Platform and enabling technologies in organic synthesis

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Editors:
Prof. Philipp Heretsch, Leibniz Universität Hannover
Prof. Andreas Kirschning, Leibniz Universität Hannover
 
This thematic issue demonstrates the development of flow chemistry from a prerogative of the petrochemical industry to a technology of enormous value for chemical synthesis and a key for sustainable manufacturing. Transformations viewed impracticable under batch conditions can be enabled by the precise reaction control of flow reactors: photochemical applications, handling of reactive intermediates or reactive reagents, and new heating concepts now allow for accelerated synthesis while only a small volume of the reaction mixture inside the flow reactor is exposed to extreme conditions. Technological advances, including miniaturization and automation, have rendered continuous flow processes an enabling technology for organic synthesis.
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Modern flow chemistry – prospect and advantage

  • Philipp Heretsch

Beilstein J. Org. Chem. 2023, 19, 33–35, doi:10.3762/bjoc.19.3

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Editorial
Published 06 Jan 2023

High-speed C–H chlorination of ethylene carbonate using a new photoflow setup

  • Takayoshi Kasakado,
  • Takahide Fukuyama,
  • Tomohiro Nakagawa,
  • Shinji Taguchi and
  • Ilhyong Ryu

Beilstein J. Org. Chem. 2022, 18, 152–158, doi:10.3762/bjoc.18.16

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Letter
Published 27 Jan 2022

Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography

  • Kian Donnelly and
  • Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 232–239, doi:10.3762/bjoc.18.27

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Published 25 Feb 2022

Shift of the reaction equilibrium at high pressure in the continuous synthesis of neuraminic acid

  • Jannis A. Reich,
  • Miriam Aßmann,
  • Kristin Hölting,
  • Paul Bubenheim,
  • Jürgen Kuballa and
  • Andreas Liese

Beilstein J. Org. Chem. 2022, 18, 567–579, doi:10.3762/bjoc.18.59

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Published 20 May 2022

Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide

  • Kyoko Mandai,
  • Tetsuya Yamamoto,
  • Hiroki Mandai and
  • Aiichiro Nagaki

Beilstein J. Org. Chem. 2022, 18, 660–668, doi:10.3762/bjoc.18.67

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Letter
Published 13 Jun 2022

Inductive heating and flow chemistry – a perfect synergy of emerging enabling technologies

  • Conrad Kuhwald,
  • Sibel Türkhan and
  • Andreas Kirschning

Beilstein J. Org. Chem. 2022, 18, 688–706, doi:10.3762/bjoc.18.70

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Review
Published 20 Jun 2022

Synthesis of odorants in flow and their applications in perfumery

  • Merlin Kleoff,
  • Paul Kiler and
  • Philipp Heretsch

Beilstein J. Org. Chem. 2022, 18, 754–768, doi:10.3762/bjoc.18.76

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Published 27 Jun 2022

Continuous flow synthesis of azobenzenes via Baeyer–Mills reaction

  • Jan H. Griwatz,
  • Anne Kunz and
  • Hermann A. Wegner

Beilstein J. Org. Chem. 2022, 18, 781–787, doi:10.3762/bjoc.18.78

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Published 30 Jun 2022

Heterogeneous metallaphotoredox catalysis in a continuous-flow packed-bed reactor

  • Wei-Hsin Hsu,
  • Susanne Reischauer,
  • Peter H. Seeberger,
  • Bartholomäus Pieber and
  • Dario Cambié

Beilstein J. Org. Chem. 2022, 18, 1123–1130, doi:10.3762/bjoc.18.115

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Published 29 Aug 2022
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