Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• can be useful as adjuvant in cancer treatment, after surgical procedure, or in combination with chemotherapy [35][36][37][38][39][40][41]. Despite its broad therapeutic potential, CUR has limited stability to light and pH, as well as poor solubility. CUR is also susceptible to degradation due to the

Dynamics of superparamagnetic nanoparticles in viscous liquids in rotating magnetic fields

• Nikolai A. Usov,
• Ruslan A. Rytov and
• Vasiliy A. Bautin

Beilstein J. Nanotechnol. 2019, 10, 2294–2303, doi:10.3762/bjnano.10.221

• ][3][19][20], certain thermal effects in combination with radiotherapy or chemotherapy can significantly improve the results of cancer treatment. One of the main technological problems of current magnetic hyperthermia development is the optimal choice of sizes and magnetic parameters of nanoparticles

• and analytical calculations. This topic has recently attracted considerable interest [33][34][35][36][37][38][39][40][41][42][43] in view of the possibility of using magnetic nanoparticles in magnetic hyperthermia for the cancer treatment. Unfortunately, in experiments [41][43] very small SAR values

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• below 100 nm and negative charges will be more suitable for lung cancer treatment. The morphology of the DiP and P2P was observed by transmission electron microscopy (TEM) and atomic force microscopy (AFM, Figure 3C,D). P2P and DiP demonstrated roughly homogeneous rod shapes in TEM but showed spherical

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• nanoparticles (AuNPs) range from molecular imaging, targeted drug delivery, gene therapy, cancer treatment or radio-sensitization and theranostics [1][4][6]. Moreover, AgNPs and AuNPs are among the most investigated engineered nanomaterials for medical use. A search performed in the Web of Science (WoS

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

• Hajar Jalili,
• Bagher Aslibeiki,
• Ali Ghotbi Varzaneh and
• Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

• ) and especially magnetic hyperthermia therapy, which is one of the efficient and new approaches for cancer treatment [4][15]. When magnetic NPs concentrated in tumor tissue are exposed to an ac magnetic field, the electromagnetic energy is converted into thermal energy, and the generated heat is used

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• engineering, and their incorporation in dental devices [25][26][27][28][29][30][31][32]. Another important medical application for nanostructures in general, and for TMDC nanostructures in particular, is targeted cancer treatment through photothermal therapy (PTT). In this method, light-responsive materials

Heating ability of magnetic nanoparticles with cubic and combined anisotropy

• Nikolai A. Usov,
• Mikhail S. Nesmeyanov,
• Elizaveta M. Gubanova and
• Natalia B. Epshtein

Beilstein J. Nanotechnol. 2019, 10, 305–314, doi:10.3762/bjnano.10.29

• ; Introduction Magnetic hyperthermia [1][2][3] is a promising therapeutic method that can be used in combination with chemotherapy or radiotherapy for cancer treatment. Iron oxide nanoparticles are among the materials most popular for application in biomedicine due to their biocompatibility, biodegradability [4

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

• Anouchka Plan Sangnier,
• Romain Aufaure,
• Laurence Motte,
• Claire Wilhelm,
• Erwann Guenin and
• Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

• , with an IC50 value of 100 µM. Under NIR irradiation a temperature increase was observed leading to a reduction of the IC50 value to 1 µM, with total tumor cell death at 100 µM. Keywords: alendronate; bisphosphonate; cancer treatment; gold nanoparticles; photothermia; Findings Bisphosphonates (BPs

• resonance leading to strong enhancement of the absorption and scattering when exposed to electromagnetic radiation [21]. Due to this plasmonic absorption, light is converted to heat [22][23][24][25][26]. Photothermal therapy (PTT) is a powerful cancer-treatment technique. Gold NPs have to be activated

Size-selected Fe₃O₄–Au hybrid nanoparticles for improved magnetism-based theranostics

• Maria V. Efremova,
• Yulia A. Nalench,
• Eirini Myrovali,
• Anastasiia S. Garanina,
• Ivan S. Grebennikov,
• Polina K. Gifer,
• Maxim A. Abakumov,
• Marina Spasova,
• Makis Angelakeris,
• Alexander G. Savchenko,
• Michael Farle,
• Natalia L. Klyachko,
• Alexander G. Majouga and
• Ulf Wiedwald

Beilstein J. Nanotechnol. 2018, 9, 2684–2699, doi:10.3762/bjnano.9.251

• properties of Fe3O4 NPs give rise to novel therapeutic approaches such as magneto-mechanical cancer treatment [4] and magnetic particle hyperthermia (MPH) [5][6][7] as well as to improvements in diagnostic techniques like magnetic resonance imaging (MRI) [8][9][10] and magnetic particle imaging (MPI) [11][12

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• MCF-7 cells [21]. Herein we report the synthesis of calcium phosphate nanoparticles loaded with 5-FU (CaP@5-FU NPs) with the goal of demonstrating enhanced efficacy in lung and colorectal cancer treatment in cell lines. The simple and reproducible reverse micellar microemulsion method was employed for

Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

• Sašo Gyergyek,
• David Pahovnik,
• Ema Žagar,
• Alenka Mertelj,
• Rok Kostanjšek,
• Miloš Beković,
• Marko Jagodič,
• Heinrich Hofmann and
• Darko Makovec

Beilstein J. Nanotechnol. 2018, 9, 1613–1622, doi:10.3762/bjnano.9.153

• Powder Technology, Ecole Polytechniquie Fédérale de Lausane, Station 12, 1015 Lausane, Switzerland 10.3762/bjnano.9.153 Abstract Nanocomposites with a high, uniform loading of magnetic nanoparticles are very desirable for applications such as electromagnetic shielding and cancer treatment based on

• , which makes it an attractive material for cancer treatment using magnetic-field-induced hyperthermia [37]. As expected, the temperature measured at 620 kHz is much higher even at lower applied magnetic field fields than in the case of 98 kHz. Figure 6c shows the comparison of the expected SLP

• potential for applications in cancer treatment based on magnetically induced hyperthermia. Mixture of ricinoleic-acid-coated iron-oxide nanoparticles with pure PMMA in toluene, NP-RA-PMMA (left container), and a colloidal suspension of the NP-PMMA-2 after polymerization (right container). The silver-grey

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

• ]. Generally, biocompatible magnetite (Fe3O4), iron oxide, iron sulfides and maghemite (Fe2O3) are synthesized using magnetotactic bacteria [156][157] that helps in targeted cancer treatment via magnetic hyperthermia, magnetic resonance imaging (MRI), DNA analysis and gene therapy [158]. Moreover, surface

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• of chemotherapy with PCX. A promising step was taken with the FDA approval of albumin nanoparticle bound PCX (Abraxane®) in 2005 for breast cancer treatment with a significantly lower dose [8]. This was considered a breakthrough in PCX formulation development as it avoided the use of solubilizers

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• mostly additive to partly synergistic induction of the cell death rate (Table 1). Discussion In addition to surgery and radiotherapy chemotherapy is the third pillar in cancer treatment. In PCa, systemic chemotherapy with DTX is mainly applied for the treatment of advanced PCa stages, whereas neoadjuvant

Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy

• Isabella Tavernaro,
• Christian Cavelius,
• Henrike Peuschel and
• Annette Kraegeloh

Beilstein J. Nanotechnol. 2017, 8, 1283–1296, doi:10.3762/bjnano.8.130

• drug carriers [3][4][5], as transfection agents [6][7], for cancer treatment by local hyperthermia [8][9], for labelling [10][11] and for bioimaging [12][13][14]. The detection of cell-associated and internalised nanoparticles and the analysis of their interactions with extracellular or subcellular

3D Nanoprinting via laser-assisted electron beam induced deposition: growth kinetics, enhanced purity, and electrical resistivity

• Brett B. Lewis,
• Robert Winkler,
• Xiahan Sang,
• Pushpa R. Pudasaini,
• Michael G. Stanford,
• Harald Plank,
• Raymond R. Unocic,
• Jason D. Fowlkes and
• Philip D. Rack

Beilstein J. Nanotechnol. 2017, 8, 801–812, doi:10.3762/bjnano.8.83

• detection [4], the study of biological systems important in determining cancer treatment options [5], and reliable, low cost, high performance magnetic hard disk drives [6]. A variety of fabrication techniques have been used to construct multi-dimensional nanostructures [7][8][9][10] with differing degrees

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• as well as DNA damage by the inhibition of topoisomerase II [1][2]. However, the second mechanism involving the increased production of ceramides inside cells has been recently postulated [3]. Application of this drug in the cancer treatment is limited because of serious side effects including drug

Simultaneous cancer control and diagnosis with magnetic nanohybrid materials

• Reza Saadat and
• Franz Renz

Beilstein J. Nanotechnol. 2016, 7, 121–125, doi:10.3762/bjnano.7.14

• detect cancer tissue with radiopharmaceuticals. By substitution of the Ga isotope with an alpha emitter the same compound could be used for cancer treatment. Furthermore the nanoparticles were connected to pH-sensitive complexes, enabling a pH-controlled assembly/disassembly and therefore the spreading

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• quantitative data (i.e., numerical values for different characterization parameters) associated with a specific class of dendrimer, poly(amidoamine) (PAMAM), which shows promise for cancer treatment. PAMAM dendrimers are three-dimensional, highly-branched, polymeric ENMs synthesized by growing shells of

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• nanocarriers for vitamin D3 delivery towards cancer treatment. Vitamin D3 vectorisation to guarantee specific action on malignant cells that avoids side effects such as hypercalcemia has been proposed. Nguyen et al. developed a formulation based on poly(vinyl neodecanoate-crosslinked-ethyleneglycol

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• compared to ZnO NP. We were able to show that the effect of ZnO NPs was improved by the formation of ZnO:Ag nanocomposites thereby improving their cell killing ability. Daylight-photodynamic therapy can provide a basis for targeted cancer treatment. However, further studies are required to evaluate the

Inorganic Janus particles for biomedical applications

• Isabel Schick,
• Steffen Lorenz,
• Dominik Gehrig,
• Stefan Tenzer,
• Wiebke Storck,
• Karl Fischer,
• Dennis Strand,
• Frédéric Laquai and
• Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

• particles used for catalysis [52][63][64], drug delivery [65], bimodal bioimaging [36][66][67][68], and biomedical applications [69][70] such as cancer treatment [71] are dumbbell-like Au@Fe3O4 nanoparticles. As no ternary Au-Fe-O phase or a gold oxide is present under the experimental conditions, there is

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• near-infrared region as a photothermal agent for in vivo cancer treatment, while scrutinising the effects originating from different graphene sizes and coatings [97]. Several research groups have focused on graphene as biosensors. Dey et al. [98] developed an amperometric cholesterol biosensor; Tang

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• , electronics, chemical labeling, optics and sensors. [4][5][6][7][8]. Nanomaterials that are biocompatible have gained research interest for biomedical applications that include cancer treatment [9][10]. Consequently, one of the challenges in synthesizing nanoscale biocompatible materials is designing