Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• NIR CW irradiation corresponded to a typical hyperthermia of cells [51][52]. To investigate the role of folate targeting in photothermal cancer therapy, folate-positive HeLa cells were incubated with AuNR-PDA-R123-folate or AuNR-PDA-R123-PEG nanocomposites of different concentrations. After incubation

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• GNR@CdSe/ZnS@FA is better than CdSe/ZnS@FA, the in vitro imaging results confirm that these nanoparticles are suitable to be used for near-infrared imaging and cancer therapy. Conclusion We have developed a multifunctional nanomaterial GNR@CdSe/ZnS and enhanced the PL intensity using the surface

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

• Anouchka Plan Sangnier,
• Romain Aufaure,
• Laurence Motte,
• Claire Wilhelm,
• Erwann Guenin and
• Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

• , in the form of PTT, we first evaluated the specific photothermal properties of Au@alendronate NPs. In cancer therapy, it is desirable to use NPs that are active in the near-infrared (NIR) region to minimize light absorption of the laser radiation by surrounding tissues [27][34]. The plasmonic

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• short biological half-life (8–20 min). In addition, it has shown nonspecific toxicity in healthy cells. Also, rapid renal clearance, quick liver-mediated metabolism by dihydro-pyrimidine dehydrogenase (DPD) enzyme, and increased digestive distress restricts the use of 5-FU in cancer therapy. It was

Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules

• María Francisca Matus,
• Martín Ludueña,
• Cristian Vilos,
• Iván Palomo and
• Marcelo M. Mariscal

Beilstein J. Nanotechnol. 2018, 9, 1328–1338, doi:10.3762/bjnano.9.126

• ; reactive force field; Introduction In recent years, the use of drug delivery systems based on polymeric nanoparticles (NPs) has generated innovative therapeutic strategies for infection and immune diseases, as well as cancer therapy [1][2][3]. Polymeric NPs have shown significant advantages compared with

Enzymatically promoted release of organic molecules linked to magnetic nanoparticles

• Chiara Lambruschini,
• Silvia Villa,
• Luca Banfi,
• Fabio Canepa,
• Fabio Morana,
• Annalisa Relini,
• Paola Riani,
• Renata Riva and
• Fulvio Silvetti

Beilstein J. Nanotechnol. 2018, 9, 986–999, doi:10.3762/bjnano.9.92

• drug is typically released to the disease area through an unspecific mechanism. Another promising drug delivery approach in cancer therapy is directed enzyme prodrug therapy (DEPT) [4][5], where a prodrug is enzymatically converted into the active form by an enzyme which is localized close to the

Synthesis and characterization of noble metal–titania core–shell nanostructures with tunable shell thickness

• Bartosz Bartosewicz,
• Marta Michalska-Domańska,
• Malwina Liszewska,
• Dariusz Zasada and
• Bartłomiej J. Jankiewicz

Beilstein J. Nanotechnol. 2017, 8, 2083–2093, doi:10.3762/bjnano.8.208

• tunable optical properties depending on the ratio of core radius and shell thickness are an excellent example of such structures [3][4]. The CSNs, with either a silica core or shell, have found many applications due to their useful properties, including surface enhanced spectroscopy or cancer therapy [4

Near-infrared-responsive, superparamagnetic Au@Co nanochains

• Varadee Vittur,
• Arati G. Kolhatkar,
• Shreya Shah,
• Irene Rusakova,
• Dmitri Litvinov and
• T. Randall Lee

Beilstein J. Nanotechnol. 2017, 8, 1680–1687, doi:10.3762/bjnano.8.168

• -thermal cancer therapy [10][11][12][13]. Results and Discussion Morphology and composition of the Au@Co nanochains The synthesis of the Au@Co nanochains proceeded using wet-chemical methods via a galvanic replacement reaction [27]. Cobalt nanoparticles were used as templates for the nanochain synthesis

• -thermal cancer therapy. In addition, these nanochains are superparamagnetic at room temperature, which offers the capacity for manipulation under an external magnetic field. Because of their dual magneto-optical properties, our Au@Co nanochains can be used for both delivery and treatment, making them a

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• as well as other lipophilic anticancer drugs for cancer therapy. In addition, by formulating with anionic and cationic amphiphilic CDs, it will be possible to enhance anticancer activity of drugs, overcoming the problem of surfactant-induced toxicity. Finally, it can be said that polycationic

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

• Liga Saulite,
• Dominyka Dapkute,
• Karlis Pleiko,
• Ineta Popena,
• Simona Steponkiene,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2017, 8, 1218–1230, doi:10.3762/bjnano.8.123

• . There were successful attempts to use a similar quantum dot–chlorin e6 complex in photodynamic cancer therapy [15]. Another study has shown that QDs, conjugated with antibodies against CD44, a marker of cancer stem-like cells, can be selectively engulfed by breast cancer cells [16]. Such surface

Photocatalysis applications of some hybrid polymeric composites incorporating TiO₂ nanoparticles and their combinations with SiO₂/Fe₂O₃

• Andreea Laura Chibac,
• Tinca Buruiana,
• Violeta Melinte and
• Emil C. Buruiana

Beilstein J. Nanotechnol. 2017, 8, 272–286, doi:10.3762/bjnano.8.30

• , Li-ion batteries, sensors, photodynamic cancer therapy or in biomaterials [1][2][3][4][5][6][7]. Since 1972, when Fujishima and Honda published their seminal work [8], much work has been focused on investigating the photocatalytic properties of TiO2 [9]. Titanium dioxide catalysts proved to be better

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• increased its efficacy by sustained release to reduce drug crystallization [33]. These results suggested that MCNs might be a good drug delivery system for delivery of MIF for cancer therapy. Pharmacokinetic study In our previous study, we found MIF showed distinct pharmacokinetic differences between

• increase the anticancer activity of MIF in several cancer cell lines and improved the oral absorption of MIF in male rats. All these results suggest that the MCNs may be further developed as a potential delivery system for MIF for cancer therapy. Experimental Materials Chitosan (deacetylation degree of 90

Multiwalled carbon nanotube hybrids as MRI contrast agents

• Nikodem Kuźnik and
• Mateusz M. Tomczyk

Beilstein J. Nanotechnol. 2016, 7, 1086–1103, doi:10.3762/bjnano.7.102

• carbon nanotubes (CNT) drug and genetic material delivery, immunotherapy or photothermal cancer therapy [1][2]. The 'quantum leap' [3] of bionanomaterials has also affected magnetic resonance imaging (MRI). This technique, which has already matured into a basic diagnostic tool in medicine, has an edge

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• cell morphological features. Keywords: 1α,25-dihydroxyvitamin D3; calcitriol; cancer therapy; drug delivery; poly(lactic-co-glycolic acid); Introduction Vitamin D3, a secosteroid hormone produced through sunlight exposure [1], can be found with different chemical structures: calciol or

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• nanocomposites could provide a new therapeutic option to selectively target cancer cells. Keywords: cancer therapy; cytotoxicity; photo-oxidation; ZnO:Ag nanocomposites; Introduction Zinc oxide (ZnO) nanoparticles (NPs) exhibit an excellent photo-oxidation activity [1] and are considered as potential

Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy

• Shanka Walia and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2015, 6, 546–558, doi:10.3762/bjnano.6.57

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• structures have potential in cancer therapy [85]. To investigate in vivo biodistribution of the BNNTs, they were functionalized with GC then radiolabeled with 99mTc [86]. After 30 min of injection into mice, the BNNTs were in the systemic circulation and accumulated in the liver, spleen and intestinal

In situ metalation of free base phthalocyanine covalently bonded to silicon surfaces

• Fabio Lupo,
• Cristina Tudisco,
• Federico Bertani,
• Enrico Dalcanale and
• Guglielmo G. Condorelli

Beilstein J. Nanotechnol. 2014, 5, 2222–2229, doi:10.3762/bjnano.5.231

• ], catalysis [5], cancer therapy [6] and molecular electronics [3][7][8]. The most promising architecture for the exploitation of the potentialities of Pc and M–Pc is the organization of the molecules in a suitable and accessible way on a solid surface. Therefore, phthalocyanine thin films have been deposited

A study on the consequence of swift heavy ion irradiation of Zn–silica nanocomposite thin films: electronic sputtering

• Compesh Pannu,
• Udai B. Singh,
• Dinesh. C. Agarwal,
• Saif A. Khan,
• Sunil Ojha,
• Ramesh Chandra,
• Hiro Amekura,
• Debdulal Kabiraj and
• Devesh. K. Avasthi

Beilstein J. Nanotechnol. 2014, 5, 1691–1698, doi:10.3762/bjnano.5.179

• yield of Au from Au–silica nanocomposite on the size of Au nanoparticles. To the best of our knowledge, no reports are available on sputtering of Zn nanoparticles embedded in silica matrix by using SHI. Zn nanoparticles have great potential for application in several fields. These can be used in cancer

• therapy, anticorrosive coating and antimicrobial coatings, in chemical reaction as catalyst, galvanization of iron and steel [30][31]. Bulk Zn has a melting point of 419.6 °C and the melting point of Zn nanoparticle varies from 250 to 420 °C depending on the size of nanoparticle [32][33]. The melting

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

• Paula M. Castillo,
• Mario de la Mata,
• Maria F. Casula,
• José A. Sánchez-Alcázar and
• Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

• ; cancer therapy; iron oxide superparamagnetic nanoparticles; polyethylene glycol; Introduction Camptothecin (CPT) is a quinoline based alkaloid, which exhibits a potent cytotoxic activity against a broad spectrum of tumours [1][2][3]. While most antineoplastic agents inhibit cancer cell proliferation by

• undesirable side effects. Due to the combined impact of cancer together with adverse side effects of many conventional chemotherapeutic agents, a significant effort is devoted to the design of nanoparticle vectors for cancer therapy [8][9][10]. Concerning CPT, attempts to improve its solubility and stability

Organic and inorganic–organic thin film structures by molecular layer deposition: A review

• Pia Sundberg and
• Maarit Karppinen

Beilstein J. Nanotechnol. 2014, 5, 1104–1136, doi:10.3762/bjnano.5.123

• process; Leskelä et al. [25] shortly review the novel materials fabricated by ALD and MLD; George [26], George et al. [27] and Lee et al. [28] focus on metal alkoxide thin films; Yoshimura et al. [29] discuss a possibility to utilize MLD in cancer therapy applications; King et al. [30] describe fine

In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers

• Tianxun Gong,
• Douglas Goh,
• Malini Olivo and
• Ken-Tye Yong

Beilstein J. Nanotechnol. 2014, 5, 546–553, doi:10.3762/bjnano.5.64

• the NIR region so that heat is generated to damage cells and tissues. This property renders them useful for photothermal therapy and imaging of cancer [7][8]. In addition, the AuNRs surface can be functionalized with ligands for targeted drug delivery to support cancer therapy in vitro and in vivo [9

Plasma-assisted synthesis and high-resolution characterization of anisotropic elemental and bimetallic core–shell magnetic nanoparticles

• M. Hennes,
• A. Lotnyk and
• S. G. Mayr

Beilstein J. Nanotechnol. 2014, 5, 466–475, doi:10.3762/bjnano.5.54

• as powerful nanotools in many areas of biology, biophysics and medicine [1]. Possible applications include their use as contrast agents for cell tracking via magnetic resonance imaging (MRI) [2], as colloidal mediators in cancer therapy (hyperthermia) [3] or as nanocarriers for targeted drug delivery

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• , Nova Southeastern University, 3200 S. University Dr., Fort Lauderdale, FL 33328, USA Department of Basic and Applied Sciences, Galgotias University, UP, 201308, India 10.3762/bjnano.5.35 Abstract Background: In the past decade, researchers have focused on developing new biomaterials for cancer therapy

• hyperthermia (HT). HT is currently used in clinical trials for cancer therapy in combination with radiotherapy and chemotherapy. One of the potential problems of HT is that it can up-regulate hypoxia-inducible factor-1 (HIF-1) expression and enhance vascular endothelial growth factor (VEGF) secretion. Results

• is slow, thus taking a fairly long time to reach the targeted temperature (39–43 °C). Therefore, the comparison between incubator HT and laser/NP HT may provide important information on the effects of different modes of HT used in cancer therapy. In a previous publication, we described the in vivo

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• systems for cancer therapy. Gadolinium compounds are used in neutron capture therapy (NCT) as an alternative for boron-10 [6][7]. NCT is mainly associated with tumor-specific delivery systems and involves the production of localized cytotoxic radiations by a non-radioactive nuclide delivered to tumor

• fungus based approach for the synthesis of this material for the first time. We show that the thermophilic fungus Humicola sp. can be used for the synthesis of Gd2O3 nanoparticles at 50 °C. Since Gd2O3 nanoparticles have proved their value in site-specific drug delivery systems for cancer therapy, we