Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

• Marian C. Bryan,
• David Wernick,
• Christopher D. Hein,
• James V. Petersen,
• John W. Eschelbach and
• Elizabeth M. Doherty

Beilstein J. Org. Chem. 2011, 7, 1141–1149, doi:10.3762/bjoc.7.132

• , Department of Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA Research Automation Technology, Department of Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA 10.3762/bjoc.7.132 Abstract The performance of

• microfluidic device; (2) simple product isolation, with no separate catalyst filtration step required; and (3) convenient screening of the reaction conditions and rapid sequential transformations facilitated by automation of the liquid handling. There have been several reports published on custom flow

Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• reproducibility due to the precise control over reaction conditions in these devices. Continuous flow technology has excellent potential for the integration of a high level of automation and for the incorporation of on-demand reaction analysis. This can be advantageous for applications such as high-throughput

Synthesis of the Benzo- fused Indolizidine Alkaloid Mimics

• Daniel L. Comins and
• Kazuhiro Higuchi

Beilstein J. Org. Chem. 2007, 3, No. 42, doi:10.1186/1860-5397-3-42

• : Experimental Section. Experimental details and full spectroscopic data for new compounds Acknowledgements We express appreciation to SCYNEXIS Chemistry & Automation, Inc. for financial support of this research. The NMR and mass spectra were obtained at NCSU instrumentation laboratories, which were established