Recent advances in the gold-catalyzed additions to C–C multiple bonds

• He Huang,
• Yu Zhou and
• Hong Liu

Beilstein J. Org. Chem. 2011, 7, 897–936, doi:10.3762/bjoc.7.103

• the Brønsted acid is both a chiral catalyst for the asymmetric cycloaddition and assists to facilitate the gold complex catalyzed hydroamination. Muratore et al. have reported an interesting example of C–N bond formation for the construction of chiral nitrogen-containing fused heterocycles 400 [191

A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation

• Benedikt Sammet,
• Mathilde Brax and
• Norbert Sewald

Beilstein J. Org. Chem. 2011, 7, 243–245, doi:10.3762/bjoc.7.32

• sulfate. A completely different route to unit B precursor 8 (Scheme 2) is based on a phase transfer catalyst (PTC) mediated asymmetric alkylation. However, the required cinchonine derived chiral catalyst is not commercially available [9]. Results and Discussion We envisaged a two step synthesis for the

Kinetics and mechanism of vanadium catalysed asymmetric cyanohydrin synthesis in propylene carbonate

• Michael North and
• Marta Omedes-Pujol

Beilstein J. Org. Chem. 2010, 6, 1043–1055, doi:10.3762/bjoc.6.119

• and β-amino alcohols [2] (Scheme 1). Asymmetric cyanohydrin synthesis can be achieved by the use of a suitable chiral catalyst, and a wide range of catalysts have been found to catalyse this reaction including enzymes [3][4], organocatalysts [5][6] and metal-based catalysts [1]. All of the most

Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

• circumventing this regioselectivity issue by exploiting the enantioselective intramolecular C–H insertion of diazoester 144 into a meso pyrrolidine using chiral catalyst 145. Unfortunately the reaction displayed low enantio- and diastereoselectivity, with the major isomer 146 having an ee of only 51% (Scheme 40