Wet-spinning of magneto-responsive helical chitosan microfibers

• Dorothea Brüggemann,
• Johanna Michel,
• Naiana Suter,
• Matheus Grande de Aguiar and
• Michael Maas

Beilstein J. Nanotechnol. 2020, 11, 991–999, doi:10.3762/bjnano.11.83

• polysaccharides such as alginate, hyaluronic acid or chitosan, are widely used as biocompatible materials since they are biochemically similar to the native extracellular matrix (ECM) [16]. Chitosan is a biopolymer that combines excellent biocompatibility, low toxicity and antibacterial properties with a low

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• commercial name Feraheme®. Although its indication is for the treatment of iron deficiency in patients with renal failure, it is also clinically used for MRI of adrenal glands and kidneys [183][184]. As they are composed of iron, a normal component of the human body, SPIONs are believed to have low toxicity

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• , semiconductor quantum dots suffer from toxicity and are susceptible to oxidation. In this context, atomically precise gold nanoclusters protected by thiol monolayers have emerged as a new class of luminescent nanomaterials. Low toxicity, bioavailability, photostability as well as tunable size, composition, and

• selective formation and imaging (Figure 8). Conclusion The unique chemical, optical and catalytic properties of gold nanoclusters have led to rapid progress in their application. This can be attributed to tunable photoluminescence, low toxicity, high bioavailability and renal clearance. The studies on

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• to be low-fouling to various proteins and negligibly cytotoxic. In a related work, the PEG-based films and capsules fabricated with redox responsive moieties via disulfide linkage showed high stability in biological buffers, low toxicity to human cells and low fouling characteristics [96]. Similar

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• question. It is of crucial importance for the overall safety and efficacy assessment that the internalization behavior of CPPs is evaluated. Furthermore, knowledge of the uptake mechanism can be essential for the development of CPP-delivery systems with cell-specificity and low toxicity. The complexity in

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency

• Arianna Gennari,
• Julio M. Rios de la Rosa,
• Erwin Hohn,
• Maria Pelliccia,
• Enrique Lallana,
• Roberto Donno,
• Annalisa Tirella and
• Nicola Tirelli

Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250

• as the cationic component in polyplexes and other drug delivery vehicles [1][2][3]. In comparison to other polycations, its main advantages are the low toxicity and its biodegradability. Biodegradation can occur both enzymatically and oxidatively [4]. A number of methods can be employed to prepare

• to 0.5 mg/mL in both models (Figure 5A). Despite the fragile nature of macrophages, the low toxicity seen for HA-coated chitosan nanoparticles is in accordance with what reported in RAW 264.7 macrophages for other HA-based nanomaterials, such as HA-coated liposomes [36] and a library of lipid

• evaluated their silencing efficiency when loaded with a functional anti-luciferase (anti-Luc) siRNA. To this end, cells were first pre-transfected with a luciferase-encoding plasmid (pGL3) using low-toxicity Lipofectamine (LTX) as a vector, and then treated with anti-Luc siRNA vectored either in

pH-Controlled fluorescence switching in water-dispersed polymer brushes grafted to modified boron nitride nanotubes for cellular imaging

• Saban Kalay,
• Yurij Stetsyshyn,
• Volodymyr Donchak,
• Khrystyna Harhay,
• Ostap Lishchynskyi,
• Halyna Ohar,
• Yuriy Panchenko,
• Stanislav Voronov and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2019, 10, 2428–2439, doi:10.3762/bjnano.10.233

• in several fields [1][2][3][4][6][7][11][12][13][14][15][16]. BNNTs were first synthesized by Chopra et al. [20] in 1995 and they are considered as the structural analog to CNTs. BNNTs are of particular interest due to their remarkable mechanical properties (e.g., Young’s modulus of 1.22 TPa) and low

• toxicity [21][22][23][24]. They are superhydrophobic in their pristine state and cannot be dispersed in aqueous media or in most organic solvents [11][22][23]. To improve the dispersibility of BNNTs in aqueous media, numerous surface functionalization methods have been used [11][25][26][27]. The

Polyvinylpyrrolidone as additive for perovskite solar cells with water and isopropanol as solvents

• Chen Du,
• Shuo Wang,
• Xu Miao,
• Wenhai Sun,
• Yu Zhu,
• Chengyan Wang and
• Ruixin Ma

Beilstein J. Nanotechnol. 2019, 10, 2374–2382, doi:10.3762/bjnano.10.228

• 0.1 cm2. The PCE continued to be over 80% of the initial PCE after 60 days of storage. FInally, the introduced PVP-doped PSCs present a low-cost and low-toxicity way to commercialize perovskite solar cells. Keywords: additive; lead nitrate aqueous solution; low-toxicity process; perovskite solar

• solar cells, and the preparation method is relatively simple. Overall, it is a low-cost, low-toxicity preparation method to commercialize perovskite solar cells. Experimental Materials Lead nitrate, polyvinylpyrrolidone, chlorobenzene and isopropanol were purchased from Aladdin. SnO2 colloid was

• performance of PSCs with PVP is characterized by a PCE of 15.19% and an average steady-state PCE of 14.55%. The solar cell with added PVP displayed a better stability in ambient air. Thus, a low-cost and low-toxicity method to commercialize perovskite solar cells has been presented. Fow chart of the

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• platforms, due to their biocompatibility and low toxicity compared to other nanomaterials, the concentration of 13C nuclear spins is diluted (1.1%) in the diamond unless they are enriched with an 13C isotope during growth, which is an expensive process. Used in bulk, a high-purity diamond can exhibit 13C T1

Green and scalable synthesis of nanocrystalline kuramite

• Andrea Giaccherini,
• Giuseppe Cucinotta,
• Stefano Martinuzzi,
• Enrico Berretti,
• Werner Oberhauser,
• Alessandro Lavacchi,
• Giovanni Orazio Lepore,
• Giordano Montegrossi,
• Maurizio Romanelli,
• Antonio De Luca,
• Massimo Innocenti,
• Vanni Moggi Cecchi,
• Matteo Mannini,
• Antonella Buccianti and
• Francesco Di Benedetto

Beilstein J. Nanotechnol. 2019, 10, 2073–2083, doi:10.3762/bjnano.10.202

• with a hydrazine-assisted solution process [12][13]) to 10.6% (using a vacuum process [14]) and 8% (obtained with an electrochemical process [15]). These multinary sulfides have extremely low toxicity, consist of earth-abundant elements [3] and can be obtained by means of processes that are more energy

Optimization and performance of nitrogen-doped carbon dots as a color conversion layer for white-LED applications

• Tugrul Guner,
• Hurriyet Yuce,
• Didem Tascioglu,
• Eren Simsek,
• Umut Savaci,
• Aziz Genc,
• Servet Turan and
• Mustafa M. Demir

Beilstein J. Nanotechnol. 2019, 10, 2004–2013, doi:10.3762/bjnano.10.197

• nanomaterials showing unique optical performance characterized by a wide wavelength tunability, high quantum yield and high photostability, while they show low toxicity and can be produced easily and at low cost [1][2][3][4][5]. The combination of such significant features renders CDots attractive for various

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

Highly ordered mesoporous silica film nanocomposites containing gold nanoparticles for the catalytic reduction of 4-nitrophenol

• Mohamad Azani Jalani,
• Leny Yuliati,
• Siew Ling Lee and
• Hendrik O. Lintang

Beilstein J. Nanotechnol. 2019, 10, 1368–1379, doi:10.3762/bjnano.10.135

• surfactant to form the material Mobil composition of matter (MCM)-41 [15]. Considering their low toxicity, their bio-degradable nature, and the fact that they are inexpensive and highly availability, non-ionic surfactants such as Brij [16] and Pluronic [17] block copolymers have also been employed as

Construction of a 0D/1D composite based on Au nanoparticles/CuBi₂O₄ microrods for efficient visible-light-driven photocatalytic activity

• Weilong Shi,
• Mingyang Li,
• Hongji Ren,
• Feng Guo,
• Xiliu Huang,
• Yu Shi and
• Yubin Tang

Beilstein J. Nanotechnol. 2019, 10, 1360–1367, doi:10.3762/bjnano.10.134

• materials promotes the dispersion and stability of 0D nanomaterials. Among the noble metal NPs, Au is considered to be one of the most promising materials because of its high photocatalytic activity, low toxicity and good biocompatibility [23][24][25]. In addition, size, shape and environment of the Au NPs

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method

• important advantage of WS2 (and of other TMDCs) nanostructures over their carbon equivalents is the low toxicity and biocompatibility, enabling their use for medical applications. Preliminary studies on rats with WS2 INTs and IFs showed no apparent toxic reaction after oral administration [18], inhalation

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• nanoparticles were of low toxicity and had bright luminescence, which make them suitable for biosensor and optical detection studies. Results and Discussion The scheme for the synthesis of GNR@CdSe/ZnS and GNR@CdSe/ZnS@FA is illustrated in Figure 1. Firstly, the CdSe/ZnS QDs bind with GNRs kept at a 5 nm

Characterization and influence of hydroxyapatite nanopowders on living cells

• Przemyslaw Oberbek,
• Tomasz Bolek,
• Adrian Chlanda,
• Seishiro Hirano,
• Sylwia Kusnieruk,
• Julia Rogowska-Tylman,
• Ganna Nechyporenko,
• Viktor Zinchenko,
• Wojciech Swieszkowski and
• Tomasz Puzyn

Beilstein J. Nanotechnol. 2018, 9, 3079–3094, doi:10.3762/bjnano.9.286

• responsible for detecting, ingesting and digesting cellular waste and microbes [79][80]. The viability results of the examined J774.1 cell line showed a small overall impact of the hydroxyapatite samples, with the exceptions of low toxicity of F202 at 300 µg/mL and a stronger toxic effect for HApSA+Si at 200

Impact of the anodization time on the photocatalytic activity of TiO₂ nanotubes

• Jesús A. Díaz-Real,
• Geyla C. Dubed-Bandomo,
• Juan Galindo-de-la-Rosa,
• Luis G. Arriaga,
• Janet Ledesma-García and
• Nicolas Alonso-Vante

Beilstein J. Nanotechnol. 2018, 9, 2628–2643, doi:10.3762/bjnano.9.244

• such as excellent chemical stability, photo-corrosion resistance, low cost, and low toxicity make TiO2 a material suitable for energy production and environmental applications, such as advanced oxidation processes for the decomposition of organic pollutants in water [2][3]. However, the material

Non-agglomerated silicon–organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties

• Asya S. Levina,
• Marina N. Repkova,
• Nadezhda V. Shikina,
• Zinfer R. Ismagilov,
• Svetlana A. Yashnik,
• Dmitrii V. Semenov,
• Yulia I. Savinovskaya,
• Natalia A. Mazurkova,
• Inna A. Pyshnaya and
• Valentina F. Zarytova

Beilstein J. Nanotechnol. 2018, 9, 2516–2525, doi:10.3762/bjnano.9.234

• known to degrade to orthosilicic acid, Si(OH)4, which is found in almost all human tissues and effectively excreted through the urine [9]. Organically modified silica nanoparticles are known for their low toxicity and biocompatibility and can be used for targeted imaging and therapy [10][11]. The

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• , retention, and low toxicity, as well as surface engineering with targeting moieties, can be used as a tool in enhancing the therapeutic efficacy of current approaches. Inorganic calcium phosphate nanoparticles have the potential to increase the therapeutic potential of antiproliferative drugs due to their

• showed a concentration-dependent toxicity on the cells irrespective of the cell lines used. In NIH 3T3 cells, considerably low toxicity was found (Figure 4A) with respect to cancer cells. The increased metabolism in cancer cells might be the reason for the enhanced cellular uptake [39] of the particles

Nanocellulose: Recent advances and its prospects in environmental remediation

• Katrina Pui Yee Shak,
• Yean Ling Pang and
• Shee Keat Mah

Beilstein J. Nanotechnol. 2018, 9, 2479–2498, doi:10.3762/bjnano.9.232

Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

• Alina M. Ermakova,
• Julia E. Morozova,
• Yana V. Shalaeva,
• Victor V. Syakaev,
• Aidar T. Gubaidullin,
• Alexandra D. Voloshina,
• Vladimir V. Zobov,
• Irek R. Nizameev,
• Olga B. Bazanova,
• Igor S. Antipin and
• Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195

• -buffered saline, the micelles of the macrocycle acquire thermoresponsive properties and exhibit a temperature-controlled release of doxorubicin in vitro. The combination of the low toxicity and the encapsulation properties of the obtained calixresorcinarene–mPEG conjugate shows promising potential for the

• various therapeutics and nanomaterials due to a number of benefits among which its low toxicity the most important [23][24]. PEG has good solubility in water and organic solvents. When being a component of polymeric micelles, it forms the outer hydrophilic shell of the micelle, contributes the colloidal

• increase of the release time of the drug bound by calixresorcinarene–PEG conjugate micelles. Thus, the aim of our investigation was synthesis of amphiphilic calixresorcinarene, functionalized by PEG fragments and the study of its potential as a low-toxicity supramolecular nanocontainer for drugs. Results

Fabrication of photothermally active poly(vinyl alcohol) films with gold nanostars for antibacterial applications

• Mykola Borzenkov,
• Maria Moros,
• Claudia Tortiglione,
• Serena Bertoldi,
• Nicola Contessi,
• Silvia Faré,
• Angelo Taglietti,
• Agnese D’Agostino,
• Piersandro Pallavicini,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2018, 9, 2040–2048, doi:10.3762/bjnano.9.193

• higher temperatures (ΔT > 40 °C) in the latter case [3][8][9][10]. Poly(vinyl alcohol) (PVA) polymer is also an attractive material for GNS-based film fabrication, as it displays a range of useful properties, namely, low toxicity, biocompatibility, hydrophilicity, chemical stability, and excellent film

Synthesis of rare-earth metal and rare-earth metal-fluoride nanoparticles in ionic liquids and propylene carbonate

• Marvin Siebels,
• Lukas Mai,
• Laura Schmolke,
• Kai Schütte,
• Juri Barthel,
• Junpei Yue,
• Jörg Thomas,
• Bernd M. Smarsly,
• Anjana Devi,
• Roland A. Fischer and
• Christoph Janiak

Beilstein J. Nanotechnol. 2018, 9, 1881–1894, doi:10.3762/bjnano.9.180

• and low toxicity [41]. Results and Discussion Decomposition of RE(amd)3 and Eu(dpm)3 Thermogravimetric analysis (TGA) revealed decomposition of the rare-earth metal(III) tris(N,N′-diisopropyl-2-methylamidinate) (RE(amd)3; RE = Pr(III), Gd(III), Er(III) and tris(2,2,6,6-tetramethyl-3,5-heptanedionato

Preparation of micro/nanopatterned gelatins crosslinked with genipin for biocompatible dental implants

• Reika Makita,
• Tsukasa Akasaka,
• Seiichi Tamagawa,
• Yasuhiro Yoshida,
• Saori Miyata,
• Hirofumi Miyaji and
• Tsutomu Sugaya

Beilstein J. Nanotechnol. 2018, 9, 1735–1754, doi:10.3762/bjnano.9.165

• of biological tissues and for the reinforcement of scaffolds. Genipin has low toxicity, being about 10,000 times less cytotoxic than other crosslinking agents, such as glutaraldehyde [47]. Crosslinking with genipin has been shown to result in an improvement in tensile strength, elastic modulus, and

• 500 nm height. Discussion Preparation of gelatin patterns In this study, we created gelatin surfaces with micro- to nanoscaled patterns using a mold and crosslinking with genipin, a low toxicity natural product. Gelatin or collagen patterning with genipin has been referred to in previously studies

• low toxicity, and biodegradable. Stability of the different gelatin patterns in cell culture medium A major finding from this study is that the stability of the different gelatin patterns in cell culture medium can be controlled by the degree of genipin crosslinking. In this preliminary study, our