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Search for "liposomes" in Full Text gives 60 result(s) in Beilstein Journal of Nanotechnology.
Rational design of block copolymer self-assemblies in photodynamic therapy
Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15
The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency
Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250
- ., liposomes [26], amphiphilic polymers [31], and gold nanoparticles [32]. We refer the reader to the excellent review of Bushell in 2002 for an extensive physico-mathematical explanation of Dm [25]. Firstly, the AF4-DLS curves (Figure 3A, left) largely overlapped. Thus, it appears that DLS alone (Figure 1
- to 0.5 mg/mL in both models (Figure 5A). Despite the fragile nature of macrophages, the low toxicity seen for HA-coated chitosan nanoparticles is in accordance with what reported in RAW 264.7 macrophages for other HA-based nanomaterials, such as HA-coated liposomes [36] and a library of lipid
Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells
Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246
- vivo cancer imaging. In this report we decorated pegylated liposomes with a GRPR antagonist peptide and studied its interaction with, and accumulation within, lung cancer cells. Results: An N-terminally cysteine modified GRPR antagonist (termed cystabn) was synthesised and shown to inhibit cell growth
- in vitro. Cystabn was used to prepare a targeted 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2000) lipid conjugate that was formulated into liposomes. The liposomes displayed desirable colloidal properties and good stability under storage conditions
- . Flow cytometric and microscopic studies showed that fluorescently labelled cystabn-decorated liposomes accumulated more extensively in GRPR over-expressing cells than matched liposomes that contained no cystabn targeting motif. Conclusion: The use of GRPR antagonistic peptides for nanoparticle
Frontiers in pharmaceutical nanotechnology
Beilstein J. Nanotechnol. 2019, 10, 2538–2540, doi:10.3762/bjnano.10.244
- applied in the development of semisolids. But we still have much to learn. Pharmaceutical science has indisputably become more complex with the discovery of nanocarrier-based delivery systems. Fueled by first successes in the 1990s, liposomes were at the forefront of cancer therapy [12][13]. The
Small protein sequences can induce cellular uptake of complex nanohybrids
Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238
- [20][21]. This peptide is produced during viral capsid maturation and is thought to enable cellular internalization of the virus. It has been shown that the MBP-fused γ-peptide is able to disrupt artificial liposomes [20][21]. Recently, we have used this His6-MBP-γ to promote the uptake of QDs by
BergaCare SmartLipids: commercial lipophilic active concentrates for improved performance of dermal products
Beilstein J. Nanotechnol. 2019, 10, 2152–2162, doi:10.3762/bjnano.10.208
- with water. Controlled release is not possible due to the high diffusion coefficient, D, in oils of low viscosity (Einstein equation). Release typically takes place very fast within seconds or milliseconds [1]. The age of smart delivery systems for skin started with the introduction of liposomes to the
- cosmetic market in 1986 from the company Dior with the product Capture. Liposomes have several advantages for dermal delivery, e.g., adhesiveness to skin due to the small nanometric size, increase of skin moisture related leading to wrinkle reduction, and a stabilization of active agents to some extent. In
- status of many polymers used, expensive large-scale production and the lack of biodegradability (no “green” products possible, thus no certification after ECOCERT/COSMOS). There were also developments of various “somes”, being derived from the liposomes and finding few applications (e.g., niosomes
Gold-coated plant virus as computed tomography imaging contrast agent
Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195
- ; computed tomography (CT); gold; nanotechnology; viruses; targeting; Introduction Numerous types of nanomaterials are currently under investigation in medicine, including dendrimers, polymeric nanoparticles (NPs), liposomes and protein-based NPs. Each system has advantages and disadvantages in terms of its
- contrast agents including gold nanoparticles (AuNPs) [13], bromine [14], platinum [15], ytterbium [16], gadolinium [4], and tungsten [15]. Many of the systems are made up of a core that is coated with a polymeric material such as liposomes [17], micelles [13], lipoproteins or polymeric nanoparticles [18
- ]. One of the first examples of such NP-based systems was reported by Caride et al. using brominated phospholipids packaged into liposomes and administered to dogs. Contrast enhancement signals of 40 HU were observed in the liver of imaged animals [14]. Two hours after injection, micelles loaded with
Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells
Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189
- antiproliferative activity against HeLa cells, which is close to that of the clinical anticancer agent paclitaxel [14]. These successful examples demonstrated that the steroidal structure of Di is promising for the discovery of new anticancer drugs. Liposomes that usually consist of phospholipids and are stabilized
- by cholesterol have been substantially investigated as drug carriers for targeting, modulating drug pharmacokinetics, and decreasing drug toxicity [15][16]. Liposomes also can be used as solubilizing media to enhance solubility and bioavailability of insoluble drugs [17]. Di and our prepared
- targeted drug delivery to tumors. These nanoparticles can passively accumulate in tumors via enhanced permeability and retention (EPR) effect, thus decreasing the toxicity of nonselective bio-distribution [27]. Considering the advantages of liposomes as a drug delivery system for chemotherapeutic drugs and
Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release
Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177
- unwanted side effects [8][9]. Liposomes, solid lipid nanoparticles, dendrimers, micelles, polymeric nanoparticles, gold nanoparticles, and carbon nanotubes are among the most common types of nanoparticle delivery systems [10]. These efforts have been reported in several studies. For example, Guo et al
- of Span 60 and chol at a 70:30 molar ratio using the reverse evaporation method for nanoparticle preparation and achieved around 68% curcumin EE [19], which is comparable with our niosomes preparation using T85 at 3:1 FRR. Similarly, Manca et al., achieved curcumin EE of about 66% using liposomes
Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products
Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162
- solution, because the application of simple suspensions to the skin normally does not provide a sufficient dermal bioavailability. Classic delivery systems such as liposomes [3] or solid lipid nanoparticles (SLNs) [4][5] do not work because the active agents do not dissolve in the lipidic phase of these
Targeting strategies for improving the efficacy of nanomedicine in oncology
Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16
- anchored to different nanoparticles for enhancing their uptake into tumoral cells or for binding to tumour vessels. As an example, cyclic NGR, which binds to the aminopeptidase receptor (CD13), was grafted on the surface of temperature-sensitive liposomes loaded with doxorubicin (Dox) for the selective
- destruction of CD13+ cancer cells as human fibrosarcoma cells (HT-1080) [36]. These liposomes released more than 75% of their payload when the temperature reached 41.3 °C whereas they maintained the Dox within their hydrophilic core at physiological temperature. Other systems widely employed for targeting
- drug-loaded liposomes for glioblastoma treatment. Glioblastoma, localized in the brain, represents one of the major challenges in drug delivery due to the necessity to pass the blood brain barrier (BBB). BBB inhibits the passage of 98% of the medicines administered through the systemic route and
Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation
Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195
- near the hydrophobic core, whereas the shell, which is composed of hydrophilic groups, ensures the stability of the system in solution. Examples for these amphiphilic compounds are surfactants [1], liposomes [2], polymers [3], and synthetic macrocycles [4]. Calixarenes and calixresorcinarenes are
Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations
Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98
- structures such as dendrimers, micelles, liposomes and polymer NPs. (iv) Composite-based nanomaterials: Composite NMs are multiphase NPs and NSMs with one phase on the nanoscale dimension that can either combine NPs with other NPs or NPs combined with larger or with bulk-type materials (e.g., hybrid
Association of aescin with β- and γ-cyclodextrins studied by DFT calculations and spectroscopic methods
Beilstein J. Nanotechnol. 2017, 8, 348–357, doi:10.3762/bjnano.8.37
- resource to controlled release strategies, which can be achieved by encapsulating aescin into liposomes [2][3], phytosomes (phospholipidic self-emulsifying particles) [10], zeolites [11], poly(lactic co-glycolic acid) nanoparticles [12] or cyclodextrins. Cyclodextrins are cyclic oligosaccharides, typically
Nanoscale isoindigo-carriers: self-assembly and tunable properties
Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34
- and hydrogen bonding. Another strategy is the use of soft matter (micelles, emulsions, dendrimers, nanospheres, solid lipid nanoparticles or liposomes) as the delivery vehicle. These studies have been encouraged by the possibility to prevent side effects, to increase drug bioavailability, to decrease
Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples
Beilstein J. Nanotechnol. 2016, 7, 1564–1573, doi:10.3762/bjnano.7.150
- enhanced to achieve low detection limits. To address this issue nanomaterials ranging from metallic nanoparticles, carbon-based structures to liposomes were used [10][11][12]. Plasmonic transducers are sensitive to changes of optical properties such as the dielectric constant and hence the refractive index
On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles
Beilstein J. Nanotechnol. 2016, 7, 1296–1311, doi:10.3762/bjnano.7.121
- serum-containing media [8][11][13][14]. Interestingly, studies using cell models like artificial liposomes or polymersomes report the uptake of SiNPs into these structures in a size-dependent manner [15]. Different groups report that silica NPs are cytotoxic in a dose, size and time-dependent manner
Reconstitution of the membrane protein OmpF into biomimetic block copolymer–phospholipid hybrid membranes
Beilstein J. Nanotechnol. 2016, 7, 881–892, doi:10.3762/bjnano.7.80
- strength up to 10 times larger than that of phospholipid bilayers [18][19][20][21][22][23][24]. Vesicles formed by synthetic block polymers (polymersomes) can be modified in a similar way as vesicles made from phospholipids (liposomes) [25][26][27][28]. Although polymer membranes are generally thicker than
Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels
Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60
- -Newtonian behavior. Their shear viscosity increases with the increase of nanoparticle volume fraction and with a drop in temperature [86]. There is also an interaction between shear stress and cell response to NPs. A study considering cell response to PEGylated poly(dopamine)-coated liposomes under shear
- stress found that without shear stress, the cellular uptake/association of both PDA-coated liposomes (LPDA) and LPDA-PEG for hepatocytes were quite similar, while myoblasts preferred to internalize/associate with LPDA. However, under shear stress, hepatocytes showed its preference to LPDA after 30 min
Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes
Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46
- includes liposomes, which are commercially available daunorubicin formulation (Daunoxome®) used in the treatment of Kaposi’s sarcoma [6]. Despite that, there are still numerous studies on the improvement of this drug delivery system aiming at enhancing drug loading into cells by using specific interactions
- between targeting agents and their receptors, such as for example folates and transferrin [7][8]. Additionally, liposomes are also prepared in such a way that simultaneous loading of two drugs into a liposome in order to improve the efficiency of the treatment is possible [9]. Dual drug loading is also
Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory
Beilstein J. Nanotechnol. 2015, 6, 1769–1780, doi:10.3762/bjnano.6.181
- advertising to contain metal and metal oxide nanomaterials, silicon-based nanomaterials (mostly SiO2 nanoparticles), and a variety of other nanomaterial components (organics, ceramics, polymers, clays, nanocellulose, liposomes, nano micelles, carnauba wax, etc.) have been growing in popularity. During the
- nanomaterials (CNT = carbon nanotubes). Major nanomaterial composition groups over time. Carbon = carbonaceous nanomaterials (carbon black, carbon nanotubes, fullerenes, graphene). Other = organics, ceramics, polymers, clays, nanocellulose, liposomes, nano micelles, carnauba wax, etc. Note the difference in
Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer
Beilstein J. Nanotechnol. 2015, 6, 1666–1676, doi:10.3762/bjnano.6.169
- exposure of the pharmaceutical through controlled release. Thus, NEDD provides a novel approach to medical therapy, including treatment of chronic diseases and genetic disorders [5]. At the present, various kinds of nanoparticles have been developed as drug carriers, such as liposomes, micelles, polymeric
Fulleropeptide esters as potential self-assembled antioxidants
Beilstein J. Nanotechnol. 2015, 6, 1065–1071, doi:10.3762/bjnano.6.107
- significant antioxidant capacity to remove hydroxyl and superoxide radicals when incorporated into liposomes [23]. With respect to the design and synthesis of fulleropyrrolidine-based hybrids, we previously showed the synthesis of fullerene–steroid esters [24] and triple hybrids consisting of fullerene
Pulmonary surfactant augments cytotoxicity of silica nanoparticles: Studies on an in vitro air–blood barrier model
Beilstein J. Nanotechnol. 2015, 6, 517–528, doi:10.3762/bjnano.6.54
- transfection and delivery studies using mainly cationic polymers or liposomes [8][24]. The positive NP surface charge enables better cellular contact and/or uptake than negatively charged or neutral molecules [25]. Nevertheless, the use of these positively charged drug and gene delivery carriers remains
Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes
Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23
- a combination of both traditional medical technology and nanotechnology, with the exploitation of nanosized materials of dimensions less than 100 nm. One such nanomedical approach to drug delivery technology that has made a great impact was the first demonstration utilizing liposomes as drug
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