Highly efficient cyclosarin degradation mediated by a β-cyclodextrin derivative containing an oxime-derived substituent

• Michael Zengerle,
• Florian Brandhuber,
• Christian Schneider,
• Franz Worek,
• Georg Reiter and
• Stefan Kubik

Beilstein J. Org. Chem. 2011, 7, 1543–1554, doi:10.3762/bjoc.7.182

• (“click-reaction”) [33] from mono-6-azido-6-deoxy-β-cyclodextrin (4) and a functionalized alkyne (Scheme 3, route B). Conjugations by copper(I)-catalyzed azide–alkyne cycloadditions have become popular in many different fields of chemistry [33][34], including cyclodextrin chemistry [35][36][37][38][39][40

Hyperbranched polyethylenimine bearing cyclodextrin moieties showing temperature and pH controlled dye release

• Indra Böhm,
• Susanne Katharina Kreth and
• Helmut Ritter

Beilstein J. Org. Chem. 2011, 7, 1130–1134, doi:10.3762/bjoc.7.130

• , Scheme S1). Briefly, compound 3 can be obtained through polymer-analogous amidation with 5-hexynoic acid and subsequent reaction with mono-(6-azido-6-desoxy)-β-cyclodextrin by click reaction under microwave assisted conditions. Synthesis of 1,4-di-N-adamantylaminoanthraquinone (2): 2 was synthesized

Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation

• Jingjing Wu,
• Hui Li and
• Song Cao

Beilstein J. Org. Chem. 2011, 7, 1070–1074, doi:10.3762/bjoc.7.123

• ][30]. Recently, we reported a novel and general strategy for the construction of a difluoromethyl compound library, and we further illustrated this strategy by application to the synthesis of CF2H-bearing pseudopeptides and 1,2,3-triazoles through Ugi and click reaction, respectively [27][30]. In

Calix[4]arene-click-cyclodextrin and supramolecular structures with watersoluble NIPAAM-copolymers bearing adamantyl units: “Rings on ring on chain”

• Bernd Garska,
• Monir Tabatabai and
• Helmut Ritter

Beilstein J. Org. Chem. 2010, 6, 784–788, doi:10.3762/bjoc.6.83

• Bernd Garska Monir Tabatabai Helmut Ritter Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany 10.3762/bjoc.6.83 Abstract We describe the calixarene-cyclodextrin-coupling via click reaction starting from

• of guest molecules are of increasing practical and theoretical interest [1][2][3]. In this context, we recently coupled cyclodextrin (CD) with cucubituril via a click reaction and investigated the special interactions with some suitable copolymers [4]. Because of their capability to form host–guest

• calixarenes and β-CD via click reaction and their application in the field of supramolecular chemistry has not yet been reported. Herein, we describe the synthesis and complexation behavior of a dual type calix[4]arene-click-cyclodextrin (4) receptor by the cycloaddition of a dipropargylether of calix[4]arene

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

• Otman Otman,
• Paul Boullanger,
• Eric Drockenmuller and
• Thierry Hamaide

Beilstein J. Org. Chem. 2010, 6, No. 58, doi:10.3762/bjoc.6.58

• alcoholic media and water. In our case, the click reaction was performed with CuSO4 and sodium ascorbate in a THF/water mixture (Figure 2). This approach was preferred to the use of other catalysts because of the applications listed in the specific area of colloidal stabilization and the ease of removal of

Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid

• Arne Homann,
• Riaz-ul Qamar,
• Sevnur Serim,
• Petra Dersch and
• Jürgen Seibel

Beilstein J. Org. Chem. 2010, 6, No. 24, doi:10.3762/bjoc.6.24

• reaction was performed according to a modified protocol of the [3+2] triazole cycloaddition [15][16]. The appropriate functionalized fluorescent detection molecule and the conditions for the click reaction (CuSO4, sodium ascorbate and tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine, TBTA) were applied in

• surface presentation of Ac4GlcNAc 16 as well as the new substrate Neu5Hex 3 was successful. The copper-catalyzed [3+2] triazole formation (“click reaction”) proved very useful for the cell surface labelling because of its bioorthogonality. The incubation of HEp-2 cells with the sialic acid analogue

• drawback of the reaction parameters and compounds used for the click reaction is the cytotoxicity of DMSO and copper. But this problem for in vivo labelling can be overcome by different reaction conditions and different detection molecules. For example, the strain-promoted click reaction with difluorinated

Dimerization of propargyl and homopropargyl 6-azido- 6-deoxy- glycosides upon 1,3-dipolar cycloaddition

• Nikolas Pietrzik,
• Daniel Schmollinger and
• Thomas Ziegler

Beilstein J. Org. Chem. 2008, 4, No. 30, doi:10.3762/bjoc.4.30

• Nikolas Pietrzik Daniel Schmollinger Thomas Ziegler Institute of Organic Chemistry, University of Tuebingen, Auf der Morgenstelle 18, 72076 Tuebingen, Germany. 10.3762/bjoc.4.30 Abstract Copper-catalyzed, thermal or microwave promoted 1,3-dipolar cycloaddition (Click Reaction) of 2-propynyl and 3

• -butynyl 2,3,4-tri-O-acetyl-6-azido-6-deoxy-glycopyranosides in the D-gluco, D-galacto and D-manno series afford the corresponding dimeric cycloaddition products. Keywords: click reaction; cyclodimerization; glycosides; triazoles; Introduction Our ongoing interest in constructing combinatorial libraries

• -triazoles which are known to be easily generated through a copper-catalyzed 1,3-dipolar cycloaddition of an organic azide and an alkynyl derivative (Click Reaction) [5][6][7]. For review articles on copper-catalyzed Click Reactions see references [8][9][10][11]. Recently, we applied this approach to a