Liquid-crystalline nanoarchitectures for tissue engineering

• Baeckkyoung Sung and
• Min-Ho Kim

Beilstein J. Nanotechnol. 2018, 9, 205–215, doi:10.3762/bjnano.9.22

• striving for decades to invent biocompatible LC nanostructures for biomedical applications [6][7]. These works cover medical imaging and spectroscopy instruments [8][9], diagnostic biosensors [10], microlens devices [11], soft actuators [12][13], and drug delivery systems [14][15]. On the other hand, LCs

• [36] and drug delivery systems [37]. For tissue regeneration, the mostly studied biomaterials are collagen and chitin, which are, respectively, protein-based and glucose-based biopolymers [38][39]. When denatured, collagen and chitin can be transformed into gelatin and chitosan, respectively, which

• morphology control, which can be further extended to directed cell differentiation. Moreover, the tissue-mimectic characteristics of LC biomaterials can be exploited for fabricating artificial organs-on-a-chip and bioinspired drug delivery systems. The tunable optical response of biological LC materials is

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective

• derivatives provide suitable nanometer-sized drug delivery systems for safe and efficient intravenous paclitaxel delivery for chemotherapy. In the light of these studies, it can be said that amphiphilic cyclodextrin nanoparticles of different surface charge can be considered as a promising alternative for

• several factors that influence the particle size, particle distribution, surface charge, homogeneity and shape of nanometer-sized drug delivery systems. These factors have a subsequent influence on the biodistribution and the fate of the nanomedicine in the body [27]. In this case, the formulation

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to

• [4][5][6][7][8][9]. It is possible to bypass the BBB and reach the tumor site directly with implantable drug delivery systems such as Gliadel®, which is the chemotherapeutic drug carmustine-loaded wafer implant. These drug delivery systems can be implanted after surgical removal of the tumor

• agents to the tumor site, while avoiding possible side effects. The development of novel drug delivery systems with reduced side effects is an important breakthrough and nanoparticles are promising in this field as they enable localized drug delivery to target sites and enhanced cellular uptake

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• complex drug delivery systems at the tumor site would minimize systemic resorption and deleterious effects to healthy tissues. Carbon nanomaterials such as CNFs and CNTs represent a much investigated option for such biomedical applications. In addition to facilitate a passive targeting, various studies

• chemoresistant cells to conventional chemotherapeutics and thus make them more prone to the cytotoxic drug effects [17][28]. One limiting factor for the application of carbon nanomaterials as drug delivery systems are their toxicity owing to their small size and structural resemblance to asbestos [33][42]. In

• ][44]. Consequently, a local application of nanomaterial-based drug delivery systems directly to the tumor site would limit their systemic resorption and thus adverse effects to other organs. Conclusion In this study we could demonstrate that the anti-proliferative and pro-apoptotic effects of two

Modeling adsorption of brominated, chlorinated and mixed bromo/chloro-dibenzo-p-dioxins on C₆₀ fullerene using Nano-QSPR

• Piotr Urbaszek,
• Agnieszka Gajewicz,
• Celina Sikorska,
• Maciej Haranczyk and
• Tomasz Puzyn

Beilstein J. Nanotechnol. 2017, 8, 752–761, doi:10.3762/bjnano.8.78

• applications, including sorbents, cancer therapeutics, drug delivery systems, computer sensors, etc. [16][17][18][19]. With the further development of nanotechnology, C60 will be produced and used in large amounts. Over time, fullerene structures will be found in the environment more often and in higher

Dispersion of single-wall carbon nanotubes with supramolecular Congo red – properties of the complexes and mechanism of the interaction

• Anna Jagusiak,
• Barbara Piekarska,
• Tomasz Pańczyk,
• Małgorzata Jemioła-Rzemińska,
• Elżbieta Bielańska,
• Barbara Stopa,
• Grzegorz Zemanek,
• Janina Rybarska,
• Irena Roterman and
• Leszek Konieczny

Beilstein J. Nanotechnol. 2017, 8, 636–648, doi:10.3762/bjnano.8.68

• ]. Functionalization also allows for the attachment of biologically active molecules – e.g., drugs, nucleic acids, antibodies or ligands for cell-surface receptors. This is especially important for targeted drug delivery systems based on CNT [13][15][18][19][20][21]. Noncovalent functionalization of CNTs is usually

• nanotubes (SWNTs) are currently intensely studied as promising drug delivery systems for cancer therapies due to such their properties as: the ability to penetrate cell membrane [16][17], high drug capacity [8][9], selective retention in the tumour [21], reduced toxic effects of the drug [5][20]. The major

• therapy. The aim of our studies is to explain whether CR-functionalized SWNTs could be used as drug delivery systems. Molecular dynamics study of SWNT–CR interactions has already been published [39]. These authors studied several combinations of parameters in order to assess how the SWNT diameter and CR

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• micellar structures of different types in micellar anionic surfactant solutions (sodium dodecyl sulfate) was determined. These findings are of practical importance and are of potential interest for the design of drug delivery systems and new nanomaterials. Keywords: drug delivery systems; dyes; isoindigo

• types of mixed surfactant–isoindigo derivative assemblies. The data obtained are expected to contribute to the development of nanodevices with interesting optical properties and pharmacological applications as drug delivery systems. Experimental Materials 1-Phenylazo-2-naphthol (Sudan I, Acros Organics

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• gelation technique (Figure 1). This technique has been widely used to prepare CNs as drug delivery systems for a variety of drugs, including either hydrophobic drugs or hydrophilic protein drugs [22][24]. Because of the strong hydrophobicity of MIF, it is hard to load MIF into blank CNs after the ionic

Influence of hydrothermal synthesis parameters on the properties of hydroxyapatite nanoparticles

• Sylwia Kuśnieruk,
• Jacek Wojnarowicz,
• Agnieszka Chodara,
• Tadeusz Chudoba,
• Stanislaw Gierlotka and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2016, 7, 1586–1601, doi:10.3762/bjnano.7.153

• and investors. Hydroxyapatite is characterized by its biocompatibility and osteoconductivity. The material has been commonly and successfully used in regenerative medicine and in drug delivery systems [3][4]. Nanostructured hydroxyapatite particles can be applied as building blocks for damaged enamel

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

• Yue Zhang and
• Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

• easily find them in, e.g., cosmetics [1], food additives [2], industrial process [3] and, especially, in medical therapy [4] and diagnostics [5]. In light of medical therapy, NPs have shown their extraordinary potential in cancer chemotherapeutics [6] and drug delivery systems [7], which successfully

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• -induced heart failure, which is mainly associated with the process of the reactive oxygen species formation as well as the formation of hydroxyl radicals by free iron cations in the Fenton reaction [4]. Therefore, numerous studies focus on the application of different drug delivery systems (DDS) to

• transport daunorubicin to cancer cells [5]. Drug delivery systems are aimed at providing enhanced transport of therapeutic agents directly to the targeted organs and tissues, which enables the elimination or significant decrease in the side effects of a drug. One of the most common type of drug nanocarriers

• -stranded DNA or RNA sequences showing high specificity and affinity to their targets, which were employed as molecular targeting agents for targeted drug transport. Carbon nanotubes (CNTs) are among the promising drug delivery systems. They attract scientists’ attention due to their properties such as

Surface coating affects behavior of metallic nanoparticles in a biological environment

• Darija Domazet Jurašin,
• Marija Ćurlin,
• Ivona Capjak,
• Tea Crnković,
• Marija Lovrić,
• Michal Babič,
• Daniel Horák,
• Ivana Vinković Vrček and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 246–262, doi:10.3762/bjnano.7.23

• delivery systems [4]. The biomedical applications of AgNPs and SPIONs imply uptake into the body, which consequently leads to interactions with protein-containing biological fluids [5][6]. Therefore, it is of increasing interest to systematically collect detailed information on their physicochemical

• great interest for application in a variety of other commercial products, such as mobile phones, textiles, food storage containers, refrigerators, and cosmetics [1][2]. SPIONs are exploited in numerous in vitro and in vivo biomedical applications, but the most important is their use in imaging and drug

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

• Manuel Häuser,
• Klaus Langer and
• Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

• use of nanoparticles as drug delivery systems has been intensively investigated and important progress has been made within the past decades, establishing reliable methods for particle preparation and characterization. Formation of nanostructures based on different materials, such as metals [1

• ], mineral compounds [2], proteins [3], and a large variety of polymers [4] is widely used in numerous scientific fields. The assembly of biocompatible nanoparticle preparation deserves special attention, if the aim is to apply these nanoparticles as drug delivery systems in vivo. A commonly used polymer

Silica-coated upconversion lanthanide nanoparticles: The effect of crystal design on morphology, structure and optical properties

• Uliana Kostiv,
• Miroslav Šlouf,
• Hana Macková,
• Alexander Zhigunov,
• Hana Engstová,
• Katarína Smolková,
• Petr Ježek and
• Daniel Horák

Beilstein J. Nanotechnol. 2015, 6, 2290–2299, doi:10.3762/bjnano.6.235

• widespread applications as drug delivery systems in the diagnosis and treatment of various diseases [1][2]. Recently, upconversion nanoparticles have shown promise as optical materials [3] and a number of reviews [4][5][6] have described their applications in drug and gene delivery [7], cell labeling and

Electroviscous effect on fluid drag in a microchannel with large zeta potential

• Dalei Jing and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2015, 6, 2207–2216, doi:10.3762/bjnano.6.226

• -mechanical systems (MEMS/NEMS) have been realized and widely used. As a significant branch of MEMS/NEMS, micro/nanofluidic systems incorporating micro/nano pumps, valves, mixers, and channels have wide applications, such as micro heat exchangers, drug delivery systems, and lab-on-a-chip bioanalysis [1][2

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• ; nanofibrous carriers; needle-free electrospinning; release kinetics; Introduction To date, numerous drug delivery systems have been developed, such as hydrogels that carry drugs or highly sophisticated electronic microchips [1][2]. The required release rates of the therapeutic agents depend on the medicinal

Atomic scale interface design and characterisation

• Carla Bittencourt,
• Chris Ewels and
• Arkady V. Krasheninnikov

Beilstein J. Nanotechnol. 2015, 6, 1708–1711, doi:10.3762/bjnano.6.174

• , where these nanomaterials have been used as substrates for neural growth, as drug delivery systems and as electrodes for both extra cellular recordings and for in vivo recordings [21]. Finally, although carbon is often seen as the “poster child” of nanomaterials, it is important not to forget the

Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer

• Ying Huang,
• Jing Ma,
• Alan L. Porter,
• Seokbeom Kwon and
• Donghua Zhu

Beilstein J. Nanotechnol. 2015, 6, 1666–1676, doi:10.3762/bjnano.6.169

• conjugates and so on [6][7][8]. Among these, the brain tumor-targeting drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in the normal brain and peripheral tissue, are a promising new approach [9]. Collaboration fosters interactions between different actors

Structural and magnetic properties of iron nanowires and iron nanoparticles fabricated through a reduction reaction

• Marcin Krajewski,
• Wei Syuan Lin,
• Hong Ming Lin,
• Katarzyna Brzozka,
• Sabina Lewinska,
• Natalia Nedelko,
• Anna Slawska-Waniewska,
• Jolanta Borysiuk and
• Dariusz Wasik

Beilstein J. Nanotechnol. 2015, 6, 1652–1660, doi:10.3762/bjnano.6.167

• inexpensive, a lot of them are biocompatible and low-toxic, it makes them very interesting from an application point of view. So far, they have been applied in many biomedical applications including magnetic resonance imaging (MRI) contrast enhancements [1], direct drug delivery systems [2], hyperthermia

• different applications. For instance, in the case of drug delivery systems nanostructures need to exhibit rather superparamagnetic behaviour with low coercivity. On the other hand, in the case of magnetic recording media there are needed materials with a high value of coercivity. Thus, it is very important

Peptide-equipped tobacco mosaic virus templates for selective and controllable biomineral deposition

• Klara Altintoprak,
• Axel Seidenstücker,
• Alexander Welle,
• Sabine Eiben,
• Petia Atanasova,
• Nina Stitz,
• Alfred Plettl,
• Joachim Bill,
• Hartmut Gliemann,
• Holger Jeske,
• Dirk Rothenstein,
• Fania Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2015, 6, 1399–1412, doi:10.3762/bjnano.6.145

• example, as a structural modifier or filler in rubber [1], food [2][3] or healthcare products [4], bioceramics for medical purposes [5], mesoporous nanoparticulate or tubular drug delivery systems as reviewed in [6], sensor surfaces [7], or biocatalytic formulations as reviewed in [8]. An important focus

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• discussed drawbacks continue to be highlighted as major challenges in developing formulations for clinical use. To overcome some of these limitations, we propose drug delivery systems for new calcitriol formulations. These nanosystems, namely nanoparticles (NPs), must meet several requirements such as

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• manifold. For example, nanomaterials find application in surgical implants to improve tissue formation or due to their antibacterial action, they may be useful for gene or drug delivery systems as well as diagnostic imaging tools [3][4][5][6][7]. On the other hand, due to the entirely new properties of NP

Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes

• Julia M. Tan,
• Jhi Biau Foo,
• Sharida Fakurazi and
• Mohd Zobir Hussein

Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23

• carriers for proteins and pharmaceuticals to treat diseases by Bangham and Horne in the 1960s [1]. Since then, multidisciplinary researchers have been actively investigating advanced drug delivery systems by directing drugs and/or carriers with sustained release properties directly to a the specific site

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

• Cornelia Loos,
• Tatiana Syrovets,
• Anna Musyanovych,
• Volker Mailänder,
• Katharina Landfester,
• G. Ulrich Nienhaus and
• Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

• new drug delivery systems and predict functionalization-dependent health hazards that nanoparticles might exhibit. Polystyrene synthesis. Spinning disc confocal microscopy of acute monocytic leukemia THP-1 cells, differentiated THP-1 cells, and human macrophages. Cell membranes are stained with

Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

• Matthias G. Wacker,
• Mahmut Altinok,
• Stephan Urfels and
• Johann Bauer

Beilstein J. Nanotechnol. 2014, 5, 2259–2266, doi:10.3762/bjnano.5.235

• Technische Universität Darmstadt, Technical Chemistry, D-64287 Darmstadt, Germany Merck KGaA, D-64287 Darmstadt, Germany 10.3762/bjnano.5.235 Abstract Human serum albumin nanoparticles have been utilized as drug delivery systems for a variety of medical applications. Since ultra-small superparamagnetic