Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor

• Bernhard Gutmann,
• Toma N. Glasnov,
• Tahseen Razzaq,
• Walter Goessler,
• Dominique M. Roberge and
• C. Oliver Kappe

Beilstein J. Org. Chem. 2011, 7, 503–517, doi:10.3762/bjoc.7.59

• continuous flow processes is becoming increasingly important. In the past few years our research group [19][20][21][22][23][24][25] has reported a number of successful case studies where initial reaction optimization for a variety of synthetic transformations was performed under batch microwave conditions

Expedient syntheses of the N-heterocyclic carbene precursor imidazolium salts IPr·HCl, IMes·HCl and IXy·HCl

• Lukas Hintermann

Beilstein J. Org. Chem. 2007, 3, No. 22, doi:10.1186/1860-5397-3-22

• source of the chloride counter ion. The choice fell on chlorotrimethylsilane (TMSCl), the "silyl version" of HCl, which is easily measured and handled. The current pricing of TMSCl is 8 €/mol, as opposed to 80–100 €/mol for HCl/dioxane (4 M). The reaction optimization went as follows: Initial experiments