Recent developments in gold-catalyzed cycloaddition reactions

• Fernando López and
• José L. Mascareñas

Beilstein J. Org. Chem. 2011, 7, 1075–1094, doi:10.3762/bjoc.7.124

• oxacyclic product 5. Importantly, the reaction also proceeds with non-aromatic 1-oxo-4-alkoxy-5-ynes [40]. Curiously, when the substrate features an internal alkyne, such as in alkynyl acetate 6, the reaction evolves through alternative mechanistic pathways [41]. In particular, Liu showed that in these

Intramolecular hydroamination of alkynic sulfonamides catalyzed by a gold–triethynylphosphine complex: Construction of azepine frameworks by 7-exo-dig cyclization

• Hideto Ito,
• Tomoya Harada,
• Hirohisa Ohmiya and
• Masaya Sawamura

Beilstein J. Org. Chem. 2011, 7, 951–959, doi:10.3762/bjoc.7.106

• enyne cycloisomerizations. The new catalytic system has expanded the scope of the reactions to six- and seven-membered ring formations, which had been difficult with the conventional catalytic systems [55]. Furthermore, we found that L1–gold(I) complex efficiently catalyzed the cyclization of internal

• alkyne substrates, which had also been difficult due to the steric repulsion between a nucleophilic center and a terminal substituent on the alkyne moiety [56]. We proposed that the cavity in the ligand forces the nucleophilic center closer to the gold-bound alkyne, resulting in the entropy-based rate

Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33