3 article(s) from Kantin, Grigory
Examples of approved spirocyclic drugs.
Jump to Figure 1
(a) Earlier reported Rh(II)-catalyzed spirocyclization of DAS with the formation of minor enol ethe...
Jump to Scheme 1
Initial attempt at Rh(II)-catalyzed O–H insertion/Claisen rearrangement.
Jump to Scheme 2
Rh2(esp)2-catalyzed O–H insertion reactions between various DAS 1 and phenols.
Jump to Scheme 3
Two-step, one-pot sequence of the Claisen rearrangement/intramolecular Michael-type spirocyclizatio...
Jump to Scheme 4
Tentative rationalization of the diastereoselectivity observed in all 5→7 transformations (shown fo...
Jump to Scheme 5
Beilstein J. Org. Chem. 2022, 18, 1649–1655, doi:10.3762/bjoc.18.177
Diverse bioactive compounds based on the privileged 1,4-DHIQ scaffold.
Strategy investigated in this work.
Jump to Figure 2
Preparation of 3(2H)-isoquinolones 11. aObtained as a 10:1 mixture of regioisomers; purified by cry...
Preparation of 4-diazo-3(2H)-isoquinolones 10. aConfirmed by single-crystal X-ray crystallography (...
TfOH-promoted arylation of diazo substrates 10. aStructure confirmed by single-crystal X-ray analys...
Unexpected outcome of the TfOH-promoted arylation of 10a with N-formyl-N-methylaniline giving rise ...
Plausible mechanism for the conversion of diazo substrates 10 to 4-aryl products 9 (shown for ArH =...
Beilstein J. Org. Chem. 2022, 18, 1070–1078, doi:10.3762/bjoc.18.109
Previously reported transformations of DAS (1) and their unusual dimerization investigated in this ...
The result of Rh(II)-catalyzed decomposition of DAS 1r.
Plausible mechanism for the formation of dimer 2a and indene 3a through the Rh(II)-catalyzed decomp...
Cytotoxicity of N-alkyl-substituted dibenzoazulenodipyrroles 2 against the A549 human lung adenocar...
Beilstein J. Org. Chem. 2022, 18, 533–538, doi:10.3762/bjoc.18.55
Subscribe to our Latest Articles RSS Feed.
Register and get informed about new articles.
Follow the Beilstein-Institut