2 article(s) from Gupton, B Frank
Commercially available antimalarial drugs.
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Current batch syntheses of the key intermediate 5-(ethyl(2-hydroxyethyl)amino)pentan-2-one (6).
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Retrosynthetic strategy to hydroxychloroquine (1).
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Schematic representation for continuous in-line extraction of 10.
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Optimization of the flow process for the synthesis of 12.
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Beilstein J. Org. Chem. 2018, 14, 583–592, doi:10.3762/bjoc.14.45
The estimated demand of for nevirapine until 2015 .
Commercial building blocks to nevirapine.
a) Current commercial process to CAPIC and b) newly developed batch synthesis to CAPIC and its brom...
Proposed synthesis to 2-bromo-4-methylnicotinonitrile using a continuous approach with the consider...
a) Flow scheme to produce the enamine intermediate 5 from isopropylidenemalononitrile (4) (see Supporting Information File 1 for...
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Flow scheme to produce the enamine 5 starting from acetone and malononitrile (See Supporting Information File 1 for details).
Comparing the long-term stability of the Al2O3 and 3 Å MS columns when the Al2O3 column temperature...
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Several byproducts were observed when producing 5 starting from acetone and malononitrile. 7 is for...
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Flow scheme to produce 2-bromo-4-methylnicotinonitrile (6b) in 81% yield from 4 with a 1 M concentr...
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Reactor scheme for the continuous synthesis of 2-bromo-4-methylnicotinonitrile (6b) with an average...
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Beilstein J. Org. Chem. 2013, 9, 2570–2578, doi:10.3762/bjoc.9.292
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