Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• procedure described above. Sample preparation The MMT nanosheets in the form of a purified powder were provided by the research group of Prof. Yinan Hao at Inner Mongolia Agricultural University. The powder was synthesized through an ultrasonic exfoliation process (240 W, 90 min) detailed in their patent

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• , enhancing stability, and reducing adverse effects. Concurrently, natural products are being extensively researched for their anticancer and immunomodulatory properties. This patent review aims to analyze publications that integrate nanotechnology with natural products to develop cancer treatments and

• immunotherapies. In this context, 17 patents were identified through the free online databases of the European Patent Office (EPO) and the World Intellectual Property Organization (WIPO). The review discusses various types of nanotechnology, including nanoparticles, nanocarriers, and nanocapsules, as well as

• agents. Consequently, the combination of natural products with nanotechnology holds significant therapeutic potential. Keywords: cancer; immunotherapy; nanotechnology; natural products; patent; review; Introduction Cancer is a disease characterized by the uncontrolled proliferation of abnormal cells

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• selectivity from H2 to CO2 [82][83]. A few years later in 1992, MMMs were reported in a patent granted to UOP LLC (now Honeywell UOP) [83]. The inventors, Kulprathipanja and coworkers, described the incorporation of inorganic fillers during the fabrication of polymeric membranes with specific permeability. By

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• examined this method in detail. The first patent for turning a polymer solution into nanofibers by electrostatic forces was issued to J. F. Cooley in 1902. Between 1934 and 1944, Anton Formhals further developed the electrospinning method and equipment and obtained new patents [43]. In the 1990s

• scaffolds containing poly(ε-caprolactone) developed by Stellenbosch Nanofiber Company are used in tissue regeneration [104]. Patents regarding polymeric nanofibers used in bone regeneration The patent search database https://worldwide.espacenet.com/ of the European Patent Office lists 700 results for the

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• -cost topical treatment. Experimental SPIONs The SPIONs used in the present study were synthesized as described in [9] (patent application registration BR 10 2020 015814 [36]). For assays, after synthesis and purification, the SPIONs were dispersed in a 70% ethanol solution (Merck, Germany). The maximum

DNA aptamer selection and construction of an aptasensor based on graphene FETs for Zika virus NS1 protein detection

• Nathalie B. F. Almeida,
• Thiago A. S. L. Sousa,
• Viviane C. F. Santos,
• Camila M. S. Lacerda,
• Thais G. Silva,
• Rafaella F. Q. Grenfell,
• Flavio Plentz and
• Antero S. R. Andrade

Beilstein J. Nanotechnol. 2022, 13, 873–881, doi:10.3762/bjnano.13.78

• the target [17]. The CE separation efficiency allows for high-affinity aptamers to be obtained with only three to five rounds. Our present study demonstrates, for the first time, the application of CE-SELEX to obtain DNA aptamers for the ZIKV NS1 protein. In particular, the ZIKV60 aptamer (patent

Progress and innovation of nanostructured sulfur cathodes and metal-free anodes for room-temperature Na–S batteries

• Marina Tabuyo-Martínez,
• Bernd Wicklein and
• Pilar Aranda

Beilstein J. Nanotechnol. 2021, 12, 995–1020, doi:10.3762/bjnano.12.75

• successfully applying Na metal-free anode strategies for RT Na–S batteries. Relevant recent patents on RT Na–S batteries Patents are a useful indicator for the innovation capacity of a scientific area and the potential commercialization of a technology. Therefore, this review includes a patent review on RT Na

• –S batteries to assess the maturity of these devices and elucidate possible technology bottlenecks. An overview search in ESPACENET [87], the European Patent Office platform, with the term “sodium-battery” showed 1451 results, with a prominent increase in the number of documents produced in the last

• instance, the development of polymer electrolytes, additives, salts, or specific materials that can be used in the preparation of components and conformation of elements of the battery. The analysis of the patent search results clearly shows a lack of specific patents dealing with the production of cathode

Enhancement in thermoelectric properties due to Ag nanoparticles incorporated in Bi₂Te₃ matrix

• Srashti Gupta,
• Dinesh Chandra Agarwal,
• Bathula Sivaiah,
• Sankarakumar Amrithpandian,
• Kandasami Asokan,
• Ajay Dhar,
• Binaya Kumar Panigrahi,
• Devesh Kumar Avasthi and
• Vinay Gupta

Beilstein J. Nanotechnol. 2019, 10, 634–643, doi:10.3762/bjnano.10.63

• matrix have been synthesized and a dramatic enhancement in ZT by 304% for 2 vol % Ag in Bi2Te3 has been reported [20]. One research group submitted a patent on solvothermally synthesized low-dimensional nanocrystals of bismuth telluride covered by 0.001 wt %, 0.05 wt % Au or 0.05 wt % Ag metallic

Filling nanopipettes with apertures smaller than 50 nm: dynamic microdistillation

• Evelyne Salançon and
• Bernard Tinland

Beilstein J. Nanotechnol. 2018, 9, 2181–2187, doi:10.3762/bjnano.9.204

• pre-amplifier of a pClamp (Axopatch 200B) and the entire electrical measurement setup is placed under a Faraday cage to prevent electrical noise. Additional Information The dynamic microdistillation technique was patented in 2013: B. Tinland, E. Guirleo (Salançon), patent WO 2013079874 A1, “Method and

Hyperthermic intracavitary nanoaerosol therapy (HINAT) as an improved approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC): Technical description, experimental validation and first proof of concept

• Daniel Göhler,
• Stephan Große,
• Alexander Bellendorf,
• Thomas Albert Falkenstein,
• Mehdi Ouaissi,
• Jürgen Zieren,
• Michael Stintz and
• Urs Giger-Pabst

Beilstein J. Nanotechnol. 2017, 8, 2729–2740, doi:10.3762/bjnano.8.272

• Nanoaerosol Therapy (HINAT) The HINAT approach, which is currently under patent application (DE 10 2016 202 316 A1 [15]), comprises improvements in aerosol generation and aerosol conditioning for the purpose of a more efficient drug application during PIPAC. A schematic illustration of the HINAT approach is

• outlet. Performance parameters and aerosol characteristics of HINAT and PIPAC-MIP as well as experimental results concerning drug deposition homogeneity and in-tissue drug penetration; last two columns provide parameter ratios. Disclosure Topas GmbH, Dresden, Germany is the holder of the patent

Functional dependence of resonant harmonics on nanomechanical parameters in dynamic mode atomic force microscopy

• Federico Gramazio,
• Matteo Lorenzoni,
• Francesc Pérez-Murano,
• Enrique Rull Trinidad,
• Urs Staufer and
• Jordi Fraxedas

Beilstein J. Nanotechnol. 2017, 8, 883–891, doi:10.3762/bjnano.8.90

• Nanoscale mechanical metrology for industrial processes and products (Patent pending), and within the framework of the PhD program in Physics of the Autonomous University of Barcelona. ICN2 acknowledges support of the Spanish MINECO through the Severo Ochoa Centers of Excellence Program under Grant SEV-2013

The cleaner, the greener? Product sustainability assessment of the biomimetic façade paint Lotusan^® in comparison to the conventional façade paint Jumbosil^®

• Florian Antony,
• Rainer Grießhammer,
• Thomas Speck and
• Olga Speck

Beilstein J. Nanotechnol. 2016, 7, 2100–2115, doi:10.3762/bjnano.7.200

• realization, at least as a prototype, is the third and final criterion [13]. The result, the technical application of self-cleaning properties is what became well known as the lotus effect. The patent application was submitted on 25th July 1995 and granted by the German Patent and Trademark Office on February

• 4th in 1999 [8]. Sto SE & Co. KGaA (79780 Stühlingen, Germany) acquired the patent rights in 2009 and holds the trademark „Lotus-Effect®“. The fact that the façade paint Lotusan® is available on the market since the late 1990s might be seen as a sufficient argument for the existence of a technical

Metal hydrides: an innovative and challenging conversion reaction anode for lithium-ion batteries

• Luc Aymard,
• Yassine Oumellal and
• Jean-Pierre Bonnet

Beilstein J. Nanotechnol. 2015, 6, 1821–1839, doi:10.3762/bjnano.6.186

• patent [44][45]. A charge–discharge efficiency of 93.9% for the conversion reaction with MgH2 is reported by the grinding addition of 3 atom % of a nickel catalyst (particle size 20 nm) in the hydride MCMB carbon mixture. In this last case the irreversible loss can be drastically reduced to 7% for a

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

• Marina E. Vance,
• Todd Kuiken,
• Eric P. Vejerano,
• Sean P. McGinnis,
• Michael F. Hochella Jr.,
• David Rejeski and
• Matthew S. Hull

Beilstein J. Nanotechnol. 2015, 6, 1769–1780, doi:10.3762/bjnano.6.181

• scientific paper or patent documentation), it is then placed in Category 1, “Extensively verified claim”. Category 5, “Not advertised by the manufacturer”, is a special class for products that have been shown to contain nanomaterials but the manufacturer does not advertise this fact anywhere in product

Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer

• Ying Huang,
• Jing Ma,
• Alan L. Porter,
• Seokbeom Kwon and
• Donghua Zhu

Beilstein J. Nanotechnol. 2015, 6, 1666–1676, doi:10.3762/bjnano.6.169

• makers about collaboration patterns and help technology managers prioritize developmental prospects. Analyzing large compilations of research publication (and/or patent) records can help track developmental trajectories and forecast innovation pathways. Topical analyses within field, not emphasized here

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• and their associated physico-chemical properties, performance, exposure scenarios, and biological effects. In this paper, we review the different informatics methods that have been applied to patent mining, nanomaterial/device characterization, nanomedicine, and environmental risk assessment. Nine

• , have also been developed [20][21]. In the following section, we describe our method for identifying the nanoinformatics literature discussed in this paper, and then review the different informatics methods that have been applied such as patent mining, nanomaterial/device characterization, nanomedicine

• citing these 7 papers as identified in PubMED and Web of Science. A final set of 14 papers were included for detailed review, and the results are presented in the following section. Review Patent mining Three groups across the globe (USA, Japan, China) have developed independent, NLP-based patent text

From lithium to sodium: cell chemistry of room temperature sodium–air and sodium–sulfur batteries

• Philipp Adelhelm,
• Pascal Hartmann,
• Conrad L. Bender,
• Martin Busche,
• Christine Eufinger and
• Juergen Janek

Beilstein J. Nanotechnol. 2015, 6, 1016–1055, doi:10.3762/bjnano.6.105

• 1969, A. E. Lyall filed a patent application on “A room-temperature-operated fuel cell comprising an oxygen electrode, a lithium metal-containing electrode, and an electrolyte comprising an inert, aprotic organic solvent […], which contains an inorganic or organic ionizable salt […]” [28

• expectations. A new and promising concept is to add soluble and redox-active molecules to the liquid electrolyte. In 2011 Liox Power Inc. filed a patent application on such “soluble oxygen evolving catalysts for rechargeable metal–air batteries” [96]. Those often called redox mediators (RM) molecules possess a

Carbon dioxide hydrogenation to aromatic hydrocarbons by using an iron/iron oxide nanocatalyst

• Hongwang Wang,
• Jim Hodgson,
• Tej B. Shrestha,
• Prem S. Thapa,
• David Moore,
• Xiaorong Wu,
• Myles Ikenberry,
• Deryl L. Troyer,
• Donghai Wang,
• Keith L. Hohn and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2014, 5, 760–769, doi:10.3762/bjnano.5.88

• gasoline [67]. Therefore, this catalytic reaction is able to transform gaseous hydrogen and carbon dioxide into high-quality fuel, which can be distributed by using the existing distribution infrastructure. Our findings are corroborated by Wright et al. (US patent 4,565,831), in which the authors describe

Visible light photooxidative performance of a high-nuclearity molecular bismuth vanadium oxide cluster

• Johannes Tucher and
• Carsten Streb

Beilstein J. Nanotechnol. 2014, 5, 711–716, doi:10.3762/bjnano.5.83

• photooxidation of the dye patent blue V as a test reaction showed high activity (quantum efficiency Φ > 7%, TOF ca. 5 min−1) and high stability under turnover conditions (TON > 1200) under irradiation with monochromatic visible light (LED light source, λ = 470 nm) [29]. In the present study, we are focusing on

Applicability and costs of nanofiltration in combination with photocatalysis for the treatment of dye house effluents

• Wolfgang M. Samhaber and
• Minh Tan Nguyen

Beilstein J. Nanotechnol. 2014, 5, 476–484, doi:10.3762/bjnano.5.55

• ) and patent blue (C27H31N2NaO6S2), by using TiO2 Degussa P25 as the photocatalyst in a lab-scale combined system with NF membranes NTR 7410 (Nitto Denko, Tokio) and have observed that it was possible to successfully treat concentrated solutions (500 mg/L) of both dyes by means of a continuous process

Functionalization of vertically aligned carbon nanotubes

• Eloise Van Hooijdonk,
• Carla Bittencourt,
• Rony Snyders and
• Jean-François Colomer

Beilstein J. Nanotechnol. 2013, 4, 129–152, doi:10.3762/bjnano.4.14

Direct-write polymer nanolithography in ultra-high vacuum

• Woo-Kyung Lee,
• Minchul Yang,
• Arnaldo R. Laracuente,
• William P. King,
• Lloyd J. Whitman and
• Paul E. Sheehan

Beilstein J. Nanotechnol. 2012, 3, 52–56, doi:10.3762/bjnano.3.6

• Woo-Kyung Lee Minchul Yang Arnaldo R. Laracuente William P. King Lloyd J. Whitman Paul E. Sheehan Chemistry Division, U.S. Naval Research Laboratory, Washington, DC 20375, USA US Patent and Trademark Office, Alexandria, VA 22314, USA Department of Mechanical Science and Engineering, University of

Superhydrophobic surfaces of the water bug Notonecta glauca: a model for friction reduction and air retention

• Petra Ditsche-Kuru,
• Erik S. Schneider,
• Jan-Erik Melskotte,
• Martin Brede,
• Alfred Leder and
• Wilhelm Barthlott

Beilstein J. Nanotechnol. 2011, 2, 137–144, doi:10.3762/bjnano.2.17

• world [5][6]. The effective self-cleaning mechanism of the Lotus flower Nelumbo nucifera is especially well known [3]. Granting of a patent in 1998 [7], followed by the introduction of the trade mark Lotus-Effect® was the start of the realisation of biomimetic self-cleaning surfaces. Another highly