3 article(s) from Singh, Virender
- Full Research Paper
- Published 02 Mar 2023
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Figure 1: Representative drug molecules based on pyrazole, thioamide, and amide derivatives.
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Figure 2: Previous and present findings for the synthesis of thioamide derivatives.
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Scheme 1: Synthesis of pyrazole C-3-tethered thioamides.
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Scheme 2: Synthesis of pyrazole C-4-tethered thioamides.
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Scheme 3: Metal- and catalyst-free preparation of pyrazole C-5-linked thioamide conjugates.
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Scheme 4: Synthesis of 4-iodopyrazole C-3-tethered thioamides.
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Scheme 5: Gram-scale scope of the current protocol.
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Scheme 6: Control experiment.
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Scheme 7: H2O2-mediated synthesis of pyrazole-pyridine conjugates with amide tethers.
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Scheme 8: Synthesis of pyrazole-pyridine conjugates 9F and 10F having amide tethers.
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Scheme 9: A tentative mechanism for the formation of pyrazole conjugates with thioamide and amide linkage.
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- Full Research Paper
- Published 26 Jul 2022
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Figure 1: Few examples of β-carboline-based drugs and bioactive natural products.
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Figure 2: 1/3-Formyl-9H-β-carboline: new synthons for the synthesis of β-carboline-fused and substituted fram...
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Figure 3: A summary of previous reports toward exploration of 3-formyl-9H-β-carbolines.
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Scheme 1: Synthesis of 3-formyl-9H-pyrido[3,4-b]indole derivatives.
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Scheme 2: Synthesis of C-3 substituted pyrido[3,4-b]indole MBH derivatives (7 and 8).
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Scheme 3: Synthesis of C-3 substituted pyrido[3,4-b]indole MBH derivatives 10.
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Figure 4: Library of C-3-substituted pyrido[3,4-b]indole MBH derivatives 7, 8 and 10.
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Figure 5: Results of optimization for fluorescence studies: a) contact time; b) concentration; c) solvent.
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Figure 6: Pictorial representation of structure–fluorescence activity relationship of C-3 substituted pyrido[...
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- Full Research Paper
- Published 20 Jul 2020
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Graphical Abstract
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Figure 1: Representative examples of some commercial drugs and biologically active alkaloids.
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Scheme 1: Synthesis of β-carboline-linked 2-nitrochalcones.
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Scheme 2: Synthesis of β-carboline-linked benzothiophenone frameworks.
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Scheme 3: Comparison of outcome of one-pot vs two-pot approach.
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Scheme 4: One-pot synthesis of β-carboline C-1-tethered benzothiophenone derivatives.
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Scheme 5: One-pot synthesis of β-carboline C-3-linked benzothiophenone derivatives.
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Scheme 6: One-pot synthesis of β-carboline-linked benzothiophene derivative 6C.
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Scheme 7: Control experiment in the presence of a radical scavenger.
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Figure 2: Proposed reaction mechanism.
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Figure 3: Fluorescence spectra of 2aA–nA, 2bB, 2hB, and 6C.
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Figure 4: Fluorescence spectra of 4aA–gA, and 4eB.
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