Efficient 1,4-addition of α-substituted fluoro(phenylsulfonyl)methane derivatives to α,β-unsaturated compounds

• G. K. Surya Prakash,
• Xiaoming Zhao,
• Sujith Chacko,
• Fang Wang,
• Habiba Vaghoo and
• George A. Olah

Beilstein J. Org. Chem. 2008, 4, No. 17, doi:10.3762/bjoc.4.17

• propynoates at room temperature to yield the corresponding adducts in moderate to excellent yields. Background Compounds with a monofluoromethyl moiety are of great importance with regards to isostere-based drug design [1][2][3][4]. Consequently, synthesis of new functionalized α-monofluorine-substituted

Multiple hydride reduction pathways in isoflavonoids

• Auli K. Salakka,
• Tuija H. Jokela and
• Kristiina Wähälä

Beilstein J. Org. Chem. 2006, 2, No. 16, doi:10.1186/1860-5397-2-16

• , and their estrogenic and other physiological properties, making them promising lead compounds for drug design. Results The reduction of isoflavones by various hydride reagents occurs by a 1,4-pathway in contrast to ordinary β-alkoxy-α,β-unsaturated ketones. Isoflavan-4-ones, cis- and trans-isoflavan-4