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Search for "activity" in Full Text gives 670 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes
Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73
- current drugs used to treat the disease. The synthesized SPIONs showed promising activity against Leishmania and can be considered a strong candidate for a new therapeutic approach for treating leishmaniases. Keywords: coconut water; Leishmaniasis; Leishmania amazonensis; nanomedicine; SPIONs
Biomimetics on the micro- and nanoscale – The 25th anniversary of the lotus effect
Beilstein J. Nanotechnol. 2023, 14, 850–856, doi:10.3762/bjnano.14.69
- the same time selectively enhance regeneration in host tissues. The authors point out that in this context, protein-based materials and especially silk materials are interesting candidates due to their natural origin, biological activity, and structural properties. These exciting recombinant
Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies
Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66
- trypanocidal activity against trypomastigotes compared to that of the free drug [18]. Among the aforementioned nanosystems, SLNs have recently gained special attention owing to their biocompatibility properties, biodegradability, relatively easy surface and composition modification, and efficacy in loading and
- higher cumulative release and considerable higher activity against amastigotes compared to previously reported BNZ-loaded NLCs. Moreover, we report the dose-response intrinsic activity of myristyl myristate, a relatively common constituent of NLCs, against T. cruzi, which might be of future interest to
- repulsion after adding a non-ionic surfactant [41]. Cytotoxicity and hemolytic activity Cytotoxicity assays using the tetrazolium 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide salt method (MTT) showed that Chinese hamster ovary cells (CHO) viability was affected by BNZ concentration in a dose
Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity
Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64
- catalytic performance in degrading the pollutants methyl orange and rhodamine B. The antibacterial activity of the nanocomposite is pH-dependent, related to the alterations in surface properties of the nanocomposite at different pH values. At pH 6, the nanocomposite demonstrated the highest antibacterial
- activity. These findings suggest that this nanocomposite has the potential to be tailored for specific applications in environmental and medicinal treatments, making it a highly promising material. Keywords: alginate; bacterial activity; catalysis; lactose; silver nanoparticles; synthesis; Introduction
- release of silver ions or electrostatic interaction between AgNPs and microbial cells, have been proposed [21][22]. The AgNPs might release silver ions capable of binding to nucleic acids, thereby, exhibiting antibacterial activity [23][24]. Consequently, any silver-containing composite material with
Nanomaterials for photocatalysis and applications in environmental remediation and renewable energy
Beilstein J. Nanotechnol. 2023, 14, 722–724, doi:10.3762/bjnano.14.58
- studies [20][21][22]. Besides, Nhu et al. [23] used rosin as a green chemical approach to fabricate ZnO nanoparticles, exhibiting a high photocatalytic activity for both methylene blue (100%) and methyl orange (82.78%) decomposition after 210 min under UV radiation. Moreover, the advantages in the
A graphene quantum dots–glassy carbon electrode-based electrochemical sensor for monitoring malathion
Beilstein J. Nanotechnol. 2023, 14, 701–710, doi:10.3762/bjnano.14.56
- the electrode are diffusion-controlled, and the linear relationship (R2 = 0.9674) between peak height and scan rate suggests an enhanced electrochemical activity. Electrochemical detection of malathion Using the modified working GQDs/GCE electrode as electrochemical sensor, a differential pulse
Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review
Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52
- surface chemistry, enabling nanosensors to achieve extremely low detection limits. Numerous nanomaterials shown in Figure 3 have different functionalities, including high conductivity, good catalytic activity, and optical and plasmonic properties, making them attractive candidates for opto-electrochemical
- materials as potent analytical tools because of their advantages in terms of portability, affordability, high sensitivity, and ease of fabrication. Through functions such as active large surface area, rapid electrode kinetics, and efficient catalytic activity, the amplification of electrochemical signals
- wide linear detection range with a detection limit of 0.05 μM. Due to the synergistic effects of the wide porosity and high specific surface area of the MOF and the outstanding catalytic activity and high conductivity of Ag nanoparticles, the hybridisation improved the electrochemical performance of
Titania nanoparticles for photocatalytic degradation of ethanol under simulated solar light
Beilstein J. Nanotechnol. 2023, 14, 616–630, doi:10.3762/bjnano.14.51
- differences in crystal structure are reflected in direct or indirect electron transitions. The bandgaps of anatase and rutile differ only by 0.2 eV, but can influence significantly the creation of electron–hole pairs, resulting in an increase of the photocatalytic activity. Anatase has a higher decomposition
- efficiency than rutile [14][31], while the highest photocatalytic activity has been found in mixed anatase/rutile TiO2 [13][32]. One possible explanation is that the difference in the crystal structure and chemical bonding results in different ionization potentials and electron affinities. Exploiting these
- ratio between anatase and rutile that yields the highest photocatalytic activity. Thus, the main scope of this study is to find the best process parameters for the pyrolysis synthesis of TiO2 powders. Another part is to obtain powders with specific mixtures of the crystallographic phases (anatase/rutile
Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials
Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43
- , by inorganic components generated by sol–gel processes from silicon alkoxides is an illustrative example of biohybrids that display the extraordinary functionality inherent to the assembled living components. For instance, bacteria such as Escherichia coli maintain their metabolic activity entrapped
- demonstrated great biocompatibility, allowing the cells to survive over long periods of time [38]. However, in the present study using chitosan-based biohybrids, we have observed that the cells did not stay alive for long. The current results point out that chitosan may exhibit antibacterial activity
- –alginate biohybrid systems (Supporting Information File 1, Figure S1). The optimization study also showed that the use of a sodium silicate concentration of 7.5% may cause an increase in the diffusional limitation, reducing the exchange of compounds necessary for the biological activity of the encapsulated
Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science
Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35
- , this has come to be explained more rationally. Nanotechnology has a significant impact not only on the extreme science of the very small size regions [27][28][29], but also on realistic materials science [30][31][32]. For example, the elucidation of catalytic sites exhibiting very high activity [33][34
- and activity are due to features at the atomic and molecular level [141][142]. It is often observed that a particular molecular structure or an atom at a particular site can be highly functional and active. Molecular nanoarchitectonics, as shown here, can be an important key to understand such aspects
Evaluation of electrosynthesized reduced graphene oxide–Ni/Fe/Co-based (oxy)hydroxide catalysts towards the oxygen evolution reaction
Beilstein J. Nanotechnol. 2023, 14, 420–433, doi:10.3762/bjnano.14.34
- catalytic activity of the catalysts with and without GO were studied. The catalysts were fabricated via a two-step electrodeposition. The first step included the deposition of GO flakes, which, in the second step, were reduced during the simultaneous deposition of NiFe or CoNiFe. As a result, NiFe-GO and
- CoNiFe-GO were fabricated without any additives directly on the nickel foam substrate. A significant improvement of the OER activity was observed after combining NiFe with GO (OER overpotential η(10 mA·cm−2): 210 mV) compared to NiFe (η: 235 mV) and GO (η: 320 mV) alone. A different OER activity was
- observed for CoNiFe-GO. Here, the overall catalytic activity (η: 230 mV) increased compared to GO alone. However, it was reduced in comparison to CoNiFe (η: 224 mV). The latter was associated with the change in the morphology and structure of the catalysts. Further OER studies showed that each of the
New trends in nanobiotechnology
Beilstein J. Nanotechnol. 2023, 14, 377–379, doi:10.3762/bjnano.14.32
- cytotoxicity activity on cancer and healthy cells. The results showed a selective cytotoxicity of the nanoparticles towards cancer cell compared to that towards monocytes. This finding gives rise to the development of a new system where cytotoxicity can be selective. This may benefit future research in the
Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31
- colloidal core Ag NPs, was confirmed by UV–vis, and FTIR analyses, and monitored by TEM microscopy. The size of nanoparticles has been determined as 11.2 and 10.3 nm for Ch/Q- and Ch/CA-Ag, respectively. The anticancer activity of Ch/Q- and Ch/CA-Ag NPs has been evaluated against U-118 MG (human
- glioblastoma) and ARPE-19 (human retinal pigment epithelium) cells. Both NPs showed anticancer activity, but Ch/Q-Ag NPs seemed to be more effective on cancer cell lines (U-118 MG) in comparison to healthy ones (ARPE-19). Furthermore, the antibacterial activity of Ch/Q- and Ch/CA-Ag NPs against Gram-negative
- as crabs, and shrimps. It is also found in the skeleton of insects and the structure of cell walls of fungi [11][12]. Chitosan, which was defined as an antimicrobial agent for the first time by Allan and Hadwiger, exhibits broad-spectrum antimicrobial activity [13][14]. In the last decade, chitosan
Polymer nanoparticles from low-energy nanoemulsions for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29
- 80/20 and water contents above 87 wt %, with droplet sizes in the 180–190 nm range. The derived ethyl cellulose nanoparticles had a size between 107 and 161 nm as estimated by TEM and SEM (Figure 2). Dexamethasone (DXM), a steroid with potent anti-inflammatory and immunosuppressant activity, was
- in the nanoemulsion. These nanoparticles were complexed with folic acid and showed low hemolytic activity (below 5%). The characteristics of the reported PIC nanoemulsions and derived ethyl cellulose nanoparticles are summarized in Table 1. 3.2 Poly(lactic-co-glycolic acid) nanoparticles Poly(lactic
- cells incubated with the loaded nanoparticles were close to 100% for GAL concentrations of 0.3 mg/mL. The pharmacological activity of GAL was preserved after encapsulation (as measured by the acetylcholinesterase inhibition test). PLGA nanoparticles prepared from a 0.16 M PBS (W)/Polysorbate 80 (S)/(4
Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles
Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28
- halted cellular activity using perfusion with a fixative, which allowed researchers to separate the passive and active transport mechanisms [31]. Nevertheless, research currently confirms the existence of a completely different active transport mechanism of NPs across the endothelium that is unrelated to
Bismuth-based nanostructured photocatalysts for the remediation of antibiotics and organic dyes
Beilstein J. Nanotechnol. 2023, 14, 291–321, doi:10.3762/bjnano.14.26
- -light spectrum. Additionally, the reverse bond between the cation and anion is more favourable for the production and transportation of holes, which facilitates photocatalytic activity. Because of this, significant efforts have been made to synthesise bismuth-based nanomaterials (BiVO4, Bi5O7I-MoO3
- photocatalytic degradation of organic dyes and antibiotics in water. The general synthesis of nanometre-sized photocatalytic materials based on bismuth employing energy-efficient techniques is examined. A critical review is also given of ways to improve the photocatalytic activity of the photocatalysts. An
- charges and, hence, increase photocatalytic activity, metallic bismuth can function as a direct plasmonic photocatalyst (similar to Au and Ag) or a co-catalyst [77]. Also, the unique layered crystal structure of Aurivillius-type bismuth oxide-based semiconductors allows for the induction of an internal
Biocatalytic synthesis and ordered self-assembly of silica nanoparticles via a silica-binding peptide
Beilstein J. Nanotechnol. 2023, 14, 280–290, doi:10.3762/bjnano.14.25
- silica precipitation in vitro [29][30][31][32]. The catalytic activity of these proteins is thought to be similar to the serine–histidine–aspartic acid (SHD) catalytic triad [33][34]. In this model, a hydrogen bond between serine and histidine increases the nucleophilicity of serine. Aspartic acid
- are substituted could help to elucidate the nature of the catalytic activity of SiBP. As mentioned above, the yield of the reactions with SiBP alone were lower compared to reactions including NH3 despite the same amount of initial precursor molecules (Figure 1c). A probable reason of this observation
- S5). The first hypothesis of the study was accepted as when used alone, the SiBP was able to catalyze the hydrolysis of precursor molecules and precipitate approx. 20 nm SiO2 particles organized in a branched fiber network. We propose that the catalytic activity is mediated either by the serine
Recent progress in cancer cell membrane-based nanoparticles for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24
- in clinical cancer treatment. Its bioavailability and antitumor activity in the antitumor process have also been shown to be enhanced by encapsulation with liver cancer cell membranes [75]. Radiotherapy also plays an important role in tumor therapy. Nevertheless, it has been hindered by the
- effectively increased in tumor tissues, and the side effects on normal tissues can be significantly reduced [92]. Quercetin (QT), a flavonoid with various functions, such as antitumor activity and radiosensitization, has been loaded into NPs and encapsulated by cancer cell membranes to further study its
- nanoparticle with radiosensitizing activity, which showed better biocompatibility and tumor targeting after coating with a cancer cell membrane [77]. Volume and weight of tumors in mice treated with biomimetic NPs and irradiation were significantly reduced compared to those of mice treated with bare NPs. The
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23
- pathway inhibitor/s EGFR signal transduction pathways can be roughly divided into a pro-survival arm with the PI3K-mTOR-AKT cascade and a proliferative arm with the Ras-Raf-Mek-Erk cascade. Enhanced kinase activity on mutated EGFR with exon 19 deletion is associated with upregulated c-MYC levels through
- additive antitumor activity via downregulation of the c-MYC–HIF-1α–VEGF signaling pathway in mutated NSCLC with exon 19 deletions (Figure 1) [32][33][34]. Several randomized clinical studies have also reported on the increased effectiveness of combined chemotherapy/EGFR TKI treatments in patients with
- activity, including the downstream TKI resistance mutations (Figure 1) [70]. Lu et al. tested the efficacy of combined siRNA treatment with gefitinib in several NSCLC cell lines (A549, H1975, and H1993). The A549 cell line carried wild-type EGFR and KRAS mutations, H1975 cells expressed L858R/T790M EGFR
Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems
Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21
- S–S linkages by intracellular glutathione (GSH). As the result, both gene editing by sgRNA/Cas9 and gene silencing by the antisense DNA cooperatively suppressed the PLK1 gene, providing remarkable antitumor activity. 4 CyD-based nanoarchitectures for effective photodynamic therapy Photodynamic
- reactive nitrogen species that are more biocidal than ROSs. Another NO-releasing β-CyD derivative (modified with N-diazoniumdiolate) showed notable bactericidal activity on a Gram-negative pathogen [80]. Other NO-releasing CyDs were also reported [81][82]. In chemodynamic therapy, ROSs are produced from
- also to increase the solubility of the protein through the binding to bulky and apolar side chains. The antiviral activity of modified CyDs towards various viruses has been previously reported as well [108]. 6.2 Molecular imprinting on CyD to bind large drugs It often happens that one CyD molecule is
A novel approach to pulsed laser deposition of platinum catalyst on carbon particles for use in polymer electrolyte membrane fuel cells
Beilstein J. Nanotechnol. 2023, 14, 190–204, doi:10.3762/bjnano.14.19
- commonly used catalyst in PEMFCs is platinum on various carbon support materials, which is used in both the anode and cathode because of its high catalytic activity toward the hydrogen oxidation reaction (HOR) and oxygen reduction reaction (ORR) [6][17][18][19][21][22][23][24][25]. Pt is also characterized
- (Figures 4b and 4c). This observation is confirmed by the almost identical shape of the Pt 4f band (the same position and width of the peaks) for sample A and the reference catalyst 20% Pt XC-72R (Table 1). RRDE measurements of ORR activity of Pt catalysts The activity of the obtained Pt-based catalysts
- was initially assessed under well-defined rotating ring-disk electrode (RRDE) conditions. The ORR activity of Pt-based catalysts was evaluated in O2-saturated 0.5 M H2SO4 solution (Figure 5, Table 2, and Supporting Information File 1, Figure S3). Figure 5 allows for a quick comparison of the
Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine
Beilstein J. Nanotechnol. 2023, 14, 165–174, doi:10.3762/bjnano.14.17
- activity including the usage in wound healing [24]. Different authors prepared CQDs by using various precursors and reported on their excellent antibacterial activity and good biocompatibility [25][26][27][28][29]. In this study o-phenylenediamine dissolved in toluene was used as precursor for CQDs
- species production Singlet oxygen generation The ability to produce reactive oxygen species (ROS) is a very important parameter for the determination of antibacterial activity of certain material. First, we examined the ROS generation of CQDs (Figure S2d, Supporting Information File 1). From this figure
- generate singlet oxygen. Both obtained results related to production of ROS indicate that there are no reactive centers in the structure of the carbon core that could enable the production of ROS. Antibacterial testing The antibacterial activity of CQDs differs from the antibacterial mechanism of
Batch preparation of nanofibers containing nanoparticles by an electrospinning device with multiple air inlets
Beilstein J. Nanotechnol. 2023, 14, 141–150, doi:10.3762/bjnano.14.15
- easily sink down, resulting in an uneven distribution of nanoparticles in the obtained fibers [17]. Due to their stable physical and chemical properties, good biocompatibility, excellent photoelectric properties, non-toxicity, strong antibacterial activity and low price, ZnO nanoparticles can be used in
Antimicrobial and mechanical properties of functionalized textile by nanoarchitectured photoinduced Ag@polymer coating
Beilstein J. Nanotechnol. 2023, 14, 95–109, doi:10.3762/bjnano.14.11
- replication [21]. Silver nanoparticles (AgNPs) have the added benefit of being ionic silver vessels, combining the latter’s antimicrobial properties with their own characteristics [16]. Pal et al. [22] demonstrated that triangular AgNPs seem to exhibit increased biocide activity compared to their spherical
- activity of the functionalized textiles was quantified via a liquid diffusion assay, while a plate diffusion assay was used to visualize the microbial growth inhibition. Preliminary tests showed that the Ag@PEG600DA-coated textile does not stay flat during immersion into microbial suspensions, despite
- in Figure 11a for E. coli and remarkably a total inhibition of growth was reached within 24 hours. The silver concentration has no significant impact on antibacterial activity, which indicates that a mere 3 wt % Ag-loaded sample is sufficient to obtain complete elimination of bacteria. The released
Induced electric conductivity in organic polymers
Beilstein J. Nanotechnol. 2022, 13, 1551–1557, doi:10.3762/bjnano.13.128
- Lab project between HSE University and Bashkir state pedagogic University. The activity of A.S.G. was supported by the Basic Research program of HSE University.
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