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Beilstein J. Org. Chem. 2025, 21, 1897–1908, doi:10.3762/bjoc.21.147
Graphical Abstract
Scheme 1: Synthesis of vicinal diamines via imino-pinacol coupling in the presence of metal-based reductants.
Scheme 2: Light-promoted imino-pinacol coupling for the synthesis of vicinal diamines.
Scheme 3: Historical perspective on electrochemical imino-coupling protocols.
Scheme 4: Stereoselective electroreductive intramolecular imino-pinacol reaction.
Scheme 5: Scope of the imino-pinacol coupling reaction. Reaction conditions: GC electrodes, NEt4BF4 (2.6 equi...
Figure 1: X-ray determined structure of chiral piperazine 2b.
Scheme 6: Continuous flow synthesis of piperazine 2a. The yield was determined by 1H NMR spectroscopy using 1...
Scheme 7: Proposed reaction mechanism.
Scheme 8: Cyclic voltammetry investigation. Cyclic voltammetry of a 0.325 M solution of Et4NBF4 in DMF (light...
Beilstein J. Org. Chem. 2016, 12, 2620–2626, doi:10.3762/bjoc.12.258
Scheme 1: L-Proline-promoted stereoselective aldol reaction in DES.
Figure 1: Experimental set-up I: test tube (d = 0.5 cm); flow 1 mL/min; DES (1.5 mL); L-proline/DES = 130 mg/...
Scheme 2: Aldol reaction under continuous flow conditions in DESs.
Beilstein J. Org. Chem. 2016, 12, 2614–2619, doi:10.3762/bjoc.12.257
Scheme 1: Continuous flow reduction of 4-nitrobenzophenone using a 0.5 mL PTFE flow reactor.
Scheme 2: Continuous flow reduction of aromatic nitro compounds.
Scheme 3: Continuous-flow reduction of aliphatic nitro compounds.
Scheme 4: Synthesis of 2-(4’-chlrophenyl)aniline (4) with a 5 mL flow reactor.
Scheme 5: Synthesis of intermediate 6, a direct precursor of the drug baclofen.
Scheme 6: Continuous-flow reduction of 1a and in-line extraction.