2 article(s) from Šebesta, Radovan
Ireland–Claisen rearrangement of allyl esters 1a–c.
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Ireland–Claisen rearrangement of 1c mediated by tertiary amines.
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Organocatalysts used in this study. Conditions: typical procedure: 1. Et3N (4.9 equiv), DCM, −60 °C...
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Solvent-free Ireland–Claisen rearrangement of cinnamyl esters.
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ωB97X-D/6-31G* calculated uncatalyzed Ireland–Claisen rearrangement of 1c. Charges on allylic oxyge...
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ωB97X-D/6-31G* calculated Schreiner thiourea (12)-catalyzed Ireland–Claisen rearrangement of 1c. Ch...
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ωB97X-D/6-31G* calculated Ph-thiourea (top) and squaramide-catalyzed (bottom) Ireland–Claisen rearr...
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a) Rate of product formation; b) reaction profile without catalyst determined by 1H NMR.
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Beilstein J. Org. Chem. 2019, 15, 2948–2957, doi:10.3762/bjoc.15.290
Structures of pregabalin and methylpregabalin.
Synthesis of the nitroalkene 6.
Catalyst screening in the Michael addition of dimethyl malonate to nitroalkene 6.
Synthesis of catalysts (Sa,R,R)-C8 and (Sa,S,S)-C8.
Transition state models for the reaction of (R)-6 with dimethyl malonate using catalyst C7 (M06-2X/...
Synthesis of 4-methylpregabalin (1).
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Beilstein J. Org. Chem. 2018, 14, 553–559, doi:10.3762/bjoc.14.42
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