Camera-enabled techniques for organic synthesis

• Steven V. Ley,
• Richard J. Ingham,
• Matthew O’Brien and
• Duncan L. Browne

Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118

• reactor consisted of a section of semipermeable polymer tubing suspended in a reagent bottle containing an atmosphere of reactive gas (Supporting Information File 3). When a liquid stream was passed through the tubing, the microporous nature of the tubing used (Teflon AF-2400) allowed gas-to-liquid

Spin state switching in iron coordination compounds

• Philipp Gütlich,
• Ana B. Gaspar and
• Yann Garcia

Beilstein J. Org. Chem. 2013, 9, 342–391, doi:10.3762/bjoc.9.39

Iron-containing mesoporous aluminosilicate catalyzed direct alkenylation of phenols: Facile synthesis of 1,1-diarylalkenes

• Satyajit Haldar and
• Subratanath Koner

Beilstein J. Org. Chem. 2013, 9, 49–55, doi:10.3762/bjoc.9.6

• the iron center in the catalyst Fe-Al-MCM-41. NaY, a microporous aluminosilicate, did not yield any product under the specified reaction conditions (Table 2, entry 1). Sartori et al. reported an electrophilic alkenylation of aromatics with phenylacetylene over zeolite HSZ-360-Y; however, this zeolite

Combined bead polymerization and Cinchona organocatalyst immobilization by thiol–ene addition

• Kim A. Fredriksen,
• Tor E. Kristensen and
• Tore Hansen

Beilstein J. Org. Chem. 2012, 8, 1126–1133, doi:10.3762/bjoc.8.125

• closely connected, to facilitate the synthesis of larger quantities of supported catalyst [6][7]. Acrylic derivatives of established organocatalysts are prepared on a gram scale by using nonchromatographic procedures and copolymerized with suitable comonomers to give cross-linked and microporous beads

• initiator, such as AIBN, could be utilized, because peroxide initiators, such as dibenzoyl peroxide, oxidise thiols. The thiol-ene polymer beads 10–12 had a distinctively soft and gel-like appearance, but were easily handled like conventional microporous beads. They had favourable swelling characteristics

• in several organic solvents, particularly in THF and CH2Cl2, despite their significant degree of cross-linking. As such, they have much in common with the CLEAR (cross-linked ethoxylate acrylate resin) resins, a type of polymer support with all the characteristics of a microporous polymer that also

Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4-bromophenol, a key intermediate of adapalene

• Nan Wang,
• Ronghua Wang,
• Xia Shi and
• Gang Zou

Beilstein J. Org. Chem. 2012, 8, 227–233, doi:10.3762/bjoc.8.23

• catalyst was reduced to 0.3 g and 0.75 g from 1.0 g, for 3 mmol 4-bromophenol (1a), the adamantylation reaction still gave 92% and 98% yields of the target product, respectively, within 4–6 h (Table 1, entries 13 and 14). However, the microporous sulfonic acid cation-exchange resin (Amberlite IR120, H

Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline

• Xacobe C. Cambeiro,
• Rafael Martín-Rapún,
• Pedro O. Miranda,
• Sonia Sayalero,
• Esther Alza,
• Patricia Llanes and
• Miquel A. Pericàs

Beilstein J. Org. Chem. 2011, 7, 1486–1493, doi:10.3762/bjoc.7.172

• -linking agent and in the other case (1b) from a home-made Merrifield resin with 8% DVB (prepared by radical copolymerization of styrene, 4-chloromethylstyrene and DVB, under previously reported conditions [77][78][79]). It is well known that slightly cross-linked (1–2% DVB) polystyrene is microporous in

• stability that can lead to structural collapse and deactivation under the pressure applied for flow operation. Polystyrene cross-linked with 8% DVB still shows significant swelling with a variety of solvents, such that its behaviour can be considered as being intermediate between those of microporous and

Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths

• Ping He,
• Stephen J. Haswell,
• Paul D. I. Fletcher,
• Stephen M. Kelly and
• Andrew Mansfield

Beilstein J. Org. Chem. 2011, 7, 1150–1157, doi:10.3762/bjoc.7.133

• [12][13]. To this end, the use of microwave heating in conjunction with microporous monolithic reactors has attracted some interest for small-scale synthesis under continuous-flow conditions [14][15][16]. One obvious problem, however, when using microwaves to heat solvents/reagents and surface