Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• in countries like India. These institutions often function as vehicles for CSR spending and tax optimization, rather than as centers of cutting-edge nanoscience. Indeed, they contribute to the perception of large-scale investment in the sector, the actual return in terms of disruptive technologies

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• for the Pt atoms and a double-zeta polarized basis set was used for all other atoms. Geometry optimization was performed with the LBFGS algorithm until all forces are converged below 0.05 eV·Å−1. The k-point density was selected to be four k-points per angstrom. In case of NEGF, the k-point density in

• h-BN with Stone–Wales defect. For graphite and bulk h-BN, we adopt a graphite unit cell with A–B stacking consisting of two layers and two atoms per layer. We perform geometry optimization, density of states (DOS) calculations, and band structure calculations. For graphite and h-BN with Stone–Wales

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• cytotoxicity and skin irritation [8]. Furthermore, the optimization of microemulsion formulations may be time-consuming and costly, and their stability is often sensitive to environmental factors (e.g., pH, salinity, and temperature). These challenges highlight the importance of a comprehensive understanding

• variability and supporting the systematic optimization of the formulation [10][12]. Therefore, the present study aimed to develop and optimize a low-surfactant microemulsion containing PEG-30 castor oil and Span® 80, based on the approach described by Dourado et al. (2022) [13], as a topical delivery system

• formulation to ensure quality consistency. Experimental design for the development and optimization of Passiflora setacea microemulsion An initial exploratory 23 full factorial applied was employed to evaluate the effects and interactions among key formulation variables (see Supporting Information File 1

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• infections dominated by this pathogen. However, their relatively weaker activity against E. coli and B. subtilis suggests that optimization may be necessary to broaden their spectrum through surface modification, particle size reduction, or combination with other antibacterial agents. Cytotoxicity of AgSbS2

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• measurements are required. Future research should prioritize a systematic parameter optimization study to establish guidelines for balancing contrast enhancement with measurement fidelity across a wide range of material systems. A particular focus should be on understanding the influence of eigenmode selection

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• due to deformation control from the FE-coupling spring but also due to interplay between molecular and continuum forces. The number of required iterations depends on the FE-coupling spring constant and should be considered during their optimization. A smaller FE-coupling spring constant leads to

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• the chromatographic separation of enantiomers. Despite these materials being highly engineered and commercially available, optimization was often done empirically. A rational design of future and improved solid phases for chiral chromatography requires that one understands how the chemical structure

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• structural integrity and effectively encapsulating a core comprising a nanoemulsion containing β-caryophyllene (NE-βCp) alongside HA. A rigorous optimization of the electrospinning process was critical, involving the systematic evaluation of key parameters. This optimization successfully identified the

• materials) [15]. However, achieving high-quality structures for biomedical use with tailored properties requires careful management of various processes, materials, and environmental parameters [16], necessitating thorough optimization of the electrospinning conditions. This includes precise control over

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• incorporated [17][18][19][20]. These findings indicate that trends in LNP characterization change by varying PEG lipids cannot be universally applied across all PEGylated LNP formulations. Rational LNP design should consider the distinct structural attributes of PEG lipid, recognizing that optimization of LNP

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• it as a quantitative, mechanistic probe that directly informs materials design and process optimization. By continuing to refine its resolution, sensitivity, and integration with complementary modalities, APXPS is positioned to contribute to pressing societal challenges, including clean energy

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• synthesis, hybrid system integration, and machine learning optimization. Together, these approaches aim to establish a comprehensive, scalable, and environmentally safe solution for the remediation of MPs in wastewater systems. Keywords: artificial intelligence; membrane technology; microplastic

• generating highly reactive radicals through techniques such as Fenton and photo-Fenton reactions, UV/H2O2 systems, ozonation, TiO2, photocatalysis, and electrochemical oxidation [53]. These methods hold potential for breaking down MPs into smaller, less harmful by products, although optimization and

• nanoparticles, enhanced through machine learning (ML) optimization, enable dual removal of MPs and organic pollutants with efficient magnetic recovery. Despite their potential, concerns remain regarding synthesis complexity, environmental safety of nanomaterials, and real-water applicability. These emerging

Few-photon microwave fields for superconducting transmon-based qudit control

• Irina A. Solovykh,
• Andrey V. Pashchenko,
• Natalya A. Maleeva,
• Nikolay V. Klenov,
• Olga V. Tikhonova and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1580–1591, doi:10.3762/bjnano.16.112

• qubits; Introduction Currently, quantum computing is under active development, opening new horizons for solving a number of problems that are difficult for classical processors, including modeling the behavior of quantum systems, optimization problems, breaking cryptographic systems, solving large

Modeling magnetic properties of cobalt nanofilms used as a component of spin hybrid superconductor–ferromagnetic structures

• Aleksey Fedotov,
• Olesya Severyukhina,
• Anastasia Salomatina and
• Anatolie Sidorenko

Beilstein J. Nanotechnol. 2025, 16, 1557–1566, doi:10.3762/bjnano.16.110

• . Due to active experimental and theoretical research on thin films, significant progress has been made in recent years. Since the information in the field of thin film technologies is updated quite rapidly, there is a need for a thorough study and optimization of the main technological processes that

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• beam shaping can be considered as an important parameter in the optimization of Si NPs synthesis in terms of morphology control of the produced NPs and as a viable approach to expand laser ablation capabilities in the field of material processing. Nanocrystalline particles of silicon were synthesized

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• ]. Unlike methods that focus on bulk transformations, this technique enables the targeted introduction and fine-tuning of specific defects, unlocking unprecedented opportunities for advanced material design and performance optimization [86]. By carefully adjusting the laser parameters, the spatial

The role of biochar in combating microplastic pollution: a bibliometric analysis in environmental contexts

• Tuan Minh Truong Dang,
• Thao Thu Thi Huynh,
• Guo-Ping Chang-Chien and
• Ha Manh Bui

Beilstein J. Nanotechnol. 2025, 16, 1401–1416, doi:10.3762/bjnano.16.102

• removal efficiency in wastewater treatment applications. Biochar synthesis techniques and functional optimization Biochar synthesis The synthesis methods for biochar, as illustrated in Figure 4, encompass traditional hydrolysis techniques and modified approaches utilizing materials such as magnetic

• magnetic biochar, further demonstrating its adaptability as a remediation tool. Despite significant progress, several critical challenges must be addressed before biochar can be widely applied for MP remediation. Optimization of surface properties remains essential to enhance removal efficiency

Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• , parylene-C encapsulation, and laser-assisted nanowire tip exposure. The nanowire electrode structure and the corresponding functionality are described. Electrochemical testing results of dopamine and glucose detection are also presented. Results and Discussion After optimization of the growth parameters

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• the drug accumulation. Optimization of these parameters helps to maximize efficacy and mitigate toxicity of the payload [39]. Infection sites often present unique microenvironmental features, a factor that nanoparticles exploit to achieve precise therapeutic delivery. For example, polymeric

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• that enable simultaneous diagnosis and therapy [132][133]. However, adding multiple components can complicate the manufacturing process and increase costs, requiring careful optimization and scale-up strategies. As shown in Figure 2, there are different types of liposomes. Liposome technology without

Wavelength-dependent correlation of LIPSS periodicity and laser penetration depth in stainless steel

• Nitin Chaudhary,
• Chavan Akash Naik,
• Shilpa Mangalassery,
• Jai Prakash Gautam and
• Sri Ram Gopal Naraharisetty

Beilstein J. Nanotechnol. 2025, 16, 1302–1315, doi:10.3762/bjnano.16.95

• fixed at 20 mW. For each wavelength, four different step sizes and scanning speeds were explored. Table 1 below displays the optimal spatial periodicity of LIPSS structures obtained for each wavelength. In this work, we fabricated LIPSS over a large area 5 mm × 5 mm and optimization was carried out for

• . The optimization regarding LIPSS was performed by varying the scanning speed and the step size between the consecutive lines to generate large-area LIPSS for each irradiation wavelength. Effect of scanning speed The comparative analysis of LSFL and HSFL spatial periodicity with varying numbers of

• patterns. Perfect overlapping optimization becomes paramount in this process; any discrepancies in overlapping, whether excessive or insufficient, can lead to the destruction of LIPSS or incomplete patterning across the large surface area. From the correlation between wavelength and spot diameter, the spot

Enhancing the photoelectrochemical performance of BiOI-derived BiVO₄ films by controlled-intensity current electrodeposition

• Huu Phuc Dang,
• Khanh Quang Nguyen,
• Nguyen Thi Mai Tho and
• Tran Le

Beilstein J. Nanotechnol. 2025, 16, 1289–1301, doi:10.3762/bjnano.16.94

• quality remains a significant challenge, affecting the reproducibility and optimization of the final photoanodes. Building on these limitations, in this study, we introduce a novel controlled-intensity current electrodeposition method to precisely tailor the deposition conditions of BiOI and subsequently

Electronic and optical properties of chloropicrin adsorbed ZnS nanotubes: first principle analysis

• Prakash Yadav,
• Boddepalli SanthiBhushan and
• Anurag Srivastava

Beilstein J. Nanotechnol. 2025, 16, 1184–1196, doi:10.3762/bjnano.16.87

• the axis of the nanotube. A density mesh cutoff of 150 Rydberg was applied to define the real-space grid for energy calculations. The ZnS NT model, consisting of 36 atoms periodically arranged along the Z-direction, was structurally optimized to achieve geometric and energetic stability. Optimization

• the changes in Zn–S bond lengths near the CP adsorption site for different orientations before and after optimization, alongside the adsorption distance between the adsorbate and adsorbent. The most significant changes in bond length were observed near the atomic positions Zn(10)–S(13)–Zn(9), which

Transfer function of an asymmetric superconducting Gauss neuron

• Fedor A. Razorenov,
• Aleksander S. Ionin,
• Nikita S. Shuravin,
• Liubov N. Karelina,
• Mikhail S. Sidel’nikov,
• Sergey V. Egorov and
• Vitaly V. Bol’ginov

Beilstein J. Nanotechnol. 2025, 16, 1160–1170, doi:10.3762/bjnano.16.85

• mentioned above (i.e., screen-mediated interaction) may become more and more severe when one connects more neurons together. This is why the search for the ways to suppress the cross-talk remains one of the main directions of the neuron’s design optimization. It is worth noting that the expression for the t

• this decreases Msq by about five times. It is also useful to eliminate sections of the SQUID that are parallel to the CL. This is the main direction of optimization of the Gauss neuron design at the present time. Conclusion In this work, the changes in the form of the transfer function (TF) of a Gauss

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• performance may be attained by means of improvements in electron transport properties and optimization of the loading of the MOF within the LbL nanostructures. The creation of well-defined soft multilayer structures comprising a variety of components represents a crucial strategy in the field of soft