Recent advances in the gold-catalyzed additions to C–C multiple bonds

• He Huang,
• Yu Zhou and
• Hong Liu

Beilstein J. Org. Chem. 2011, 7, 897–936, doi:10.3762/bjoc.7.103

• result in the formation of multi-ring products from a single substrate [149]. In 2010, a concise synthetic method for the generation of fused indoles (291–293), by a gold-catalyzed cascade cyclization of diynes 290 was developed by Hirano and co-workers [150]. The reaction gave aryl annulated[a

Synthesis of chiral mono(N-heterocyclic carbene) palladium and gold complexes with a 1,1'-biphenyl scaffold and their applications in catalysis

• Lian-jun Liu,
• Feijun Wang,
• Wenfeng Wang,
• Mei-xin Zhao and
• Min Shi

Beilstein J. Org. Chem. 2011, 7, 555–564, doi:10.3762/bjoc.7.64

• '-dimethoxybiphenyl-2,2'-diamine was treated with adamantane-2-carbonyl chloride in the presence of Et3N at room temperature (25 °C) in DCM to afford the corresponding amide (S)-1c in 71% yield. According to the synthetic method for the synthesis of compound (S)-6a, NHC–Au complex (S)-6c was successfully prepared in

The cross-metathesis of methyl oleate with cis-2-butene-1,4-diyl diacetate and the influence of protecting groups

• Arno Behr and
• Jessica Pérez Gomes

Beilstein J. Org. Chem. 2011, 7, 1–8, doi:10.3762/bjoc.7.1

• has become a routine and competent synthetic method for the formation of carbon–carbon double bonds [1][2][3][4][5]. Among investigations of ring opening metathesis polymerisation [6] and ring closing metathesis [7], the olefin cross-metathesis has demonstrated its great importance in providing access

Preparation of aminoethyl glycosides for glycoconjugation

• Robert Šardzík,
• Gavin T. Noble,
• Martin J. Weissenborn,
• Andrew Martin,
• Simon J. Webb and
• Sabine L. Flitsch

Beilstein J. Org. Chem. 2010, 6, 699–703, doi:10.3762/bjoc.6.81

• that aminoethyl glycosides are conveniently conjugated to surfaces containing activated carboxylates, they have become a useful generic anomeric functional group for glycoconjugation. The importance of this linker merits efforts into finding a robust synthetic method than can be used by scientists who

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

• Norio Shibata,
• Andrej Matsnev and
• Dominique Cahard

Beilstein J. Org. Chem. 2010, 6, No. 65, doi:10.3762/bjoc.6.65

• products by simple filtration or washing [20]. Since it was of interest to find an attractive synthetic method to make these reagents commercially available, Umemoto and co-workers developed a new route appropriate for the large-scale preparation of S-(trifluoromethyl)dibenzothiophenium salts. For instance

Anion receptors containing thiazine-1,1-dioxide heterocycles as hydrogen bond donors

• Hong-Bo Wang,
• James A. Wisner and
• Michael C. Jennings

Beilstein J. Org. Chem. 2010, 6, No. 50, doi:10.3762/bjoc.6.50

• potential versatility of the synthetic method described here that the elusive 2,6-disulfonamidopyridine host 4 (Figure 2) that would provide a more direct comparison to 2 is at present unknown and likely synthesized only with some difficulty. The syntheses of receptors 1 and 2 are summarized in Scheme 1. α

A practical synthesis of the ¹³C/¹⁵N- labelled tripeptide N-formyl- Met-Leu-Phe, useful as a reference in solid- state NMR spectroscopy

• Sven T. Breitung,
• Jakob J. Lopez,
• Gerd Dürner,
• Clemens Glaubitz,
• Michael W. Göbel and
• Marcel Suhartono

Beilstein J. Org. Chem. 2008, 4, No. 35, doi:10.3762/bjoc.4.35

• Wolfgang Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany 10.3762/bjoc.4.35 Abstract A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully

Ru-catalyzed dehydrogenative coupling of carboxylic acids and silanes - a new method for the preparation of silyl ester

• Guo-Bin Liu and
• Hong-Yun Zhao

Beilstein J. Org. Chem. 2008, 4, No. 27, doi:10.3762/bjoc.4.27

• esters are formed in the case of coupling nitro-, bromo-, and chlorobenzoic acid with silanes. We believe that the Ru3(CO)12/EtI-catalyzed dehydrosilylation of carboxylic acids with silanes provides another important protocol for a one-step, highly selective, atom-economical and efficient synthetic

• method. We are currently broadening the scope of this dehydrosilylation of carboxylic acids and silanes in our laboratory and the results will be published elsewhere. Experimental To a mixture of propionic acid (40 mmol, 2.96 g), and triethylsilane (40 mmol, 4.64 g) in toluene (20 ml) was added Ru3(CO)12

One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines

• Dipak Prajapati,
• Partha P. Baruah,
• Baikuntha J. Gogoi and
• Jagir S. Sandhu

Beilstein J. Org. Chem. 2006, 2, No. 5, doi:10.1186/1860-5397-2-5

• ring products 3 (Scheme 1). This mechanism explains the formation of both the products 3 &4 i.e. the presence of an aliphatic CH and loss of PhCN from M+, although they differ in their tautomeric forms. Further study of this effective synthetic method is in progress. To investigate further the