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Search for "platforms" in Full Text gives 107 result(s) in Beilstein Journal of Organic Chemistry.
Camera-enabled techniques for organic synthesis
Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118
- immediately for automated decision making. Such technologies are sufficiently practical and economical to permit widespread use, not just confined to academic laboratories. With the ready availability of cheap CCD devices and computational platforms such as Arduino [73] and Raspberry Pi [74] (Figure 16), the
- tablet computers (such as the ARM-based processor found on the Raspberry Pi) allows computational platforms to be more mobile in nature and thus better suited for deployment within the synthesis laboratory environment. In a recent patent application [77] the authors disclose a device for monitoring
Palladium-catalyzed dual C–H or N–H functionalization of unfunctionalized indole derivatives with alkenes and arenes
Beilstein J. Org. Chem. 2012, 8, 1730–1746, doi:10.3762/bjoc.8.198
- pyridine or nicotine platforms (PyOx and NicOx, respectively) [68][69]. A moderate level of enantiocontrol (up to 51 % ee) was seen in 5-exo-trig cyclization of the 3-alkenylindole 19 (n = 1) in the presence of ligands 20 and 21, to yield 22, whilst the outcome of the 6-exo-trig cyclization of indole 19 (n
Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
Beilstein J. Org. Chem. 2012, 8, 986–993, doi:10.3762/bjoc.8.111
- activity, thus exemplifying their role in drug development [2][3][4][5][6][7][8]. Moreover, the challenging molecular architecture of spirooxindoles is appealing to chemists because it evokes novel synthetic strategies that address configurational demands and provides platforms for further reaction
Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS
Beilstein J. Org. Chem. 2012, 8, 753–762, doi:10.3762/bjoc.8.86
- generally compatible with other platforms in our laboratories, such as through the formation of SAMs on gold [18] or by coupling into maleimide-functionalised surfaces in a chemoselective fashion [19]. For the initial studies two carbohydrate derivatives, 5 and 7, were synthesised. The α-D-mannoside 5 would
Synthesis of glycosylated β3-homo-threonine conjugates for mucin-like glycopeptide antigen analogues
Beilstein J. Org. Chem. 2010, 6, No. 47, doi:10.3762/bjoc.6.47
- structural modifications assuming that the conformations remain similar to those of the natural antigens. In this respect, hybrid peptides in which β3-homo-amino acids are used to strategically replace α-amino acids might be of interest as platforms for carbohydrate-based vaccines. That is because such mixed
- of the epithelial mucin MUC1 and an N-terminal non-immunogenic triethylene glycol spacer. The latter can be used for further conjugation to immunostimulants (e.g., BSA [35] or tetanus toxoid [36]) and for immobilisation onto microarray platforms [37] within functional immunological studies. The MUC1
Continuous flow based catch and release protocol for the synthesis of α-ketoesters
Beilstein J. Org. Chem. 2009, 5, No. 23, doi:10.3762/bjoc.5.23
- effectively and cleanly bring about chemical transformations, especially in multistep mode [17][30][31][32][33][34][35][36][37]. Given the success of these concepts, it is not surprising that we would want to adapt these principles to various flow-chemical synthesis platforms to effectuate automated multistep
A divergent asymmetric approach to aza-spiropyran derivative and (1S,8aR)-1-hydroxyindolizidine
Beilstein J. Org. Chem. 2007, 3, No. 41, doi:10.1186/1860-5397-3-41
- drug for the treatment of cancer.[15] In addition, these molecules serve as platforms for testing synthetic strategies, and several asymmetric syntheses of both enantiomers of 1-hydroxyindolizidine (3) have been reported. [27][28][29][30][31][32][33][34]In continuation of our efforts in the development
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