6 article(s) from Shishkina, Svetlana V
Graphical Abstract
Scheme 1: Synthesis of tetrahydroazolopyrimidine derivatives.
Scheme 2: Various multicomponent reactions involving pyruvic acids (pyruvates) and different α-aminoazoles.
Scheme 3: Synthesis of 4-arylamino-substituted tetrahydroquinolines.
Scheme 4: Ultrasound-assisted multicomponent reactions of 3-amino-1,2,4-triazole or 5-amino-1H-pyrazole-4-car...
Scheme 5: Synthesis of 3-cyano-7-(4-methoxyphenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-5-carboxylic acid (7)....
Scheme 6: Proposed reaction mechanism.
Figure 1: Alternative structures A and B for the tetrahydroazolopyrimidines 4.
Figure 2: Molecular structure of ethyl 5-(4-bromophenyl)-3-cyano-7-((4-cyano-1H-pyrazol-5-yl)amino)-4,5,6,7-t...
Figure 3: Chains of 4g molecules in the crystal phase.
Graphical Abstract
Scheme 1: An overview of heterocyclic acids used in the Ugi reaction.
Scheme 2: Synthesis of pyrazolopyridine carboxylic acids 4 [45] and 7 [45] in Doebner-type reaction.
Figure 1: Molecular structure of N-(2-(tert-butylamino)-1-(4-chlorophenyl)-2-oxoethyl)-6-(4-methoxyphenyl)-3-...
Graphical Abstract
Figure 1: Chemical structures of hosts 1–6 and guests 7–10.
Figure 2: HF/6-311+G** calculated 3D molecular electrostatic potential of the guests 7–10. The color code spa...
Figure 3: Partial 1H NMR spectra (300 MHz, CD3CN/CDCl3 4:3, v/v) of (a) free host 3, (b) 3 and 1.0 equiv of 7...
Figure 4: The changes observed in the UV–vis spectra during the titration of clip 2 with paraquat (7) in acet...
Figure 5: Stability constant dependence for the complexes (lgK) of molecular clips 1–5 with guests 7–10 on th...
Figure 6: Molecular structures of complexes of clips 3, 2 and 5 with paraquat (7). Anions and solvate molecul...
Figure 7: Crystal packing of molecules in complexes of clips 2, 3 and 5 with paraquat (7). Anions and solvate...
Figure 8: Molecular structures of complexes 2@8 and 3@8. The hydrogen bonds are shown by blue lines. Anions a...
Figure 9: Molecular structures of complexes 2@9 and 3@9. The hydrogen bonds are represented by blue lines. An...
Figure 10: Molecular structures of complexes 2@10 and 3@10. Anions and solvate molecules are omitted for clari...
Graphical Abstract
Scheme 1: Aminoazoles in GBB-3CR and Ugi-4CR.
Scheme 2: Reactivity of 5-amino-N-aryl-1H-pyrazole-4-carboxamide and 3-amino-5-methylisoxazole in GBB-3CR and...
Figure 1: Alternative structures A and B for compounds 4 and 6.
Figure 2: Selected data of HSQC and HMBC experiments for compound 4a.
Figure 3: Molecular structure of 3-(tert-butylamino)-2-(4-chlorophenyl)-N-(4-fluorophenyl)-1H-imidazo[1,2-b]p...
Figure 4: Selected data of NOE and HSQC experiments for compound 9d.
Figure 5: Molecular structure of N-(2-(tert-butylamino)-1-(4-chlorophenyl)-2-oxoethyl)-N-(5-methylisoxazol-3-...
Graphical Abstract
Scheme 1: Some three-component reactions involving N-aryl-3-oxobutanamides.
Scheme 2: Some Biginelli-type three-component condensations with salicylaldehyde.
Scheme 3: Three-component heterocyclization of 5-amino-3-methylisoxazole (1), salicylaldehyde (2) and N-(2-me...
Figure 1: The possible structure of an intermediate complex in reactions forming the heterocycles 6.
Scheme 4: Possible pathways for the three-component reaction of 5-amino-3-methylisoxazole (1), salicylaldehyd...
Figure 2: Alternative structures 5a and 5'a for dihydroisoxazolopyridine 5a and selected NOESY correlations.
Figure 3: Alternative structures 6a, 6'a and 6''a for compound 6a.
Figure 4: Selected data from NOESY experiments and relative stereochemistry of stereogenic centers at positio...
Figure 5: Molecular structure of compound 6a according to X-ray diffraction data.
Graphical Abstract
Figure 1: The NOE correlations of the signals in 1H NMR spectra of compounds 4b–4d.
Figure 2: Molecular structure of spirooxindole 4a according to X-ray diffraction data.
Figure 3: The NOE correlations of the signals in 1H NMR spectrum of compound 6c.
Figure 4: Molecular structure of spirooxindole 6a observed in crystal phase as solvate with methanol accordin...
Scheme 1: The mechanism of the regioselective synthesis of compounds 4 and 6.
Figure 5: Conformations of acrylamide and benzoylacrylic acid.
Figure 6: The Fukui function indices of acrylamide, azomethine ylide and benzoylacrylic acid.
Scheme 2: The synthesis of compounds 7a–7c.
Figure 7: The selected COSY, NOESY and HMBC correlations of the signals in the 1H and 13C NMR spectra of comp...
Scheme 3: Tentative reaction mechanism for the decarboxylative cyclative rearrangement of the initial three-c...