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Search for "biostability" in Full Text gives 6 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis and bioactivity of pyrrole-conjugated phosphopeptides

  • Qiuxin Zhang,
  • Weiyi Tan and
  • Bing Xu

Beilstein J. Org. Chem. 2022, 18, 159–166, doi:10.3762/bjoc.18.17

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  • investigated the physical properties (enzyme-catalyzed hydrogelation or supramolecular structural transformation) [62][70] and biological properties (cell viability, biostability, and cell-selective growth inhibition) [43][62] of the naphthylacetyl N-terminal-capped phosphopeptides. These studies have produced
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Published 31 Jan 2022

Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

  • Nikita Brodyagin,
  • Martins Katkevics,
  • Venubabu Kotikam,
  • Christopher A. Ryan and
  • Eriks Rozners

Beilstein J. Org. Chem. 2021, 17, 1641–1688, doi:10.3762/bjoc.17.116

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Published 19 Jul 2021

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

  • Sergii Afonin,
  • Oleg Babii,
  • Aline Reuter,
  • Volker Middel,
  • Masanari Takamiya,
  • Uwe Strähle,
  • Igor V. Komarov and
  • Anne S. Ulrich

Beilstein J. Org. Chem. 2020, 16, 39–49, doi:10.3762/bjoc.16.6

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  • the ring-closed and ring-opened isomers, we can presume that homodimerization may affect the way in which the peptides interact with their molecular targets, or it may compromise their long-term biostability. Likewise, an elongation of the β-sheet core and an increase in cationic charge density
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Published 07 Jan 2020

A new approach to silicon rhodamines by Suzuki–Miyaura coupling – scope and limitations

  • Thines Kanagasundaram,
  • Antje Timmermann,
  • Carsten S. Kramer and
  • Klaus Kopka

Beilstein J. Org. Chem. 2019, 15, 2569–2576, doi:10.3762/bjoc.15.250

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  • Cancer Consortium (DKTK), Heidelberg, Germany 10.3762/bjoc.15.250 Abstract Background: Silicon rhodamines are of particular interest because of their advantageous dye properties (fluorescence- and biostability, quantum efficiency, tolerance to photobleaching). Therefore, silicon rhodamines find frequent
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Published 29 Oct 2019

6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

  • Sibylle Frei,
  • Andrei Istrate and
  • Christian J. Leumann

Beilstein J. Org. Chem. 2018, 14, 3088–3097, doi:10.3762/bjoc.14.288

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  • cellular delivery, the biostability, the affinity and specificity for target RNA sequences are crucial [11]. A powerful strategy to increase the affinity for complementary RNA and to improve the ON biostability is the conformational restriction of the flexible backbone by additional ring systems and
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Published 20 Dec 2018

Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide

  • Dan Yuan,
  • Xuewen Du,
  • Junfeng Shi,
  • Ning Zhou,
  • Abdulgader Ahmed Baoum,
  • Khalid Omar Al Footy,
  • Khadija Omar Badahdah and
  • Bing Xu

Beilstein J. Org. Chem. 2015, 11, 1352–1359, doi:10.3762/bjoc.11.145

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  • .11.145 Abstract This article reports the synthesis of a new class of conjugates containing a nucleobase, a peptidic epitope, and a saccharide and the evalution of their gelation, biostability, and cell compatibility. We demonstrate a facile synthetic process, based on solid-phase peptide synthesis of
  • proteolytic stabilities of the conjugates depend on the functional peptidic epitopes. We found that TTPV is proteolytic resistant and LGFNI is susceptible to proteolysis. In addition, all the conjugates are compatible to the mammalian cells tested. Keywords: biocompatibility; biostability; nucleobase
  • (stargazin) [14] and LGFNI is from a synapse associated protein 102 (SAP102) [15]. We connected these two functional peptide sequences with a nucleobase, and saccharide (or not). After investigating the gelation, biostability, and cell-compatibility properties of these conjugates (1–8), we found that all the
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Published 03 Aug 2015
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