Pd-catalysed [3 + 3] annelations in the stereoselective synthesis of indolizidines

• Olivier Y. Provoost,
• Andrew J. Hazelwood and
• Joseph P. A. Harrity

Beilstein J. Org. Chem. 2007, 3, No. 8, doi:10.1186/1860-5397-3-8

• reasons for this difference in catalyst activity are unclear at present, we speculate that n-BuLi may be responsible for the formation of hitherto uncharacterised phosphine ligands BunP(OiPr)3-n that promote the annelation over simple P(OiPr)3. Indeed, analogous alkoxide substitution reactions of