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Search for "inhibition" in Full Text gives 187 result(s) in Beilstein Journal of Nanotechnology.
PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system
Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144
- binding to DNA, CPT antitumor activity is due to inhibition of the nuclear enzyme topoisomerase I [4][5]. In spite of its potential as chemotherapeutic agent, CPT suffers from a reduced in vivo antitumor efficacy owing to its poor water-solubility and chemical instability (Figure 1). CPT-derivatives with
Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone
Beilstein J. Nanotechnol. 2014, 5, 610–621, doi:10.3762/bjnano.5.72
- an inhibition of the differentiation of osteoclasts from their respective precursor cells (Figure 1B). In addition, after exposure of SaOS-2 cells to biosilica these cells increase the synthesis of the bone morphogenetic protein 2 (BMP2), a cytokine that induces osteoblast differentiation and
Mesoporous cerium oxide nanospheres for the visible-light driven photocatalytic degradation of dyes
Beilstein J. Nanotechnol. 2014, 5, 517–523, doi:10.3762/bjnano.5.60
- . Control experiments were performed in the absence of scavengers (black line, Figure 5a). The established scavengers used include sodium oxalate for h+ (red), CrO3 for e− (green), isopropanol for •OH (blue), and 1,4-benzoquinone for •OOH/•O2− (grey, Figure 5a) [5]. The inhibition of photocatalytic activity
Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating
Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35
- by using a cell culture incubator. The results indicated that the promotion of HSP70 was minimized during rapid heating. As mentioned before, ROS can activate the expression of HSP70. The inhibition of HSP70 during rapid-rate and low thermal dose heating could possibly mean the abolishment of ROS
- significantly impact cell growth. It is also noteworthy that NP concentrations equivalent to 5 µM IR820 had a slight cell growth inhibition effect on MES-SA cells. This is in line with our previous observations on the cytotoxicity effects of free IR820 on MES-SA, and seems to be related to the fact that drug
- (STATs) to the HSP70 promoters in vascular smooth muscle cells (VSMCs) [32]. This group exposed VSMCs to H2O2 and found that the cytoplasmic janus tyrosine kinase 2 (JAK2)/STAT pathway can up-regulate HSP70 and minimize oxidative stress effects on the cells. The inhibition of HSP70 expression under laser
3D-nanoarchitectured Pd/Ni catalysts prepared by atomic layer deposition for the electrooxidation of formic acid
Beilstein J. Nanotechnol. 2014, 5, 162–172, doi:10.3762/bjnano.5.16
- density of 0.26 A·mg−1 at −0.2 V because of the oxidation of HCOOH. A further increase of the potential leads to a decrease of the current density due to the oxidation of the palladium and the inhibition of the catalytic activity of the metallic system by reaction intermediates [9][41]. On the reverse
Some reflections on the understanding of the oxygen reduction reaction at Pt(111)
Beilstein J. Nanotechnol. 2013, 4, 956–967, doi:10.3762/bjnano.4.108
- similar decrease in current in this potential region during the reduction of H2O2 [25], suggest that adsorbed hydrogen on the electrode, Hads, may prevent the O–O bond cleavage and block reactive surface sites. Therefore only two electrons are exchanged in this potential range [17][23]. This inhibition by
New hybrid materials based on poly(ethyleneoxide)-grafted polysilazane by hydrosilylation and their anti-fouling activities
Beilstein J. Nanotechnol. 2013, 4, 671–677, doi:10.3762/bjnano.4.75
- shows the influence of the length of the grafted PEO and of the Si–H/allyl ratio on the bacterial adhesion in VNSS media. Compared to the unmodified PSZ coating, all PSZ-PEO surfaces exhibit lower levels of bacteria adhesion. The inhibition efficiency varies inversely with the ratio of Si–H/allyl. It is
- , there is 0.29 chains of allyl-PEO per ten Si–H groups of the PSZ chain. The bacterial adhesion inhibition depends on the grafting density and the chain length of PEO. The role of the grafting density is more important than that of the chain length. The PSZ-PEO350 coatings prepared at a ratio SiH/allyl
Functionalization of vertically aligned carbon nanotubes
Beilstein J. Nanotechnol. 2013, 4, 129–152, doi:10.3762/bjnano.4.14
- prevented, extending the catalyst lifetime [50]. Another positive effect of the use of the oxidant is the inhibition of Ostwald ripening if injected during the annealing treatment of the catalyst film; the Ostwald ripening causes the formation of large particles thus reducing the yield of the CNT synthesis
Paper modified with ZnO nanorods – antimicrobial studies
Beilstein J. Nanotechnol. 2012, 3, 684–691, doi:10.3762/bjnano.3.78
- bacteria Escherichia coli were found to be inhibited in an area that is 239% and 163% the area of the paper sample under different room lighting conditions, i.e., halogen and fluorescent lamp illumination, respectively. For Gram-positive bacteria Staphylococcus aureus the zones of inhibition surrounding
- measure of zones of inhibition (edge of the square inhibition zone in centimeters) around the paper squares of side 1.5 cm for different samples with ZnO nanorods. The antimicrobial activity in the dark is due to the slow release of Zn2+ ions arising from partial dissolution of ZnO in the moist
- inhibits the growth of microbes coming in contact with it but also prevents microbial growth in the area surrounding the paper [21]. The zones of inhibition around the paper samples are shown in Figure 2. In our experiments we observed comparable zones of inhibition for E. coli after incubation times of 24
The oriented and patterned growth of fluorescent metal–organic frameworks onto functionalized surfaces
Beilstein J. Nanotechnol. 2012, 3, 570–578, doi:10.3762/bjnano.3.66
- surface occurs indeed selectively on the MUDA-functionalized surface (square areas), while the HDT surface shows remarkable inhibition of [Zn2(adc)2(dabco)] nucleation. The AFM measurement (Figure 7b,c) shows more details of the SURMOF pattern. In contrast to the nonpatterned MTCA surface, the [Zn2(adc)2
Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages
Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51
- . Different concentrations of nanoparticles were taken up by double-stable Mo/Ma cells over 24 h; the nanoparticle-concentration ranged from 0 to 320 μg/mL MNP-SN38 in fresh medium. After 24 h, the inhibition of cell proliferation was measured by using the MTT assay (Figure 4). We found only 20% of inhibition
- of nanoparticles contained 0.427 mg of iron, indicating that this amount of iron would be high enough for alternating magnetic field hyperthermia in combination with chemotherapy [54]. The MTT assay indicated that 8 pg of iron can be easily loaded in each cell (20% inhibition of cell proliferation
- ) (Figure 4 and Figure 7). It is even possible to load 16 pg of iron in each cell (with 50% inhibition of cell proliferation) indicating that 2.1·10−15 mol of SN38 can be easily loaded in each delivery cell. To test the release of SN38 by the self-contained Tet-On Advanced system, Mo/Ma cells were plated in
Conducting composite materials from the biopolymer kappa-carrageenan and carbon nanotubes
Beilstein J. Nanotechnol. 2012, 3, 415–427, doi:10.3762/bjnano.3.48
- commonly referred to as E407 (European Union specification) as well as being approved by the US Food and Drug Administration as a direct food additive [40]. Recent demonstrations of other applications include their use in drug delivery for the inhibition of viral infections [41][42]. Glycerin (or glycerol
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