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Search for "cells" in Full Text gives 1085 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review
Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22
- improved the antimicrobial activity of the nanofibers against a wide range of bacteria [190]. In tissue engineering applications, aligned fibers are particularly effective as they better mimic the inductive environment, such as that of human tendon stem/progenitor cells, compared to random fibers [191
- ]. Aligned fibers also guide human mesenchymal stem cells toward cardiomyogenesis and enhance myoblast differentiation [192][193]. Research has demonstrated that aligned nanofibers can accelerate the recovery of highly organized structures, such as nerve cells, tendons, and ligaments. Additionally, aligned
- nanofibers provide topographic guidance to cells, promoting cell adhesion, proliferation, and migration. Most importantly, aligned fibers are a prominent type of nanofiber that closely mimics the fibers in the ECM of native tissue [194]. Radially aligned nanofiber patches of chitosan/PVA with thyme essential
Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide
Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18
- aim to prepare nanocarriers with the potential to prolong the drug circulation time, cross the blood–brain–tumor barrier (BBTB), and provide targeted and controlled drug release in the brain tumor cells. Cytotoxicity and effects on cell membrane integrity of the blank and TMZ-loaded dual
- -functionalized carbon nanostructures (CNs) were evaluated in vitro on a GBM cell line (U87MG), as well as their radiosensitizing properties after exposure of the pre-treated GBM cells to gamma radiation with a standard clinical dose for patients with GBM. All prepared formulations underwent biopharmaceutical and
- suitable for crossing the BBTB and targeting brain cancer cells. A biphasic drug release profile was observed for all functionalized TMZ-loaded formulations in simulated in vivo conditions, with a sustained release pointing to the potential for controlled release of TMZ in brain tumor cells. The
Recent advances in photothermal nanomaterials for ophthalmic applications
Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16
- photothermal conversion of iron oxide minimizes the necessary laser energy. The mechanical force generated by laser-induced VNBs enables the selective destruction of single corneal cells. The PLA films aid in precisely positioning the photothermal therapy, restrain the dispersion of iron oxide nanoclusters
- sufficiently soft film to tightly cover the tissue can ensure direct contact between the VNBs produced by the film and tumor cells. The experimental results indicate that using more and higher-energy laser pulses produces more and larger vapor bubbles, which can kill cells at some distance from the film. A
- , aiding in the precise identification of treated areas. Au nanorods, when combined with anti-epithelial cell adhesion molecule (EpCAM), accurately target EpCAM+Y79 retinoblastoma cancer cells [108]. The targeted cells are deemed to be destroyed by VNBs induced by optimally parameterized femtosecond
Probing the potential of rare earth elements in the development of new anticancer drugs: single molecule studies
Beilstein J. Nanotechnol. 2025, 16, 187–194, doi:10.3762/bjnano.16.15
- chemotherapeutic drugs by characterizing the binding of three rare earths (ytterbium, neodymium, and erbium) to double-stranded DNA, which is one of the main targets for these drugs inside cells. The three elements presented a significant interaction with the biopolymer in buffers of physiological relevance
- interdisciplinary research to find, produce, and test drug candidates until they can reach the market [1][2]. Cancer chemotherapy, for instance, is a type of treatment that deserves improvements not only in the efficacy of the drugs employed to kill tumor cells, but also in reducing the occurrence of the well-known
- side effects related to these therapies. Actually, both aspects depend on the development of new drugs and/or drug carriers that can improve the selectivity of these anticancer agents to reach their specific targets inside tumor cells [3][4][5]. Although commonly used in a number of technological
Comparison of organic and inorganic hole transport layers in double perovskite material-based solar cell
Beilstein J. Nanotechnol. 2025, 16, 119–127, doi:10.3762/bjnano.16.11
- Deepika K Arjun Singh Department of Applied Sciences, The Northcap University, Gurugram, India 10.3762/bjnano.16.11 Abstract Perovskite solar cells (PSCs) are in the focus of the photovoltaic industry. Lead-free double perovskite solar cells (DPSCs) have become an essential alternative of lead
- , that is, La2NiMnO6 (LNMO), is studied with the organic and inorganic hole transport layers (HTLs) Cu2O and PEDOT:PSS. Our study yields a significant improvement in the power conversion efficiency (PCE) of perovskite solar cells with two types of HTLs. The optimized devices achieved a maximum PCE of
- % Mn doping and an Eu compact layer, an efficiency of 4.20% was obtained. Currently, perovskite solar cells (PSCs) are attracting the attention of research communities worldwide because of their outstanding and unique properties. PSCs possess desirable characteristics such as cost-effectiveness
Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy
Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10
- from research to clinical application faces significant hurdles, primarily due to interactions with the mononuclear phagocyte system (MPS). After administration in host bodies, NCs encounter systems of phagocytic cells, predominantly resident macrophages such as Kupffer cells (KCs) in the liver and
- macrophages and the challenges of NC filtering by the MPS and conclude with innovative strategies to exploit these interactions for therapeutic benefit. 2 Physiological functions of macrophages 2.1 Macrophage origin and functions Macrophages are immune cells derived from the yolk sac, fetal liver in mice, or
- strong pro-inflammatory response. These cells release cytokines such as tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β, essential for pathogen clearance and initiating immune defense mechanisms [19]. However, if an inflammation remains active for extended periods, it can contribute to
Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258
Beilstein J. Nanotechnol. 2025, 16, 78–89, doi:10.3762/bjnano.16.8
- . ZnO NPs are known to generate reactive oxygen species (ROS), including hydroxyl radicals and superoxide ions, upon interaction with bacterial cells. These ROS disrupt bacterial cell membranes, cause oxidative stress, and damage cellular components, ultimately leading to cell death. Additionally, ZnO
- NPs can release Zn2+ ions, which interact with bacterial enzymes and proteins, further compromising cellular functions. The small size and high surface area of the nanoparticles enhance their interaction with bacterial cells, improving antibacterial efficacy. Significant inhibitory effects against S
- the given bacteria. Regarding antiproliferative effects, our study exhibited an average IC50 value of 98.53 µg/mL against HT-29 cell lines. In contrast, Mohd Yusof et al. [9][23] evaluated cell viability using the MTT assay on Vero cells, revealing viability at concentrations from 100 µg/mL at 24 h
Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research
Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7
- professional antigen-presenting cell (APC) models using unmodified SiO2 nanomaterials [50] compared with differently surface-functionalised particles [51]. As a model for APCs, monocyte-derived dendritic cells were generated from human whole blood samples as a preliminary step, again building a BIODA-type of
Theoretical study of the electronic and optical properties of a composite formed by the zeolite NaA and a magnetite cluster
Beilstein J. Nanotechnol. 2025, 16, 44–53, doi:10.3762/bjnano.16.5
- in two different unit cells is possible because there exists a linear operator and its inverse that allow us to go from a trigonal to a cubic cell representation and vice versa. Figure 2a and Figure 2b display the structures and Fe–O bond distances of a magnetite cluster in both the isolated form and
- spectrum. Geometry and Fe–O bond lengths for a magnetite cluster under two different conditions: (a) outside the NaA zeolite and (b) inside the NaA zeolite. Bond lengths are in angstroms. The optimized NaA-M composite is represented by two different types of cells: (a) a trigonal cell and (b) a cubic cell
A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery
Beilstein J. Nanotechnol. 2025, 16, 11–24, doi:10.3762/bjnano.16.2
- , indicating no agglutination (K(−), Figure 3). The positive control (K(+), Figure 3) displayed agglutinated cells (mixture of erythrocytes of blood groups IV and II) evenly distributed in the well. The results revealed that CA-RA exposure to blood samples did not induce agglutination across a wide
- antidote delivery. Under healthy conditions, with a neutral pH and normal glucose concentrations, the nanocarrier is found to be stable. The employed resorcinarenes and the nanocarrier exhibit good hemocompatibility and low cytotoxicity with respect to human embryonic lung cells (WI38) and a healthy liver
- Cytell Cell Imaging multifunctional system (GE Healthcare Life Science, Sweden) [38]. The experiments utilized a Chang liver cell line (human liver cells) from the N.F. Gamaleya National Research Center for Epidemiology and Microbiology and a cell culture of WI-38 VA 13 subline 2RA (human embryo lung
Mechanistic insights into endosomal escape by sodium oleate-modified liposomes
Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131
- .15.131 Abstract Endosomal entrapment significantly limits the efficacy of drug delivery systems. This study investigates sodium oleate-modified liposomes (SO-Lipo) as an innovative strategy to enhance endosomal escape and improve cytosolic delivery in 4T1 triple-negative breast cancer cells. We aimed to
- reduction of resazurin to resorufin by metabolically active cells. The data reveal that Unmodified-Lipo exhibited minimal cytotoxicity at lower lipid concentrations (15.625 to 250 µM), with no statistically significant differences compared to untreated control cells (p > 0.05). However, at a concentration
- candidate for drug delivery applications. The data support the use of SO as a safe modification in liposomal formulations, particularly in contexts where minimizing cytotoxicity is paramount. Cellular uptake The cellular uptake of DiD-labeled liposomes (Unmodified-Lipo, SO-Lipo, and AUR-Lipo) in 4T1 cells
Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification
Beilstein J. Nanotechnol. 2024, 15, 1654–1666, doi:10.3762/bjnano.15.130
- are increasingly interested in studying the protein corona on extracellular vesicles (EVs), mainly exosomes, which play an important role in the transmission of molecular signals in the body. The influence of the protein corona on EVs on their interaction with body cells, including cells of the immune
Heterogeneous reactions in a HFCVD reactor: simulation using a 2D model
Beilstein J. Nanotechnol. 2024, 15, 1627–1638, doi:10.3762/bjnano.15.128
- –metal devices exhibiting blue and white electroluminescence [7][8]. It was found that these films exhibit photoconductive and photoelectric effects suitable for electroluminescence and photovoltaics applications [9][10], as well as for other applications such as solar cells and anodes for Li batteries
Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications
Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127
- Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in the treatment of various complex human diseases. This strategy enhances drug delivery by leveraging the innate properties of cellular components, thereby improving biocompatibility and
- replicating the characteristics or functions of native cells [19]. Nanoparticle coating involves obtaining nanoparticles (Figure 1-2A), which can be organic or inorganic in structure (Figure 2A), and conjugating them with functional ligands (Figure 1-2B) or biological structures, such as cell membranes
- -based nanocarriers is understanding the fundamental building blocks, size, shape, and biological properties to mimic real cells and enable their internalization [31][32]. One efficient strategy for producing biomimetic nanocarriers involves camouflage with biological membranes. The phospholipids
Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties
Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126
- . Macroscopically observable mucilage is often a transparent, gel-like capsule formed around the diaspore after hydration with water (Figure 1). At the microscale mucilage exhibits, before hydration, successive layers formed by adcrustation in the mucilaginous cells of the seed/fruit coat (the outermost covering of
- hydration [8][22][38]. Mucilage, which is produced by the mucilaginous cells of diaspores in a form of densely packed layers, has the ability of loosening its structure after hydration into an easily accessible 3D fibrillar network [7][13][14][39] (Figure 3 and Figure 4 below). One of the key components of
- typical part of plant cells, and its basic chemical composition includes cellulose, hemicelluloses, and pectic polysaccharides [44][45][46][47]. Cellulose is a linear polymer composed of β-1,4-linked ᴅ-glucose [47]. The cellulose chains are held together by intramolecular hydrogen bonds, forming cellulose
Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility
Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125
- particles have been identified as 80–90% in the liver, 5–8% in the spleen, and 1–2% in the bone marrow [30]. One of the major organs where nanoparticles are likely to accumulate, depending on the route of administration, is the liver [31][32][33], where Kupffer cells can quickly uptake large nanoparticles
- , lysosomes, the Golgi apparatus, and the endoplasmic reticulum [44][45]. Wu and colleagues found that Fe3O4 NPs up to 5 nm in size can penetrate cells and initiate the Fenton reaction, resulting in the formation of genotoxic •OH radicals [20]. Moreover, iron overload in cells can lead to ferroptosis [46][47
- Fe3O4 NPs on liver tissue revealed practically no direct hepatotoxic properties. Increases in ALT and AST activities in some groups (Figure 1 and Figure 2) may be associated with effects of these agents also on the mitochondria of other cell types. Toxicity in cells leads to weakened mitochondrial
Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123
- vectors are nanomaterials or nanomaterial-based formulations as so-called nanopesticides, providing new, modern, and low-cost formulations [9][10] with the ability to penetrate through the exoskeleton into mosquito cells, causing mortality after binding to proteins or DNA [11]. Nanomaterials provide
- of toxicity of AgNPs in mosquito larvae has recently been reported (Figure 3). The small size of AgNPs is linked to two pathways of action. First, AgNPs can pass through the insect cuticle and penetrate individual cells. The second way is the ingestion of AgNPs by larvae through their generalist
- eating habits. For both pathways, damage to the midgut, epithelial cells, and cortex in mosquito larvae can be observed, resulting in physiological changes such as shrinkage in the abdominal region, change in the shape of the thorax and loss of lateral hairs, oral brushes, and anal gills. These processes
Ultrablack color in velvet ant cuticle
Beilstein J. Nanotechnol. 2024, 15, 1554–1565, doi:10.3762/bjnano.15.122
- role in thermal regulation [32]. Additionally, previous studies have suggested a potential association between dark colors in velvet ants and photoprotection [16]. In this case, the dark cuticle would function as a radiation filter to prevent ultraviolet radiation from reaching the cells underneath
The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential
Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121
- -across and QSPR, has been recently introduced and applied to the prediction of NM cytotoxicity [44], power conversion efficiency of organic dyes in dye-sensitized solar cells [45][46], detonation heat for nitrogen containing compounds [47], and to the prediction of surface area of perovskite materials
Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies
Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118
- improve the selective delivery of drugs/phytochemicals to specific tissues or cells. A site-specific targeting approach enhances the therapeutic efficacy of phytochemicals and reduces systemic toxicity. In addition to enhancing solubility and targeting, PLHNPs offer controlled release properties that are
- in the distribution of phytochemicals throughout the body rather than targeting specific tissues or cells. Non-specific distribution increases the risk of off-target effects and systemic toxicity, reducing the concentration of the phytochemical at the desired site of action and decreasing therapeutic
- , prolongs their circulation time in the body, and enhances their therapeutic effectiveness [42][43]. Additionally, surface engineering of PLHNPs with different ligands facilitates specific delivery of drug/phytochemicals to desired tissues or cells, reduces their adverse effects, and improves their
Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model
Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117
- simulations reveals that the critical irradiation dose for nanocrystallinity collapse varies among different simulation cells. Not only the size, but also the crystallographic orientation, shape of the grains, and structure of the grain boundaries have a strong impact on the stability of the nanocrystalline
- phase [7]. In all cells, the grains undergo a phase transition from a pure high-density fcc phase to a mixture of fcc and bcc phases during prolonged irradiation. These simulations confirm that the phase transition occurs because of the ground-state energies of the compositions rather than the
Strain-induced bandgap engineering in 2D ψ-graphene materials: a first-principles study
Beilstein J. Nanotechnol. 2024, 15, 1440–1452, doi:10.3762/bjnano.15.116
- unchanged under the influence of mechanical strain, preserving its initial characteristic of having a direct bandgap. This behavior offers opportunities for these materials in various vital applications in photodetectors, solar cells, LEDs, pressure and strain sensors, energy storage, and quantum computing
- that remains unchanged under mechanical strain. This outcome offers various critical applications of ψ-graphane in photodetectors, solar cells, LEDs, pressure and strain sensors, energy storage, and quantum computing. The mechanical strain tolerance of pristine and fully hydrogenated ψ-graphene is
- space group P2mg [39]. The unit cell of ψ-graphene contains 12 carbon atoms. In comparison, the unit cells of ψ-graphone and ψ-graphane consist of 12 carbons and six hydrogens and 12 carbons and 12 hydrogen atoms, respectively (Figure 1) [38][39]. For the sampling of the Brillouin zone, we used a well
Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control
Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114
- wavelength-selective nature of DBRs makes them particularly attractive for solar cell applications, where the ability to control the absorption spectrum can lead to significant performance improvements [38][39][40]. Colloidal quantum dot (CQD) solar cells are attracting significant research due to their
- potential as a next-generation photovoltaic technology [41][42]. These cells offer a compelling alternative to traditional silicon solar cells because of the low manufacturing cost. Additionally, CQDs possess a unique property – their bandgap can be tuned by adjusting the size of the dots. This allows them
- to capture a wider range of sunlight compared to traditional materials, potentially leading to higher solar energy conversion efficiency [43]. Bae et al. focussed on lead sulfide (PbS) CQDs solar cells where they addressed the major challenge of charge carrier recombination which limits the
Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals
Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113
- considered a challenge because of the existence of the blood–brain barrier (BBB, Figure 1), which is composed of several cell types [7]. The BBB is a dynamic and selective interface between the systemic circulation and the brain [8]. The structure of the healthy BBB relies on the endothelial cells and the
- tight barrier formed using tight junctions [9][10][11]. These are surrounded by other cell types, such as astrocytes and pericytes. Astrocytes are crucial for the formation and maintenance of the BBB, which leads to an adequate association between the cells and the BBB. Pericytes are also important
- regulatory cells for the homeostasis of the BBB. The interaction between astrocytes and pericytes plays a vital role in brain vasculogenesis and the maintenance of the BBB [12]. Overall, the high selectivity of the BBB provides optimal conditions for CNS homeostasis [13]. Because of the presence of the BBB
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