Beilstein J. Org. Chem.2017,13, 2115–2121, doi:10.3762/bjoc.13.208
, Lebanon Université de Rennes 1, Institut des Sciences Chimiques de Rennes, CNRS UMR 6226, Avenue du Général Leclerc, 35042 Rennes Cedex, France 10.3762/bjoc.13.208 Abstract Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been
coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity.
Keywords: aerobic oxidative coupling; imidazo[1,2-a]-N-heterocycles; gem-difluoroalkyl derivatives; propargylic fluorides; Introduction
Nitrogen-containing heterocyclic
, respectively. On the other hand, two nucleophilic substitution reactions using phenol and morpholine gave the expected heterocycles 10 and 11 in 73% and 23% yields, respectively.
Conclusion
In summary, we developed a short and completely regioselective method for the synthesis of imidazo[1,2-a]-N-heterocycles
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Graphical Abstract
Figure 1:
Representative examples of bioactive imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, imidazopyr...