Synthesis of the fluorescent amino acid rac-(7-hydroxycoumarin-4-yl)ethylglycine

• Manfred Braun and
• Torsten Dittrich

Beilstein J. Org. Chem. 2010, 6, No. 69, doi:10.3762/bjoc.6.69

• , alkylation of a glycine enolate with the primary bromide 5 was anticipated. Indeed, its use as the electrophilic component in the coupling with the benzophenone-derived imine of tert-butyl glycine 6, which functioned, after deprotonation, as a synthetic equivalent of a glycine enolate synthon, led to the

Pd/C-mediated synthesis of α-pyrone fused with a five-membered nitrogen heteroaryl ring: A new route to pyrano[4,3-c]pyrazol-4(1H)-ones

• Dhilli Rao Gorja,
• Venkateswara Rao Batchu,
• Ashok Ettam and
• Manojit Pal

Beilstein J. Org. Chem. 2009, 5, No. 64, doi:10.3762/bjoc.5.64

• bioactive molecules, the pyrazole framework plays an important role in pharmaceutical research. We therefore believe that the present methodology and the product pyranopyrazol-4-one being a potential synthon for more complex heterocycles may find wide applications in organic synthesis, especially in

Coaxial electrospinning of liquid crystal-containing poly(vinylpyrrolidone) microfibres

• Eva Enz,
• Ute Baumeister and
• Jan Lagerwall

Beilstein J. Org. Chem. 2009, 5, No. 58, doi:10.3762/bjoc.5.58

• 8CB (Synthon Chemicals GmbH) was pumped at room temperature through an inner capillary of 320 μm inner and 450 μm outer diameter (fused silica tubing, BGB Analytik AG). The spinneret–collector distance was kept constant at 10 cm. With a high voltage power supply (Gamma High Voltage Research) a voltage

Preparation and Diels–Alder/cross coupling reactions of a 2-diethanolaminoboron- substituted 1,3-diene

• Liqiong Wang,
• Cynthia S. Day,
• Marcus W. Wright and
• Mark E. Welker

Beilstein J. Org. Chem. 2009, 5, No. 45, doi:10.3762/bjoc.5.45

• serve as a synthon for a host of other organic dienes, we took cycloadducts 3–5 and proved that they could be cross coupled efficiently to iodobenzene, 4-trifluoromethyl-1-iodobenzene, and 4-iodoanisole (Table 2, Scheme 3). Cross coupled cycloadducts 6–14 were all isolated in good to excellent yield and

• –Alder reactions that we have prepared to date. We have also demonstrated that this boron-substituted diene can serve as a synthon for a host of organic dienes via cross coupling reactions which we performed on Diels–Alder reaction cycloadducts. Experimental Preparation of 1,3-butadiene-2-diethanolamine

(−)-Complanine, an inflammatory substance of marine fireworm: a synthetic study

• Kazuhiko Nakamura,
• Yu Tachikawa and
• Daisuke Uemura

Beilstein J. Org. Chem. 2009, 5, No. 12, doi:10.3762/bjoc.5.12

• inflammatory substance of Eurythoe complanata, was accomplished by a “chiral synthon” approach. The absolute configuration of this molecule was determined to be R. Keywords: chiral synthon; complanine; inflammatory substance; marine fireworm; total synthesis; Introduction Toxic marine annelids were first

• absolute structure of complanine was unambiguously determined by means of synthetic methodology by a “chiral synthon” approach. Related amino alcohols possessing olefins from marine natural resources have been identified [3][4], but synthetic studies of these compounds have not been reported. Results and

Recent progress on the total synthesis of acetogenins from Annonaceae

• Nianguang Li,
• Zhihao Shi,
• Yuping Tang,
• Jianwei Chen and
• Xiang Li

Beilstein J. Org. Chem. 2008, 4, No. 48, doi:10.3762/bjoc.4.48

Allylsilanes in the synthesis of three to seven membered rings: the silylcuprate strategy

• Asunción Barbero,
• Francisco J. Pulido and
• M. Carmen Sañudo

Beilstein J. Org. Chem. 2007, 3, No. 16, doi:10.1186/1860-5397-3-16

• (Scheme 9). As shown in Scheme 9, the strategy employed allows the selective formation or 1- or 3-substituted derivatives, where the coupling of a C2 acetylenic synthon and a C2 epoxide synthon provides a new and useful [2+2] annulation strategy for the preparation of the strained cyclobutene ring. The

Molecular recognition. 1. Crystal structures of hexaazamacrocyclic amines containing p-xylylene spacers and their adducts with acids

• Teresa Borowiak,
• Grzegorz Dutkiewicz,
• Maciej Kubicki,
• Marek Pietraszkiewicz,
• Agnieszka Gil and
• Rainer Mattes

Beilstein J. Org. Chem. 2005, 1, No. 16, doi:10.1186/1860-5397-1-16

• plane of symmetry in the space group Pbnm, three fumaric anions, one of them occupying the same special position across the plane of symmetry and seven water molecules. The ionic synthon is shown in Figure 1. The hexa-protonated cation adopts a rectangular conformation similar to that in the structure

• for compound 1-FUM and CCDC 203505 for compound 1-N-Me. Copies of the information may be obtained free of charge from the Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (Fax: +44-12323-336-033; E-mail: deposit@ccdc.cam.ac.uk or www: http://www.ccdc.cam.ac.uk). The ionic synthon of 1-FUM built