Iron-catalyzed domino coupling reactions of π-systems

• Austin Pounder and
• William Tam

Beilstein J. Org. Chem. 2021, 17, 2848–2893, doi:10.3762/bjoc.17.196

β-Amino functionalization of cinnamic Weinreb amides in ionic liquid

• Yi-Ning Wang,
• Guo-Xiang Sun and
• Gang Qi

Beilstein J. Org. Chem. 2016, 12, 2372–2377, doi:10.3762/bjoc.12.231

• Yi-Ning Wang Guo-Xiang Sun Gang Qi School of Chemistry & Chemical Engineering, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China 10.3762/bjoc.12.231 Abstract 2-Ns-Protected β-amino Weinreb amides were synthesized by aminochlorination of α,β-unsaturated Weinreb amides in an ionic

• distinct advantages of the use of 2-NsNCl2 as an inexpensive and stable nitrogen/halogen source and the ionic liquid as a recyclable reaction media. Nine examples were examined, and modest to good isolated chemical yields (40–83%) were obtained. Keywords: aminochlorination; β-amino functionalization

• reaction conditions required for the removal of the N-protecting groups. With the aminochlorination developed in the past few years [31], we found that when the aminochlorination reactions of α,β-unsaturated ketones 3 were carried out in ionic liquid, [BMIM][NTf2] (1-n-butyl-3-methylimidazolium bis

One-pot stereoselective synthesis of α,β-differentiated diamino esters via the sequence of aminochlorination, aziridination and intermolecular S_N2 reaction

• Yiwen Xiong,
• Ping Qian,
• Chenhui Cao,
• Haibo Mei,
• Jianlin Han,
• Guigen Li and
• Yi Pan

Beilstein J. Org. Chem. 2014, 10, 1802–1807, doi:10.3762/bjoc.10.189

• results, a proposed reaction mechanism for this one-pot reaction is illustrated in Scheme 4, which contains the sequence of aminochlorination, aziridination and followed by the SN2 nucleophilic ring-opening. The first step is the Cu-catalyzed aminochlorination reaction of methyl cinnamate 1a resulting in

• directly from α,β-unsaturated esters has been developed. The reaction sequence includes copper-catalyzed aminochlorination, aziridination and SN2 nucleophilic ring-opening reaction. This one-pot reaction is operationally convenient and can tolerate a variety of substrates affording the target products in

Formal synthesis of (−)-agelastatin A: an iron(II)-mediated cyclization strategy

• Daisuke Shigeoka,
• Takuma Kamon and
• Takehiko Yoshimitsu

Beilstein J. Org. Chem. 2013, 9, 860–865, doi:10.3762/bjoc.9.99

• aminochlorination reagent system, i.e., FeCl2 (0.5 equiv)/Bu4NCl (1.2 equiv) in EtOH, in turn, furnished the corresponding chloride 5b in 39% yield as the major product (Table 1, entry 2). Our recent studies on the iron(II)-mediated aminobromination reactions of structurally simple N-tosyloxycarbamates with FeBr2