Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• showed good performance in the Franz diffusion test and rodent pharmacokinetic studies due to the nanoparticle size and faster dissolution as compared with the commercial DCS powder. These DCS nanocrystal formulations could offer a new approach for the development of an advanced drug delivery system for

• polymers can provide gastric protection against gastric-irritating compounds and/or stomach acidity, leading to improved drug release performance. We aimed to fabricate DCS nanocrystals and study their physicochemical and biological properties. The DCS already has great water solubility (Log P = −1.72), so

• were prepared for in vivo PK study. The detailed compositions for the capsule formulations are described next. Enteric capsule formulation F: Kollicoat MAE 30 DP (BASF pharma), a reliable, high-performance film coating based on methacrylic acid-ethyl acrylate copolymer (1:1), is specifically designed

Superconducting spin valve effect in Co/Pb/Co heterostructures with insulating interlayers

• Andrey A. Kamashev,
• Nadir N. Garif’yanov,
• Aidar A. Validov,
• Vladislav Kataev,
• Alexander S. Osin,
• Yakov V. Fominov and
• Ilgiz A. Garifullin

Beilstein J. Nanotechnol. 2024, 15, 457–464, doi:10.3762/bjnano.15.41

• verify the so far unconfirmed earlier results by Deutscher and Meunier on an F1/S/F2 heterostructure with oxidized interlayers [Deutscher, G.; Meunier, F. Phys. Rev. Lett. 1969, 22, 395. https://doi.org/10.1103/PhysRevLett.22.395] and suggest an alternative route to optimize the performance of

Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection

• Le Hong Tho,
• Bui Xuan Khuyen,
• Ngoc Xuan Dat Mai and
• Nhu Hoa Thi Tran

Beilstein J. Nanotechnol. 2024, 15, 426–434, doi:10.3762/bjnano.15.38

• NFT and SDZ, respectively. Besides, the linearity coefficients are extremely close to 1 in the range of 10−8 to 10−3 M of concentration, and the SERS substrate shows remarkable uniformity along with great selectivity. This powerful SERS performance indicates that DESs have tremendous potential in the

• biosensors are commonly made of LSPR materials [17]. With the development of synthesis techniques, numerous nanostructures of noble metals have been extensively studied to improve the intrinsic parameters of sensors. Silver nanoparticles (Ag NPs) exhibit great performance in sensing applications owing to the

• best LSPR properties among the noble metals [18]. One of the decisive factors regarding the SERS performance of Ag NP-based platforms is the agglomeration state of the nanoparticles [19], which directly affects the “hot spots”. There have been many studies in which agglomeration of Ag NPs was adjusted

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• sites. In this regard, nanomaterials exhibit CAT-like activity with the ability to generate O2 from H2O2 to increase the performance of PDT and PTT in tumors. For example, nano-MnO2 with acid-/redox-responsive properties could decompose acidic H2O2 at the tumor sites by exhibiting CAT activity [168

Insect attachment on waxy plant surfaces: the effect of pad contamination by different waxes

• Elena V. Gorb and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 385–395, doi:10.3762/bjnano.15.35

• decemlineata Say, Gastrophysa viridula De Geer, Chrysolina americana L. (all Chrysomelidae), C. septempunctata, and H. axyridis (both Coccinellidae) showing a distinct sexual dimorphism in structure and attachment performance of adhesive pads [15][17][24][25][39][40][41][42], as well as on mushroom-shaped

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• benznidazole. Nanomedicines reduce toxicity and increase the effectiveness of current oncological therapies. Could nanomedicines improve the treatment of the neglected CD? This question will be addressed in this review, first by critically discussing selected reports on the performance of benznidazole and

• BNZ, and their contribution is examined below. The in vitro performance of BNZ loaded into nanoparticles (Nps) is shown in Table 1. In many of these reports, formulations were tested on different parasite stages (epimastigote, trypomastigote, and amastigote), and their cytotoxicity was assessed on

• acute phase of the infection. The project eventually gave up on its attempts to formulate BNZ in nanomedicines and focused on clinical trials of reduced BNZ doses for the treatment of the chronic phase [23]. In parallel to the BERENICE project, several reports showed the in vivo performance of different

Comparative electron microscopy particle sizing of TiO₂ pigments: sample preparation and measurement

• Ralf Theissmann,
• Christopher Drury,
• Markus Rohe,
• Thomas Koch,
• Jochen Winkler and
• Petr Pikal

Beilstein J. Nanotechnol. 2024, 15, 317–332, doi:10.3762/bjnano.15.29

• particles on each image, and to correctly identify the particle edges. Effective image acquisition and analysis requires training and routine performance checks for both the personnel capturing the images and those interpreting them. Results Electron microscopy measurements of E171 samples and related

• decreases. This demonstrates that producing E171 in such a way that it contains a high proportion of nanoparticles is in fact undesirable from a product performance point of view as such material is an inefficient pigment with poor tinting strength. Conclusion We have found that when a common set of E171

• these laboratory samples and a grey paste evaluation, a technique commonly used in the pigment industry since the 1930s to evaluate pigment performance. The particle size of E171 TiO2 with an SSA of 12 m2/g was found to be at the upper limit for untreated anatase to be used as a pigment. Materials with

Investigating structural and electronic properties of neutral zinc clusters: a G₀W₀ and G₀W₀Г₀⁽¹⁾ benchmark

• Sunila Bakhsh,
• Muhammad Khalid,
• Sameen Aslam,
• Muhammad Sohail,
• Muhammad Aamir Iqbal,
• Mujtaba Ikram and
• Kareem Morsy

Beilstein J. Nanotechnol. 2024, 15, 310–316, doi:10.3762/bjnano.15.28

• structural properties of neutral Zn clusters by employing the PW91 functional. Analyzing the performance of different functionals for Zn clusters, it can be concluded that the LDA overestimates the binding energy significantly. Our PBE results are in good agreement with the PW91 results reported by Iokibe et

Ultrasensitive and ultrastretchable metal crack strain sensor based on helical polydimethylsiloxane

• Shangbi Chen,
• Dewen Liu,
• Weiwei Chen,
• Huajiang Chen,
• Jiawei Li and
• Jinfang Wang

Beilstein J. Nanotechnol. 2024, 15, 270–278, doi:10.3762/bjnano.15.25

• metal crack sensors that exhibit exceptional performance in terms of ultrahigh sensitivity and ultrahigh stretchability. This is achieved by incorporating a helical structure into the substrate through a modeling process and, subsequently, depositing a thin film of gold onto the polydimethylsiloxane

• film deposited on a microstructured polydimethylsiloxane (PDMS) substrate [21]. The sensor exhibits exceptional strain sensitivity, allowing for stretching of up to 20% strain. Liu et al. have successfully developed a strain sensor that exhibits high-performance characteristics [22]. A fish-scale-like

• that operated by separating overlapping CNTs embedded within a silicone elastomer [25]. The resulting sliding and disconnection of these CNTs contribute to the exceptional performance of the strain sensor, which demonstrates ultrahigh sensitivity with a GF of 42300 at a strain range of 125–145

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• aqueous solution, showing promising prospects for use in magnetically targeted therapy. Determination of photothermal stability and efficiency To evaluate the photothermal performance of the nanostructures, the NPs were irradiated with an 808 nm laser at a power density of 1 W/cm2 for 5 min. A slight

Quantitative wear evaluation of tips based on sharp structures

• Ke Xu and
• Houwen Leng

Beilstein J. Nanotechnol. 2024, 15, 230–241, doi:10.3762/bjnano.15.22

• evaluation of the effects that different scanning parameters have on tip wear. This detailed assessment is instrumental for optimizing scanning conditions, ultimately enhancing the longevity and performance of the AFM tip in various applications. Effect of scanning parameters on tip wear The wear test

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• the adsorption heatmaps. Supporting Information File 25: Supporting material. Supporting Information File 26: 820-Milk-protein-table. Acknowledgements The authors extend their gratitude to the Irish Centre for High-End Computing (ICHEC) and the UCD Sonic High-Performance Computing Centre for

Modification of graphene oxide and its effect on properties of natural rubber/graphene oxide nanocomposites

• Nghiem Thi Thuong,
• Le Dinh Quang,
• Vu Quoc Cuong,
• Cao Hong Ha,
• Nguyen Ba Lam and
• Seiichi Kawahara

Beilstein J. Nanotechnol. 2024, 15, 168–179, doi:10.3762/bjnano.15.16

• also attracted significant interest. This material with exceptionally high specific surface area, high mechanical properties, and high thermal conductivity is expected to prepare high-performance rubber composites [21][22][23]. In our recent work [24], we successfully designed a DPNR/GO composite by

CdSe/ZnS quantum dots as a booster in the active layer of distributed ternary organic photovoltaics

• Gabriela Lewińska,
• Piotr Jeleń,
• Zofia Kucia,
• Maciej Sitarz,
• Łukasz Walczak,
• Bartłomiej Szafraniak,
• Jerzy Sanetra and
• Konstanty W. Marszalek

Beilstein J. Nanotechnol. 2024, 15, 144–156, doi:10.3762/bjnano.15.14

• was determined. The resistivity of the layers was determined using impedance spectroscopy. Simulations (General-Purpose Photovoltaic Device Model) showed a performance improvement in the cells with quantum dots of 0.36–1.45% compared to those without quantum dots. Keywords: efficiency; luminescence

• nanodot applications include quantum performance enrichment for diodes [15][16], memory devices [17][18], transistors [19][20], and solar cells. They are also widely used in biological applications [21][22][23]. QDs have been used in various functions of solar cells, including electron- or hole

• fluorophores emitting light signifies the occurrence of the quenching process. Spectroscopic ellipsometry Spectroscopic ellipsometry studies were performed to determine changes in optical performance with temperature. A multilayer model with a silicon substrate layer was fitted to the obtained Ψ and Δ values

Enhanced feedback performance in off-resonance AFM modes through pulse train sampling

• Mustafa Kangül,
• Navid Asmari,
• Santiago H. Andany,
• Marcos Penedo and
• Georg E. Fantner

Beilstein J. Nanotechnol. 2024, 15, 134–143, doi:10.3762/bjnano.15.13

• -built tip scanner system to compare their imaging performance. A grid sample (squared pits of 10 μm XY pitch and 200 nm depth) was chosen, since it has sharp topography changes on the pit edges and a small tilting angle on the flat surface, providing both high-frequency and low-frequency disturbances to

• in both measurements were set just below the values that would lead to observable oscillations. Height images in Figure 4A show that the pulse sampling method has better tracking performance for rapid topography changes of the pits. The method provides sharper responses at the pit edges, indicating

• improved performance of the new method for high-frequency disturbances. The line profile in Figure 4B demonstrates that, for the traditional ORT method, the tip loses contact with the surface and re-establishes contact only after a few ORT cycles (known as parachuting). In pulse sampling mode, the duration

In situ optical sub-wavelength thickness control of porous anodic aluminum oxide

• Aleksandrs Dutovs,
• Raimonds Popļausks,
• Oskars Putāns,
• Vladislavs Perkanuks,
• Aušrinė Jurkevičiūtė,
• Tomas Tamulevičius,
• Uldis Malinovskis,
• Iryna Olyshevets,
• Donats Erts and
• Juris Prikulis

Beilstein J. Nanotechnol. 2024, 15, 126–133, doi:10.3762/bjnano.15.12

• the pore openings of the PAAO [16]. An influence of PAAO thickness variation in the range from 500 nm to 5 μm on biosensor performance using gold-capped PAAO has been reported [17]. Usually, the PAAO thickness is determined by the anodization time and growth rate. Although the thickness accuracy can

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• physical, chemical, and biological characteristics compared to those of bulk materials [11]. The enhanced performance of nanoparticles could be attributed to their high specific surface area-to-volume ratio [10]. The availability of a variety of biological, chemical, and physical methods of synthesis

Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti

• Jonatas L. Duarte,
• Leonardo Delello Di Filippo,
• Anna Eliza Maciel de Faria Mota Oliveira,
• Rafael Miguel Sábio,
• Gabriel Davi Marena,
• Tais Maria Bauab,
• Cristiane Duque,
• Vincent Corbel and
• Marlus Chorilli

Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10

• the release of cymene and myrcene from the nanoemulsions was performed at specific time intervals: 30 min and 1, 2, 4, 6, 8, 12, and 24 h. Each measurement was repeated six times to ensure reliability. The released compounds were quantified by high-performance liquid chromatography, following a

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• exhibited excellent performance in repairing bone defects [3][26], healing diabetic foot ulcers [27], promoting hemostasis [28], acting as anti-leishmanial drugs [29], and inhibiting microbial agents [27][30]. Zhou et al. [31] developed hybrids of nanofibers and microparticles for dual-step controlled

• in the nanofiber matrix, which could allow the gradual diffusion of BBR inside the nanofibers to the aqueous medium. Antibacterial performance of BBR-loaded nanofiber scaffolds To evaluate the antibacterial efficiency of BBR-loaded nanofiber scaffolds in the relationship with their BBR release

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• Rs corresponds to solution resistance, Rct is related to charge transfer resistance at the interface of the solution and the electrode material, while CPE is a constant phase element, which represents capacitive performance of the electrode. The circuit parameters and their standard deviations were

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• disappearance of the flagellum in the promastigote parasites treated with doses of NE above the IC50. Peixoto and collaborators developed epoxy-α-lapachone-loaded microemulsions (ME). They assessed the ME in vivo performance against L. amazonensis in infected BALB/c mice. The ME droplet size was smaller than

• proven by the strong intracellular fluorescence levels. Furthermore, NLCs increased the in vitro leishmanicidal activity of curc (IC50: 105.49 ± 3.71 μg/mL) when compared to curc-free NLCs (IC50: 165.06 ± 4.64 μg/mL). Similar performance occurred in vivo in axenic amastigotes, (IC50 of the curc-NLC

• : 190.3 ± 3.19 and IC50 value of the curc-free: 243.56 ± 2.89 μg/mL) corroborating the improvements in the leishmanicidal response after entrapment of curc in the nanostructure. This biological performance was also observed in artemether-NLC against L.infantum. Nanostructured lipid carriers conferred an

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• , and topical routes, and they are biodegradable, biocompatible, and non-immunogenic [45]. Moreover, they improve the therapeutic performance of the drug by protecting it from the biological environment and restricting effects to target cells, thereby reducing the clearance of the drug [45]. Drugs for

unDrift: A versatile software for fast offline SPM image drift correction

• Tobias Dickbreder,
• Franziska Sabath,
• Lukas Höltkemeier,
• Ralf Bechstein and
• Angelika Kühnle

Beilstein J. Nanotechnol. 2023, 14, 1225–1237, doi:10.3762/bjnano.14.101

• determine the drift velocity from the apparent movement of stationary features either by automatic evaluation of the cross-correlation image or based on positions identified manually by the user. We demonstrate the performance and reliability of unDrift using three challenging examples, namely images

• positions for drift correction [5][12][25][29][30][31][32]. Note that all drift correction algorithms applied by unDrift rely on information contained within the measurement data solely; thus, unDrift allows for the investigation of unknown structures. To demonstrate the performance of unDrift, we apply our

• evaluation are recorded by unDrift and can be downloaded in a separate csv file. Results and Discussion To demonstrate the performance of unDrift, we will now apply the software to experimental situations where the drift correction is either especially challenging or time-consuming. Challenging experimental

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH₃)₂Cl]₂

• Elif Bilgilisoy,
• Ali Kamali,
• Thomas Xaver Gentner,
• Gerd Ballmann,
• Sjoerd Harder,
• Hans-Peter Steinrück,
• Hubertus Marbach and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98

• monolayer is high. This could be probed in a non-steady-state experiment similar to those reported for Pt(CO)2X2 (X = Cl, Br) and several other potential FEBID precursors [57]. Conclusion In the current study, we evaluated the performance of [Au(CH3

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• , Taiwan (R.O.C.) Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 40227, Taiwan (R.O.C.) 10.3762/bjnano.14.96 Abstract Surface micro- and nanostructures profoundly affect the functional performance of nerve regeneration implants by modulating neurite responses