Decarboxylative 1,3-dipolar cycloaddition of amino acids for the synthesis of heterocyclic compounds

• Xiaofeng Zhang,
• Xiaoming Ma and
• Wei Zhang

Beilstein J. Org. Chem. 2023, 19, 1677–1693, doi:10.3762/bjoc.19.123

• ]isoquinolines. Pseudo-four-component reaction for the synthesis of tetrahydropyrrolothiazoles 29 and 30 (>4:1 dr). One-pot two-step synthesis of spirooxindole-pyrrolothiazoles 31 (>4:1 dr). Acknowledgements We would like to thank all our co-workers who worked on the research projects highlighted in this paper

One-pot double annulations to confer diastereoselective spirooxindolepyrrolothiazoles

• Juan Lu,
• Bin Yao,
• Desheng Zhan,
• Zhuo Sun,
• Yun Ji and
• Xiaofeng Zhang

Beilstein J. Org. Chem. 2022, 18, 1607–1616, doi:10.3762/bjoc.18.171

• ; pyrrolothiazoles; spirooxindole; Introduction Nitrogen-containing heterocycles play a dominant role as a structural fragment of therapeutic agents in medicinal chemistry and drug discovery [1][2][3][4][5][6][7][8][9]. The nitrogen-containing heterocyclic moieties are currently discovered in more than 75% of the

• eliminating the intermediate purification. It is an efficient way to build up novel spirooxindolepyrrolothiazoles for drug discovery screening. Bioactive Spirooxindole-pyrrolothiazoles. Graphical representation of the green metrics (AE, AEf, CE, RME, OE and MP) analysis for processes A and B. The higher the