Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• . This sensitivity is sufficient for the detection and monitoring of this persistent pollutant in drinking water. As mentioned previously, the discrimination of chiral substances is a rather tough goal in sensor design. However, the detection of chiral amino acids is an unavoidable matter in technologies

• biomolecules including amino acids [156], peptides [157][158][159], sugars [160][161], nucleic acid bases [162][163], and nucleotides [164][165][166] at well-designed interfacial environments. In order to design and fabricate sensors with better performance, interfacial nanoarchitectonics should be crucial

• used to realize switching recognition selectivity between ʟ- and ᴅ-amino acids [176][177]. Chiral sensing can be tuned by mechanical deformation of the receptor membrane at the interfacial environment. Two-dimensional deformation of cholesterol-substituted triazacyclononane monolayer was used to

Chiral nanostructures self-assembled from nitrocinnamic amide amphiphiles: substituent and solvent effects

• Hejin Jiang,
• Huahua Fan,
• Yuqian Jiang,
• Li Zhang and
• Minghua Liu

Beilstein J. Nanotechnol. 2019, 10, 1608–1617, doi:10.3762/bjnano.10.156

• , amino acids [9][10][11], oligopeptides [12][13], saccharides [14][15][16], steroids [17][18] and diaminocyclohexane derivatives [19][20] have been reported to self-assemble into helical structures, mimicking the natural helical structures found in biological systems. Generally speaking, the common

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

• ]. Although molecular recognition via hydrogen bonding are quite difficult in a highly polar aqueous media, the molecular recognition of sugars [145][146], peptides [147][148][149], amino acids [150], nucleic acid bases [151][152], and nucleotides [153][154] is accomplishable at the air–water interface even

• conformational changes of molecular receptors at the air–water interface results in a change of the chiral selectivity towards aqueous amino acids [174][175], or of the optimum guest structure from thymine to uracil derivatives [176][177]. Regulation of molecular interaction at liquid interfaces yields a novel

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• -essential amino acids (NEA), 1% (v/v) L-alanyl-L-glutamine (200 mM), and 1% (v/v) penicillin/streptomycin (100 U/mL) (serum-free medium). For the identification of corona proteins by LC–MS/MS analysis a larger particle surface area was required. Thus, 1000 µL of either FBS or human serum were added to an

• cm2 flasks with DMEM supplemented with 10% (v/v) FBS, 1% (v/v) non-essential amino acids (NEA), 1% (v/v) L-alanyl-L-glutamine (200 mM), 1% (v/v) penicillin/streptomycin (100 U/mL) at 37 °C, 100% humidity in a 10% CO2 atmosphere. Cells were subcultivated twice a week at a ratio of approximately 1:5

Outstanding chain-extension effect and high UV resistance of polybutylene succinate containing amino-acid-modified layered double hydroxides

• Adam A. Marek,
• Vincent Verney,
• Christine Taviot-Gueho,
• Grazia Totaro,
• Laura Sisti,
• Annamaria Celli and
• Fabrice Leroux

Beilstein J. Nanotechnol. 2019, 10, 684–695, doi:10.3762/bjnano.10.68

• melt compounding process. The Mg2Al-based PBS nanocomposites, dispersed with inorganic–organic hybrid materials (layered double hydroxides, LDHs), were functionalized with the amino acids L-histidine (HIS) and L-phenylalanine (PHE). The rheological and anti-ultraviolet (anti-UV) properties were

• ]. LDHs are considered to be “green” and low environmental impact fillers [12], biocompatible [13] and food compatible [14]. Indeed the choice of organo-modified LDH using amino acids, and among them the protein-building amino acids, has already been demonstrated [15]. Having in mind that UV stabilization

• should require UV absorption properties for the organic molecule, any proteinogenic amino acids presenting cycle in their backbone will be preferentially considered. Tyrosine and tryptophan have been studied for their UV stabilizing properties; however, histidine (HIS) and (PHE) are rarely reported. One

Mechanical and thermodynamic properties of Aβ₄₂, Aβ₄₀, and α-synuclein fibrils: a coarse-grained method to complement experimental studies

• Adolfo B. Poma,
• Horacio V. Guzman,
• Mai Suan Li and
• Panagiotis E. Theodorakis

Beilstein J. Nanotechnol. 2019, 10, 500–513, doi:10.3762/bjnano.10.51

• of the individual amino-acid chains in these structures. Fibrils consisting of either 40-mer or 42-mer amyloid chains (it contains two additional hydrophobic amino acids) are particularly interesting. For example, Aβ40 typically assembles into two-fold or three-fold symmetries (see Figure 1), while

• achieve this by applying different types of deformation (e.g., tension, shearing and indentation) and analysing the intermolecular contacts between amino acids. Our simulations reveal significant differences in the mechanical behaviour between Aβ40 and Aβ42 and α-syn fibrils. Moreover, we find that the α

• to a van der Waals radius, as proposed by Tsai and co-workers [49]. A sphere with the radius enlarged by a factor of 1.24 is built around the atom. If two amino acids have heavy atoms with overlapping spheres, then we consider a native contact between those two Cα atoms. In Figure 2, we show the CG

Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition

• Leva Momtazi,
• Henrik H. Sønsteby and
• Ola Nilsen

Beilstein J. Nanotechnol. 2019, 10, 399–411, doi:10.3762/bjnano.10.39

• previous study on organic–inorganic MLD materials, in which we used amino acids as organic linkers to form titaminates [22]. We here build on that knowledge and expand the range of bioactive MLD materials to now include nucleobases as organic linkers. The films have been prepared by combining titanium

• tetra-isopropoxide (TTIP) with thymine, uracil, and adenine (Figure 1). We have recently reported a significant increase in the proliferation rate of rat conjunctival goblet cells cultured on substrates coated with these hybrid materials based on amino acids, and also the currently presented nucleobases

• , respectively. The increase in refractive index with temperature is similar to what we observed for the Ti-amino acids films in our previous study while the density of these materials was less affected by temperature as compared to the density of the Ti-nucleobase films [22]. After one day of exposure in air

Mechanism of silica–lysozyme composite formation unravelled by in situ fast SAXS

• Tomasz M. Stawski,
• Daniela B. van den Heuvel,
• Rogier Besselink,
• Dominique J. Tobler and
• Liane G. Benning

Beilstein J. Nanotechnol. 2019, 10, 182–197, doi:10.3762/bjnano.10.17

• of the opposite active sites in the side-on orientation (i.e., both active sites show similar binding properties). In such a case one should indeed expect the DLPCA mode of aggregation, with the binding of the protein to the silica NP surfaces taking place through specific amino acids at the opposite

A novel polyhedral oligomeric silsesquioxane-modified layered double hydroxide: preparation, characterization and properties

• Xianwei Zhang,
• Zhongzhu Ma,
• Hong Fan,
• Carla Bittencourt,
• Jintao Wan and
• Philippe Dubois

Beilstein J. Nanotechnol. 2018, 9, 3053–3068, doi:10.3762/bjnano.9.284

• ][19], amino acids [20], anionic dyes [11], and compounds of biological origin, such as β-cyclodextrin and eugenol derivatives [9][10][13][21]. However, most of these current modifiers do not have satisfactory thermal stability and are flammable, reducing the thermal and fire stability of the LDHs

Colloidal chemistry with patchy silica nanoparticles

• Pierre-Etienne Rouet,
• Cyril Chomette,
• Laurent Adumeau,
• Etienne Duguet and
• Serge Ravaine

Beilstein J. Nanotechnol. 2018, 9, 2989–2998, doi:10.3762/bjnano.9.278

• colloidal molecules The binding of the aminated dimpled particles with the satellites is based on amide bonding, i.e., peptidic coupling, extensively studied in biochemistry for the modification of amino acids [25]. The carboxylic groups are not reactive enough toward amino groups, and a simple and well

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• high molecular weight, such as silica, chitosan, poly(amino acids), poly(acrylic acid), hyaluronic acid, alginic acid, poly(vinyl alcohol), polyethylenimine, dextran, or poly(ethylene glycol) (PEG) [10][11][12]. The latter one is known to escape recognition by reticuloendothelial system prolonging thus

Nanoscale characterization of the temporary adhesive of the sea urchin Paracentrotus lividus

• Ana S. Viana and
• Romana Santos

Beilstein J. Nanotechnol. 2018, 9, 2277–2286, doi:10.3762/bjnano.9.212

• repetitive structural unit within the adhesive. According to the authors, since the adhesive is proteinaceous in nature, this repetitive hidden length corresponds approximately to the number of amino acids involved in the intermolecular β-sheet, which in that case was 43 amino acids [1]. In the present study

Colorimetric detection of Cu²⁺ based on the formation of peptide–copper complexes on silver nanoparticle surfaces

• Gajanan Sampatrao Ghodake,
• Surendra Krishna Shinde,
• Rijuta Ganesh Saratale,
• Avinash Ashok Kadam,
• Ganesh Dattatraya Saratale,
• Asad Syed,
• Fuad Ameen and
• Dae-Young Kim

Beilstein J. Nanotechnol. 2018, 9, 1414–1422, doi:10.3762/bjnano.9.134

• appropriate to develop analytical applications. It can be concluded that amino acids bind to the nanoparticle surfaces through NH2–OH hydrogen bonds and electrostatic interactions [17]. In the N 1s spectrum two peaks were identified. The peak at 398.2 eV was allocated to deprotonated nitrogen bindings (N–C=O

Noble metal-modified titania with visible-light activity for the decomposition of microorganisms

• Maya Endo,
• Zhishun Wei,
• Kunlei Wang,
• Baris Karabiyik,
• Kenta Yoshiiri,
• Paulina Rokicka,
• Bunsho Ohtani,
• Agata Markowska-Szczupak and
• Ewa Kowalska

Beilstein J. Nanotechnol. 2018, 9, 829–841, doi:10.3762/bjnano.9.77

• membrane by alteration of the membrane viscosity and disruption of ionic pumps [60]. It is assumed that fine gold NPs more effectively clogged the channels (called porins), which allowed for passive transports of various ions, amino acids and other important molecules. This mechanism is independent on

Bombyx mori silk/titania/gold hybrid materials for photocatalytic water splitting: combining renewable raw materials with clean fuels

• Stefanie Krüger,
• Michael Schwarze,
• Otto Baumann,
• Christina Günter,
• Michael Bruns,
• Christian Kübel,
• Dorothée Vinga Szabó,
• Rafael Meinusch,
• Verónica de Zea Bermudez and
• Andreas Taubert

Beilstein J. Nanotechnol. 2018, 9, 187–204, doi:10.3762/bjnano.9.21

• a scaffold for photocatalyst synthesis. Instead of plasma chemistry, however, we employed a much softer wet chemistry method for materials synthesis. B. mori silk contains numerous amino acids, predominantly glycine, alanine, serine, and tyrosine [37][38]. As numerous amide and hydroxyl groups are

L-Lysine-grafted graphene oxide as an effective adsorbent for the removal of methylene blue and metal ions

• Yan Yan,
• Jie Li,
• Fangbei Kong,
• Kuankuan Jia,
• Shiyu He and
• Baorong Wang

Beilstein J. Nanotechnol. 2017, 8, 2680–2688, doi:10.3762/bjnano.8.268

• (20 mL) at 90 °C for 12 h. The L-lysine modified graphene sheets were obtained by filtration and washed by 5 wt % NaHCO3, deionized water, and ethanol to remove the unreacted amino acids, respectively. Finally, the sample was dried under vacuum at 50 °C. The whole route of synthesis is shown in Scheme

Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology

• Clelia Galati,
• Natalia Spinella,
• Lucio Renna,
• Danilo Milardi,
• Francesco Attanasio,
• Michele Francesco Maria Sciacca and
• Corrado Bongiorno

Beilstein J. Nanotechnol. 2017, 8, 2446–2453, doi:10.3762/bjnano.8.243

• , and scientists believe that the observed build-up of plaque between nerve cells could be the cause of cell death [1]. Two peptides, 40 and 42 amino acids long, known as Aβ40 and Aβ42 amyloid, are the main constituents of the fibrillar plaques [2]. Although amyloid fibrils were initially considered the

• in [42] this peptide was assembled using the microwave-assisted solid-phase peptide synthesis strategy on a Liberty Peptide Synthesiser. All Fmoc-amino acids were introduced according to the TBTU/HOBT/DIEA activation method, as reported elsewhere [11]. Semax was purchased from Caslo, with a purity of

Methionine-mediated synthesis of magnetic nanoparticles and functionalization with gold quantum dots for theranostic applications

• Arūnas Jagminas,
• Agnė Mikalauskaitė,
• Vitalijus Karabanovas and
• Jūrate Vaičiūnienė

Beilstein J. Nanotechnol. 2017, 8, 1734–1741, doi:10.3762/bjnano.8.174

• attachment of gold species. In recent publications amino acids such as methionine [19] and lysine [24] have been reported to be effective capping agents to control the size of magnetite [19] and Co ferrite [24] NPs during co-precipitation synthesis [25]. The main goal of the methionine capping was the

Luminescent supramolecular hydrogels from a tripeptide and nitrogen-doped carbon nanodots

• Maria C. Cringoli,
• Slavko Kralj,
• Marina Kurbasic,
• Massimo Urban and
• Silvia Marchesan

Beilstein J. Nanotechnol. 2017, 8, 1553–1562, doi:10.3762/bjnano.8.157

• allows several molecular precursors to be employed, such as amino acids in aqueous solution [3]. As an example, L-tyrosine was used to form hydrophobic CNDs able to sense ions and silver nanoparticles [4]. Arginine or cysteine have also been efficiently employed as starting materials through a

• water [24]. In 2012, the first systems of uncapped tripeptides were reported to self-assemble into nanostructured hydrogels at physiological conditions and without the need for organic solvents. These tripeptides were heterochiral, that is, composed of both D- and L-amino acids, and they formed

• ][31] and bearing unnatural D-amino acids [32][33] are attractive biomaterials that may display higher durability relative to traditional peptide counterparts, in addition to better biocompatibility and the possibility to incorporate bioactive motifs relative to non-peptide hydrogels. Therefore, in the

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• Taxus brevifolia and further obtained semi-synthetically [1]. Its unique antimitotic mechanism depends on inducing the microtubule stabilization and inhibiting the depolymerization of microtubules [2]. PCX binds to N-terminal 31 amino acids of the β-tubulin proteins in microtubules and stabilizes

Low uptake of silica nanoparticles in Caco-2 intestinal epithelial barriers

• Dong Ye,
• Mattia Bramini,
• Delyan R. Hristov,
• Sha Wan,
• Anna Salvati,
• Christoffer Åberg and
• Kenneth A. Dawson

Beilstein J. Nanotechnol. 2017, 8, 1396–1406, doi:10.3762/bjnano.8.141

• Medium (cDMEM) supplemented with 10% FBS, 5 mL MEM non-essential amino acids (100 X), 5 mL Penicillin-Streptomycin (100 X, 10,000 units Penicillin and 10,000 µg Streptomycin) in a cell incubator at 37 °C in a humidified 5% CO2 atmosphere. Cells were trypsinised from the flasks when 80–90% confluence was

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• previously described [27][28]. Cell culture The human PCa cell line DU-145 (HTB-81; ATCC, Rockville, MD, USA) was cultured in Dulbecco’s modified minimum essential medium supplemented with 10% fetal bovine serum, 1% 1 M HEPES buffer and 1% MEM non-essential amino acids (all from Invitrogen, Karlsruhe

Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy

• Isabella Tavernaro,
• Christian Cavelius,
• Henrike Peuschel and
• Annette Kraegeloh

Beilstein J. Nanotechnol. 2017, 8, 1283–1296, doi:10.3762/bjnano.8.130

• amounts of salts, amino acids and proteins. In aqueous media, electrostatic repulsion contributes to particle stabilisation. In presence of salts at neutral pH values, this type of stabilisation might be ineffective. In contrast, the formation of a protein corona at the interface between particle surface

Evaluation of quantum dot conjugated antibodies for immunofluorescent labelling of cellular targets

• Jennifer E. Francis,
• David Mason and
• Raphaël Lévy

Beilstein J. Nanotechnol. 2017, 8, 1238–1249, doi:10.3762/bjnano.8.125

• 75 cm2 flask at 37 °C with 5% CO2, minimum essential media (MEM, Life Technologies, UK) supplemented with 10% (v/v) foetal calf serum (FCS), and 1% non-essential amino acids (NEAA). Cells were split 1,000,000 cells/mL when ≥80% confluent with trypsin-EDTA. Rat mammary (Rama) 27 fibroblasts were

Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

• Mohamed Hamed Misbah,
• Mercedes Santos,
• Luis Quintanilla,
• Christina Günter,
• Matilde Alonso,
• Andreas Taubert and
• José Carlos Rodríguez-Cabello

Beilstein J. Nanotechnol. 2017, 8, 772–783, doi:10.3762/bjnano.8.80

• . In the present work, an elastin-like recombinamer bearing lysine amino acids distributed along the recombinamer chain has been cross-linked via Huisgen [2 + 3] cycloaddition. The recombinamer contains the SNA15 peptide domains inspired by salivary statherin, a peptide epitope known to specifically

• of sample nomenclature), where the guest amino acid X can be any of the natural or synthetic L-amino acids except L-proline. ELRs exhibit an intrinsic inverse temperature transition (Tt) in aqueous solution. Thus, below Tt, the ELR chains are highly hydrated, which gives rise to well-solvated

• ) amino acids [36]. The addition of specific functional domains further broadens the application potential of ELRs. The SNA15 domain exhibits a high affinity for CP and is able to nucleate mineral phases from calcium- and phosphate-containing solutions [36][37]. Moreover, its α-helical conformation and