Beilstein J. Org. Chem.2023,19, 107–114, doi:10.3762/bjoc.19.11
, Australia Discovery Biology, Griffith University, Nathan, QLD 4111, Australia NatureBank, Griffith University, Nathan, QLD 4111, Australia 10.3762/bjoc.19.11 Abstract Nine new fluorinated analogues were synthesised by late-stage functionalisation using Diversinate™ chemistry on the Open Source Malaria (OSM
PDF
Graphical Abstract
Scheme 1:
Synthesis of ether triazolopyrazine derivatives 4–9.
Beilstein J. Org. Chem.2022,18, 1544–1552, doi:10.3762/bjoc.18.164
, 3010, Australia Biodiversity and Geosciences, Queensland Museum, Grey Street, Brisbane, 4101, Australia 10.3762/bjoc.18.164 Abstract In order to further expand the NatureBank open access compound library, chemical investigations of the Australian marine sponge, Ianthella basta, were undertaken since
marine natural product, ianthesine E (2). The chemical structure of the new compound was determined following detailed spectroscopic and spectrometric data analysis. These two compounds (1 and 2) along with seven previously reported marine bromotyrosine alkaloids from the NatureBank open access library
(6), hexadellin A (9) and bastadin 4 (5) showed inhibition towards larval motility after 72 h of exposure with IC50 values of 1.6 µM, 10.0 µM and 33.3 µM, respectively.
Keywords: alkaloid; anthelmintic; biodiscovery; bromotyrosine; 5-debromopurealidin H; Ianthella; NatureBank; sponge; Introduction
PDF
Graphical Abstract
Figure 1:
UHPLC–UV chromatogram (254 nm) of the CH2Cl2/MeOH extract of Ianthella basta (NB6021519); retention...