Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• vehicles that can incorporate SN38 by chemical conjugation or physical entrapment. Polymeric micelles, liposomes and thermally sensitive polymer-based nanoparticles, as well as multi-armed-PEG-functionalized nanographene oxide, have been used as carriers for the delivery of SN38 into biological systems [21

• ][22][23][24][25][26]. SN38-loaded polymeric micelles (NK012) have been used in preclinical and clinical studies against various types of cancer. Specific accumulation of this formulation to the tumor site by the EPR effect (enhanced permeation and retention), and sustained release of SN38 in tumor

Mesoporous MgTa₂O₆ thin films with enhanced photocatalytic activity: On the interplay between crystallinity and mesostructure

• Jin-Ming Wu,
• Igor Djerdj,
• Till von Graberg and
• Bernd M. Smarsly

Beilstein J. Nanotechnol. 2012, 3, 123–133, doi:10.3762/bjnano.3.13

• , the SAXS scattering maxima can still be discerned after calcination up to 1000 °C. Therefore, the present ordered mesoporous MgTa2O6 film possessed a relatively high thermal stability. This property was attributed to the special templating properties of KLE, which forms relatively large micelles

Template-assisted formation of microsized nanocrystalline CeO₂ tubes and their catalytic performance in the carboxylation of methanol

• Jörg J. Schneider,
• Meike Naumann,
• Christian Schäfer,
• Armin Brandner,
• Heiko J. Hofmann and
• Peter Claus

Beilstein J. Nanotechnol. 2011, 2, 776–784, doi:10.3762/bjnano.2.86

• , which form spherical and cylindrical micelles, and which could thus allow for a better contact of the inorganic ceria sol with the electrospun polymer fibres during impregnation. After spray-coating followed by sol–gel transformation to the ceramic green body at 80 °C overnight, the green body was

Surface induced self-organization of comb-like macromolecules

• Konstantin I. Popov,
• Vladimir V. Palyulin,
• Martin Möller,
• Alexei R. Khokhlov and
• Igor I. Potemkin

Beilstein J. Nanotechnol. 2011, 2, 569–584, doi:10.3762/bjnano.2.61

• unusual viscoelastic properties (super-soft elastomers) [5][14], may form micelles as big as 300 nm [15] and have extremely interesting 2D conformational behavior in the adsorbed state [4]. Brush copolymers with diblock and triblock copolymers as side chains can be used for the creation of well defined

• behavior [46][47][48]. Both scaling theory [46][47] and simulations [47][48] predicted that collapse of the main chain with increase of hydrophobicity in densely grafted combs would lead to formation of a necklace of intramolecular starlike micelles, with hydrophobic corelike domains connected by extended

• bridges and hydrophilic corona formed by the grafts (Figure 1). Scaling analysis reveals that the formation of finite-size intramolecular micelles happens only in a narrow range of interaction parameters near the transition point. A similar pearl-necklace structure was detected experimentally for core

Nanoscaled alloy formation from self-assembled elemental Co nanoparticles on top of Pt films

• Luyang Han,
• Ulf Wiedwald,
• Johannes Biskupek,
• Kai Fauth,
• Ute Kaiser and
• Paul Ziemann

Beilstein J. Nanotechnol. 2011, 2, 473–485, doi:10.3762/bjnano.2.51

• ) substrates, respectively. For this purpose, metallic Co nanoparticles (diameter 7 nm) were prepared with a spacing of 100 nm by deposition of precursor-loaded reverse micelles, subsequent plasma etching and reduction on flat Pt surfaces. The samples were then annealed at successively higher temperatures

• probe microscopy techniques [5], one is left with processes relying on the self-assembly of colloids or micelles [6][7][8]. In the context of magnetic NPs, two prominent examples, both dealing with the preparation of magnetically attractive FePt NPs, which successfully demonstrated fulfillment of the

• orientation of the STO substrates we find a cube-on-cube growth of the Pt film on the STO(100) with orientations Pt(100)||STO(100) and Pt[010]||STO[010]. Co nanoparticles on Pt films The preparation of metal NPs is based on spherical reverse micelles formed by the diblock copolymer poly(styrene)[m]-block-poly

Platinum nanoparticles from size adjusted functional colloidal particles generated by a seeded emulsion polymerization process

• Nicolas Vogel,
• Ulrich Ziener,
• Achim Manzke,
• Alfred Plettl,
• Paul Ziemann,
• Johannes Biskupek,
• Clemens K. Weiss and
• Katharina Landfester

Beilstein J. Nanotechnol. 2011, 2, 459–472, doi:10.3762/bjnano.2.50

• concentrations were below the critical value for micelle formation (cmc). Such concentrations are used in conventional emulsion polymerization and lead to particles nucleated in monomer swollen micelles [13]. Figure 3b and c show representative SEM micrographs of the resulting dispersions. For both cases

Organic–inorganic nanosystems

• Paul Ziemann

Beilstein J. Nanotechnol. 2011, 2, 363–364, doi:10.3762/bjnano.2.41

• the application to pre-patterned substrates acting as templates. In the above example, diblock-copolymers will form spherical micelles within a certain window of block lengths in a properly chosen solvent, and such micelles can be used as carriers for a metal precursor during their self-organization

• loaded micelles or, more generally, colloids, the organic carriers are completely removed after their self-organization by various plasma treatments while the precursor compounds are transformed into metal oxides or, finally, into metals. In this way, hexagonal ordered arrays of metal nanoparticles can

Novel acridone-modified MCM-41 type silica: Synthesis, characterization and fluorescence tuning

• Maximilian Hemgesberg,
• Gunder Dörr,
• Yvonne Schmitt,
• Andreas Seifert,
• Zhou Zhou,
• Robin Klupp Taylor,
• Sarah Bay,
• Stefan Ernst,
• Markus Gerhards,
• Thomas J. J. Müller and
• Werner R. Thiel

Beilstein J. Nanotechnol. 2011, 2, 284–292, doi:10.3762/bjnano.2.33

• decrease of ordering with increasing bulk of the organic groups, although all exhibited very high specific surface areas. As the formation of micelles will strongly depend on the nature of the organic molecule and its concentration, it was decided to keep the amount of precursor 1 at 10 mol % with respect

Review and outlook: from single nanoparticles to self-assembled monolayers and granular GMR sensors

• Alexander Weddemann,
• Inga Ennen,
• Anna Regtmeier,
• Camelia Albon,
• Annalena Wolff,
• Katrin Eckstädt,
• Nadine Mill,
• Michael K.-H. Peter,
• Jochen Mattay,
• Carolin Plattner,
• Norbert Sewald and
• Andreas Hütten

Beilstein J. Nanotechnol. 2010, 1, 75–93, doi:10.3762/bjnano.1.10

• technique which is based on a thermally stabile, isotropic dispersion of two immiscible solvents, in which the micro domains of one or both solvents are stabilized by tensides on the boundary layer. Such behavior is well known from tensides in water which form micelles due to hydrophilic head groups and

• hydrophobic tails. Such micelles have a size of 1 to 50 nm depending on the tenside concentration [18]. The precursor is confined within these defined droplets which may, thus, act as nanoreactors in which particle growth is initiated. A typical result obtained by the use of an isopropanol/water emulsion and

Preparation and characterization of supported magnetic nanoparticles prepared by reverse micelles

• Ulf Wiedwald,
• Luyang Han,
• Johannes Biskupek,
• Ute Kaiser and
• Paul Ziemann

Beilstein J. Nanotechnol. 2010, 1, 24–47, doi:10.3762/bjnano.1.5

• ) nanoparticles were prepared by exploiting the self-organization of precursor loaded reverse micelles. Achievements and limitations of the preparation approach are critically discussed. We show that self-assembled metallic nanoparticles can be prepared with diameters d = 2–12 nm and interparticle distances D

• conservation of nanoparticles by Au photoseeding is presented. Keywords: Co; CoPt; core–shell particles; FePt; magnetic anisotropy; magnetic particles; plasma etching; reverse micelles; self-assembly; Introduction Magnetic nanoparticles have been the focus of research for over 60 years [1][2]. These

• colloidal approach where NPs are formed within a liquid, the preparation of precursor loaded reverse micelles has been developed [36][37]. Here, precursor filled diblock-co-polymers are used to form hexagonally ordered arrays on different substrates by dip-coating [38]. In a second step, NPs are formed on

Sensing surface PEGylation with microcantilevers

• Natalija Backmann,
• Natascha Kappeler,
• Thomas Braun,
• François Huber,
• Hans-Peter Lang,
• Christoph Gerber and
• Roderick Y. H. Lim

Beilstein J. Nanotechnol. 2010, 1, 3–13, doi:10.3762/bjnano.1.2

• transition in the layer (see Discussion). To further characterize the conformation of the PEG layer, we repeated our AFM measurements in 20% 2-propanol which is a poor solvent for PEG. This is because polymer brushes are known to form more compact “collapsed” clusters, known as pinned micelles, in poor

• dependent on the applied imaging force. In this case, the AFM image resolution does not change when the imaging force is varied between 30 pN and 120 pN. Here, it is noteworthy that only the underlying Au surface and aggregates of collapsed PEG chains (pinned micelles) are resolved. Sensing the reversible