Platform and enabling technologies in organic synthesis

  1. editorImage
  1. Editors:
    Prof. Philipp Heretsch, Leibniz Universität Hannover
    Prof. Andreas Kirschning, Leibniz Universität Hannover

This thematic issue demonstrates the development of flow chemistry from a prerogative of the petrochemical industry to a technology of enormous value for chemical synthesis and a key for sustainable manufacturing. Transformations viewed impracticable under batch conditions can be enabled by the precise reaction control of flow reactors: photochemical applications, handling of reactive intermediates or reactive reagents, and new heating concepts now allow for accelerated synthesis while only a small volume of the reaction mixture inside the flow reactor is exposed to extreme conditions. Technological advances, including miniaturization and automation, have rendered continuous flow processes an enabling technology for organic synthesis.

High-speed C–H chlorination of ethylene carbonate using a new photoflow setup

  1. Takayoshi Kasakado,
  2. Takahide Fukuyama,
  3. Tomohiro Nakagawa,
  4. Shinji Taguchi and
  5. Ilhyong Ryu
  • Letter
  • Published 27 Jan 2022

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  • Supp. Info
Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 152–158, doi:10.3762/bjoc.18.16

  • Full Research Paper
  • Published 25 Feb 2022
Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 232–239, doi:10.3762/bjoc.18.27

Shift of the reaction equilibrium at high pressure in the continuous synthesis of neuraminic acid

  1. Jannis A. Reich,
  2. Miriam Aßmann,
  3. Kristin Hölting,
  4. Paul Bubenheim,
  5. Jürgen Kuballa and
  6. Andreas Liese
  • Full Research Paper
  • Published 20 May 2022

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Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 567–579, doi:10.3762/bjoc.18.59

Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide

  1. Kyoko Mandai,
  2. Tetsuya Yamamoto,
  3. Hiroki Mandai and
  4. Aiichiro Nagaki
  • Letter
  • Published 13 Jun 2022

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  • Supp. Info
Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 660–668, doi:10.3762/bjoc.18.67

  • Review
  • Published 20 Jun 2022

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Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 688–706, doi:10.3762/bjoc.18.70

Synthesis of odorants in flow and their applications in perfumery

  1. Merlin Kleoff,
  2. Paul Kiler and
  3. Philipp Heretsch
  • Review
  • Published 27 Jun 2022

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Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 754–768, doi:10.3762/bjoc.18.76

Continuous flow synthesis of azobenzenes via Baeyer–Mills reaction

  1. Jan H. Griwatz,
  2. Anne Kunz and
  3. Hermann A. Wegner
  • Full Research Paper
  • Published 30 Jun 2022

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  • Supp. Info
Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 781–787, doi:10.3762/bjoc.18.78

Heterogeneous metallaphotoredox catalysis in a continuous-flow packed-bed reactor

  1. Wei-Hsin Hsu,
  2. Susanne Reischauer,
  3. Peter H. Seeberger,
  4. Bartholomäus Pieber and
  5. Dario Cambié
  • Full Research Paper
  • Published 29 Aug 2022

  • PDF

  • Supp. Info
Graphical Abstract

Beilstein J. Org. Chem. 2022, 18, 1123–1130, doi:10.3762/bjoc.18.115

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