Nanoinformatics: spanning scales, systems and solutions

• Iseult Lynch,
• Diego S. T. Martinez,
• Kunal Roy and
• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 423–427, doi:10.3762/bjnano.17.28

• nanomaterials physicochemical properties, structural features, and biomolecule interactions using both physics-based and machine-learning (ML) approaches; (ii) prediction of nanomaterials toxicity including development of novel toxicity-related descriptors; (iii) solution-focussed approaches applying advanced

• nanomaterials, thus helping to fill the current gap in the toxicity data for zebrafish [8]. A major driver of the development of nanomaterials, nanoinformatics and ML/AI is the potential for solutions to real-world issues, whether in nanomedicine, nano-enabled agriculture, or environmental remediation

• approaches to establish a framework for representing materials-related information and facilitate interoperability across diverse tools. The approach highlights the role of digital twins in nanomaterials development and examines the impact of knowledge engineering in establishing data and information

Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes

• Valentina I. Gorbacheva,
• Alexey S. Grabovoy,
• Polina S. Marukhina,
• Anastasiia O. Syrocheva and
• Ekaterina P. Kolesova

Beilstein J. Nanotechnol. 2026, 17, 396–422, doi:10.3762/bjnano.17.27

• examines recent progress in the development of BNPs for cancer photodynamic therapy, with particular attention to their ability to target tumors, counteract hypoxia, and stimulate the immune system. We also explore their use in treating different types of cancer, the emergence of multifunctional platforms

• and active targeting mechanisms, (iii) controlled and stimuli-responsive release profiles, (iv) overcoming of tumor hypoxia, (v) efficient light conversion, and (vi) the development of multifunctional platforms by combining PDT with other therapeutic modalities [38]. Additionally, nanoparticles enable

• theranostic applications [39] by facilitating tumor visualization through various imaging techniques [40], including fluorescence imaging [41], computed tomography [42], and magnetic resonance imaging (MRI) [43]. The development of nanobiotechnology in PDT opens new horizons for creating more effective and

Eco-efficient materials for agricultural crops based on a mineral rich in MOR- and HEU-type zeolites

• Esperanza Yamile de la Nuez-Pantoja,
• Inocente Rodríguez-Iznaga,
• Gerardo Rodríguez-Fuentes,
• Vitalii Petranovskii,
• Ariel Martínez García,
• José Juan Calvino Gámez and
• Daniel Goma Jiménez

Beilstein J. Nanotechnol. 2026, 17, 381–395, doi:10.3762/bjnano.17.26

• development of plants, as evidenced in the cultivation tests. Keywords: adsorption; agroecological fertilizer; ion exchange; MOR–HEU zeolite mixture; natural zeolite; Introduction Traditional chemical fertilizers, widely used in agriculture, undergo significant nutrient losses resulting from dissolution and

• natural zeolites are a viable alternative for the development of efficient, agroecologically sustainable, and low-cost fertilizer materials for massive applications [3][4]. Natural zeolites are porous crystalline hydrated aluminosilicates. They have a three-dimensional, rigid, negatively charged structure

• losses during dissolution [6][7][8][9]; also, more than 30% of their total weight is water, which provides additional moisture during hot and dry periods. These characteristics make zeolites potentially applicable in agriculture for the development of modern fertilizers with controlled release and

Polycatecholamine nanocoatings on stainless steel: the effect on attachment of human fibroblasts and platelets

• Paulina Trzaskowska,
• Ewa Rybak,
• Maciej Trzaskowski,
• Kamil Kopeć,
• Jakub Krzemiński,
• Rafał Podgórski,
• Hatice Genc,
• Mehtap Civelek and
• Iwona Cicha

Beilstein J. Nanotechnol. 2026, 17, 365–380, doi:10.3762/bjnano.17.25

• controlled nanoscale surface features in the development of next-generation bioactive coatings for medical implants and blood-contacting devices. Experimental Materials and methods Stainless steel samples Stainless steel 316L discs (14 mm in diameter, 0.8 mm in thickness) were laser-cut by STOMILEX (Poland

Ferroelectric nanodot reservoir for neuromorphic computing

• Anna Razumnaya,
• Yuri Tikhonov,
• Dmitrii Naidenko,
• Léo Boron,
• Valerii Vinokur and
• Igor Lukyanchuk

Beilstein J. Nanotechnol. 2026, 17, 352–364, doi:10.3762/bjnano.17.24

• implementations. Contactless interfaces Contactless input and output methods of data integration between the reservoir and external neuromorphic interfaces are of particular importance for the development of scalable, high-resolution, ultrafast, and non-invasive neuromorphic systems. They enable direct

Beam shaping techniques for pulsed laser ablation in liquids: Unlocking tunable control of nanoparticle synthesis in liquids

• Sergio Molina-Prados,
• Nadezhda M. Bulgakova,
• Alexander V. Bulgakov,
• Jesus Lancis,
• Gladys Mínguez Vega and
• Carlos Doñate-Buendia

Beilstein J. Nanotechnol. 2026, 17, 309–342, doi:10.3762/bjnano.17.22

Fast vortex dynamics and relaxation times in NbRe-based heterostructures

• Francesco De Chiara,
• Zahra Makhdoumi Kakhaki,
• Francesco Avitabile,
• Francesco Colangelo,
• Abhishek Kumar,
• Carmine Attanasio and
• Carla Cirillo

Beilstein J. Nanotechnol. 2026, 17, 292–302, doi:10.3762/bjnano.17.20

• optimization of superconducting quantum technologies, including superconducting detectors [10][11][12], superconducting qubits [13][14], and superconducting nano- and microstrips used in high-speed electronics [15], as well as for the development of hybrid architectures enabling magnon–fluxon interactions [16

Advancing nanolithography: a comprehensive review of materials for local anodic oxidation with AFM

• Matteo Lorenzoni

Beilstein J. Nanotechnol. 2026, 17, 275–291, doi:10.3762/bjnano.17.19

• provide a comprehensive understanding of material selection in LAO and its implications for advancing nanotechnology. Keywords: local anodic oxidation; nanofabrication; scanning probe lithography; Review 1 Introduction Advancements in nanotechnology have led to the development of numerous nanoscale

• positive and negative tone as well as self-development reactions within ultrathin molecular resist layers [56][65][66], with resolutions reaching sub-10 nm scales [67]. As demonstrated by Prof. Ivo W. Rangelov and colleagues, FEL relies on the high-intensity electric fields generated at the sharp AFM tip

• potential for advancing protein patterning, tissue engineering, biomedical implants, and biosensor development. LAO offers a promising route for fabricating superconducting quantum devices by enabling direct, nanoscale patterning of Josephson junctions without conventional lithography. Using a biased AFM

Durable antimicrobial activity of fabrics functionalized with zeolite ion-exchanged nanomaterials against Staphylococcus aureus and Escherichia coli

• Perla Sánchez-López,
• Kendra Ramirez Acosta,
• Sergio Fuentes Moyado,
• Ruben Dario Cadena-Nava and
• Elena Smolentseva

Beilstein J. Nanotechnol. 2026, 17, 262–274, doi:10.3762/bjnano.17.18

• functionalization. This method demonstrates a simple and industry-compatible approach for producing durable antimicrobial cotton fabrics. Keywords: antimicrobial activity; Escherichia coli; fabrics functionalization; ion exchange; nanomaterial; Staphylococcus aureus; zeolite; Introduction The development of

Comparative study on 3D morphologies of delignified, single tracheids and fibers of five wood species

• Helen Gorges,
• Felicitas von Usslar,
• Cordt Zollfrank,
• Silja Flenner,
• Imke Greving,
• Martin Müller,
• Clemens F. Schaber,
• Chuchu Li and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2026, 17, 239–250, doi:10.3762/bjnano.17.16

• a key role in preventing cell collapse under high tensile stress or/and inner pressure exerted by the water column during transpiration [8]. Wood delignification is a crucial process in various industries, particularly pulp and paper production, biofuel generation, and the development of advanced

• insights for applications in computer modelling of mechanical properties of fibers and tracheids and for development of novel bio-inspired materials for the industry. Material and Methods Wood samples Wood samples of five different species were used in this study, namely, spruce (Picea abies (L.) H.Karst

• fibers, in general, show wider lumina than softwood tracheids. Environmental factors, such as higher environmental temperatures and less compact, well-aerated soils also promote the development of fibers and tracheids with larger lumina [37][38], which very likely result from high evaporation, as well as

Gold nanoparticle-decorated reduced graphene oxide as a highly effective catalyst for the selective α,β-dehydrogenation of N-alkyl-4-piperidones

• Brenda Flore Kenyim,
• Mihir Tzalis,
• Marilyn Kaul,
• Robert Oestreich,
• Aysenur Limon,
• Chancellin Pecheu Nkepdep and
• Christoph Janiak

Beilstein J. Nanotechnol. 2026, 17, 218–238, doi:10.3762/bjnano.17.15

• development of highly efficient catalysts is of constant interest for advancements in organic chemistry, particularly in oxidation, hydrogenation, and coupling reactions. Gold nanoparticles (AuNPs) have emerged as exceptionally effective catalysts for facilitating these types of reactions [3][4]. The unique

Micro- and nanoscale effects in biological and bioinspired materials and surfaces

• Thies H. Büscher,
• Rhainer Guillermo Ferreira,
• Manuela Rebora and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2026, 17, 214–217, doi:10.3762/bjnano.17.14

• materials research and technology development. Thies H. Büscher, Rhainer Guillermo Ferreira, Manuela Rebora, and Stanislav N. Gorb Kiel, Uberaba, and Perugia, January 2026

Time of flight secondary ion mass spectrometry imaging of contaminant species in chemical vapour deposited graphene on copper

• Barry Brennan,
• Vlad-Petru Veigang-Radulescu,
• Philipp Braeuninger-Weimer,
• Stephan Hofmann and
• Andrew J. Pollard

Beilstein J. Nanotechnol. 2026, 17, 200–213, doi:10.3762/bjnano.17.13

• ; Introduction The development of high quality, high throughput, and highly consistent chemical vapour deposition (CVD) processes for the growth of graphene is one of the major milestones that need to be overcome before the potential properties of graphene can be fully realised for device purposes [1][2][3][4

Structure-dependent thermochromism of PAZO thin films: theory and experiment

• Georgi Mateev,
• Dean Dimov,
• Nataliya Berberova-Buhova,
• Nikoleta Kircheva,
• Todor Dudev,
• Ludmila Nikolova,
• Elena Stoykova,
• Keehoon Hong,
• Dimana Nazarova,
• Silvia Angelova and
• Lian Nedelchev

Beilstein J. Nanotechnol. 2026, 17, 186–199, doi:10.3762/bjnano.17.12

• -00001, Development of Holo-TV Core Technologies for Hologram Media Services). The financial support by the Bulgarian National Science Fund (BNSF) under contract КП-06-Н88/2 is gratefully acknowledged. The computational studies performed by N.K., T.D., and S.A. were funded by the Bulgarian National

Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• Georgia Melagraki Hellenic Military Academy, Vari, Greece 10.3762/bjnano.17.11 Abstract Nanotechnology is revolutionizing different sectors such as medicine, energy, defence, and environmental science by enabling the development of materials and technologies with exceptional precision and

• considerations into the earliest stages of material development. Advances in machine learning (ML) and artificial intelligence (AI) have further enhanced the effectiveness of SSbD by providing predictive modelling, risk assessment, decision-making tools, and the ability to computationally screen candidate

• , engineered nanomaterials (ENMs) have been employed for environmental applications, such as water purification and pollutant removal, addressing some of the most pressing ecological challenges [4][5]. Nanotechnology has significant applications in defence [6], particularly in the development of lightweight

From shield to spear: Charge-reversible nanocarriers in overcoming cancer therapy barriers

• Madhuri Yeduvaka,
• Pooja Mittal,
• Ameer Boyalakuntla,
• Usman Bee Shaik,
• Himanshu Sharma,
• Thakur Gurjeet Singh,
• Siva Nageswara Rao Gajula and
• Lakshmi Vineela Nalla

Beilstein J. Nanotechnol. 2026, 17, 159–175, doi:10.3762/bjnano.17.10

• advancements in nanocarrier-based cancer therapy, recent research has increasingly emphasised refining their physicochemical traits, especially surface charge, to boost therapeutic outcomes. A notable development in this context is the emergence of charge-reversible nanoscale drug delivery systems (CR-NDDSs

• development. Xia et al. developed redox/pH dual-responsive nanoparticles with reversible surface charge which were prepared using HA-SH and CS for the controlled release of the anticancer drug DOX [77]. Zhou et al. developed a pH-responsive charge-reversal polyelectrolyte, and an integrin αVβ3 antibody

• groups and the need for precise control over physicochemical characteristics further increase manufacturing costs and delay clinical development. Maintaining stability during storage is another critical concern, as environmental factors such as temperature fluctuations and light exposure may induce

Capabilities of the 3D-MLSI software tool in superconducting neuron design

• Irina E. Tarasova,
• Nikita S. Shuravin,
• Liubov N. Karelina,
• Fedor A. Razorenov,
• Evgeny N. Zhardetsky,
• Aleksandr S. Ionin,
• Mikhail M. Khapaev and
• Vitaly V. Bol’ginov

Beilstein J. Nanotechnol. 2026, 17, 122–138, doi:10.3762/bjnano.17.8

• inductances has not yet been obtained, and the optimal parameter values are selected numerically [1][31][39][40][41][42]. A generalized theory of the Gauss neuron, accounting for the interaction of all five elements of the experimental device, is currently under development by our group. The necessity of

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• -positive CRC. To the best of our knowledge, this is the first study to report the development and in vitro evaluation of liposomes and immunoliposomes co-encapsulating 5-FU and R-PE. Thus, liposomes containing 25 mg or 50 mg of soybean phosphatidylcholine (SPC), diesterolphosphatidylcholine (DSPC

• , the HSPC 50 formulation containing R-PE and 5-FU, functionalized with cetuximab, is a promising alternative for the development of co-encapsulation delivery systems as a phototheranostic nanocarriers. Keywords: colorectal cancer; immunoliposomes; photodynamic therapy; R-phycoerythrin; 5-fluorouracil

• by the National Cancer Institute (USA). 2.2 Formulation development 2.2.1 Liposomes Liposomes were prepared by the lipid film hydration method as previously described [18], based on phospholipid/Chol/DSPE–PEG 2000 (70:20:5) with eight different compositions varying the lipid type (HSPC, DSPC, DPPC

Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings – a comprehensive review

• Giuseppe Cesare Lama,
• Marino Lavorgna,
• Letizia Verdolotti,
• Federica Recupido,
• Giovanna Giuliana Buonocore and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2026, 17, 63–96, doi:10.3762/bjnano.17.6

• explores recent advancements in protective strategies for heritage materials including stone, concrete, ceramic, glass, metal, wood, and textiles. Special attention is given to the development and application of superhydrophobic and superoleophobic coatings, which offer promising defense against moisture

• , the actual focus of the modern conservators and researchers in the field is on the design and the development of innovative materials and techniques to guarantee the safety and the preservation of the selected artwork, preventing possible damages and considering all the potential threats [17]. One of

Subdigital integumentary microstructure in Cyrtodactylus (Squamata: Gekkota): do those lineages with incipiently expressed toepads exclusively exhibit adhesive setae?

• Philipp Ginal,
• Yannick Ecker,
• Timothy Higham,
• L. Lee Grismer,
• Benjamin Wipfler,
• Dennis Rödder,
• Anthony Russell and
• Jendrian Riedel

Beilstein J. Nanotechnol. 2026, 17, 38–56, doi:10.3762/bjnano.17.4

• early-stage development of macroscopically visible incipient toepads. Using SEM and phylogenetic comparative analyses, our objectives were to (a) clarify how integumentary microstructural traits relate to the presence of incipient toepads and (b) identify potential adaptations linked to specific habitat

• types. We hypothesized that (1) species showing incipient toepad development will possess setae, while those lacking obvious macrostructural modifications should exhibit only spines, prongs, or spinules. Additionally, we hypothesized that either (2) the presence of setae is associated with arboreal

• active distoproximal hyperextension of the digits [46][47][48]. In anoles, the pattern of setal length change and the direction of digit detachment from the substratum is reversed [47], and this is also the case in lineages of geckos that exhibit the most basic expression of toepad development [36]. In

Reduced graphene oxide paper electrode for lithium-ion cells – towards optimized thermal reduction

• Agata Pawłowska,
• Magdalena Baran,
• Stefan Marynowicz,
• Aleksandra Izabela Banasiak,
• Adrian Racki,
• Adrian Chlanda,
• Tymoteusz Ciuk,
• Marta Wolczko and
• Andrzej Budziak

Beilstein J. Nanotechnol. 2026, 17, 24–37, doi:10.3762/bjnano.17.3

• vacancies enable adsorption sites for electrolyte ions [57]. This research contributes to the development of thermal reduction methods of free-standing rGO thin films, that is, rGO paper. It is worth emphasizing that the presented material was prepared without any additional surfactants or binding agents

• gravimetric capacity below 200 mAh/g obtained during cycling at 100 mA/g current density. The basic rGO paper parameters investigated herein allow for further development of graphene paper electrode materials with a particular focus on functionalization and the graphene paper thickness. (a) Scheme of a

• XPS spectra: samples T600 and T800. Funding The research leading to these results has received funding from the National Centre for Research and Development, Poland, under Grant Agreement No. MERA.NET3/2021/83/I4BAGS/2022 for project “Ion Implantation for Innovative Interface modifications in Battery

Terahertz-range on-chip local oscillator based on Josephson junction arrays for superconducting quantum-limited receivers

• Fedor V. Khan,
• Lyudmila V. Filippenko,
• Andrey B. Ermakov,
• Mikhail Yu. Fominsky and
• Valery P. Koshelets

Beilstein J. Nanotechnol. 2025, 16, 2296–2305, doi:10.3762/bjnano.16.158

• , Moscow Region, 141701, Russian Federation 10.3762/bjnano.16.158 Abstract In this paper we present the results of the development, fabrication, measurements, and analysis of terahertz-range oscillators based on Josephson junction arrays embedded into the central electrode of a coplanar line. The

• local oscillator (LO) [4]. This effect together with the operation at cryogenic temperatures and the quantum nature of the mixer itself allow for the development of receivers with the noise temperature Tn only a few times higher than the quantum limit ≈hf/kB, where h and kB are the Planck and Boltzmann

Improving magnetic properties of Mn- and Zn-doped core–shell iron oxide nanoparticles by tuning their size

• Dounia Louaguef,
• Ghouti Medjahdi,
• Sébastien Diliberto,
• Klaus M. Seemann,
• Thomas Gries,
• Joelle Bizeau,
• Damien Mertz,
• Eric Gaffet and
• Halima Alem

Beilstein J. Nanotechnol. 2025, 16, 2285–2295, doi:10.3762/bjnano.16.157

• development of magnetic nanoparticles with enhanced SAR and improved biocompatibility has been a major objective in the field of nanomedicine. Among the various materials used for magnetic hyperthermia, superparamagnetic iron oxide nanoparticles (SPIONs), such as magnetite (Fe3−δO4) and maghemite (γ-Fe2O3

• microscopy (HRTEM) provides a comprehensive understanding of the material’s composition and properties. This work paves the way for the development of next-generation biocompatible magnetic nanoparticles for cancer therapy and other biomedical applications. Materials and Methods Materials Iron

Chiral plasmonic nanostructures fabricated with circularly polarized light

• Tian Qiao and
• Ming Lee Tang

Beilstein J. Nanotechnol. 2025, 16, 2245–2264, doi:10.3762/bjnano.16.154

• . Additionally, the optical chirality at the near field is greater than that of the incident CPL, increasing the polarization selectivity of the interactions between molecules and CPL [17][18]. After more than two decades of development, the synthesis of cPNSs has evolved from nanolithography and self-assembly

• fundamental studies are needed to develop material platforms to advance more complicated commercial applications. Integrating nanolithography with CPL-induced solution synthesis can facilitate the construction of chiral metamaterials. This approach will accelerate material development and enhance the

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• dot (CD)- and quantum dot (QD)-based sensors). The advent of optical biosensing technologies has resulted in a new era for VB12 analysis, characterized by the development of innovative CD- and QD-based sensors. These nanomaterials offer several advantages over conventional methods, including enhanced

• ]. This water-soluble micronutrient is essential for improving brain and nervous system functions, blood cell development, bone health improvement, energy and DNA production, fertility and embryo development, control of neurological symptoms (e.g., stress, depression, dementia, and visual disturbances

• populations, vegetarians and vegans, pregnant women, and breastfeeding infants of VB12-deficient mothers, particularly in developing countries [10][38][39][40]. VB12 has a pivotal role in the development of the fetal and neonatal brain. Therefore, mothers with vegetarian and vegan diets should significantly