as starting material

Exploring surface charge dynamics: implications for AFM height measurements in 2D materials

• Mario Navarro-Rodriguez,
• Andres M. Somoza and
• Elisa Palacios-Lidon

Beilstein J. Nanotechnol. 2024, 15, 767–780, doi:10.3762/bjnano.15.64

• ], sensors [2], and biomedical applications [3][4], among other areas [5][6][7][8]. Graphene-related materials [8], transition metal dichalcogenides [9], boron nitride [10], and MXenes [11], among many others, exhibit novel and exotic properties, which markedly differ from their bulk counterparts [12]. This

Green synthesis of biomass-derived carbon quantum dots for photocatalytic degradation of methylene blue

• Dalia Chávez-García,
• Mario Guzman,
• Viridiana Sanchez and
• Rubén D. Cadena-Nava

Beilstein J. Nanotechnol. 2024, 15, 755–766, doi:10.3762/bjnano.15.63

• properties for advanced photocatalytic applications. Furthermore, the assessment of luminescence activity unveiled the potential of CQDs for biomedical imaging, particularly with upconversion luminescence. This presents opportunities for targeted cell identification and drug delivery. This study underscores

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• Mahatma Gandhi Marg, Lucknow 226001, India Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India Biomedical Applications Group, CSIR-Central Scientific Instruments Organisation, Sector 30C, Chandigarh 160030, India 10.3762/bjnano.15.56 Abstract Photothermal conversion of light

• absorb NIR/IR wavelengths show efficient heat-generating capability. It is due to the strong absorption and scattering of light from visible to NIR/IR region that has brought radical advancement in the field of biomedical sciences. The manifestation of longitudinal surface plasmon resonance (LSPR) at the

• biomedical soft materials [21]. Similarly, a very recent introduction of kappa-carrageenan (k-CG) into the field of nanotechnology has shown immense potential in the synthesis of plasmonic metal nanoparticles [22]. K-carrageenan is well known and is being used in several biomedical applications due to its

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• size on the probability to cross the BBB by using the endothelial brain cell method. The results indicated that the intracellular uptake of NPs strongly depends on the NP size. This characteristic has a direct impact on biomedical applications. When NPs serve as carriers for drug delivery through

Aero-ZnS prepared by physical vapor transport on three-dimensional networks of sacrificial ZnO microtetrapods

• Veaceslav Ursaki,
• Tudor Braniste,
• Victor Zalamai,
• Emil Rusu,
• Vladimir Ciobanu,
• Vadim Morari,
• Daniel Podgornii,
• Pier Carlo Ricci,
• Rainer Adelung and
• Ion Tiginyanu

Beilstein J. Nanotechnol. 2024, 15, 490–499, doi:10.3762/bjnano.15.44

• pollutants from the atmosphere and from water, in other catalytic processes, including photocatalytic water splitting, in energy production and storage, in microfluidic systems, in drug delivery and other biomedical applications, in sensing, in electronic, photoelectronic, optoelectronic and nanophotonic

Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection

• Le Hong Tho,
• Bui Xuan Khuyen,
• Ngoc Xuan Dat Mai and
• Nhu Hoa Thi Tran

Beilstein J. Nanotechnol. 2024, 15, 426–434, doi:10.3762/bjnano.15.38

• co-workers [23]. This restricts the applicability of Ag NPs in the biomedical field and leads to the requirement for more eco-friendly products. Recently, deep eutectic solvents (DESs) have been introduced to the chemical synthesis of nanomaterials. DESs show superior properties including high

• regarding the detection of NFT and SDZ, we demonstrate application aspects of our product, showing the great potential of DESs in sensing and biomedical applications. Results and Discussion Formation of Ag NPs-DES We have developed new and simple strategy to fabricate Ag NPs-DES in which ascorbic acid was

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• collaboration between chemistry, biomedical fields, nanomaterials science, and physics is needed to accurately control the shape, size, and morphology of metal-based nanoantioxidants for more specific accumulation. Classification of antioxidant nanomaterials. Multi-antioxidant activities of ceria nanoplates. (a

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• ’ magnetization cycle, as Bloch and Neel theorized [11][13]. Superparamagnetic iron oxide nanoparticles for drug delivery, diagnosis, and cancer therapy have gained wider acceptance in biomedical applications [14]. They have received notable attention in clinical applications such as early disease diagnosis (e.g

Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti

• Jonatas L. Duarte,
• Leonardo Delello Di Filippo,
• Anna Eliza Maciel de Faria Mota Oliveira,
• Rafael Miguel Sábio,
• Gabriel Davi Marena,
• Tais Maria Bauab,
• Cristiane Duque,
• Vincent Corbel and
• Marlus Chorilli

Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10

• ]. Biocompatibility assessment is an essential aspect of the development of NEs, particularly for biomedical and cosmetic applications, as it determines the safety and efficacy of the formulations. The assessment involves evaluating the potential cytotoxicity and genotoxicity of the NEs on different cell types and

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• Le Thi Le Hue Thi Nguyen Liem Thanh Nguyen Huy Quang Tran Thuy Thi Thu Nguyen Phenikaa University Nano Institute (PHENA), Phenikaa University, Hanoi 12116, Vietnam School of Material Science and Technology, Hanoi University of Science and Technology, Hanoi 11600, Vietnam Faculty of Biomedical

• cytotoxicity test revealed that the BBR NPs/PLA nanofiber scaffold did not induce any changes in morphology and proliferation of MA-104 cell monolayers. It suggests that the BBR/PLA and BBR NPs/PLA nanofiber scaffolds can be used in different biomedical applications, such as wound dressing, drug delivery

• strongly affect the release behavior of the drug from nanofiber scaffolds [14][17][18][19]. Polylactic acid (PLA), a synthetic polymer that has been approved by the FDA for biomedical usage, is commonly used for drug delivery systems due to its biocompatibility and biodegradability [20]. Yuan et al. [17

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• , drugs, metal nanoparticles, metal oxide nanoparticles, carbon nanotubes, or biomolecules. This is a very important advantage that opens ways of designing composite hydrogels with various properties and applications such as biomedical [8][9][10], biosensors [11][12][13], wearable electronics [14][15][16

• were tested for biomedical applications. Nevertheless, they show that the impedance trend that we obtained is similar to that of other hydrogel materials presented in the literature. Additionally, experimental EIS data was modelled with simple electrical equivalent circuit (insert in Figure 4a), where

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• Technological Innovation Laboratory - Department of Physiological Sciences, Biomedical Institute, R. Frei Caneca, 94, Rio de Janeiro, Brazil 10.3762/bjnano.15.2 Abstract Schistosomiasis causes over 200,000 deaths annually. The current treatment option, praziquantel, presents limitations, including low