Silicon microgrooves for contact guidance of human aortic endothelial cells

• Sara Fernández-Castillejo,
• Pilar Formentín,
• Úrsula Catalán,
• Josep Pallarès,
• Lluís F. Marsal and
• Rosa Solà

Beilstein J. Nanotechnol. 2017, 8, 675–681, doi:10.3762/bjnano.8.72

• that allows one to link bioconjugators such as collagen [30]. Collagen is an attractive tool for biomedical applications as it is the most abundant protein in mammalian tissues [31]. We have recently reported the development of collagen-coated silicon-based microstructures, classified as nanoporous

Dispersion of single-wall carbon nanotubes with supramolecular Congo red – properties of the complexes and mechanism of the interaction

• Anna Jagusiak,
• Barbara Piekarska,
• Tomasz Pańczyk,
• Małgorzata Jemioła-Rzemińska,
• Elżbieta Bielańska,
• Barbara Stopa,
• Grzegorz Zemanek,
• Janina Rybarska,
• Irena Roterman and
• Leszek Konieczny

Beilstein J. Nanotechnol. 2017, 8, 636–648, doi:10.3762/bjnano.8.68

• and form supramolecular and protruding structures. This explains the high CR binding capacity of carbon nanotubes. The presented system – containing SWNTs covered with CR – offers a wide range of biomedical applications. Keywords: Congo red; single-wall carbon nanotubes; supramolecular compounds

Comparison of four methods for the biofunctionalization of gold nanorods by the introduction of sulfhydryl groups to antibodies

• Xuefeng Wang,
• Zhong Mei,
• Yanyan Wang and
• Liang Tang

Beilstein J. Nanotechnol. 2017, 8, 372–380, doi:10.3762/bjnano.8.39

• biomedical applications. Given that thiol moieties have a high affinity to conjugate with gold surfaces via Au–S bonds, chemically modifying biological molecules, such as antibodies, which anchors them to gold surface through Au–S interaction, is regarded as attractive. In our previous work, we reported a

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• electrical properties [1][2][3][4][5]. This makes possible to develop new technologies for biodiagnostics, biomedical applications, including photothermal therapy [6][7][8], study of biomembranes [9] and dynamically probing cells [10][11]. (ii) These heterocyclic compounds found applications in various

Functionalized TiO₂ nanoparticles by single-step hydrothermal synthesis: the role of the silane coupling agents

• Antoine R. M. Dalod,
• Lars Henriksen,
• Tor Grande and
• Mari-Ann Einarsrud

Beilstein J. Nanotechnol. 2017, 8, 304–312, doi:10.3762/bjnano.8.33

• Because of the high surface-to-volume ratio, the intrinsic properties of titanium dioxide (TiO2) nanoparticles have led to exploitation in many fields such as in photocatalysis [1], solar cells [2], and in biomedical applications [3]. The naturally occurring phases of TiO2 are rutile (thermodynamically

From iron coordination compounds to metal oxide nanoparticles

• Mihail Iacob,
• Carmen Racles,
• Codrin Tugui,
• George Stiubianu,
• Adrian Bele,
• Liviu Sacarescu,
• Daniel Timpu and
• Maria Cazacu

Beilstein J. Nanotechnol. 2016, 7, 2074–2087, doi:10.3762/bjnano.7.198

• surfaces are often used for biomedical applications (e.g., biosensing, hyperthermia and MRI) [10]. In biomedical applications, the morphology of the nanoparticle significantly influences both pharmacokinetics and cell uptake [11]. Nanoparticles are also preferred as fillers for polymers to induce certain

Facile fabrication of luminescent organic dots by thermolysis of citric acid in urea melt, and their use for cell staining and polyelectrolyte microcapsule labelling

• Nadezhda M. Zholobak,
• Anton L. Popov,
• Alexander B. Shcherbakov,
• Nelly R. Popova,
• Mykhailo M. Guzyk,
• Valeriy P. Antonovich,
• Alla V. Yegorova,
• Yuliya V. Scrypynets,
• Inna I. Leonenko,
• Alexander Ye. Baranchikov and
• Vladimir K. Ivanov

Beilstein J. Nanotechnol. 2016, 7, 1905–1917, doi:10.3762/bjnano.7.182

• crystals (quantum dots, Q-dots) are a good alternative to common fluorescent dyes in a variety of biomedical applications, mainly due to their high photostability and relatively large Stokes shift [1][2][3], but Q-dots typically contain heavy metals (lead, cadmium) and chalcogens (selenium, tellurium

• of luminescent C-dots in 2004 [18], the number of annual peer-reviewed publications on the biomedical applications of C-dots dramatically increases – especially in comparison with the relatively smooth growth of publications on other fluorescent nanoparticles (for instance, REE-based). Typically, С

3D printing of mineral–polymer bone substitutes based on sodium alginate and calcium phosphate

• Aleksey A. Egorov,
• Alexander Yu. Fedotov,
• Anton V. Mironov,
• Vladimir S. Komlev,
• Vladimir K. Popov and
• Yury V. Zobkov

Beilstein J. Nanotechnol. 2016, 7, 1794–1799, doi:10.3762/bjnano.7.172

• pores sizes and good interconnectivity, which are of great importance for the design of 3D bone substitutes for biomedical applications. The CP phase was formed upon mixing of the polymer slurry containing ammonium hydrogen phosphate with a calcium chloride aqueous solution during the printing process

Influence of hydrothermal synthesis parameters on the properties of hydroxyapatite nanoparticles

• Sylwia Kuśnieruk,
• Jacek Wojnarowicz,
• Agnieszka Chodara,
• Tadeusz Chudoba,
• Stanislaw Gierlotka and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2016, 7, 1586–1601, doi:10.3762/bjnano.7.153

• nanoparticles (nano-HAp) are better positioned to serve as an apatite substitute of bone in biomedical applications than micrometer-sized hydroxyapatite (micro-HAp) [8]. The impact of nano-HAp particles with different morphology on highly malignant melanoma cells was analyzed. The obtained results showed that

Effect of tetramethylammonium hydroxide/isopropyl alcohol wet etching on geometry and surface roughness of silicon nanowires fabricated by AFM lithography

• Siti Noorhaniah Yusoh and
• Khatijah Aisha Yaacob

Beilstein J. Nanotechnol. 2016, 7, 1461–1470, doi:10.3762/bjnano.7.138

• requirements of SOI applications have been developed. The geometry and surface roughness of the devices are the factors that must be improved in order to upgrade the possible device performance in many fields, such as biomedical applications. The etching process has been studied by many researchers in order to

Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles

• Tudor Braniste,
• Ion Tiginyanu,
• Tibor Horvath,
• Simion Raevschi,
• Serghei Cebotari,
• Marco Lux,
• Axel Haverich and
• Andres Hilfiker

Beilstein J. Nanotechnol. 2016, 7, 1330–1337, doi:10.3762/bjnano.7.124

• ]. Nanoparticle-based systems are the best choice for biomedical applications not only due to their small size (from 1 to 100 nm), but also due to their potency, which results from their high surface area for active molecules. Over the last decade, many studies have been performed on the interaction between

• carbon nanotubes (MWCNTs) with a diameter less than 30 nm are less toxic than particles larger than 50 nm [6]. Nearly all current and future biomedical applications implicate intravascular transport of nanoparticles, thereby blood is the predominant carrier for nanoparticles and nanoparticle clusters

• , which make it promising for biomedical applications. Recently, it was shown that GaN does not require surface treatment for biocompatibility [18]. Bulk GaN is nontoxic for cells with or without peptide functionalization of the surface, with only very low amounts of gallium being released during the cell

Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters

• Silvia Varela-Aramburu,
• Richard Wirth,
• Chian-Hui Lai,
• Guillermo Orts-Gil and
• Peter H. Seeberger

Beilstein J. Nanotechnol. 2016, 7, 1278–1283, doi:10.3762/bjnano.7.118

• serves to functionalize the nanoclusters. The resulting non-cytotoxic nanoclusters are taken up by cells and constitute a tuneable platform for biomedical applications including drug delivery. Keywords: biomedical applications; carbohydrates; functionalization; gold nanoclusters; robust; Findings

Multiwalled carbon nanotube hybrids as MRI contrast agents

• Nikodem Kuźnik and
• Mateusz M. Tomczyk

Beilstein J. Nanotechnol. 2016, 7, 1086–1103, doi:10.3762/bjnano.7.102

• , the unique combination of features that is found in nanoparticles has opened up a new era of biomaterials. These offer several advantages of great importance to biomedical applications, e.g., the possibility of appropriate size and shape designed for the desired target, modulation of their

The role of morphology and coupling of gold nanoparticles in optical breakdown during picosecond pulse exposures

• Yevgeniy R. Davletshin and
• J. Carl Kumaradas

Beilstein J. Nanotechnol. 2016, 7, 869–880, doi:10.3762/bjnano.7.79

• (LIB) effect [17]. Nanostructure fabrication [18], cell nanosurgery [19], and laser-induced breakdown spectroscopy [20][21] are applications where the use of nanoparticles for LIB enhancement has produced promising results. In biomedical applications, nanoparticle-mediated LIB is a non-linear laser

Facile synthesis of water-soluble carbon nano-onions under alkaline conditions

• Gaber Hashem Gaber Ahmed,
• Rosana Badía Laíño,
• Josefa Angela García Calzón and
• Marta Elena Díaz García

Beilstein J. Nanotechnol. 2016, 7, 758–766, doi:10.3762/bjnano.7.67

• ) properties, such as broad excitation spectra, tunable emission wavelength and stable PL, high stability against photobleaching, C-dots are attracting considerable attention in analytical sensing, bioimaging, photo-reduction of metals and biomedical applications [2][3][4][5][6]. C-dots may be

• conventional synthetic methods such as arc-discharge and chemical vapor deposition are insoluble in water, which restricts their use in analytical, biological and biomedical applications. Our results showed that water-soluble C-onions could be prepared by a simple carbonization method using tomatoes as carbon

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

• Claudia Koch,
• Fabian J. Eber,
• Carlos Azucena,
• Alexander Förste,
• Stefan Walheim,
• Thomas Schimmel,
• Alexander M. Bittner,
• Holger Jeske,
• Hartmut Gliemann,
• Sabine Eiben,
• Fania C. Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54

• dyes for imaging purposes either tracing the virus itself, or targeting specific cells or organs [73][74][75][76], antigens for the development of vaccines as reviewed in great detail [77][78][79], drugs or imaging reagents for increasingly elaborated biomedical applications [80][81][82] with numerous

Antibacterial activity of silver nanoparticles obtained by pulsed laser ablation in pure water and in chloride solution

• Brunella Perito,
• Emilia Giorgetti,
• Paolo Marsili and
• Maurizio Muniz-Miranda

Beilstein J. Nanotechnol. 2016, 7, 465–473, doi:10.3762/bjnano.7.40

• suitable for biomedical applications than those prepared with common, wet chemical preparation techniques. To date, only a few investigations into the antimicrobial effect of AgNPs produced by PLAL have been performed. These have mainly been performed by ablation in water with nanosecond pulse widths. We

Surface coating affects behavior of metallic nanoparticles in a biological environment

• Darija Domazet Jurašin,
• Marija Ćurlin,
• Ivona Capjak,
• Tea Crnković,
• Marija Lovrić,
• Michal Babič,
• Daniel Horák,
• Ivana Vinković Vrček and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 246–262, doi:10.3762/bjnano.7.23

• great interest for application in a variety of other commercial products, such as mobile phones, textiles, food storage containers, refrigerators, and cosmetics [1][2]. SPIONs are exploited in numerous in vitro and in vivo biomedical applications, but the most important is their use in imaging and drug

• delivery systems [4]. The biomedical applications of AgNPs and SPIONs imply uptake into the body, which consequently leads to interactions with protein-containing biological fluids [5][6]. Therefore, it is of increasing interest to systematically collect detailed information on their physicochemical

• may serve as desirable barriers preventing NPs from agglomeration in biomedical applications [18]. Moreover, when NPs enter a biological fluid, electrostatic, dispersive, and covalent interactions cause proteins to adsorb on NP surfaces, leading to the formation of a dynamic protein corona [30][36][37

Fabrication and characterization of novel multilayered structures by stereocomplexion of poly(D-lactic acid)/poly(L-lactic acid) and self-assembly of polyelectrolytes

• Elena Dellacasa,
• Li Zhao,
• Gesheng Yang,
• Laura Pastorino and
• Gleb B. Sukhorukov

Beilstein J. Nanotechnol. 2016, 7, 81–90, doi:10.3762/bjnano.7.10

• structures for biotechnological and biomedical applications, such as biosensors and carriers for drug delivery, led researchers to extend this technique beyond multilayer structure fabrication based on electrostatic interactions [7][8][9][10][11]. Over the years, other interactions such as covalent bonding

• promising drug delivery carriers for biomedical applications. The combination of the physical and mechanical properties of such materials could make it possible to modify characteristic features, such as surface morphology, in order to modulate important delivery factors, like permeability and release rate

Silica-coated upconversion lanthanide nanoparticles: The effect of crystal design on morphology, structure and optical properties

• Uliana Kostiv,
• Miroslav Šlouf,
• Hana Macková,
• Alexander Zhigunov,
• Hana Engstová,
• Katarína Smolková,
• Petr Ježek and
• Daniel Horák

Beilstein J. Nanotechnol. 2015, 6, 2290–2299, doi:10.3762/bjnano.6.235

• in OM, serving as both solvent and surface binding ligand [20]. Because the particle size plays a key role in biomedical applications, e.g., for internalization of nanoparticles by cells of the reticuloendothelial system [32], the effects of both reaction temperature and time were investigated to

• transitions, respectively. These bands were induced by 4f–4f transitions of the Er3+ ions. Because the red light photons are important for prospective biomedical applications, the I545/I660 ratio should be rather low and the total luminescence intensity high. The ratio of green to red emission intensities

• TEM/ED measurements confirmed the presence of cubic α- and hexagonal β-phases in the crystallites. The latter form is preferred in biomedical applications due to its high upconversion efficiency. From a synthetic point of view, temperature had the greatest influence on the resulting crystalline

Fabrication of hybrid nanocomposite scaffolds by incorporating ligand-free hydroxyapatite nanoparticles into biodegradable polymer scaffolds and release studies

• Balazs Farkas,
• Marina Rodio,
• Ilaria Romano,
• Alberto Diaspro,
• Romuald Intartaglia and
• Szabolcs Beke

Beilstein J. Nanotechnol. 2015, 6, 2217–2223, doi:10.3762/bjnano.6.227

• of chemical similarity between synthetic HA and the natural bone mineral, a large number of studies have introduced synthetic HA as bone replacement material for biomedical applications [3][4]. The benefits of synthetic HA, most notably its biocompatibility, slow biodegradability and good

• osteoconductive and osteoinductive capabilities [5][6], made it a platform for large-scale biomedical applications, such as controlled drug release and bone tissue engineering materials [7][8]. Lee et al. [9] reported on cellular responses to crosslinkable poly(propylene fumarate)/hydroxyapatite nanocomposites

• ], combustion preparation [11] and various wet chemistry techniques [12][13]. However, these routes have drawbacks regarding the synthesis attributed to the use of hazardous surfactants that are not suitable for biomedical applications [14]. Pulsed laser ablation of solid targets in liquids (PLAL) for the

An adapted Coffey model for studying susceptibility losses in interacting magnetic nanoparticles

• Mihaela Osaci and
• Matteo Cacciola

Beilstein J. Nanotechnol. 2015, 6, 2173–2182, doi:10.3762/bjnano.6.223

• Calabria, Italy 10.3762/bjnano.6.223 Abstract Background: Nanoparticles can be used in biomedical applications, such as contrast agents for magnetic resonance imaging, in tumor therapy or against cardiovascular diseases. Single-domain nanoparticles dissipate heat through susceptibility losses in two modes

• frequencies and amplitudes of external magnetic fields for biomedical applications, especially for tumor therapy by magnetic hyperthermia. Keywords: hyperthermia; magnetic nanoparticles; relaxation process; specific loss power; susceptibility losses; Introduction Magnetic nanoparticles are important for

A facile method for the preparation of bifunctional Mn:ZnS/ZnS/Fe₃O₄ magnetic and fluorescent nanocrystals

• Houcine Labiadh,
• Tahar Ben Chaabane,
• Romain Sibille,
• Lavinia Balan and
• Raphaël Schneider

Beilstein J. Nanotechnol. 2015, 6, 1743–1751, doi:10.3762/bjnano.6.178

• properties, which are discussed herein. The approach described in this study is anticipated to be useful and cost-effective for biological and biomedical applications requiring both fluorescence and magnetic characteristics. Results and Discussion Synthesis and structural/microstructural characterization The

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• important that the Fe3O4 nanoparticles are stable under physiological conditions that are necessary for biomedical applications, it is crucial to use controllable synthesis conditions in order to obtain monodisperse, uniform nanoparticles with desired properties [18]. Despite their low toxicity, fine

• [35]. Given that the applications of such nanoparticles are based on their sufficient magnetic properties, the use of TMC (with better magnetic properties as compared to the classical chitosan system) is recommended, especially in biomedical applications. Thermogravimetric analysis (TGA) During the

• -containing nanocomposites is more than that of polymer/Fe3O4 nanoparticles, which is likely due to the relatively heavy weight of Au nanoparticles. Cell viability assay One of the most important factors for employing nanomaterials in biomedical applications is related to their safety and biocompatibility

Structural and magnetic properties of iron nanowires and iron nanoparticles fabricated through a reduction reaction

• Marcin Krajewski,
• Wei Syuan Lin,
• Hong Ming Lin,
• Katarzyna Brzozka,
• Sabina Lewinska,
• Natalia Nedelko,
• Anna Slawska-Waniewska,
• Jolanta Borysiuk and
• Dariusz Wasik

Beilstein J. Nanotechnol. 2015, 6, 1652–1660, doi:10.3762/bjnano.6.167

• inexpensive, a lot of them are biocompatible and low-toxic, it makes them very interesting from an application point of view. So far, they have been applied in many biomedical applications including magnetic resonance imaging (MRI) contrast enhancements [1], direct drug delivery systems [2], hyperthermia