Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions

• Anna V. Epanchintseva,
• Julia E. Poletaeva,
• Dmitrii V. Pyshnyi,
• Elena I. Ryabchikova and
• Inna A. Pyshnaya

Beilstein J. Nanotechnol. 2019, 10, 2568–2578, doi:10.3762/bjnano.10.248

• increase in the volume of the reaction mixture led to an increased surface area by a factor of 4.3. The incubation of the components in different media is often required when creating complicated nanoconstructions. We tested the stability of the noncovalent AuNP-siRNA in various solutions, including

• that the freshly prepared suspension is homogeneous and has high colloidal stability in various solutions, except for the DMEM medium. A ten-fold increase in the reaction volume led to a decrease of about 10% in the surface density of AuNP-siRNA nanoconstructions, which caused changes in the

• and eight days at 4 °C by the methods of TEM, DLS, and electrophoresis. The storage of sample ×1 for 24 h led to an increase in the number of the AuNP-siRNA chains and the appearance of loose branched “figures” of different shapes (Figure 3B) compared with the freshly prepared suspension (Figure 1A

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• devices based on the combination of dicyanomethylene and pyranine as organic dyes supported on zinc single-layered hydroxide” [31]. In this article, two fluorescent organic dyes, dicyanomethylene and pyranine, emit visible light upon blue LED excitation and are tethered to single layer hydroxide platelets

• and then embedded into a silicone polymer. These coatings deliver white-light emission when placed above a blue LED. Health Functionalized nanoparticles are highly investigated as possible platforms for disease diagnosis and therapy, leading to potential applications in nanomedicine. The state-of-the

Label-free highly sensitive probe detection with novel hierarchical SERS substrates fabricated by nanoindentation and chemical reaction methods

• Jingran Zhang,
• Tianqi Jia,
• Yongda Yan,
• Li Wang,
• Peng Miao,
• Yimin Han,
• Xinming Zhang,
• Guangfeng Shi,
• Yanquan Geng,
• Zhankun Weng,
• Daniel Laipple and
• Zuobin Wang

Beilstein J. Nanotechnol. 2019, 10, 2483–2496, doi:10.3762/bjnano.10.239

• . We experimentally verified that the distribution of Raman intensities is uniform along the same direction. Combining the nanoindentation process method with the chemical redox reaction method led to Ag/Cu substrates with high reproducibility and uniformity. Effect of Raman enhancement performance

Air oxidation of sulfur mustard gas simulants using a pyrene-based metal–organic framework photocatalyst

• Ghada Ayoub,
• Mihails Arhangelskis,
• Xuan Zhang,
• Florencia Son,
• Timur Islamoglu,
• Tomislav Friščić and
• Omar K. Farha

Beilstein J. Nanotechnol. 2019, 10, 2422–2427, doi:10.3762/bjnano.10.232

• oxidation under the same conditions of irradiation, and the same MOF content, but in the absence of O2 saturation step, also led to complete conversion of CEES into the sulfoxide. Specifically, under such conditions the complete conversion of CEES was observed after 2 hours, with a half-life of 13.5 minutes

Semitransparent Sb₂S₃ thin film solar cells by ultrasonic spray pyrolysis for use in solar windows

• Jako S. Eensalu,
• Atanas Katerski,
• Erki Kärber,
• Lothar Weinhardt,
• Monika Blum,
• Clemens Heske,
• Wanli Yang,
• Ilona Oja Acik and
• Malle Krunks

Beilstein J. Nanotechnol. 2019, 10, 2396–2409, doi:10.3762/bjnano.10.230

• more rapidly dampened in Sb2S3, as evident from the absorption coefficient (Figure 3c), and related photoexcitation in the Sb2S3 occurs closer to the side of incidence, i.e., the ETM/Sb2S3 interface. Hence, we are led to conclude that the holes photogenerated near the ETM/Sb2S3 interface, which must

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• the same resistance to deformation [11], confirming that CUR is located in the core of the polymeric micelle (as shown by the localization analysis) and therefore did not alter the interactions between P407 and C974P in order to change the viscosity. Otherwise, the increase in temperature led to the

• flow, and then after the weakening of the structure, the ability to start to flow [61]. Both an increase in temperature and incorporation of CUR led to significant differences (p < 0.05) in the yield value. The significant increase in yield value with an increase in temperature and subsequent micelle

• structuring can be explained by the transition from liquid to gel. However, the increase of CUR led to a significant decrease in the yield value, probably due to the higher exposure of the hydrophilic portion to water [62][63]. The hysteresis area of the formulations was investigated by RheoWin 4.10.0000

Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

• Nashrawan Lababidi,
• Valentin Sigal,
• Aljoscha Koenneke,
• Konrad Schwarzkopf,
• Andreas Manz and
• Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

• increase in the flow speed of the aqueous phase from 10–100 µL/min led to a reduction in the mean diameter of the NPs from 150 to 70 nm at a flow ratio of 0.05 (Figure 1). This evidence points to the fact that most likely the polymer concentration decreases by increasing the aqueous phase flow rate, thus

• organic phase, which led to impeded diffusivity of the organic phase into the aqueous phase, and thus to a longer mixing time. Also, it appears that a large number of nuclei are formed and the high concentration of polymer per unit volume promotes particle growth, therefore larger particles were obtained

• microfluidics in combination with a specific muco-inert surface chemistry led to a promising drug delivery system with enhanced mucus penetration. Moreover, a high absolute curcumin encapsulation efficiency of ≈67.15% was obtained using microfluidics. Furthermore, the encapsulation was clearly improved in

Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials

• Stefania Ordanini,
• Wanda Celentano,
• Anna Bernardi and
• Francesco Cellesi

Beilstein J. Nanotechnol. 2019, 10, 2192–2206, doi:10.3762/bjnano.10.212

• -functionalized monomer, starting from a four-arm initiator based on poly(ε-caprolactone), led to a library of glucose-functionalized aggregates able to bind the glucose- and mannose-binding lectin Concanavalin A (Con A) [12]. The combination of ATRP of protected alkyne monomers and a copper-catalyzed azide

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• procedure for a sandwich-type immunomagnetic sensor. Electrochemical immunoassays with disposable microfluidic devices led to excellent linearity, reproducibility, and fast detection at low-cost, while showing excellent agreement with the standard method ELISA. Importantly, the approach for the immunoassays

BergaCare SmartLipids: commercial lipophilic active concentrates for improved performance of dermal products

• Florence Olechowski,
• Rainer H. Müller and
• Sung Min Pyo

Beilstein J. Nanotechnol. 2019, 10, 2152–2162, doi:10.3762/bjnano.10.208

• shown in [27][28]. Applying a lipid particle film to the skin led to the formation of a lipid layer thicker than the normal barrier, resulting in D values below the D values of the normal lipid film on skin (Figure 7, upper row). The thickness of the created lipid film by applying lipid particle

Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• their DPPC shell are provided in Table 2 and Figure 6. The addition of dendronized IONPs led to a significant change in the MB mean radius and the size distribution for all the dendronized IONPs investigated, confirming their presence in the MB shell. A mean radius as small as 1.0 ± 0.2 µm was obtained

• with the fluorinated dendrons C2F5OEG8Den and C4F9OEG8Den, which is comparable to that measured for a non-dendronized DPPC shell. By comparison, the use of hydrogenated dendrons led to an increase in the MB mean radius. The stability of the MBs prepared with the fluorinated IONPs, given by the half

• therefore selected C2F5OEG8Den, which is the dendron that led to the smallest and most stable MBs. The hydrocarbon analog C2H5OEG8Den was also investigated for comparison. The DPPC concentration was set in order to obtain a discontinuous DPPC film (i.e., DPPC domains), allowing for the measurement of the

Green and scalable synthesis of nanocrystalline kuramite

• Andrea Giaccherini,
• Giuseppe Cucinotta,
• Stefano Martinuzzi,
• Enrico Berretti,
• Werner Oberhauser,
• Alessandro Lavacchi,
• Giovanni Orazio Lepore,
• Giordano Montegrossi,
• Maurizio Romanelli,
• Antonio De Luca,
• Massimo Innocenti,
• Vanni Moggi Cecchi,
• Matteo Mannini,
• Antonella Buccianti and
• Francesco Di Benedetto

Beilstein J. Nanotechnol. 2019, 10, 2073–2083, doi:10.3762/bjnano.10.202

• ; Introduction In the last decade, advances in materials science and nanoscience have led to the development of new solar cell technologies. Today, they hold promise to overcome the environmental issues created by silicon-based devices. Such devices are difficult to decommission, their production requires energy

• ). Conversely, adding a third Lorentzian component to the sample analysis of sample S2 led to a reduction of the R factor of 0.6%. The results of the fits show that the widths of the Lorentzian profiles are clearly wider than the widths found in the literature [11][30][69][70]. These values are related to size

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• preparation by solvent displacement led to the smallest nanoparticles. In PLGA nanoparticles, the drug load could be optimised using solvent displacement at pH 7 reaching 53 µg doxorubicin/mg nanoparticle. These PLGA nanoparticles displayed sustained doxorubicin release kinetics compared to the more burst

Synthesis of highly active ETS-10-based titanosilicate for heterogeneously catalyzed transesterification of triglycerides

• Muhammad A. Zaheer,
• David Poppitz,
• Khavar Feyzullayeva,
• Marianne Wenzel,
• Jörg Matysik,
• Radomir Ljupkovic,
• Aleksandra Zarubica,
• Alexander A. Karavaev,
• Andreas Pöppl,
• Roger Gläser and
• Muslim Dvoyashkin

Beilstein J. Nanotechnol. 2019, 10, 2039–2061, doi:10.3762/bjnano.10.200

• not notably affect the crystallinity, which is fully restored after the calcination (see Table S10 of Supporting Information File 1). However, partial removal of the framework has led to the appearance of crack-looking defects on the surface of ETS-10, less noticeable on the crystals treated for 30

• noting that the appearance of mesopores after treatment has led to the change of the isotherm shape from type I (typical for microporous solids) to a combination of types I and IV, as is expected for micro–mesoporous materials [37]. It was suggested that exposure of the ETS-10 framework to H2O2 solution

• increases from 0.110 cm3 g−1 for the parent titanosilicate to 0.131 cm3 g−1 after 60 min of treatment. The application of calcination has led to a slightly lower mesopore volume for P-ETS-10/60 (0.098 cm3 g−1) and C-P-ETS-10/60 (0.084 cm3 g−1) and to micropore volumes of 0.131 cm3 g−1 and 0.105 cm3 g−1

Optimization and performance of nitrogen-doped carbon dots as a color conversion layer for white-LED applications

• Tugrul Guner,
• Hurriyet Yuce,
• Didem Tascioglu,
• Eren Simsek,
• Umut Savaci,
• Aziz Genc,
• Servet Turan and
• Mustafa M. Demir

Beilstein J. Nanotechnol. 2019, 10, 2004–2013, doi:10.3762/bjnano.10.197

• as color conversion layers in a white-LED configuration to generate white light. In order to resolve the red deficiency of this configuration, a commercial red phosphor was integrated into the system. Moreover, the N-CDots were also processed into polymer/N-CDot composite fibers, for which we

• to inorganic phosphors that are commonly employed in white-LED configurations. Keywords: color conversion layer; electrospinning; nitrogen-doped carbon dots; PVP; solid-state lighting; white LED; white-light generation; Introduction Light-emitting carbon dots (CDots) are a new class of

• solid-state lighting, provides a promising strategy to reduce electricity consumption, and WLEDs are expected to replace traditional lighting products in the future [24][25][26][27]. A WLED mainly consists of a blue or UV LED chip and phosphors as color conversion layers [28][29][30][31][32]. A typical

Facile synthesis of carbon nanotube-supported NiO//Fe₂O₃ for all-solid-state supercapacitors

• Shengming Zhang,
• Xuhui Wang,
• Yan Li,
• Xuemei Mu,
• Yaxiong Zhang,
• Jingwei Du,
• Guo Liu,
• Xiaohui Hua,
• Yingzhuo Sheng,
• Erqing Xie and
• Zhenxing Zhang

Beilstein J. Nanotechnol. 2019, 10, 1923–1932, doi:10.3762/bjnano.10.188

• each LED) in parallel, indicating good practicability of the device. In addition, it can continuously power a blue LED for nearly 27 s (video in Supporting Information File 2). The Ragone plot of the device is presented in Figure 8d with some previously reported results. The device exhibits a high

• compared with previously reported results [39][40][41][42][43][44][45]. Supporting Information Supporting Information File 115: Specific capacitance calculation and additional figures. Supporting Information File 116: Video showing the ASC powering a blue LED for about 27 seconds. Acknowledgements This

Preservation of rutin nanosuspensions without the use of preservatives

• Pascal L. Stahr and
• Cornelia M. Keck

Beilstein J. Nanotechnol. 2019, 10, 1902–1913, doi:10.3762/bjnano.10.185

• active ingredient occurs, changes in the IC50 value during storage can be observed [35]. As methanol is a good solvent for rutin, the addition of the nanocrystals to the methanolic DPPH solution led to a complete dissolution of the rutin nanocrystals. Hence, all rutin remaining in the formulations was

Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints

• Elvira Rozhina,
• Ilnur Ishmukhametov,
• Svetlana Batasheva,
• Farida Akhatova and
• Rawil Fakhrullin

Beilstein J. Nanotechnol. 2019, 10, 1818–1825, doi:10.3762/bjnano.10.176

• radical polymerization [13]. The versatility of cell surface engineering methods has led to intersections between these routes yielding functionalised cells with multiple functionalities [14]. Relatively solid microbial cells with cell walls as well as soft mammal cells (including human cells) were used

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• (Figure 4a), ionic species triggered apoptosis in 86% and 95% of cells at the highest concentrations applied, i.e., 1 mg Ag L−1 and 25 mg Au L−1, respectively. Silver and gold NPs were safer, inducing at tested doses less than 20% of apoptotic events (Figure 4b). However, treatment with GSH-AuNPs led to a

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

• Elisabetta Esposito,
• Maddalena Sguizzato,
• Markus Drechsler,
• Paolo Mariani,
• Federica Carducci,
• Claudio Nastruzzi,
• Giuseppe Valacchi and
• Rita Cortesi

Beilstein J. Nanotechnol. 2019, 10, 1789–1801, doi:10.3762/bjnano.10.174

• in mixture (1:1 w/w) with the liquid caprylic/capric triglycerides (miglyol), characterized by C8–C10 chains. With regard to surfactant concentration, higher poloxamer amounts, namely 3 and 4% w/w with respect to the aqueous phase, have been tested. However, the increase of poloxamer led to foam

Biocatalytic oligomerization-induced self-assembly of crystalline cellulose oligomers into nanoribbon networks assisted by organic solvents

• Yuuki Hata,
• Yuka Fukaya,
• Toshiki Sawada,
• Masahito Nishiura and
• Takeshi Serizawa

Beilstein J. Nanotechnol. 2019, 10, 1778–1788, doi:10.3762/bjnano.10.173

• and DMF made the CD spectroscopy measurement impossible under the same conditions. Although incubation with the organic solvents for 6 h hardly affected the CD spectra (Figure 4a), incubation for 72 h led to a change in the spectra (Figure 4b), showing a change in the secondary structure of CDP. These

Synthesis of nickel/gallium nanoalloys using a dual-source approach in 1-alkyl-3-methylimidazole ionic liquids

• Ilka Simon,
• Julius Hornung,
• Juri Barthel,
• Jörg Thomas,
• Maik Finze,
• Roland A. Fischer and
• Christoph Janiak

Beilstein J. Nanotechnol. 2019, 10, 1754–1767, doi:10.3762/bjnano.10.171

• deficient with a ratio of 28:72 atom % (±2 atom %). After 24 h of dispersion, the initial 1:1 ratio led to almost exclusively NiGa nanoparticles. Thus, a dispersion time of 24 h before microwave decomposition is needed to gain phase-pure NiGa nanoparticles without Ga(Ni) nanoparticles as by-products. We

• ]. For example, the reaction of Ni(COD)2 with four equivalents of GaCp* in n-hexane led to the formation of Ni(GaCp*)4 clusters [56]. Thus, the formation of such intermetallic clusters in ionic liquids is a working hypothesis for the required dispersion time of 24 h. To validate the formation of “large

• internal alkyne diphenylacetylene with NiGa@[BMIm][BF4] led to the formation of a Z/E-mixture of diphenylethene [30]. During catalysis with nanoparticles in ionic liquids a two-phase system is often formed with the nanoparticles suspended in the denser ionic liquid in the lower phase and the organic

Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

• David Hespeler,
• Sanaa El Nomeiri,
• Jonas Kaltenbach and
• Rainer H. Müller

Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162

• baseline correction and the 0.15 molar NaCl solution used in this study also led to differences from the values reported in the literature. The assumption that nanometer-sized rutin particles are present in the raw material is supported by the fact that the measured Cs value increased from 30 to 70 µg/mL

• with increasing amount of rutin powder (from 0.28 mg/mL to 2.03 mg/mL) added to the solvent (i.e., more nanometer-sized rutin was added which dissolved and led to this increase in the measured solubility). In contrast to the rutin powder, in this study, an increased Cs of about 160 µg/mL was obtained

Stationary beam full-field transmission helium ion microscopy using sub-50 keV He⁺: Projected images and intensity patterns

• Michael Mousley,
• Santhana Eswara,
• Olivier De Castro,
• Olivier Bouton,
• Nico Klingner,
• Christoph T. Koch,
• Gregor Hlawacek and
• Tom Wirtz

Beilstein J. Nanotechnol. 2019, 10, 1648–1657, doi:10.3762/bjnano.10.160

• thickness fringes seen in transmission electron microscopy (TEM) have been observed in a HIM and have possible explanations involving diffraction [19] or inelastic scattering [23] of He+ ions. This observation led to computational work investigating coherent scattering, channeling and diffraction of He

Chiral nanostructures self-assembled from nitrocinnamic amide amphiphiles: substituent and solvent effects

• Hejin Jiang,
• Huahua Fan,
• Yuqian Jiang,
• Li Zhang and
• Minghua Liu

Beilstein J. Nanotechnol. 2019, 10, 1608–1617, doi:10.3762/bjnano.10.156

• hydrogen bonding eventually led to different packing of the self-assembled molecules. The strong hydrogen bonding favored the formation of right-handed nanohelical structures, while the opposite chirality of the left-handed superhelix of 3NCLG was attributed to the weak hydrogen bonding in these assemblies

• molecular chirality of the three NCLG molecules was derived from the same source, i.e., ʟ-glutamic acid. At the same time, the variation in the substituted position also led to different gelation abilities. Additionally, it was demonstrated that the chirality of a nanostructure can also be regulated by