Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• treatments. Although the past decade has witnessed extraordinary progress in developing nanoantioxidants, further research is still required to overcome the limitations of metal-based nanoantioxidants and to bring this technology closer to clinical practice. Future research needs to focus on the toxicology

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• corona content and optimize the processes in food and chemical industry. The presented methodology can be easily extended to other molecules, materials, and contexts involving the bionano interface such as environmental safety, health, medical devices, or toxicology. Schematic representation of the life

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• Technical University of Athens, 9 Heroon Polytechniou str. Zografou Campus, 15780 Athens, Greece School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, Oregon, USA Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

• Nabojit Das,
• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69

• Nabojit Das Akash Kumar Raja Gopal Rayavarapu Nanomaterial Toxicology Laboratory, Nanomaterial Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow 226001, India Academy of Scientific and Innovative Research (AcSIR

• synthesizing various nanomaterials (NMs) for potential chemical and biological applications. Acknowledgements RRG is thankful to CSIR-Indian Institute of Toxicology Research, Lucknow for providing the infrastructure and support. The CSIR-IITR publication committee has approved this review article and the

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• Silver (nano) that insufficient data on AgNP physicochemical properties and toxicology in cosmetics hinder the health hazards caused by AgNPs [5]. Earlier, the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) raised questions on how different forms of Ag used in consumer and

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• Medical Toxicology Lab, Department of Zoology, Government College University Lahore, Lahore-54000, Pakistan 10.3762/bjnano.12.24 Abstract Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. The purpose of the current

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

• Sandra Senyo Fometu,
• Guohua Wu,
• Lin Ma and
• Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

• a model organism since it has provided relevant data in various fields and its application does not spark any bioethical issues [81]. Despite the milestones achieved in genomics, the use of silkworms as a model to study mammalian toxicology is limited due to differences in biological processes and

• relationship with mammals [99], thus, it cannot express or fully mimic the mammalian biological system. This limits their application as a model organism to evaluate the efficacy of drugs in certain toxicology studies. The silkworm as a model organism provides a fresh perspective on how to solve scientific

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• /Pubmed and Web of Science (WoS) for article and review papers and books reporting on effects, uses, in vivo and in vitro tests, toxicology, synthesis and properties of SPIONs. We used single terms or combinations of one or more of the listed terms. This search was carried out for the period between June

• ]. This strengthens the point that for every type of nanoparticles, full toxicology analyses with meaningful and adequate in vitro to in vivo correlations are required. Freund and co-workers [45] used 56Fe SPIONs covered in 14C oleic acid to radiolabel and quantify the accumulated Fe. They proved that the

• weight [127]. In an extensive toxicology experiment on iron nanoparticles, Volkovova et al. [171] found that the lethal dose for 50% of rats is 36 mg Fe/kg body weight. Their study was focused on the SPION effects on the liver, where they found only mild necrosis and lipidosis, but the paper did not

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• Aniela Bittner Angelique D. Ducray Hans Rudolf Widmer Michael H. Stoffel Meike Mevissen Division of Veterinary Pharmacology and Toxicology, Vetsuisse Faculty, University of Bern, Länggassstrasse 124, 3012 Bern, Switzerland Department of Neurosurgery, Research Unit, Inselspital, University of Bern

Nanocellulose: Recent advances and its prospects in environmental remediation

• Katrina Pui Yee Shak,
• Yean Ling Pang and
• Shee Keat Mah

Beilstein J. Nanotechnol. 2018, 9, 2479–2498, doi:10.3762/bjnano.9.232

• toxicology) for some cases, further optimization and improvement must be made. Furthermore, the fabrication of nanocellulose-based adsorbents is mostly established based on CNF, and limited when it comes to CNC. Nanocellulose-based photocatalysts Recently, numerous inorganic-organic hybrid-based

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

• Nagamalai Vasimalai,
• Vânia Vilas-Boas,
• Juan Gallo,
• María de Fátima Cerqueira,
• Mario Menéndez-Miranda,
• José Manuel Costa-Fernández,
• Lorena Diéguez,
• Begoña Espiña and
• María Teresa Fernández-Argüelles

Beilstein J. Nanotechnol. 2018, 9, 530–544, doi:10.3762/bjnano.9.51

• , 4715-330 Braga, Portugal UCIBIO-REQUIMTE, Laboratory of Toxicology, Biological Sciences Department, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050–313 Porto, Portugal Center of Physics, University of Minho, 4710-057 Braga, Portugal Department of Physical and

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs)

• Michelle Romero-Franco,
• Hilary A. Godwin,
• Muhammad Bilal and
• Yoram Cohen

Beilstein J. Nanotechnol. 2017, 8, 989–1014, doi:10.3762/bjnano.8.101

• , the approach is not built for direct analysis of quantitative data or handling of areas of missing information. The Decision-making framework for the grouping and testing of nanomaterials (DF4Nano grouping) was designed by the European Center for Ecotoxicology and Toxicology of Chemicals (ECETOC

• the environment, and consumption of resources [67]. According to the Society of Environmental Toxicology and Chemistry (SETAC), LCA consists of the following steps: i) goal scope and definition (e.g., establishment of the product under analysis and study objectives); ii) life cycle inventory analysis

Phospholipid arrays on porous polymer coatings generated by micro-contact spotting

• Sylwia Sekula-Neuner,
• Monica de Freitas,
• Lea-Marie Tröster,
• Tobias Jochum,
• Pavel A. Levkin,
• Michael Hirtz and
• Harald Fuchs

Beilstein J. Nanotechnol. 2017, 8, 715–722, doi:10.3762/bjnano.8.75

• and Synchrotron Radiation (IPS), Laboratory for Applications of Synchrotron Radiation (LAS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany

The cleaner, the greener? Product sustainability assessment of the biomimetic façade paint Lotusan^® in comparison to the conventional façade paint Jumbosil^®

• Florian Antony,
• Rainer Grießhammer,
• Thomas Speck and
• Olga Speck

Beilstein J. Nanotechnol. 2016, 7, 2100–2115, doi:10.3762/bjnano.7.200

• , CEDnon-renewable as sum of the aforementioned), the ReCiPe environmental impact assessment model in the version of 2008, the IPCC method regarding the global warming potential (GWP) and the USEtox model for dealing with toxicology aspects related to the production and use of the two paints. A short

• products regarding toxicology aspects within the LCA. In the course of conducting the LCA, the demand for titanium dioxide in both paints could be identified as main driver of toxicity potential indicator results. Regarding the base-case scenario, Lotusan® shows about 20% higher USEtoxhumantox indicator

Nanoinformatics for environmental health and biomedicine

• Rong Liu and
• Yoram Cohen

Beilstein J. Nanotechnol. 2015, 6, 2449–2451, doi:10.3762/bjnano.6.253

• nanomaterials for their various intended applications, large amounts of data are being generated for better understanding and mapping the toxicology and pharmacology of nanomaterials. Nanomaterials data are typically sought regarding their physicochemical and structural properties, environmentally related

Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials

• Andrew Williams and
• Sabina Halappanavar

Beilstein J. Nanotechnol. 2015, 6, 2438–2448, doi:10.3762/bjnano.6.252

• toxicology tools have been assessed using both in vitro and in vivo models for their suitability and applicability for toxicity testing of NMs. However, these tools are single-endpoint-based or targeted in nature, investigate only one type of response at a time, and lack detailed mechanistic information [44

An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

• Richard L. Marchese Robinson,
• Mark T. D. Cronin,
• Andrea-Nicole Richarz and
• Robert Rallo

Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202

Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials

• Christina M. Powers,
• Karmann A. Mills,
• Stephanie A. Morris,
• Fred Klaessig,
• Sharon Gaheen,
• Nastassja Lewinski and
• Christine Ogilvie Hendren

Beilstein J. Nanotechnol. 2015, 6, 1860–1871, doi:10.3762/bjnano.6.189

• (e.g., chemistry, toxicology, ecology, risk assessment, material science). The complexity of developing tools for accessing, sharing, and viewing data relevant to nanomaterials has generated an entire field known as nanoinformatics. This paper is one in a series and focuses on a particular aspect of

NanoE-Tox: New and in-depth database concerning ecotoxicity of nanomaterials

• Katre Juganson,
• Angela Ivask,
• Irina Blinova,
• Monika Mortimer and
• Anne Kahru

Beilstein J. Nanotechnol. 2015, 6, 1788–1804, doi:10.3762/bjnano.6.183

• Katre Juganson Angela Ivask Irina Blinova Monika Mortimer Anne Kahru Laboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn

• nanotoxicology by 2005 and the ‘pioneering’ NPs in environmental safety studies were CNTs, fullerenes, TiO2, SiO2 and ZnO. The analysis of the journals that contributed to the database revealed that more than half of the relevant papers originated from seven journals: Environmental Toxicology and Chemistry (29

• papers), Environmental Science & Technology (25), Chemosphere (18), Environmental Pollution (12), Aquatic Toxicology (12), Science of the Total Environment (11), and Journal of Hazardous Materials (10 papers) (Table S4, Supporting Information File 1). Analysis of the database: physico-chemical

The Nanomaterial Data Curation Initiative: A collaborative approach to assessing, evaluating, and advancing the state of the field

• Christine Ogilvie Hendren,
• Christina M. Powers,
• Mark D. Hoover and
• Stacey L. Harper

Beilstein J. Nanotechnol. 2015, 6, 1752–1762, doi:10.3762/bjnano.6.179

• , NC, USA current affiliation: Office of Transportation and Air Quality, Office of Air and Radiation, U.S. EPA, Ann Arbor, MI, USA National Institute for Occupational Safety and Health, Morgantown, WV, USA Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA

• important to chemistry, materials science and toxicology fields as a whole. However, drawing on existing experience with standards development, data handling and data integration to address viable solutions for complex data integration within the scope of nanomaterial data may serve as a specific case that

The eNanoMapper database for nanomaterial safety information

• Nina Jeliazkova,
• Charalampos Chomenidis,
• Philip Doganis,
• Bengt Fadeel,
• Roland Grafström,
• Barry Hardy,
• Janna Hastings,
• Markus Hegi,
• Vedrin Jeliazkov,
• Nikolay Kochev,
• Pekka Kohonen,
• Cristian R. Munteanu,
• Haralambos Sarimveis,
• Bart Smeets,
• Pantelis Sopasakis,
• Georgia Tsiliki,
• David Vorgrimmler and
• Egon Willighagen

Beilstein J. Nanotechnol. 2015, 6, 1609–1634, doi:10.3762/bjnano.6.165

• , Lucca, Italy in silico toxicology Gmbh (IST), Basel, Switzerland 10.3762/bjnano.6.165 Abstract Background: The NanoSafety Cluster, a cluster of projects funded by the European Commision, identified the need for a computational infrastructure for toxicological data management of engineered nanomaterials

• originating from diverse systems. Within this cluster, eNanoMapper works towards supporting the collaborative safety assessment for ENMs by creating a modular and extensible infrastructure for data sharing, data analysis, and building computational toxicology models for ENMs. Results: The eNanoMapper database

• studies in which toxicology or biological interference of the nanomaterials have been studied, in addition to an accurate physicochemical characterisation. Data input, data formats, provenance, visualisation The framework should allow for the representation of data and facts compatible with regulatory

Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish

• Zitao Zhou,
• Jino Son,
• Bryan Harper,
• Zheng Zhou and
• Stacey Harper

Beilstein J. Nanotechnol. 2015, 6, 1568–1579, doi:10.3762/bjnano.6.160

• Zitao Zhou Jino Son Bryan Harper Zheng Zhou Stacey Harper School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, Oregon, 97330, United States Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, 97330, United

• estimation; modelling; nanomaterials; nanotechnology; toxicology; Introduction Accelerated advancements in nanotechnology and nanoscience have found applications in a variety of scientific fields, leading to a rapid increase in the types of engineered nanoparticles on the market. In particular, zinc oxide

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• Institute of Applied Physics, Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Straße 1, 76131 Karlsruhe, Germany Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany Department of Physics

• functionality, etc. should be investigated. Additionally, even for industrial applications (e.g., coatings in automotive and other types of industries) toxicology studies are warranted. In this study, we demonstrated that polystyrene and polylactide particles are taken up not only by hMSCs, but also at a

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• are available on NP pharmacology and toxicology in humans and animals [8][9]. However, despite all advancements in in vitro testing including permanent or primary cell lines and ex vivo organ cultures, the complexity of a living organism cannot be modeled in a test tube or culture dish. In this regard

Size-dependent density of zirconia nanoparticles

• Agnieszka Opalinska,
• Iwona Malka,
• Wojciech Dzwolak,
• Tadeusz Chudoba,
• Adam Presz and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2015, 6, 27–35, doi:10.3762/bjnano.6.4

• as a luminescent material, the luminescence intensity increases with crystallite size [17]. The size and surface properties of NPs are also important for toxicology and health applications. The size of the NPs can influence their distribution in the human body and the mechanism of their penetration