2 article(s) from Gupton, B. Frank
Commercially available antimalarial drugs.
Jump to Figure 1
Current batch syntheses of the key intermediate 5-(ethyl(2-hydroxyethyl)amino)pentan-2-one (6).
Jump to Scheme 1
Retrosynthetic strategy to hydroxychloroquine (1).
Jump to Scheme 2
Schematic representation for continuous in-line extraction of 10.
Jump to Scheme 3
Optimization of the flow process for the synthesis of 12.
Jump to Scheme 4
Beilstein J. Org. Chem. 2018, 14, 583–592, doi:10.3762/bjoc.14.45
The estimated demand of for nevirapine until 2015 .
Commercial building blocks to nevirapine.
a) Current commercial process to CAPIC and b) newly developed batch synthesis to CAPIC and its brom...
Proposed synthesis to 2-bromo-4-methylnicotinonitrile using a continuous approach with the consider...
a) Flow scheme to produce the enamine intermediate 5 from isopropylidenemalononitrile (4) (see Supporting Information File 1 for...
Jump to Figure 2
Flow scheme to produce the enamine 5 starting from acetone and malononitrile (See Supporting Information File 1 for details).
Comparing the long-term stability of the Al2O3 and 3 Å MS columns when the Al2O3 column temperature...
Jump to Figure 3
Several byproducts were observed when producing 5 starting from acetone and malononitrile. 7 is for...
Jump to Scheme 5
Flow scheme to produce 2-bromo-4-methylnicotinonitrile (6b) in 81% yield from 4 with a 1 M concentr...
Jump to Scheme 6
Reactor scheme for the continuous synthesis of 2-bromo-4-methylnicotinonitrile (6b) with an average...
Jump to Scheme 7
Beilstein J. Org. Chem. 2013, 9, 2570–2578, doi:10.3762/bjoc.9.292
Subscribe to our Latest Articles RSS Feed.
Register and get informed about new articles.
Follow the Beilstein-Institut