Carbohydrate-auxiliary assisted preparation of enantiopure 1,2-oxazine derivatives and aminopolyols

  1. Marcin Jasiński1,2,
  2. Dieter Lentz1,§ and
  3. Hans-Ulrich Reissig1

1Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, D-14195 Berlin, Germany
2Department of Organic and Applied Chemistry, University of Łódź, Tamka 12, PL-91-403 Poland

  1. Corresponding author email

§ Responsible for X-ray crystal-structure determination

This article is part of the Thematic Series "Synthesis in the glycosciences II".

Guest Editor: T. K. Lindhorst
Beilstein J. Org. Chem. 2012, 8, 662–674. https://doi.org/10.3762/bjoc.8.74
Received 27 Jan 2012, Accepted 28 Mar 2012, Published 30 Apr 2012

Abstract

An approach to enantiopure hydroxylated 2H-1,2-oxazine derivatives is presented utilizing the [3 + 3] cyclisation of lithiated alkoxyallenes and an L-erythrose-derived N-glycosyl nitrone as precursors. This key step proceeded only with moderate diastereoselectivity, but allowed entry into both enantiomeric series of the resulting 3,6-dihydro-2H-1,2-oxazines. Their enol ether double bond was then subjected to a hydroboration followed by an oxidative work-up, and finally the auxiliary was removed. The described three-step procedure enabled the synthesis of enantiopure hydroxylated 1,2-oxazines. Typical examples were treated with samarium diiodide leading to enantiopure acyclic aminopolyols. We also report on our attempts to convert these compounds into enantiopure hydroxylated pyrrolidine derivatives.

Keywords: aminopolyols; carbohydrates; chiral auxiliaries; lithiated alkoxyallenes; 1,2-oxazines; pyrroles; pyrrolidines; samarium diiodide

Introduction

During the last few decades carbohydrate-derived nitrones have turned out to be particularly attractive tools for the synthesis of structurally complex compounds [1-4]. Employed mainly as 1,3-dipoles in cycloadditions [5,6] or as imine analogues in nucleophilic additions [7,8], these nitrones very often furnish the corresponding products in a highly selective manner. In this context, reactions of lithiated alkoxyallenes with enantiopure nitrones are particularly of interest since they lead by a [3 + 3] cyclisation process to 1,2-oxazine derivatives with excellent diastereoselectivity [9]. We previously reported on the unusually diverse synthetic potential of carbohydrate-derived 1,2-oxazines allowing the smooth and flexible preparation of various highly functionalised compounds, including de novo syntheses of carbohydrates and their mimetics, as well as N-heterocycles [10-12]. Although the reactions of lithiated alkoxyallenes, with nitrones bearing substituents with stereogenic centres at the carbon atom, were studied in our group in great detail [13], N-glycosyl-substituted nitrones have so far not been used as electrophiles for this purpose. This type of nitrone has been introduced and broadly studied by Vasella and co-workers [14-20] and has also been used by other groups [21-25]. They observed moderate to high diastereoselectivities for 1,3-dipolar cycloadditions and for nucleophilic additions. Successful applications of these easily removable auxiliaries in the syntheses of biologically active agents were also reported [26-31]. Apart from the obvious reactivity of N-glycosyl nitrones of type 1 leading to five-membered heterocycles A or to N,N-disubstituted hydroxylamine derivatives B, a twofold nucleophilic addition of an excess of organometallic reagents furnishing compounds of type C (Nu1 = Nu2) was described and discussed by Goti et al. (Scheme 1) [32]. In selected examples, the synthesis of differently substituted products (Nu1 ≠ Nu2) was possible by consecutive additions of the appropriate Grignard reagents [33]. Here we report on the application of a nitrone with an L-erythronolactone-derived auxiliary for the synthesis of 3,6-dihydro-2H-1,2-oxazine derivatives of type D. Their selected transformations, including hydroboration of the enol ether moiety, oxidative work-up, glycosyl cleavage, and samarium diiodide-induced reactions, are presented as well.

[1860-5397-8-74-i1]

Scheme 1: Reactivity of N-glycosyl nitrones 1 towards dipolarophiles and nucleophiles leading to products of type A, B, C and D.

Results and Discussion

In continuation of our recent exploration of L-erythrose-derived nitrones for the synthesis of 3,6-dihydro-2H-1,2-oxazine derivatives [34], we turned our attention to benzaldehyde-derived nitrone 1a, which is readily available in a three-step procedure starting from L-arabinose. L-Erythronolactone was first prepared [35] and was subsequently treated with N-benzylhydroxylamine [36], and the resulting product was oxidised with activated MnO2 [37] to furnish the desired compound 1a in 51% overall yield. The initial experiment with 1a was carried out under typical conditions with 2.4 equiv of lithiated methoxyallene at −78 °C in THF. Similarly to previous results for more rigid cyclic nitrones [38], the formation of the intermediate N-hydroxylamines 2 (Scheme 2) was clearly observed. These primarily formed compounds were not isolated, but (in the presence of a drying agent) they underwent slow cyclisation in Et2O solution at room temperature to furnish the desired 1,2-oxazine derivative as a mixture of separable diastereomers (3S)-3a and (3R)-3a in 25% and 8% yield, respectively (Table 1, entry 3). The 1,2-oxazines were accompanied by a complex mixture of by-products, from which only two compounds 4 (1%) and 5 (3%) could be isolated in pure form (Figure 1). After tedious optimisation with respect to stoichiometry, temperature, time, concentration, etc. (selected results are presented in Table 1), we found that running the reaction from −130 to −80 °C, followed by standing overnight at room temperature, allowed the synthesis of 3a with an overall yield of 75% and a ratio of diastereomers of ca. 2:1 (49% and 22% after separation of the isomers, Table 1, entry 7). When the reaction was scaled up to 3.50 g of 1a the expected diastereomers of 1,2-oxazines 3a were obtained with no decrease in yield (78%). As illustrated in Scheme 2, lithiated (2-trimethylsilyl)ethoxyallene and benzyloxyallene were also examined under the optimised reaction conditions and furnished the expected diastereomers of 1,2-oxazine derivatives 3b and 3c in 51% and 65% yield, respectively.

[1860-5397-8-74-i2]

Scheme 2: Additions of lithiated alkoxyallenes to L-erythrose-derived nitrone 1a leading to 3,6-dihydro-2H-1,2-oxazine derivatives 3 via the respective N-hydroxylamines 2.

Table 1: Selected reaction conditions of nitrone 1a with lithiated methoxyallene.

entry lithiated methoxyallene (equiv)a T (°C) time (h) (3S)-3a / (3R)-3a ratiob yieldc [%]
1 10.0 −78 1.0 tracesd
2 3.0 −78 1.0 3:1 26
3 2.4 −78 1.0 3:1 33
4 2.2 −78 1.0 3:1 38
5 1.5 −78 1.0 2.5:1 26
6 2.2 −100 → −80 1.0 2:1 51
7 2.2 −130 → −80 1.5 2:1 75

aReactions performed in 1.1 mmol scale with respect to 1a. bCrude product. cCombined yield of isolated (3S)-3a and (3R)-3a. dOnly the major diastereomer (3S)-3a was detected.

[1860-5397-8-74-1]

Figure 1: By-products 4 and 5 isolated from the reaction of nitrone 1a with lithiated methoxyallene.

The mixtures of diastereomers of crude 1,2-oxazines 3ac were easily separated by standard column chromatography and characterised by spectroscopic methods. However, in certain cases additional purification was necessary to obtain analytically pure samples. The absolute configuration of the newly generated stereogenic centre could not be determined based on NMR techniques. For instance, in the 1H NMR spectra of the diastereomeric products (3S)-3a and (3R)-3a, the signals of the benzylic protons assigned to C-3 of the 1,2-oxazine ring appear as singlets at 4.85 and 4.48 ppm, respectively. Due to the unhindered rotation of the auxiliary moiety similar correlation peaks in NOE experiments were observed for both isomers. Fortunately, the minor product (3R)-3a isolated as an amorphous solid could be recrystallised from ethyl acetate solution to give crystals suitable for an X-ray crystallographic analysis (Figure 2). The X-ray analysis of (3R)-3a shows a well-defined half-chair conformation of the 1,2-oxazine ring, with four carbon atoms in plane and with ONCC and OCCC torsion angles of −60° and 13°, respectively. The bulky N-substituent occupies a pseudo-equatorial position and the phenyl group is in a pseudo-axial position. Since characteristic shift patterns in the 1H NMR spectra for both diastereomeric series are observed, the configuration at C-3 of the TMSE derivatives (b) and benzyloxy analogues (c) could be assigned as well with high certainty.

[1860-5397-8-74-2]

Figure 2: Single-crystal X-ray analysis of (3R)-3a (ellipsoids are drawn at a 50% probability level).

The stereochemical outcome observed for the reactions studied also deserves some comment. Whereas lithiated methoxy- and TMS-ethoxyallene yielded the diastereomers in ca. 2:1 ratio, in the case of lithiated benzyloxyallene a significant switch of the selectivity to an approximate 1:2 ratio was observed. According to the model proposed in the literature [7,18,20] for the addition of nucleophiles, the stereochemical course is governed by a competition of steric and electronic effects. As presented in Figure 3, the bulky benzyloxy substituent favours the anti-addition and hence yields the (3R)-configured product as the major compound. In contrast, the less hindered lithiated methoxyallene enables a syn-attack supported by a “kinetic anomeric effect”, stabilizing the respective transition state [20] and furnishing the (3S)-configured 1,2-oxazine. In all tested examples the level of diastereoselectivity was only low to moderate, and the interpretation should therefore not be exaggerated. Alternative conformations explaining the results are certainly possible.

[1860-5397-8-74-3]

Figure 3: Model proposed for the addition of lithiated allenes to nitrone 1a.

The fragmentation of the primarily formed allenyl N-hydroxylamines of type 2 leading to 1,3-dienes such as 4 (Figure 1) by retro-nitroso-ene reaction was discussed in earlier work [13], but the formation of pyrrole derivative 5 is unprecedented for the reactions of nitrones and lithiated alkoxyallenes. The 1H NMR spectrum of 5 shows four singlets (3H each) assigned to three methyl groups and one methoxy substituent. Additionally, a broad singlet at δ = 8.98 ppm attributed to the NH functionality, an OH group at 2.11 ppm (dd, J ≈ 4.0, 8.1 Hz) coupling with the adjacent methylene group, and a characteristic set of multiplets of the [1,3]dioxolane and the phenyl moieties could be found. The signals of four quaternary carbon atoms in the 13C NMR spectrum evidenced the presence of the pyrrole structure. Finally, the HMBC experiment proved the proposed substitution pattern at the pyrrole ring. HRMS and elemental analysis allowed identification of 5 as a 2,3,4,5-tetrasubstituted pyrrole derivative.

As shown in Table 1, entries 1–3, a higher excess of lithiated methoxyallene resulted in a significant decrease in the yield of 1,2-oxazine derivatives. For example, in the case of 10 equiv of lithiated methoxyallene (Table 1, entry 1) only a trace amount of (3S)-3a (<5%) and numerous side products were found in the crude product, including compound 5. On the other hand, no pyrrole 5 could be detected when only a slight excess of methoxyallene was used (Table 1, entry 5) or when the reaction was performed at lower temperatures (Table 1, entries 6 and 7). These observations prompted us to postulate that the surprising formation of 5 is the result of a double addition of lithiated methoxyallene to nitrone 1a as illustrated in Scheme 3, the crucial step being the (reversible) opening of the tetrahydrofuran ring of the primary addition product E. The resulting new nitrone F can then react with the second equiv of lithiated methoxyallene to give the double adduct G. After aqueous work-up, hydroxylamine derivative H underwent a ring-closure to 1,2-oxazetidine derivative I. It is known that this class of compounds can suffer a thermally induced [2 + 2] cycloreversion involving N–O bond cleavage [39,40], which, in our case, led to the formation of methyl acrylate and imine J. This imine underwent subsequent cyclisation to zwitterion K and two proton shifts, probably via 3-exomethylene compound L, finally led to pyrrole 5. This mechanism is certainly speculative but offers a possibility to explain the formation of the tetrasubstituted pyrrole 5. The structure of the intermediate double-addition product H suggests that other by-products may be formed, e.g., two different N-allenylmethyl-substituted 3,6-dihydro-2H-1,2-oxazines or an isomeric pyrrole derivative. The numerous sets of signals in the 1H NMR spectrum as well as additional spots seen on TLC of the crude reaction mixtures support this assumption, but none of these possible by-products could be isolated.

[1860-5397-8-74-i3]

Scheme 3: Speculative mechanistic suggestion for the formation of tetrasubstituted pyrrole derivative 5.

With respect to the enormous importance of polyhydroxylated N-heterocycles as carbohydrate-mimicking glycosidase inhibitors [41-45], the introduction of an additional hydroxyl moiety into 1,2-oxazine derivatives was an essential goal in several studies by our group [34,46-48]. A series of 5-hydroxy-1,2-oxazine derivatives was successfully prepared by the well known hydroboration/oxidation protocol, with yields and selectivities strongly depending on the relative configuration of the employed 1,2-oxazine derivative and on the presence of additives [34,48]. In general, syn-configured 1,2-oxazines (with respect to the relative configuration at C-3 and the neighbouring stereogenic centre at the carbohydrate-derived C-3-substituent) were found to be excellent substrates, leading to the desired alcohols exclusively with very high degrees of stereoselectivity. In an extension of these studies, selected compounds of type 3 were hydroxylated following the general methodology. As shown in Scheme 4, each of the (3S)-configured 1,2-oxazines 3a and 3b furnished a pair of hydroxylated products 6, 7 and 8, 9, respectively, in high combined yields (83% and 93%) and almost the same ratio (approximately 3:2) of cis-trans/trans-trans isomers. The stereoselectivity for this series is apparently only low. On the other hand, for (3R)-3a a ca. 3:1 ratio of hydroxylated products was observed based on the 1H NMR spectrum of the crude mixture; however, the minor product 10 was isolated in 13% yield only, whereas the major product was obtained in a satisfying 66% yield. We assume that the observed low facial selectivity results predominantly from the moderate hindrance exhibited by the neighbouring phenyl substituent, which in the case of the (3S)-series probably occupies a pseudo-equatorial position in the half-chair conformation of the 3,6-dihydro-2H-1,2-oxazine derivatives 3. The higher stereoselectivity of the hydroboration of (3R)-3a is probably caused by the pseudo-axial location of the phenyl group (as evidenced by the X-ray analysis, Figure 2), shielding one side more efficiently. The carbohydrate-derived N-substituent is relatively far away from the two reacting carbon atoms and very likely has no strong, direct influence on the observed diastereoselectivities.

[1860-5397-8-74-i4]

Scheme 4: Introduction of a 5-hydroxy group into 1,2-oxazine derivatives 3 by a hydroboration/oxidation protocol; (a) BH3·THF (4.0 equiv), THF, −30 °C to rt, 3 h; (b) NaOH, H2O2 (30%), −10 °C to rt, overnight.

All products 611 obtained by the hydroboration/oxidation protocol were easily purified and separated by column chromatography and finally deprotected by treatment with acid. This afforded a series of the desired, highly functionalised tetrahydro-2H-1,2-oxazine derivatives 1215, including ent-12 and ent-13 (Table 2). Reaction of the trans-trans-configured 4-methoxy-1,2-oxazines 6 and 10 with a methanolic solution of HCl (1 M) at elevated temperatures enabled the smooth cleavage of the glycosyl bond to give the N-unsubstituted derivatives 12 and ent-12 in high yields (Table 2, entries 1 and 5). The cis-trans-configured compound pair 7 and 11 provided similar results, yielding the expected enantiomers 13 and ent-13 (Table 2, entries 2 and 6). As expected, the enantiomers show nicely matching optical rotations with opposite sign. In the case of the TMSE-protected derivative 9, selective removal of the N-protective group could be achieved under the applied conditions. After prolonged reaction times (16 h) there was no significant change in the tested sample. A complete deprotection of 9 leading to dihydroxylated compound 15 was possible in high overall yield (75%) by using ion-exchange resin DOWEX-50 at 50 °C (Table 2, entry 4). As shown for compound 8, simultaneous cleavage was also possible, and the analytically pure compound 14 was isolated in comparable yield (Table 2, entry 3). Alternatively, demethylation of 12 by treatment with boron tribromide at low temperatures [49] also provided the expected compound 14 (Table 2, entry 7); however, the analytically pure sample of this compound could only be isolated in 18% yield. Therefore, the protocol applying a TMS-ethyl substituent as a more easily removable O-protective group turned out to be much more effective. All enantiopure 1,2-oxazines 1215 were isolated as colourless crystals, which were prone to sublimation.

Table 2: Acid-induced cleavages of N- and O-protective groups of 5-hydroxy-1,2-oxazine derivatives 611; conditions: (a) HCl (1 M) in MeOH, 40 °C, 3.5 h; (b) DOWEX-50, EtOH, 50 °C, 4 d; (c) BBr3 (3 equiv), CH2Cl2, −78 °C (1 h) then rt, overnight.

[Graphic 1]
entry N-glycosyl 1,2-oxazine conditions product yield mp/[α]D22
1 [Graphic 2]
6
(a) [Graphic 3]
12
79% 110–112 °C/
+60.1 (c 1.05, CHCl3)
2 [Graphic 4]
7
(a) [Graphic 5]
13
83% 112–113 °C/
+47.9 (c 1.00, CHCl3)
3 [Graphic 6]
8
(b)a [Graphic 7]
14
78% 153–154 °C/
+33.8 (c 1.05, CH3OH)
4 [Graphic 8]
9
(a) then (b) [Graphic 9]
15
75%b 190–192 °C/
+65.6 (c 1.26, CH3OH)
5 [Graphic 10]
10
(a) [Graphic 11]
ent-12
84% 110–112 °C/
−61.5 (c 1.18, CHCl3)
6 [Graphic 12]
11
(a) [Graphic 13]
ent-13
92% 110–113 °C/
−48.8 (c 1.10, CHCl3)
7 [Graphic 14]
12
(c) [Graphic 15]
14
18% c

aReaction time prolonged to 10 days; boverall yield for two steps; cmelting point and spectroscopic data correspond with the sample of compound 14 obtained from 8 (Table 2, entry 3).

The 1H NMR spectrum of transtrans configured 14 also deserves a short comment. Similarly to the previously described 2,4- and 2,5-dimethyltetrahydro-1,2-oxazine derivatives [50], significant long-range couplings could be observed in the 1H NMR spectrum. The low-field shifted multiplet (4.12–4.19 ppm) assigned to the equatorial 6-H showed additional couplings of <2.5 Hz. However, due to 4-H/5-H overlapping, selective decoupling of this complex spin system was not possible. An indirect proof for the observed phenomenon was found in the 1H NMR spectrum (Supporting Information File 2) of 14 prior to purification, i.e., still containing BBr3, which acts here as a shift reagent. The influence of the coordinated boron species resulted not only in a strong low-field shift but it also simplified the spectrum, and thus, only geminal and vicinal couplings (J = 12.2 Hz and J = 5.4 Hz) for the equatorial 6-H could be found. On the other hand, a possible nitrogen and/or ring inversion usually measurable at lower temperatures should be taken into account [51]. As expected, no significant changes in the shift pattern were observed in a series of 1H NMR spectra measured at elevated temperatures, both in methanol-d4 (up to 50 °C) and DMSO-d6 (up to 80 °C). Moreover, in the 13C NMR spectrum only one set of sharp signals was observed.

Due to their similarity to carbohydrate derivatives, hydroxylated 1,2-oxazines such as 1215 may already have interesting biological activity, but their functional groups also open several options for subsequent transformations into other relevant compound classes. By reductive ring opening the corresponding amino polyols should be accessible. Since compounds of type 12 contain a benzylamine substructure, standard methods that may possibly attack this moiety, such as catalytic hydrogenation, should be avoided. As an alternative, samarium diiodide is an attractive reagent for this purpose. Apart from its extraordinary potential for the formation of new carbon–carbon bonds [52-54], the cleavage of N–O bonds in a chemoselective fashion is also well documented [55-57]. The application of samarium diiodide for 1,2-oxazine ring opening allowed efficient syntheses of numerous polyhydroxylated heterocycles, such as pyrrolidine [46], azetidine [47], furan [58], and pyran derivatives [59]. Gratifyingly, the treatment of tetrahydro-2H-1,2-oxazine derivatives 12 and 13 with an excess of SmI2 in tetrahydrofuran smoothly provided the expected amino alcohols 16 and 17 in excellent yields (Scheme 5).

[1860-5397-8-74-i5]

Scheme 5: Samarium diiodide-induced ring opening of tetrahydro-2H-1,2-oxazine derivatives 12 and 13.

In order to compare the behaviour of a compound still bearing the N-auxiliary, we converted tetrahydro-2H-1,2-oxazine 7 into the O-benzylated derivative 18 under standard conditions (Scheme 6). Treatment of this protected compound with samarium diiodide furnished a complex mixture of products from which only the two amino alcohols 19 and 20 were isolated, in low yield. The formation of 20 could be explained by a subsequent SmI2-mediated reduction of the C=N bond formed by ring opening of 19, which contains a hemiaminal moiety. This suggestion is supported by the 1H NMR spectrum of 19 in which a second set of signals could be easily detected. Thus, the direct use of 1,2-oxazine derivatives still containing the carbohydrate-derived auxiliary at the nitrogen is apparently not sufficiently selective during samarium diiodide-promoted reactions.

[1860-5397-8-74-i6]

Scheme 6: Reaction of tetrahydro-2H-1,2-oxazine 18 with samarium diiodide. (a) NaH (1.4 equiv), BnBr (1.2 equiv), DMF, 0 °C to rt, overnight.

The successful transformation of N-benzyl-substituted tetrahydro-2H-1,2-oxazine derivatives into polyhydroxylated pyrrolidine derivatives [46] prompted us to select compound 13 as a precursor and to examine the described methods with this substrate. First, the free hydroxy group was protected as a trimethylsilyl ether and, after SmI2-induced ring opening, the expected product 22 was clearly identified based on TLC monitoring. However, the attempted isolation and purification of this compound by column chromatography provided amino alcohol 17 as the only product in high yield (92%). The limited stability of the TMS protective group is evident from the results presented in Scheme 7. Treatment of freshly prepared unpurified 22 with an excess of mesyl chloride and triethylamine yielded a complex product mixture. The isolated compounds 2326 clearly indicate that the migration of the TMS group not only takes place in an intramolecular fashion to the terminal hydroxy function to furnish 24, but it also occurs intermolecularly leading to the disilylated mesylamide 23. The desired pyrrolidine derivative 25 was obtained only as a minor product (5%). The major isolated component, N,O-dimesylated pyrrolidine 26 (35%) derives from 25 by TMS-cleavage and subsequent mesylation of the OH group.

[1860-5397-8-74-i7]

Scheme 7: Attempted synthesis of pyrrolidine derivatives from precursor 13. (a) TMSCl (1.5 equiv), imidazole, DMAP, CH2Cl2, rt, overnight; (b) SmI2, THF, 1.5 h, rt; (c) CHCl3, rt, overnight; (d) MsCl (4 equiv), Et3N, CH2Cl2, rt, overnight.

To overcome these apparent difficulties, tert-butyldimethylsilyl-protected compound 27 was prepared. Samarium diiodide-mediated ring opening under standard conditions furnished the expected amino alcohol 28 in excellent yield (Scheme 8). An attempted cyclisation of 28 using tosyl chloride in the presence of triethylamine was not successful but led to N-tosylated compound 31 in 24% yield. A partial epimerisation at the benzylic position and slow decomposition of precursor 28 could also be observed under the reaction conditions applied, and none of the desired pyrrolidine derivatives could be found in the crude product. Purification on a silica gel column yielded two fractions containing a mixture of the C-4 epimeric N,O-di-tosylated compounds (14%, ca. 1:1 ratio) and a mixture of the respective tosylamides (41%, ca. 4:1 ratio). Additional chromatography of the latter fraction enabled isolation of compound 31 in the pure state (24%). Isolation of other by-products was not possible.

[1860-5397-8-74-i8]

Scheme 8: Synthesis of TBS-protected tetrahydro-2H-1,2-oxazine 27 and its transformation into pyrrolidine derivatives 29, 30 and 32. (a) TBSCl (2.0 equiv), imidazole, DMAP, CH2Cl2, rt, 5 d; (b) SmI2, THF, 1.5 h, rt; (c) MsCl (2.0 equiv), Et3N, CH2Cl2, rt, overnight; (d) LDA (5.4 equiv), rt, 16 h; (e) pTsCl (2.2 equiv), Et3N, CH2Cl2, rt, overnight; (f) CBr4 (1.2 equiv), PPh3 (1.2 equiv), Et3N (1.1 equiv), CH2Cl2, rt, overnight; (g) HCl (1 M) in MeOH, rt, 3 d.

Fortunately, the use of mesyl chloride was more efficient to achieve cyclisation of 28. Application of this reagent afforded pyrrolidine derivative 29 in acceptable overall yield. The different reaction outcome observed for the transformations of 28 with the two sulfonyl chlorides is probably a consequence of the bulkiness of the TBS group. The small sulfene intermediate, generated from mesyl chloride, smoothly reacts with the terminal OH group to give the respective mesylate, which subsequently cyclises to afford pyrrolidine 29. On the other hand, the more bulky tosyl chloride competitively attacks the amino group. As illustrated in Scheme 8, the attempted conversion of 29 into the free secondary amine 30 by treatment with LDA [60] was not very efficient. The target compound was accompanied by a mixture of dihydropyrrole derivatives, which were very likely formed by deprotonation at the benzylic position and subsequent elimination.

Finally, freshly prepared unpurified 28 was subjected to the conditions of an Appel reaction [61] providing, after 16 hours at room temperature, pyrrolidine derivative 30 in 33% yield. Again, the relatively low efficacy could be explained by the destructive role of the base required for the subsequent cyclisation step. Cleavage of the TBS-moiety under acidic conditions furnished the desired hydroxylated pyrrolidine 32 in good yield. An attempted direct conversion of the unprotected amino diol 17 into 32 by treatment with tetrabromomethane in the presence of triphenylphosphine gave no satisfactory results, possibly due to the formation of the corresponding oxirane and its diverse, subsequent reactions.

Conclusion

We achieved the efficient synthesis of enantiopure hydroxylated tetrahydro-2H-1,2-oxazine derivatives using, in the key step, lithiated alkoxyallenes and a phenyl-substituted nitrone 1a bearing an L-erythronolactone-derived auxiliary as starting materials. Moderate levels of diastereoselectivity were observed for the formation of the 1,2-oxazine ring and for the subsequent hydroboration step. However, due to the easy separation of the formed products by standard column chromatography, the presented protocol opens up access to enantiopure products with both absolute configurations in different relative configurations, in a relatively short time. The described procedure supplements known protocols employing terpene units [62] and carbohydrate-derived auxiliaries [63,64] for the asymmetric synthesis of the 1,2-oxazine derivatives. More recently, the use of (–)-menthol as a chiral auxiliary was presented for the separation of diastereomeric 6H-1,2-oxazines [65,66]. Subsequent transformations of the newly prepared tetrahydro-2H-1,2-oxazines, utilizing samarium diiodide as the key reagent for the chemoselective ring opening, enable a smooth access to novel phenyl-substituted aminopolyols. Their transformation into hydroxylated pyrrolidine derivatives so far proceeds only with moderate efficacy, but this may certainly be optimised in the future.

Experimental

General methods. Reactions were generally performed under an inert atmosphere (argon) in flame-dried flasks. Solvents and reagents were added by syringe. Solvents were purified with a MB SPS-800-dry solvent system. Triethylamine was distilled from CaH2 and stored over KOH under an atmosphere of argon. Other reagents were purchased and used as received without further purification unless stated otherwise. Products were purified by flash chromatography on silica gel (230–400 mesh, Merck or Fluka). Unless stated otherwise, yields refer to analytically pure samples. NMR spectra were recorded with Bruker (AC 250, AC 500, AVIII 700) and JOEL (ECX 400, Eclipse 500) instruments. Chemical shifts are reported relative to TMS or solvent residual peaks (1H: δ = 0.00 ppm [TMS], δ = 3.31 ppm [CD3OD], δ = 7.26 ppm [CDCl3]; 13C: δ = 49.0 ppm [CD3OD], δ = 77.0 ppm [CDCl3]). Integrals are in accordance with assignments and coupling constants are given in Hertz. All 13C NMR spectra are proton-decoupled. For detailed peak assignments, 2D spectra were measured (COSY, HMQC, HMBC). IR spectra were measured with a Nexus FT-IR spectrometer fitted with a Nicolet Smart DuraSample IR ATR. MS and HRMS analyses were performed with a Varian Ionspec QFT-7 (ESI–FT ICRMS) instrument. Elemental analyses were obtained with a Vario EL or a Vario EL III (Elementar Analysensysteme GmbH) instrument. Melting points were measured with a Reichert apparatus (Thermovar) and are uncorrected. Optical rotations ([α]D) were determined with a Perkin–Elmer 241 polarimeter at the temperatures given. Single crystal X-ray data were collected with a Bruker SMART CCD diffractometer (Mo Kα radiation, λ = 0.71073 Å, graphite monochromator); the structure solution and refinement was performed by using SHELXS-97 [67] and SHELXL-97 [67] in the WINGX system [68]. CCDC-864241 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from the Cambridge Crystallographic Data Centre via http://www.ccdc.cam.ac.uk/data_request/cif.

Typical procedure for the preparation of 1,2-oxazine derivatives by addition of a lithiated alkoxyallene to nitrone 1a (Procedure 1)

Lithiated methoxyallene was generated under an atmosphere of dry argon by treating a solution of methoxyallene (357 mg, 0.42 mL, 5.06 mmol) in dry THF (20 mL) with n-BuLi (2.5 M in hexanes; 2.0 mL, 5.0 mmol) at −40 °C. After 5 min, the resulting mixture was cooled to −130 °C (n-pentane/liq. N2 bath), and a solution of nitrone 1a (606 mg, 2.30 mmol) in dry THF (15 mL) was added under vigorous stirring. The partially solidified mixture was allowed to reach −80 °C within 1.5 h and was quenched with water. Then, warming to room temperature was followed by extraction with Et2O (3 × 25 mL), and the combined organic layers were stirred overnight with the drying agent (MgSO4). When cyclisation of the primarily formed allene adducts was complete (TLC monitoring, hexane/ethyl acetate 4:1, p-anisaldehyde stain) the solvents were removed in vacuo to yield a light orange oil (763 mg). The crude material was filtered through a short silica gel pad (hexane/ethyl acetate 3:1) to yield a mixture of diastereomers (574 mg, 75%, 2:1 ratio), which were separated by column chromatography (silica gel, hexane/ethyl acetate 7:1, gradient to 5:1) to give (3S)-3a (380 mg, 49%, first eluted) as a pale yellow oil and (3R)-3a (170 mg, 22%) as a colourless solid. An analytically pure sample of (3R)-3a was obtained by recrystallisation from ethyl acetate.

(3S,3a’S,4’S,6a’S)-2-(2’,2’-Dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4’-yl)-4-methoxy-3-phenyl-3,6-dihydro-2H-[1,2]oxazine ((3S)-3a): [Graphic 17] +133.4 (c 1.12, CHCl3); 1H NMR (CDCl3, 700 MHz) δ 1.32, 1.41 (2 s, 3H each, 2 Me), 3.47 (s, 3H, OMe), 4.03 (d, J = 9.5 Hz, 1H, 6’-H), 4.23–4.27 (ddbr, J ≈ 3.5, 9.5 Hz, 1H, 6’-H), 4.30 (dd, J = 4.3, 13.7 Hz, 1H, 6-H), 4.40 (s, 1H, 4’-H), 4.62 (dtbr, J ≈ 2.0, 13.7 Hz, 1H, 6-H), 4.85 (sbr, 1H, 3-H), 4.87 (dtbr, J ≈ 1.3, 4.3 Hz, 1H, 5-H), 4.88–4.90 (m, 2H, 3a’-H, 6a’-H), 7.26–7.33, 7.34–7.38 (2 m, 5H, Ph) ppm; 13C NMR (CDCl3, 126 MHz) δ 24.5, 26.3 (2 q, 2 Me), 54.8 (q, OMe), 63.5 (d, C-3), 67.3 (t, C-6), 76.6 (t, C-6’), 81.2, 84.2 (2 d, C-3a’, C-6a’), 92.1 (d, C-5), 94.7 (d, C-4’), 111.6 (s, C-2’), 128.0, 128.3, 129.7, 136.2 (3 d, s, Ph), 154.9 (s, C-4) ppm; IR (ATR) [Graphic 16]: 3085–2840 (=C-H, C-H), 1670 (C=C), 1225, 1075, 1055 (C-O) cm−1; ESI–TOF (m/z): [M + Na]+ calcd for C18H23NNaO5, 356.1474; found, 356.1479; Anal. calcd for C18H23NO5 (333.4): C, 64.85; H, 6.95; N, 4.20; found: C, 64.81; H, 6.98; N, 4.15.

(3R,3a’S,4’S,6a’S)-2-(2’,2’-Dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4’-yl)-4-methoxy-3-phenyl-3,6-dihydro-2H-[1,2]oxazine ((3R)-3a): mp 110–113 °C; crystals suitable for X-ray analysis were obtained from AcOEt solution by cooling (fridge); Crystal data: C18H23NO5, M = 333.37, orthorhombic, a = 5.6042(12) Å, b = 16.756(4) Å, c = 17.839(4) Å, α = 90.00°, β = 90.00°, γ = 90.00°, V = 1675.2(6) Å3, T = 133(2) K, space group P2(1)2(1)2(1), Z = 4, Mo Kα, 23651 reflections measured, 4186 independent reflections (Rint = 0.0178). R1 = 0.0307 (I > 2σ(I)); wR(F2) = 0.0782 (all data); GOOF(F2) = 1.048. [Graphic 17] −87.0 (c 1.36, CHCl3); 1H NMR (CDCl3, 500 MHz) δ 1.34, 1.44 (2 s, 3H each, 2 Me), 3.49 (s, 3H, OMe), 3.89 (d, J = 9.9 Hz, 1H, 6’-H), 4.03 (dd, J = 4.0, 9.9 Hz, 1H, 6’-H), 4.41 (ddd, J = 1.7, 3.2, 14.3 Hz, 1H, 6-H), 4.48 (sbr, 1H, 3-H), 4.54 (ddd, J = 1.6, 2.4, 14.3 Hz, 1H, 6-H), 4.72 (s, 1H, 4’-H), 4.80 (dd, J = 4.0, 6.1 Hz, 1H, 6a’-H), 4.90 (tbr, J ≈ 3.0 Hz, 1H, 5-H), 5.03 (d, J = 6.1 Hz, 1H, 3a’-H), 7.27–7.34, 7.36–7.40 (2 m, 5H, Ph) ppm; 13C NMR (CDCl3, 126 MHz) δ 24.7, 26.3 (2 q, 2 Me), 54.6 (q, OMe), 63.6 (d, C-3), 65.2 (t, C-6), 74.5 (t, C-6’), 81.1 (d, C-6a’), 81.5 (d, C-3a’), 91.7 (d, C-5), 96.4 (d, C-4’), 112.0 (s, C-2’), 127.8, 128.3, 129.0, 138.1 (3 d, s, Ph), 153.1 (s, C-4) ppm; IR (ATR) [Graphic 16]: 3060–2840 (=C-H, C-H), 1675 (C=C), 1220, 1100, 1050 (C-O) cm−1; ESI–TOF (m/z): [M + Na]+ calcd for C18H23NNaO5, 356.1474; found, 356.1470; Anal. calcd for C18H23NO5 (333.4): C, 64.85; H, 6.95; N, 4.20; found: C, 64.85; H, 6.83; N, 4.11.

Typical procedure for hydroborations of 1,2-oxazines (Procedure 2)

To a solution of 1,2-oxazine (3S)-3a (268 mg, 0.80 mmol) in dry THF (20 mL), a solution of BH3·THF (1 M in THF, 3.2 mL, 3.2 mmol) was added at −30 °C. The solution was warmed to room temperature and stirred for 3 h, then cooled to −10 °C and an aq NaOH solution (2 M, 4.8 mL) followed by H2O2 (30%, 1.6 mL) were added. Stirring at room temperature was continued overnight. After addition of a sat. aq Na2S2O3 solution, the layers were separated, the water layer was extracted with Et2O (3 × 15 mL), the combined organic layers were dried with MgSO4 and filtered, and the solvents were removed under reduced pressure. The crude products (321 mg, 3:2 ratio) were separated by chromatography column (silica gel, hexane/ethyl acetate 1:1) to give 5-hydroxy-1,2-oxazines 6 (92 mg, 33%, first eluted) and 7 (141 mg, 50%) as hygroscopic, colourless semisolids.

(3S,4S,5S,3’aS,4’S,6’aS)-2-(2’,2’-Dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4’-yl)-4-methoxy-3-phenyl-[1,2]oxazinan-5-ol (6): [Graphic 17] +131.2 (c 1.02, CHCl3); 1H NMR (CDCl3, 500 MHz) δ 1.28, 1.35 (2 s, 3H each, 2 Me), 2.60 (d, J = 1.9 Hz, 1H, OH), 2.90 (s, 3H, OMe), 3.41 (ddd, J = 1.4, 6.7, 9.4 Hz, 1H, 4-H), 3.66–3.72 (m, 2H, 5-H, 6-H), 3.93 (d, J = 9.4 Hz, 1H, 3-H), 3.93 (d, J = 9.5 Hz, 1H, 6’-H), 4.07 (dd, J ≈ 11, 16 Hz, 1H, 6-H), 4.19 (dd, J = 4.4, 9.5 Hz, 1H, 6’-H), 4.41 (s, 1H, 4’-H), 4.81 (dd, J = 4.4, 6.1 Hz, 1H, 6a’-H), 4.86 (d, J = 6.1 Hz, 1H, 3a’-H), 7.28–7.42 (m, 5H, Ph) ppm; 13C NMR (CDCl3, 126 MHz) δ 24.5, 26.2 (2 q, 2 Me), 60.5 (q, OMe), 67.6 (d, C-3), 70.6 (d, C-5), 71.4 (t, C-6), 77.4 (t, C-6’), 81.3 (d, C-6a’), 84.4 (d, C-3a’), 87.6 (d, C-4), 94.8 (d, C-4’), 111.7 (s, C-2’), 128.3, 128.8*, 136.8 (2 d, s, Ph) ppm; *higher intensity; IR (ATR) [Graphic 16]: 3440 (O-H), 3090–2830 (=C-H, C-H), 1205, 1055 (C-O) cm−1; ESI–TOF (m/z): [M + Na]+ calcd for C18H25NNaO6, 374.1580; found, 374.1581; Anal. calcd for C18H25NO6 (351.4): C, 61.52; H, 7.17; N, 3.99; found: C, 61.43; H, 7.15; N, 3.85.

(3S,4R,5R,3a’S,4’S,6a’S)-2-(2’,2’-Dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4’-yl)-4-methoxy-3-phenyl-[1,2]oxazinan-5-ol (7): [Graphic 17] +138.2 (c 1.41, CHCl3); 1H NMR (CDCl3, 500 MHz) δ 1.28, 1.34 (2 s, 3H each, 2 Me), 2.44 (d, J = 7.7 Hz, 1H, OH), 3.10 (s, 3H, OMe), 3.21 (mc, 1H, 4-H), 3.75 (sbr, 1H, 5-H), 3.82 (d, J = 12.2 Hz, 1H, 6-H), 3.94 (d, J = 9.4 Hz, 1H, 6’-H), 4.21 (dd, J = 4.6, 9.4 Hz, 1H, 6’-H), 4.36 (dd, J = 1.4, 12.2 Hz, 1H, 6-H), 4.45 (d, J = 2.3 Hz, 1H, 3-H), 4.60 (s, 1H, 4’-H), 4.81 (tbr, J ≈ 5.2 Hz, 1H, 6a’-H), 4.94 (d, J = 6.1 Hz, 1H, 3a’-H), 7.24–7.31, 7.42–7.45 (2 m, 5H, Ph) ppm; 13C NMR (CDCl3, 126 MHz) δ 24.5, 26.3 (2 q, 2 Me), 59.3 (q, OMe), 62.7 (d, C-3), 65.3 (d, C-5), 71.0 (t, C-6), 77.5 (t, C-6’), 80.4 (d, C-4), 81.1 (d, C-6a’), 84.5 (d, C-3a’), 95.6 (d, C-4’), 111.6 (s, C-2’), 127.8, 128.3, 129.5, 136.4 (3 d, s, Ph) ppm; IR (ATR) [Graphic 16]: 3455 (O-H), 3090–2830 (=C-H, C-H), 1215, 1085, 1050 (C-O) cm−1; ESI–TOF (m/z): [M + Na]+ calcd for C18H25NNaO6, 374.1580; found, 374.1579; Anal. calcd for C18H25NO6 (351.4): C, 61.52; H, 7.17; N, 3.99; found: C, 61.43; H, 7.17; N, 3.87.

Typical protocol for glycosyl bond cleavage (Procedure 3)

1,2-Oxazine 6 (425 mg, 1.21 mmol) was dissolved in 1 N HCl in MeOH (14 mL) and heated at 40 °C for 3.5 h (TLC monitoring, hexane/AcOEt 1:2, potassium permanganate stain). Then the mixture was allowed to reach room temperature, quenched with sat. aq NaHCO3 solution and extracted with Et2O (3 × 30 mL). The combined organic layers were dried with MgSO4 and filtered, and the solvents were removed. The purification by column chromatography (silica gel, dichloromethane/methanol 40:1) yielded 12 (201 mg, 79%) as a colourless solid.

(3S,4S,5S)-4-Methoxy-3-phenyl-[1,2]oxazinan-5-ol (12): mp 110–112 °C; [Graphic 17] +60.1 (c 1.05, CHCl3); 1H NMR (CDCl3, 500 MHz) δ 3.02 (s, 3H, OMe), 3.37 (tbr, J ≈ 8.5 Hz, 1H, 4-H), 3.71–3.81 (m, 2H, 5-H, 6-H), 3.91 (d, J = 9.2 Hz, 1H, 3-H), 4.14 (dd, J = 4.1, 9.7 Hz, 1H, 6-H), 2.60, 5.48 (2 sbr, 2H, NH, OH), 7.31–7.38, 7.40–7.43 (2 m, 5H, Ph) ppm; 13C NMR (CDCl3, 126 MHz) δ 60.4 (q, OMe), 67.0 (t, C-3), 70.9 (d, C-5), 72.3 (t, C-6), 86.9 (d, C-4), 128.4, 128.6, 128.7, 136.3 (3 d, s, Ph) ppm; IR (ATR) [Graphic 16]: 3405–3260 (O-H, N-H), 3065–2830 (=C-H, C-H), 1105, 1055 (C-O) cm−1; ESI–TOF (m/z): [M + H]+ calcd for C11H16NO3, 210.1130; found, 210.1127; Anal. calcd for C11H15NO3 (209.2): C, 63.14; H, 7.23; N, 6.69; found: C, 63.14; H, 7.23; N, 6.66.

Typical procedure for the reactions with samarium diiodide (Procedure 4)

To a solution of SmI2 (ca. 0.1 M in THF, 15 mL, ~1.5 mmol) at room temperature was added dropwise a solution of 5-hydroxy-1,2-oxazine 12 (102 mg, 0.49 mmol) in degassed THF (10 mL). After the mixture was stirred for 3 h it was quenched with sat. aq sodium potassium tartrate solution and extracted with Et2O (20 mL), and then with CH2Cl2 (3 × 15 mL). The combined organic layers were dried with MgSO4, filtered and the solvents were removed under reduced pressure to give the spectroscopically pure product as a yellow oil in almost quantitative yield. Filtration through a short silica gel pad (dichloromethane/methanol 15:1) yielded 16 (97 mg, 94%) as a colourless oil.

(2S,3S,4S)-4-Amino-3-methoxy-4-phenylbutane-1,2-diol (16): [Graphic 17] +12.2 (c 1.48, CHCl3); 1H NMR (CDCl3, 500 MHz) δ 3.31 (dd, J = 2.1, 5.3 Hz, 1H, 3-H), 3.39 (s, 3H, OMe), 3.57 (dd, J = 4.6, 11.1 Hz, 1H, 1-H), 3.72 (dd, J = 6.1, 11.1 Hz, 1H, 1-H), 3.77–3.80 (m, 1H, 2-H), 4.58 (d, J = 5.3 Hz, 1H, 4-H), 7.28–7.33, 7.36–7.43 (2 m, 5H, Ph) ppm; 13C NMR (CDCl3, 126 MHz) δ 55.9 (d, C-4), 59.3 (q, OMe), 63.4 (t, C-1), 70.7 (d, C-2), 83.0 (d, C-3), 127.1, 128.1, 128.8, 138.6 (3 d, s, Ph) ppm; IR (ATR) [Graphic 16]: 3490–3230 (O-H, N-H), 3065–2810 (=C-H, C-H), 1075 (C-O) cm−1; ESI–TOF (m/z): [M + H]+ calcd for C11H18NO3, 212.1292; found, 212.1282.

Supporting Information

Supporting Information File 1: Experimental procedures and characterisation data.
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Supporting Information File 2: 1H NMR and 13C NMR spectra of synthesised compounds.
Format: PDF Size: 9.6 MB Download

Acknowledgements

Generous support of this work by the Foundation for Polish Science (postdoctoral fellowship to M. J.), the Deutsche Forschungsgemeinschaft, and Bayer Healthcare is most gratefully acknowledged. We also thank Dr. R. Zimmer for valuable discussions and help during the preparation of the manuscript.

References

  1. Merino, P. In Science of Synthesis; Padwa, A., Ed.; Thieme: Stuttgart, Germany, 2004; Vol. 1, p 511.
    Return to citation in text: [1]
  2. Gothelf, K. V.; Jørgensen, K. A. Chem. Rev. 1998, 98, 863–910. doi:10.1021/cr970324e
    Return to citation in text: [1]
  3. Merino, P.; Tejero, T. Molecules 1999, 4, 169–179. doi:10.3390/40700169
    Return to citation in text: [1]
  4. Revuelta, J.; Cicchi, S.; Goti, A.; Brandi, A. Synthesis 2007, 485–504. doi:10.1055/s-2007-965914
    Return to citation in text: [1]
  5. Osborn, H. M. I.; Gemmell, N.; Harwood, L. M. J. Chem. Soc., Perkin Trans. 1 2002, 2419–2438. doi:10.1039/b200549m
    Return to citation in text: [1]
  6. Fišera, L. Top. Heterocycl. Chem. 2007, 7, 287–323. doi:10.1007/7081_2007_076
    Return to citation in text: [1]
  7. Lombardo, M.; Trombini, C. Synthesis 2000, 759–774. doi:10.1055/s-2000-6269
    Return to citation in text: [1] [2]
  8. Merino, P.; Franco, S.; Merchan, F. L.; Tejero, T. Synlett 2000, 442–454. doi:10.1055/s-2000-6555
    Return to citation in text: [1]
  9. Schade, W.; Reissig, H.-U. Synlett 1999, 632–634. doi:10.1055/s-1999-2662
    Return to citation in text: [1]
  10. Brasholz, M.; Reissig, H.-U.; Zimmer, R. Acc. Chem. Res. 2009, 42, 45–56. doi:10.1021/ar800011h
    Return to citation in text: [1]
  11. Pfrengle, F.; Reissig, H.-U. Chem. Soc. Rev. 2010, 39, 549–557. doi:10.1039/B914356D
    Return to citation in text: [1]
  12. Bouché, L.; Reissig, H.-U. Pure Appl. Chem. 2012, 84, 23–36. doi:10.1351/PAC-CON-11-09-20
    Return to citation in text: [1]
  13. Helms, M.; Schade, W.; Pulz, R.; Watanabe, T.; Al-Harrasi, A.; Fišera, L.; Hlobilová, I.; Zahn, G.; Reissig, H.-U. Eur. J. Org. Chem. 2005, 1003–1019. doi:10.1002/ejoc.200400627
    Return to citation in text: [1] [2]
  14. Vasella, A. Helv. Chim. Acta 1977, 60, 1273–1295. doi:10.1002/hlca.19770600417
    Return to citation in text: [1]
  15. Aebischer, B.; Vasella, A. Helv. Chim. Acta 1983, 66, 789–794. doi:10.1002/hlca.19830660310
    Return to citation in text: [1]
  16. Vasella, A.; Voeffray, R.; Pless, J.; Huguenin, R. Helv. Chim. Acta 1983, 66, 1241–1252. doi:10.1002/hlca.19830660424
    Return to citation in text: [1]
  17. Huber, R.; Knierzinger, A.; Obrecht, J.-P.; Vasella, A. Helv. Chim. Acta 1985, 68, 1730–1747. doi:10.1002/hlca.19850680629
    Return to citation in text: [1]
  18. Bernet, B.; Krawczyk, E.; Vasella, A. Helv. Chim. Acta 1985, 68, 2299–2311. doi:10.1002/hlca.19850680825
    Return to citation in text: [1] [2]
  19. Huber, R.; Vasella, A. Helv. Chim. Acta 1987, 70, 1461–1476. doi:10.1002/hlca.19870700603
    Return to citation in text: [1]
  20. Huber, R.; Vasella, A. Tetrahedron 1990, 46, 33–58. doi:10.1016/S0040-4020(01)97582-9
    Return to citation in text: [1] [2] [3]
  21. Mancini, F.; Piazza, M. G.; Trombini, C. J. Org. Chem. 1991, 56, 4246–4252. doi:10.1021/jo00013a032
    Return to citation in text: [1]
  22. Fišera, L.; Al-Timari, U. A. R.; Ertl, P.; Prónayová, N. Monatsh. Chem. 1993, 124, 1019–1029. doi:10.1007/BF00814148
    Return to citation in text: [1]
  23. Cicchi, S.; Marradi, M.; Corsi, M.; Faggi, C.; Goti, A. Eur. J. Org. Chem. 2003, 4152–4161. doi:10.1002/ejoc.200300353
    Return to citation in text: [1]
  24. Fässler, R.; Frantz, D. E.; Oetiker, J.; Carreira, E. M. Angew. Chem., Int. Ed. 2002, 41, 3054–3056. doi:10.1002/1521-3773(20020816)41:16<3054::AID-ANIE3054>3.0.CO;2-B
    Return to citation in text: [1]
  25. Ritter, T.; Carreira, E. M. Angew. Chem., Int. Ed. 2005, 44, 936–938. doi:10.1002/anie.200461934
    Return to citation in text: [1]
  26. Mzengeza, S.; Whitney, R. A. J. Org. Chem. 1988, 53, 4074–4081. doi:10.1021/jo00252a035
    Return to citation in text: [1]
  27. Ashwell, M.; Guo, X.; Sinnot, M. L. J. Am. Chem. Soc. 1992, 114, 10158–10166. doi:10.1021/ja00052a011
    Return to citation in text: [1]
  28. Basha, A.; Henry, R.; McLaughlin, M. A.; Ratajczyk, J. D.; Wittenberger, S. J. J. Org. Chem. 1994, 59, 6103–6106. doi:10.1021/jo00099a052
    Return to citation in text: [1]
  29. Lantos, I.; Flisak, J.; Liu, L.; Matsuoka, R.; Mendelson, W.; Stevenson, D.; Tubman, K.; Tucker, L.; Zhang, W.-Y.; Adams, J.; Sorenson, M.; Garigipati, R.; Erhardt, K.; Ross, S. J. Org. Chem. 1997, 62, 5385–5391. doi:10.1021/jo9621736
    Return to citation in text: [1]
  30. Tamura, O.; Kanoh, A.; Yamashita, M.; Ishibashi, H. Tetrahedron 2004, 60, 9997–10003. doi:10.1016/j.tet.2004.08.023
    Return to citation in text: [1]
  31. Borrello, L.; Chiacchio, U.; Corsaro, A.; Pistarà, V.; Iannazzo, D. ARKIVOC 2009, viii, 112–124.
    Return to citation in text: [1]
  32. Bonanni, M.; Marradi, M.; Cicchi, S.; Faggi, C.; Goti, A. Org. Lett. 2005, 7, 319–322. doi:10.1021/ol047691e
    Return to citation in text: [1]
  33. Bonanni, M.; Marradi, M.; Cicchi, S.; Goti, A. Synlett 2008, 197–202. doi:10.1055/s-2007-1000934
    Return to citation in text: [1]
  34. Jasiński, M.; Lentz, D.; Reissig, H.-U. Eur. J. Org. Chem. accepted. doi:10.1002/ejoc.201200158
    Return to citation in text: [1] [2] [3]
  35. Thompson, D. K.; Hubert, C. N.; Wightman, R. H. Tetrahedron 1993, 49, 3827–3840. doi:10.1016/S0040-4020(01)90234-0
    Return to citation in text: [1]
  36. Dondoni, A.; Perrone, D. Tetrahedron 2003, 59, 4261–4273. doi:10.1016/S0040-4020(03)00631-8
    Return to citation in text: [1]
  37. Cicchi, S.; Marradi, M.; Goti, A.; Brandi, A. Tetrahedron Lett. 2001, 42, 6503–6505. doi:10.1016/S0040-4039(01)01222-9
    Return to citation in text: [1]
  38. Pulz, R.; Cicchi, S.; Brandi, A.; Reissig, H.-U. Eur. J. Org. Chem. 2003, 1153–1156. doi:10.1002/ejoc.200390169
    Return to citation in text: [1]
  39. Moderhack, D.; Lorke, M. Angew. Chem., Int. Ed. Engl. 1980, 19, 45–46. doi:10.1002/anie.198000451
    Return to citation in text: [1]
  40. Schaumann, E.; Ketcham, R. Angew. Chem., Int. Ed. Engl. 1982, 21, 225–247. doi:10.1002/anie.198202253
    And references cited therein.
    Return to citation in text: [1]
  41. Winchester, B. G. Tetrahedron: Asymmetry 2009, 20, 645–651. doi:10.1016/j.tetasy.2009.02.048
    Return to citation in text: [1]
  42. Davis, B. G. Tetrahedron: Asymmetry 2009, 20, 652–671. doi:10.1016/j.tetasy.2009.03.013
    Return to citation in text: [1]
  43. Asano, N. Cell. Mol. Life Sci. 2009, 66, 1479–1492. doi:10.1007/s00018-008-8522-3
    Return to citation in text: [1]
  44. Benalla, W.; Bellahcen, S.; Bnouham, M. Curr. Diabetes Rev. 2010, 6, 247–254. doi:10.2174/157339910791658826
    Return to citation in text: [1]
  45. Moreno-Clavijo, E.; Carmona, A. T.; Moreno-Vargas, A. J.; Molina, L.; Robina, I. Curr. Org. Synth. 2011, 8, 102–133. doi:10.2174/157017911794407700
    Return to citation in text: [1]
  46. Pulz, R.; Al-Harrasi, A.; Reissig, H.-U. Org. Lett. 2002, 4, 2353–2355. doi:10.1021/ol0260573
    Return to citation in text: [1] [2] [3]
  47. Dekaris, V.; Reissig, H.-U. Synlett 2010, 42–46. doi:10.1055/s-0029-1218531
    Return to citation in text: [1] [2]
  48. Dekaris, V.; Pulz, R.; Al-Harrasi, A.; Lentz, D.; Reissig, H.-U. Eur. J. Org. Chem. 2011, 3210–3219. doi:10.1002/ejoc.201100230
    Return to citation in text: [1] [2]
  49. McOmie, J. F. W.; Watts, M. L.; West, D. E. Tetrahedron 1968, 24, 2289–2292. doi:10.1016/0040-4020(68)88130-X
    Return to citation in text: [1]
  50. Riddell, F. G. Tetrahedron 1975, 31, 523–525. doi:10.1016/0040-4020(75)85023-X
    Return to citation in text: [1]
  51. Riddell, F. G. Tetrahedron 1981, 37, 849–858. doi:10.1016/S0040-4020(01)97649-5
    Return to citation in text: [1]
  52. Edmonds, D. J.; Johnston, D.; Procter, D. J. Chem. Rev. 2004, 104, 3371–3404. doi:10.1021/cr030017a
    Return to citation in text: [1]
  53. Nicolaou, K. C.; Ellery, S. P.; Chen, J. S. Angew. Chem., Int. Ed. 2009, 48, 7140–7165. doi:10.1002/anie.200902151
    Return to citation in text: [1]
  54. Beemelmanns, C.; Reissig, H.-U. Chem. Soc. Rev. 2011, 40, 2199–2210. doi:10.1039/c0cs00116c
    Return to citation in text: [1]
  55. Chiara, J. L.; Destabel, C.; Gallego, P.; Marco-Contelles, J. J. Org. Chem. 1996, 61, 359–360. doi:10.1021/jo951571q
    Return to citation in text: [1]
  56. Keck, G. E.; Wager, T. T.; McHardy, S. F. Tetrahedron 1999, 55, 11755–11772. doi:10.1016/S0040-4020(99)00486-X
    Return to citation in text: [1]
  57. Jung, S. H.; Lee, J. E.; Koh, H. Y. Bull. Korean Chem. Soc. 1998, 19, 33–35.
    Return to citation in text: [1]
  58. Bressel, B.; Egart, B.; Al-Harrasi, A.; Pulz, R.; Reissig, H.-U.; Brüdgam, I. Eur. J. Org. Chem. 2008, 467–474. doi:10.1002/ejoc.200700792
    Return to citation in text: [1]
  59. Al-Harrasi, A.; Reissig, H.-U. Angew. Chem., Int. Ed. 2005, 44, 6227–6231. doi:10.1002/anie.200501127
    Return to citation in text: [1]
  60. Ritter, T.; Stanek, K.; Larrosa, I.; Carreira, E. M. Org. Lett. 2004, 6, 1513–1514. doi:10.1021/ol049514j
    Return to citation in text: [1]
  61. Appel, R. Angew. Chem., Int. Ed. Engl. 1975, 14, 801–811. doi:10.1002/anie.197508011
    Return to citation in text: [1]
  62. Arnold, T.; Reissig, H.-U. Synlett 1990, 514–516. doi:10.1055/s-1990-21147
    Return to citation in text: [1]
  63. Arnold, T.; Orschel, B.; Reissig, H.-U. Angew. Chem., Int. Ed. Engl. 1992, 31, 1033–1035. doi:10.1002/anie.199210331
    Return to citation in text: [1]
  64. Defoin, A.; Joubert, M.; Heuchel, J.-M.; Strehler, C.; Streith, J. Synthesis 2000, 1719–1726. doi:10.1055/s-2000-8214
    Return to citation in text: [1]
  65. Buchholz, M.; Hiller, F.; Reissig, H.-U. Eur. J. Org. Chem. 2002, 2838–2843. doi:10.1002/1099-0690(200208)2002:16<2838::AID-EJOC2838>3.0.CO;2-O
    Return to citation in text: [1]
  66. Zimmer, R.; Buchholz, M.; Collas, M.; Angermann, J.; Homann, K.; Reissig, H.-U. Eur. J. Org. Chem. 2010, 4111–4121. doi:10.1002/ejoc.201000425
    Return to citation in text: [1]
  67. Sheldrick, G. M. Acta Crystallogr., Sect. A 2008, 64, 112–122. doi:10.1107/S0108767307043930
    Return to citation in text: [1] [2]
  68. Farrugia, L. J. J. Appl. Crystallogr. 1999, 32, 837–838. doi:10.1107/S0021889899006020
    Return to citation in text: [1]

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