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Search for "antioxidant" in Full Text gives 100 result(s) in Beilstein Journal of Organic Chemistry.

Chemical and biosynthetic potential of Penicillium shentong XL-F41

  • Ran Zou,
  • Xin Li,
  • Xiaochen Chen,
  • Yue-Wei Guo and
  • Baofu Xu

Beilstein J. Org. Chem. 2024, 20, 597–606, doi:10.3762/bjoc.20.52

Graphical Abstract
  • over 260 secondary metabolites from Penicillium [5], exhibiting not only antibacterial and anticancer activities but also potent antioxidant properties, inhibition of GSK-3β and α-glucosidase activities, and interaction with the pregnane X receptor (PXR). These compounds are categorized into
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Published 15 Mar 2024

A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001

  • Rattiya Janthanom,
  • Yuta Kikuchi,
  • Hiroki Kanto,
  • Tomoyasu Hirose,
  • Arisu Tahara,
  • Takahiro Ishii,
  • Arinthip Thamchaipenet and
  • Yuki Inahashi

Beilstein J. Org. Chem. 2024, 20, 497–503, doi:10.3762/bjoc.20.44

Graphical Abstract
  • but showed potent antioxidant activity. Keywords: antioxidant activity; dihydroxybenzoic acid analog; rare actinomycetes; Introduction Actinomycetes are Gram-positive bacteria with high GC content in their genome. They are well-known as the main producers of bioactive compounds such as antibiotic
  • , anticancer, antitumor, antiinflammatory, antihyperglycemic, antiapoptotic, immunosuppressant, and antioxidant compounds [1][2][3]. According to natural product screening since the 1920s, about 30,000 compounds derived from microbial sources have been reported [4]. Over 10,000 compounds are produced by
  • ). Antioxidant activity of 1 was measured via the DPPH radical. 1 showed potent DPPH radical scavenging activity with an IC50 value of 5.0 μg·mL−1, which is lower than that of trolox (IC50; 7.5 μg·mL−1) (Table 2). In contrast, 1 did not show antimicrobial activity against Gram-positive and Gram-negative bacteria
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Published 29 Feb 2024

Synthesis of 5-arylidenerhodanines in L-proline-based deep eutectic solvent

  • Stéphanie Hesse

Beilstein J. Org. Chem. 2023, 19, 1537–1544, doi:10.3762/bjoc.19.110

Graphical Abstract
  • classical organic solvents were used. The expected compounds are recovered by a simple filtration after hydrolysis and no purification is required. Those derivatives were studied for their antioxidant activities and the results are consistent with those reported in the literature indicating that phenolic
  • compounds are the more active ones. Keywords: antioxidant; deep eutectic solvent; Knoevenagel; ʟ-proline DES; rhodanine; Introduction Rhodanines and related five-membered heterocycles with multiple heteroatoms (i.e., thiazolidinediones, thiazolidinones, hydantoins, thiohydantoins) are very interesting
  • screenings and they present a wide spectrum of pharmacological activities [1][2]. Thus, for example, 3,4-dihydroxybenzylidenerhodanine (A) showed a high antioxidant activity with 71.2% of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity [3]. Naphthalen-2-ylmethylidenerhodanine (B) has been
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Published 04 Oct 2023

Synthesis and biological evaluation of Argemone mexicana-inspired antimicrobials

  • Jessica Villegas,
  • Bryce C. Ball,
  • Katelyn M. Shouse,
  • Caleb W. VanArragon,
  • Ashley N. Wasserman,
  • Hannah E. Bhakta,
  • Allen G. Oliver,
  • Danielle A. Orozco-Nunnelly and
  • Jeffrey M. Pruet

Beilstein J. Org. Chem. 2023, 19, 1511–1524, doi:10.3762/bjoc.19.108

Graphical Abstract
  • diseases. For instance, Argemone mexicana has been reported to possess a wide range of biological activities, such as anticancer, antimicrobial, anti-inflammatory, antidiabetic, and antioxidant actions [7]. The A. mexicana plant has been used in traditional medicine for centuries [8]. Our previous work
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Published 29 Sep 2023

Synthesis of ether lipids: natural compounds and analogues

  • Marco Antônio G. B. Gomes,
  • Alicia Bauduin,
  • Chloé Le Roux,
  • Romain Fouinneteau,
  • Wilfried Berthe,
  • Mathieu Berchel,
  • Hélène Couthon and
  • Paul-Alain Jaffrès

Beilstein J. Org. Chem. 2023, 19, 1299–1369, doi:10.3762/bjoc.19.96

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Published 08 Sep 2023

Non-noble metal-catalyzed cross-dehydrogenation coupling (CDC) involving ether α-C(sp3)–H to construct C–C bonds

  • Hui Yu and
  • Feng Xu

Beilstein J. Org. Chem. 2023, 19, 1259–1288, doi:10.3762/bjoc.19.94

Graphical Abstract
  • , various dicarbonyl compounds could be coupled with 2,4-disubstituted 3,6-dihydro-2H-pyrans (DHPs). The DHP motif is a structural component of several bioactive natural products and synthetic drugs with antioxidant, antipsychotic, antibacterial, antifungal, antiviral, and anticancer activities [106][107
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Published 06 Sep 2023

Five new sesquiterpenoids from agarwood of Aquilaria sinensis

  • Hong Zhou,
  • Xu-Yang Li,
  • Hong-Bin Fang,
  • He-Zhong Jiang and
  • Yong-Xian Cheng

Beilstein J. Org. Chem. 2023, 19, 998–1007, doi:10.3762/bjoc.19.75

Graphical Abstract
  • inhibition [8], anti-inflammatory [10], antiasthmatic [11], antidiabetic [12], and antioxidant [13] activities, have been reported for agarwood extracts [14][15]. Our group recently reported five structurally intriguing and biologically active sesquiterpene dimers [16], which attracted our interest to gain
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Published 30 Jun 2023

Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach

  • Dileep Kumar Singh and
  • Rajesh Kumar

Beilstein J. Org. Chem. 2023, 19, 928–955, doi:10.3762/bjoc.19.71

Graphical Abstract
  • chose nicotinamide as the catalyst for this study because it has a pKa of 3.43 and could act as a chemical antioxidant. In some cases, aminophenol hydrochloride is the only form of the corresponding aminophenol that can be isolated, so use of aminophenol hydrochloride as the starting material is also an
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Published 27 Jun 2023

Facile access to 3-sulfonylquinolines via Knoevenagel condensation/aza-Wittig reaction cascade involving ortho-azidobenzaldehydes and β-ketosulfonamides and sulfones

  • Ksenia Malkova,
  • Andrey Bubyrev,
  • Stanislav Kalinin and
  • Dmitry Dar’in

Beilstein J. Org. Chem. 2023, 19, 800–807, doi:10.3762/bjoc.19.60

Graphical Abstract
  • derivatives have been recently reported to possess intriguing pharmacological activities [3] including antiprotozoal [4][5][6][7], antitubercular [8][9], anticancer [10][11], anti-inflammatory [12], antioxidant [13], anti-HIV [14], antifungal [15], and an antineurodegenerative effect [16]. Hence, designing
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Published 09 Jun 2023

Nucleophile-induced ring contraction in pyrrolo[2,1-c][1,4]benzothiazines: access to pyrrolo[2,1-b][1,3]benzothiazoles

  • Ekaterina A. Lystsova,
  • Maksim V. Dmitriev,
  • Andrey N. Maslivets and
  • Ekaterina E. Khramtsova

Beilstein J. Org. Chem. 2023, 19, 646–657, doi:10.3762/bjoc.19.46

Graphical Abstract
  • anticonvulsant agents had been developed based on PBTA derivatives (Figure 1) [2]. In addition, series of PBTAs (Figure 1) were found to exhibit antibacterial, antifungal, antioxidant, and cytotoxic activities [3][4]. Several strategies have been developed for the synthesis of PBTA derivatives [2][3][4][5][6][7
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Published 11 May 2023

Discrimination of β-cyclodextrin/hazelnut (Corylus avellana L.) oil/flavonoid glycoside and flavonolignan ternary complexes by Fourier-transform infrared spectroscopy coupled with principal component analysis

  • Nicoleta G. Hădărugă,
  • Gabriela Popescu,
  • Dina Gligor (Pane),
  • Cristina L. Mitroi,
  • Sorin M. Stanciu and
  • Daniel Ioan Hădărugă

Beilstein J. Org. Chem. 2023, 19, 380–398, doi:10.3762/bjoc.19.30

Graphical Abstract
  • , Polytechnic University of Timişoara, Carol Telbisz 6, 30001 Timişoara, Romania 10.3762/bjoc.19.30 Abstract The goal of the study was the discrimination of β-cyclodextrin (β-CD)/hazelnut (Corylus avellana L.) oil/antioxidant ternary complexes through Fourier-transform infrared spectroscopy coupled with
  • solubility and bioaccessibility of the hazelnut oil components and antioxidants can be increased, as well as the controlled release of bioactive compounds (fatty acid glycerides and antioxidant flavonoids, namely hesperidin, naringin, rutin, and silymarin). The appropriate method for obtaining the ternary
  • total number of 26 variables). Other valuable classifications were obtained for the antioxidant flavonoids, with a high similarity for hesperidin and naringin, according to FTIR–PCA, as well as for ternary complexes depending on molar ratios. The FTIR–PCA coupled technique is a fast, nondestructive and
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Published 28 Mar 2023

Nostochopcerol, a new antibacterial monoacylglycerol from the edible cyanobacterium Nostochopsis lobatus

  • Naoya Oku,
  • Saki Hayashi,
  • Yuji Yamaguchi,
  • Hiroyuki Takenaka and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2023, 19, 133–138, doi:10.3762/bjoc.19.13

Graphical Abstract
  • limited number of attempts include an antifungal lipopeptide nostofungicidine [4] and an antioxidant nostocionone [5] from Nostoc commune, an unusual antibacterial n−1 fatty acid from N. verrucosum [2], and the sacrolides, antimicrobial oxylipin macrolactones from Aphanothece sacrum [6][7]. Nostochopsis
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Published 09 Feb 2023

Preparation of β-cyclodextrin/polysaccharide foams using saponin

  • Max Petitjean and
  • José Ramón Isasi

Beilstein J. Org. Chem. 2023, 19, 78–88, doi:10.3762/bjoc.19.7

Graphical Abstract
  • that saponins possess anticancer properties, by limiting proliferation and metastasis. This has been tested on different cancers such as leukemia [16], breast cancer [17] or prostate cancer to cite only a few of them [18]. They also present antimicrobial, antioxidant, anti-inflammatory, antidiabetic
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Published 24 Jan 2023

Total synthesis of grayanane natural products

  • Nicolas Fay,
  • Rémi Blieck,
  • Cyrille Kouklovsky and
  • Aurélien de la Torre

Beilstein J. Org. Chem. 2022, 18, 1707–1719, doi:10.3762/bjoc.18.181

Graphical Abstract
  • ], antifeedant [7][8][9], antituberculosis [10], cytotoxic [11] and antioxidant [12] properties. The grayanane family comprises more than 160 natural products, and new members are isolated every year. For instance, 13 new grayanane natural products were reported since 2020 [13][14][15][16]. Grayanane
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Published 12 Dec 2022

Derivatives of benzo-1,4-thiazine-3-carboxylic acid and the corresponding amino acid conjugates

  • Péter Kisszékelyi,
  • Tibor Peňaška,
  • Klára Stankovianska,
  • Mária Mečiarová and
  • Radovan Šebesta

Beilstein J. Org. Chem. 2022, 18, 1195–1202, doi:10.3762/bjoc.18.124

Graphical Abstract
  • hydrogenation; Introduction Heterocyclic compounds with a benzothiazine moiety are attractive building blocks in medicinal chemistry. Benzo-1,4-thiazine derivatives possess a wide range of biological and pharmacological properties, such as anticancer and antitumor, antioxidant, antimicrobial, antibacterial
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Published 09 Sep 2022

A Streptomyces P450 enzyme dimerizes isoflavones from plants

  • Run-Zhou Liu,
  • Shanchong Chen and
  • Lihan Zhang

Beilstein J. Org. Chem. 2022, 18, 1107–1115, doi:10.3762/bjoc.18.113

Graphical Abstract
  • host against oxidative radicals generated by UV irradiation [25][32]. To verify the antioxidative effect of the isoflavone dimers, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-based antioxidant activity was performed [33]. The results showed that while 2 and 3 had an activity roughly
  • equal to the monomers 4 and 6, 1 displayed a roughly twofold radical scavenging capacity (Figure S9, Supporting Information File 1). This is in agreement with the previous report that the configuration of the hydroxy group of the B-ring plays a key role in the antioxidant activity [34]. Thus, CYP158C1
  • might provide an alternative pathway for antioxidant biosynthesis by using exogenous metabolites as substrates. The native substrate for CYP158C1, presumably produced by the clustered T3PKS, has yet to be identified. The broad substrate specificity of CYP158C1 towards plant polyphenols suggests a
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Published 26 Aug 2022

Isolation and biosynthesis of daturamycins from Streptomyces sp. KIB-H1544

  • Yin Chen,
  • Jinqiu Ren,
  • Ruimin Yang,
  • Jie Li,
  • Sheng-Xiong Huang and
  • Yijun Yan

Beilstein J. Org. Chem. 2022, 18, 1009–1016, doi:10.3762/bjoc.18.101

Graphical Abstract
  • Streptomyces species [1][2][3][4]. Meanwhile, these types of compounds exhibit a broad spectrum of bioactivities, including antitumor [5][6], antibacterial [7][8], antioxidant [9][10][11][12], immunosuppressive [13], and antithrombotic activities [14]. The biosynthesis of the p-terphenyls has been studied
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Published 09 Aug 2022

Synthetic strategies for the preparation of γ-phostams: 1,2-azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides

  • Jiaxi Xu

Beilstein J. Org. Chem. 2022, 18, 889–915, doi:10.3762/bjoc.18.90

Graphical Abstract
  • analogues of γ-lactams, showing various biological activities, such as anti-inflammatory [15][16], antioxidant [17][18], and antitumor [18][19][20] (Figure 1). Various synthetic methods of 1,2-azaphospholidine 2-oxide and 1,2-azaphospholine 2-oxide derivatives have been developed to date. Two major
  • tautomerization and intramolecular aminolysis. Non-aminolysis byproduct 234 was obtained in 25% (Scheme 37). Both of the chromene-fused 5-oxo-1,2-azaphospholidine 2-oxide derivatives 233 and 234 showed good antioxidant and antitumor activities [17]. [4 + 1] Annulation via formations of both C–C and C–N bonds When
  • dioxane for 2 h. It was generated from the intramolecular aminolysis of diphenyl 3,5-di(tert-butyl)-4-hydroxyphenyl-(2,6-diaminopyridin-3-yl)methylphosphonate (251) and showed excellent antioxidant activity (Scheme 40) [18]. Conclusion 1,2-Azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides are
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Published 22 Jul 2022

Synthesis of bis-spirocyclic derivatives of 3-azabicyclo[3.1.0]hexane via cyclopropene cycloadditions to the stable azomethine ylide derived from Ruhemann's purple

  • Alexander S. Filatov,
  • Olesya V. Khoroshilova,
  • Anna G. Larina,
  • Vitali M. Boitsov and
  • Alexander V. Stepakov

Beilstein J. Org. Chem. 2022, 18, 769–780, doi:10.3762/bjoc.18.77

Graphical Abstract
  • substances. Many biologically active natural products have a spirocyclic skeleton in their structure [1][2]. In this regard, there is interest in studying heterocyclic spiro compounds for drug discovery. These compounds were found to exhibit a broad range of biological activities, including antioxidant [3
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Published 29 Jun 2022

Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities

  • Viktor A. Zapol’skii,
  • Isabell Berneburg,
  • Ursula Bilitewski,
  • Melissa Dillenberger,
  • Katja Becker,
  • Stefan Jungwirth,
  • Aditya Shekhar,
  • Bastian Krueger and
  • Dieter E. Kaufmann

Beilstein J. Org. Chem. 2022, 18, 524–532, doi:10.3762/bjoc.18.54

Graphical Abstract
  • falciparum strain [19]. Certain 7-chloroquinolinyl-pyrazole derivatives have also shown antibacterial [20], hypoglycemic as well as antioxidant activity [21] or can be used as selective nonpeptide neurotensin receptor type 2 compounds [22]. Some azolylquinolines have been used as agrochemical fungicides
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Published 09 May 2022

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

  • Ruan Carlos B. Ribeiro,
  • Patricia G. Ferreira,
  • Amanda de A. Borges,
  • Luana da S. M. Forezi,
  • Fernando de Carvalho da Silva and
  • Vitor F. Ferreira

Beilstein J. Org. Chem. 2022, 18, 53–69, doi:10.3762/bjoc.18.5

Graphical Abstract
  • ) for the preparation of 32 with antioxidant properties was investigated by Gouda in 2012 [81]. Intermediate 18 was treated with two equivalents of 30 resulting in bispyrazolopyridine 31, which after treatment with refluxing acetic acid produced imidazopyrazole 32 (Scheme 7). Compounds 31 and 32 were
  • evaluated against their antioxidant activity and exhibited promising activity. Protein tyrosine phosphatase 1B (PTP1B) is essential in the dephosphorylation of the activated insulin receptor, and inhibition of this enzyme would be an excellent strategy for the treatment of type 2 diabetes. Ahn and co
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Published 05 Jan 2022

Host–guest interaction and properties of cucurbit[8]uril with chloramphenicol

  • Lin Zhang,
  • Jun Zheng,
  • Guangyan Luo,
  • Xiaoyue Li,
  • Yunqian Zhang,
  • Zhu Tao and
  • Qianjun Zhang

Beilstein J. Org. Chem. 2021, 17, 2832–2839, doi:10.3762/bjoc.17.194

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  • cucurbit[n]urils can be used as non-toxic and safe drug carriers [29][30][31], among which cucurbit[8]uril (Q[8]) [32] has a large cavity. Q[8] interacts with a variety of small drug molecules such as chrysin, oroxin A and B, baicalein, etc., which can enhance the solubility, stability, antioxidant and
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Published 03 Dec 2021

Photophysical, photostability, and ROS generation properties of new trifluoromethylated quinoline-phenol Schiff bases

  • Inaiá O. Rocha,
  • Yuri G. Kappenberg,
  • Wilian C. Rosa,
  • Clarissa P. Frizzo,
  • Nilo Zanatta,
  • Marcos A. P. Martins,
  • Isadora Tisoco,
  • Bernardo A. Iglesias and
  • Helio G. Bonacorso

Beilstein J. Org. Chem. 2021, 17, 2799–2811, doi:10.3762/bjoc.17.191

Graphical Abstract
  • imines, Schiff bases have the general organic function -C=N- [2], and are known to have a wide range of biological activities, including antioxidant [3], antitubercular [4], antibacterial [5], antimicrobial [6], and antifungal properties [7], in addition to their role as chemosensors [8] (Figure 1
  • trifluoromethylated hybrid system comprising the Schiff base scaffolds from some 6-aminoquinolines and salicylaldehyde derivatives in order to analyze and evaluate their photophysical, photostability, and antioxidant properties for possible future applications in the pharmacological areas or materials sciences
  • here highlights their potential as dyes in photobiological applications. Conclusion In conclusion, we reported the synthesis and photophysical and antioxidant properties of a new series of ten novel Schiff bases 3. The scaffolds 3 could be synthesized by a simple condensation reaction between 6
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Published 01 Dec 2021

Transition-metal-free intramolecular Friedel–Crafts reaction by alkene activation: A method for the synthesis of some novel xanthene derivatives

  • Tülay Yıldız,
  • İrem Baştaş and
  • Hatice Başpınar Küçük

Beilstein J. Org. Chem. 2021, 17, 2203–2208, doi:10.3762/bjoc.17.142

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  • , antitumor, antioxidant, and anticarcinogenic. Experimental General information The majority of the chemicals used in this work were commercially available from Merck or Aldrich. The starting compounds 1a–l were prepared by Ullmann coupling of 2-fluorobenzaldehyde and substituted phenols. Compounds 2a–l were
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Published 30 Aug 2021

Catalyzed and uncatalyzed procedures for the syntheses of isomeric covalent multi-indolyl hetero non-metallides: an account

  • Ranadeep Talukdar

Beilstein J. Org. Chem. 2021, 17, 2102–2122, doi:10.3762/bjoc.17.137

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  • displayed high efficiency for activating AhR. Bis(indol-3-yl)selanes possess antioxidant properties. Pioneered by Wilshire [94], their syntheses were studied by Abele [95], Naidu [96], Yang [83], Thurow [97], and Talukdar [98]. The work of Abele in 2004 involved refluxing SeO2 with N-unprotected indole in
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Published 19 Aug 2021
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