Chemical modification allows phallotoxins and amatoxins to be used as tools in cell biology

• Jan Anderl,
• Hartmut Echner and
• Heinz Faulstich

Beilstein J. Org. Chem. 2012, 8, 2072–2084, doi:10.3762/bjoc.8.233

• of cells was determined by measuring the 570 nm absorbance of each well using a microplate reader (Molecular Devices). IC50 values were calculated as the concentration of toxin required to reduce the absorbance to 50% of the control cultures. Microscopic studies Exponentially growing fibroblasts were

Design and synthesis of quasi-diastereomeric molecules with unchanging central, regenerating axial and switchable helical chirality via cleavage and formation of Ni(II)–O and Ni(II)–N coordination bonds

• Vadim A. Soloshonok,
• José Luis Aceña,
• Hisanori Ueki and
• Jianlin Han

Beilstein J. Org. Chem. 2012, 8, 1920–1928, doi:10.3762/bjoc.8.223

• *) and (Ra*,Ph*,Rc*) occurs by intramolecular trans-coordination of Ni–NH and Ni–O bonds providing a basis for a chiral switch model. Keywords: axial chirality; central chirality; chiral switches; coordination bonds; functional materials; helical chirality; modular structural design; molecular devices

Synthesis and characterization of low-molecular-weight π-conjugated polymers covered by persilylated β-cyclodextrin

• Aurica Farcas,
• Ana-Maria Resmerita,
• Andreea Stefanache,
• Mihaela Balan and
• Valeria Harabagiu

Beilstein J. Org. Chem. 2012, 8, 1505–1514, doi:10.3762/bjoc.8.170

• materials for use in molecular devices, the construction of mechanically interlocked molecules, such as rotaxanes and polyrotaxanes, has attracted considerable attention [19][20][21][22][23]. A rotaxane assembly comprises a macrocyclic component (host) encircling an axle (guest) through noncovalent

Control over molecular motion using the cis–trans photoisomerization of the azo group

• Estíbaliz Merino and
• María Ribagorda

Beilstein J. Org. Chem. 2012, 8, 1071–1090, doi:10.3762/bjoc.8.119

• . This transformation induces a molecular movement and a significant geometric change, therefore the azobenzene unit is an excellent candidate to build dynamic molecular devices. We describe selected examples of systems containing an azobenzene moiety and their motions and geometrical changes caused by

• the cis configuration (Figure 7) [95]. Azobenzene-based molecular devices Among the systems with the inclusion and complexation properties of ions [97][98][99][100], several classes of compounds called azophanes, azocrowns [101][102][103][104], azocryptands, azocyclodextrins and azocalixarenes [105

• of optical molecular devices composed of different kinds of organic systems interconnected through an azobenzene unit as the epicentre of the motion. First, a molecular switch was synthesized capable of making a motion similar to the opening and closing of scissors. This switch consists of a central

The effect of the formyl group position upon asymmetric isomeric diarylethenes bearing a naphthalene moiety

• Renjie Wang,
• Shouzhi Pu,
• Gang Liu and
• Shiqiang Cui

Beilstein J. Org. Chem. 2012, 8, 1018–1026, doi:10.3762/bjoc.8.114

• ; Introduction In the past decade, photochromic materials have received much attention because of their applications in potential photoswitchable, molecular devices and optical memory storage systems [1]. Among these materials, the utilization of diarylethene derivatives in molecular electronics, optical memory

Toward unidirectional switches: 2-(2-Hydroxyphenyl)pyridine and 2-(2-methoxyphenyl)pyridine derivatives as pH-triggered pivots

• Christina Tepper and
• Gebhard Haberhauer

Beilstein J. Org. Chem. 2012, 8, 977–985, doi:10.3762/bjoc.8.110

• ], rotors [19][20][21][22] and shuttles [23][24][25][26][27][28] that can be controlled chemically, electrochemically, thermally or by illumination have been described. One of the most challenging aspects in the design of molecular devices is the creation of synthetic molecular motors, which utilize the

• for molecular devices [49][50][51][52][53][54][55][56], 2-(2-hydroxyphenyl)pyridine and 2-(2-methoxyphenyl)pyridine derivatives, to our best knowledge, have only been used as ligands for metal complexes, but not for the construction of molecular switches [57][58][59][60][61][62][63]. Similar compounds

Versatile supramolecular reactivity of zinc-tetra(4-pyridyl)porphyrin in crystalline solids: Polymeric grids with zinc dichloride and hydrogen-bonded networks with mellitic acid

• Sophia Lipstman and
• Israel Goldberg

Beilstein J. Org. Chem. 2009, 5, No. 77, doi:10.3762/bjoc.5.77

• further significance to studies of surface-based crystallizations of monolayer and multilayer hydrogen-bonded networks and metal–organic frameworks on various substrates [26][27], in the context of the design of novel molecular devices. Experimental The ZnTPyP, 1,4,5,8-naphthalenetetracarboxylic acid