Discovery of unguisin J, a new cyclic peptide from Aspergillus heteromorphus CBS 117.55, and phylogeny-based bioinformatic analysis of UngA NRPS domains

• Sharmila Neupane,
• Marcelo Rodrigues de Amorim and
• Elizabeth Skellam

Beilstein J. Org. Chem. 2024, 20, 321–330, doi:10.3762/bjoc.20.32

• Sharmila Neupane Marcelo Rodrigues de Amorim Elizabeth Skellam Department of Chemistry, University of North Texas, 1155 Union Circle, Denton, TX 76203, USA BioDiscovery Institute, University of North Texas, 1155 Union Circle, Denton, TX 76203, USA Instituto de Química de São Carlos, Universidade

• would like to thank Dr. Hongjun Pan for his kindness and teachings in the acquisition of NMR spectra as well as Jean Christophe Cocuron from the Bioanalytical Facilities (BAF) for HRMS data. Funding This project was supported by UNT Department of Chemistry and BioDiscovery Institute start-up funds, the

Digyalipopeptide A, an antiparasitic cyclic peptide from the Ghanaian Bacillus sp. strain DE2B

• Adwoa P. Nartey,
• Aboagye K. Dofuor,
• Kofi B. A. Owusu,
• Anil S. Camas,
• Hai Deng,
• Marcel Jaspars and
• Kwaku Kyeremeh

Beilstein J. Org. Chem. 2022, 18, 1763–1771, doi:10.3762/bjoc.18.185

• -Accra, Ghana Department of Biomedical Engineering, Faculty of Engineering, University of Samsun, Ballica Campus 55420, Samsun, Turkey Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, Scotland, UK 10.3762/bjoc.18.185 Abstract During the continued isolation

Using UHPLC–MS profiling for the discovery of new sponge-derived metabolites and anthelmintic screening of the NatureBank bromotyrosine library

• Sasha Hayes,
• Aya C. Taki,
• Kah Yean Lum,
• Joseph J. Byrne,
• Merrick G. Ekins,
• Robin B. Gasser and
• Rohan A. Davis

Beilstein J. Org. Chem. 2022, 18, 1544–1552, doi:10.3762/bjoc.18.164

• (6), hexadellin A (9) and bastadin 4 (5) showed inhibition towards larval motility after 72 h of exposure with IC50 values of 1.6 µM, 10.0 µM and 33.3 µM, respectively. Keywords: alkaloid; anthelmintic; biodiscovery; bromotyrosine; 5-debromopurealidin H; Ianthella; NatureBank; sponge; Introduction

• products, warranting inclusion in current and future biodiscovery programs. Verongid sponges have been a prolific source of bioactive and novel bromotyrosine-derived alkaloids with more than 374 compounds currently reported [1]. Whilst this particular structure class includes a large number of simple

• a biodiscovery program utilising a subset of marine specimens acquired from the Australian Institute of Marine Science (AIMS) [13] that have recently been added to the NatureBank biota repository. UHPLC–MS studies of several Verongida extracts from this new collection were analysed in order to

Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B

• Emmanuel T. Oluwabusola,
• Olusoji O. Adebisi,
• Fernando Reyes,
• Kojo S. Acquah,
• Mercedes De La Cruz,
• Larry L. Mweetwa,
• Joy E. Rajakulendran,
• Digby F. Warner,
• Deng Hai,
• Rainer Ebel and
• Marcel Jaspars

Beilstein J. Org. Chem. 2021, 17, 2390–2398, doi:10.3762/bjoc.17.156

• Emmanuel T. Oluwabusola Olusoji O. Adebisi Fernando Reyes Kojo S. Acquah Mercedes De La Cruz Larry L. Mweetwa Joy E. Rajakulendran Digby F. Warner Deng Hai Rainer Ebel Marcel Jaspars Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK Department of

• Wang of the Marine Biodiscovery Centre, Aberdeen for assisting in NMR, mass spectrometry and Marfey analyses, respectively. We also appreciate the support of Dr. Soji Fakoya and Blessing Akinboyo of Ondo State University of Science and Technology, Okitipupa, Nigeria, for their support in the collection

DNA with zwitterionic and negatively charged phosphate modifications: Formation of DNA triplexes, duplexes and cell uptake studies

• Yongdong Su,
• Maitsetseg Bayarjargal,
• Tracy K. Hale and
• Vyacheslav V. Filichev

Beilstein J. Org. Chem. 2021, 17, 749–761, doi:10.3762/bjoc.17.65

• Yongdong Su Maitsetseg Bayarjargal Tracy K. Hale Vyacheslav V. Filichev School of Fundamental Sciences, Massey University, Private Bag 11-222, 4442 Palmerston North, New Zealand Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand 10.3762/bjoc.17.65 Abstract Two phosphate

Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis

• Darcy J. Atkinson,
• Briar J. Naysmith,
• Daniel P. Furkert and
• Margaret A. Brimble

Beilstein J. Org. Chem. 2016, 12, 2325–2342, doi:10.3762/bjoc.12.226

• Darcy J. Atkinson Briar J. Naysmith Daniel P. Furkert Margaret A. Brimble School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3 Symonds Street, Auckland, New Zealand

• the University of Auckland, the Maurice Wilkins Centre for Molecular Biodiscovery and the Roskill Freemasons Trust for financial support of this work.

Preparation of conjugated dienoates with Bestmann ylide: Towards the synthesis of zampanolide and dactylolide using a facile linchpin approach

• Jingjing Wang,
• Samuel Z. Y. Ting and
• Joanne E. Harvey

Beilstein J. Org. Chem. 2015, 11, 1815–1822, doi:10.3762/bjoc.11.197

• Jingjing Wang Samuel Z. Y. Ting Joanne E. Harvey Centre for Biodiscovery, School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand 10.3762/bjoc.11.197 Abstract Bestmann ylide [(triphenylphosphoranylidene)ketene] acts as a chemical

Heronapyrrole D: A case of co-inspiration of natural product biosynthesis, total synthesis and biodiscovery

• Jens Schmidt,
• Zeinab Khalil,
• Robert J. Capon and
• Christian B. W. Stark

Beilstein J. Org. Chem. 2014, 10, 1228–1232, doi:10.3762/bjoc.10.121

• : biomimetic synthesis; biosynthesis; heronapyrroles; microbial biodiscovery; natural products; nitropyrroloterpenes; Introduction Heronapyrroles A–C (Figure 1) were first reported in 2010 by Capon et al. from a marine-derived Streptomyces sp. (CMB-M0423) obtained from a shallow water sand sample collected