Nanoparticles based on the zwitterionic pillar[5]arene and Ag⁺: synthesis, self-assembly and cytotoxicity in the human lung cancer cell line A549

• Dmitriy N. Shurpik,
• Denis A. Sevastyanov,
• Pavel V. Zelenikhin,
• Pavel L. Padnya,
• Vladimir G. Evtugyn,
• Yuriy N. Osin and
• Ivan I. Stoikov

Beilstein J. Nanotechnol. 2020, 11, 421–431, doi:10.3762/bjnano.11.33

• Dmitriy N. Shurpik Denis A. Sevastyanov Pavel V. Zelenikhin Pavel L. Padnya Vladimir G. Evtugyn Yuriy N. Osin Ivan I. Stoikov Kazan Federal University, A.M. Butlerov Chemistry Institute, 420008 Kremlevskaya, 18, Kazan, Russian Federation Institute of Fundamental Medicine and Biology, Kazan Federal

• and 2D biomedical coatings. Keywords: cytotoxicity; macrocyclic receptors; nanoparticles; pillar[5]arene; self-assembly; silver; Introduction The first use of silver (Ag) as a medicine dates back to Hippocrates, who used it as an antibacterial agent for the treatment of ulcers [1]. Over the past

Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy

• María Sanromán Iglesias and
• Marek Grzelczak

Beilstein J. Nanotechnol. 2020, 11, 263–284, doi:10.3762/bjnano.11.20

• techniques are without parallel in the analysis of genetic material and the detection of mutations, they require an operation by specialized personnel in large infrastructures such as hospitals or research centers. The democratization of liquid biopsy and therefore the advancement of personal medicine needs

• influence the promoter activity (gene expression), the activity of messenger RNA (mRNA), gene conformation (stability) and the translational efficiency. Keeping in mind the importance of these modifications, SNPs can be proposed as biomarkers in the clinical diagnosis of diseases, personalized medicine and

• in the further development of personalized medicine. Alterations in cell-free DNA. Cell-free DNA can be released from both cancerous and normal cells located in the tumor environment through apoptosis, necrosis or secretion. Once in the bloodstream, cfDNA may exist either free or associated with

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• ) effect [2][3], constituted the triggering factor for the development of a whole new part of medicine, namely nanomedicine. Indeed, the observed spontaneous accumulation was explained by the existence of disjunctions between endothelial cells in the proximity of inflamed and cancerous tissues, which

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• Ivana Ruseska Andreas Zimmer Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz, 8010 Graz, Austria 10.3762/bjnano.11.10 Abstract In today’s modern era of medicine, macromolecular compounds such as proteins, peptides and nucleic acids

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency

• Arianna Gennari,
• Julio M. Rios de la Rosa,
• Erwin Hohn,
• Maria Pelliccia,
• Enrique Lallana,
• Roberto Donno,
• Annalisa Tirella and
• Nicola Tirelli

Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250

• of Health Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, Stopford Building, University of Manchester and Manchester Academic Health Science Centre, Manchester, M13 9PT, United Kingdom

Fully amino acid-based hydrogel as potential scaffold for cell culturing and drug delivery

• Dávid Juriga,
• Evelin Sipos,
• Orsolya Hegedűs,
• Gábor Varga,
• Miklós Zrínyi,
• Krisztina S. Nagy and
• Angéla Jedlovszky-Hajdú

Beilstein J. Nanotechnol. 2019, 10, 2579–2593, doi:10.3762/bjnano.10.249

• usually complicated and expensive [3]. Recently, various types of polymer-based hydrogels have been developed for purposes of tissue engineering and regenerative medicine [26]. Most of these polymers try to mimic or recreate the natural environment of the cells, namely the extracellular matrix (ECM) [27

Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions

• Anna V. Epanchintseva,
• Julia E. Poletaeva,
• Dmitrii V. Pyshnyi,
• Elena I. Ryabchikova and
• Inna A. Pyshnaya

Beilstein J. Nanotechnol. 2019, 10, 2568–2578, doi:10.3762/bjnano.10.248

• Anna V. Epanchintseva Julia E. Poletaeva Dmitrii V. Pyshnyi Elena I. Ryabchikova Inna A. Pyshnaya Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Lavrent’ev av., 8, Novosibirsk, 630090, Russian Federation 10.3762/bjnano.10.248 Abstract Gold

Frontiers in pharmaceutical nanotechnology

• Matthias G. Wacker

Beilstein J. Nanotechnol. 2019, 10, 2538–2540, doi:10.3762/bjnano.10.244

• was proclaimed to revolutionize medicine, but what we are seeing at present is a slow transformation rather than a revolutionary overthrow. Now more than ever, the potential for clinical translation will be in the spotlight. In many areas, nanotechnology is already accepted, for example, in the

Small protein sequences can induce cellular uptake of complex nanohybrids

• Jan-Philip Merkl,
• Malak Safi,
• Christian Schmidtke,
• Fadi Aldeek,
• Johannes Ostermann,
• Tatiana Domitrovic,
• Sebastian Gärtner,
• John E. Johnson,
• Horst Weller and
• Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

• culture, epifluorescence z-stack, epifluorescence control experiments, flow cytometry, further instrumentation. Supporting Information File 300: Additional experimental data. Acknowledgements This work was supported by the State Excellence Initiative “Nanotechnology in Medicine” from the Free and

Polyvinylpyrrolidone as additive for perovskite solar cells with water and isopropanol as solvents

• Chen Du,
• Shuo Wang,
• Xu Miao,
• Wenhai Sun,
• Yu Zhu,
• Chengyan Wang and
• Ruixin Ma

Beilstein J. Nanotechnol. 2019, 10, 2374–2382, doi:10.3762/bjnano.10.228

• organic polymers. As a non-ionic polymer compound, polyvinylpyrrolidone (PVP) shows excellent solubility and physiological compatibility and is extensively applied in medicine, food, and cosmetics, which are closely related to the health of people [29]. PVP is commonly integrated in PSCs, which is

The role of Ag⁺, Ca²⁺, Pb²⁺ and Al³⁺ adions in the SERS turn-on effect of anionic analytes

• Stefania D. Iancu,
• Andrei Stefancu,
• Vlad Moisoiu,
• Loredana F. Leopold and
• Nicolae Leopold

Beilstein J. Nanotechnol. 2019, 10, 2338–2345, doi:10.3762/bjnano.10.224

• Stefania D. Iancu Andrei Stefancu Vlad Moisoiu Loredana F. Leopold Nicolae Leopold Faculty of Physics, Babeș-Bolyai University, Kogalniceanu 1, 400084 Cluj-Napoca, Romania Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Manastur 3-5, 400372 Cluj

Atomic force acoustic microscopy reveals the influence of substrate stiffness and topography on cell behavior

• Yan Liu,
• Li Li,
• Xing Chen,
• Ying Wang,
• Meng-Nan Liu,
• Jin Yan,
• Liang Cao,
• Lu Wang and
• Zuo-Bin Wang

Beilstein J. Nanotechnol. 2019, 10, 2329–2337, doi:10.3762/bjnano.10.223

• for the tissue regeneration therapy in biomedicine. Keywords: atomic force acoustic microscopy (AFAM); cell growth; nanopattern; stiffness; SU-8 photoresist; topography; Introduction The interactions of cells with extracellular matrices (ECMs) play important roles in regenerative medicine and tissue

• the substrate to the cells. This approach is useful for the investigation of biological processes, tissue development and cell-based regenerative medicine. Fabrication of SU-8 films and differentiation of L929 cells cultured on the surfaces. (a) The fabrication process for producing tunable stiffness

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• [26][27][28]. Curcuminoids, derived from curcuma root (Curcuma longa), have been used for many centuries in Asian countries as a spice and coloring agent, but also as a medicine [29]. This group of yellow polyphenols are composed of curcumin (CUR), demetoxycurcumin and bis-demetoxycurcumin, which

Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

• Nashrawan Lababidi,
• Valentin Sigal,
• Aljoscha Koenneke,
• Konrad Schwarzkopf,
• Andreas Manz and
• Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

• applications. Keywords: curcumin; human pulmonary mucus; microfluidics; muco-penetrating nanoparticles; nanomedicine; permeability; PLGA nanoparticles; Introduction In the last decades, the application of nanotechnology in medicine has gained significant attention, especially in the biomedical field for

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• B. Rabindran Jermy Vijaya Ravinayagam Widyan A. Alamoudi Dana Almohazey Hatim Dafalla Lina Hussain Allehaibi Abdulhadi Baykal Muhammet S. Toprak Thirunavukkarasu Somanathan Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal

• University, P.O. Box 1982, 31441 Dammam, Saudi Arabia Deanship of Scientific Research & Department of Nano-Medicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi Arabia Department of Neuroscience Research, Institute for

Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• with a C2F5-terminated dendron. The combined use of fluorinated dendrons and a supernatant fluorocarbon gas is a straightforward, effective method for preparing magnetic microbubbles that could facilitate the development of future applications in medicine. Finally, the AFM analysis of the DPPC/iron

Gold-coated plant virus as computed tomography imaging contrast agent

• Alaa A. A. Aljabali,
• Mazhar S. Al Zoubi,
• Khalid M. Al-Batanyeh,
• Ali Al-Radaideh,
• Mohammad A. Obeid,
• Abeer Al Sharabi,
• Walhan Alshaer,
• Bayan AbuFares,
• Tasnim Al-Zanati,
• Murtaza M. Tambuwala,
• Naveed Akbar and
• David J. Evans

Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195

• , Jordan Yarmouk University - Faculty of Medicine, Department of Basic Medical Sciences, Irbid, Jordan Yarmouk University - Faculty of Science, Department of Biological Sciences, Irbid, Jordan Hashemite University - Department of Medical Imaging, Zarqa, Jordan National Agricultural Research Center, Amman

• , Jordan University of Jordan - Cell Therapy Center, Amman, Jordan SAAD Centre for Pharmacy and Diabetes, School of Pharmacy and Pharmaceutical Science Ulster University, Coleraine, UK University of Oxford - Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK John Innes Centre, Norwich Research

• ; computed tomography (CT); gold; nanotechnology; viruses; targeting; Introduction Numerous types of nanomaterials are currently under investigation in medicine, including dendrimers, polymeric nanoparticles (NPs), liposomes and protein-based NPs. Each system has advantages and disadvantages in terms of its

Porous silver-coated pNIPAM-co-AAc hydrogel nanocapsules

• William W. Bryan,
• Riddhiman Medhi,
• Maria D. Marquez,
• Supparesk Rittikulsittichai,
• Michael Tran and
• T. Randall Lee

Beilstein J. Nanotechnol. 2019, 10, 1973–1982, doi:10.3762/bjnano.10.194

• Interest in the preparation and utilization of uniquely structured nanocomposites continues to expand due to their potential use in electronics, optics, magnetism, medicine, catalysis, and energy applications [1][2][3][4][5][6]. The physical and chemical properties of these materials provide significant

Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents

• Natalia E. Gervits,
• Andrey A. Gippius,
• Alexey V. Tkachev,
• Evgeniy I. Demikhov,
• Sergey S. Starchikov,
• Igor S. Lyubutin,
• Alexander L. Vasiliev,
• Vladimir P. Chekhonin,
• Maxim A. Abakumov,
• Alevtina S. Semkina and
• Alexander G. Mazhuga

Beilstein J. Nanotechnol. 2019, 10, 1964–1972, doi:10.3762/bjnano.10.193

• spectroscopy; MRI contrast agents; nanocrystalline materials; NMR spectroscopy; Raman spectroscopy; Introduction Nowadays, magnetic nanoparticles (MNPs) are widely used in biology and medicine. A large number of studies [1][2][3][4] have shown different prospects of their use for sample preparation, in

• , the structure and composition of the particular magnetic material strongly influences the behavior of the nanoparticles. Thus, they should be precisely studied before being used in biology and medicine. MRI is a widely approved procedure used to visualize tissue in vivo and to reveal pathological foci

The influence of porosity on nanoparticle formation in hierarchical aluminophosphates

• Matthew E. Potter,
• Lauren N. Riley,
• Alice E. Oakley,
• Panashe M. Mhembere,
• June Callison and
• Robert Raja

Beilstein J. Nanotechnol. 2019, 10, 1952–1957, doi:10.3762/bjnano.10.191

• : aluminophosphate; catalysis; hierarchical catalysts; nanoparticles; porosity; Findings The controlled synthetic design of metallic nanoparticles has generated significant interest in recent decades due to their implementation in a range of fields, including medicine [1], optics [2] and catalysis [3]. Given the

Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints

• Elvira Rozhina,
• Ilnur Ishmukhametov,
• Svetlana Batasheva,
• Farida Akhatova and
• Rawil Fakhrullin

Beilstein J. Nanotechnol. 2019, 10, 1818–1825, doi:10.3762/bjnano.10.176

• Elvira Rozhina Ilnur Ishmukhametov Svetlana Batasheva Farida Akhatova Rawil Fakhrullin Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan 420008, Republic of Tatarstan, Russian Federation 10.3762/bjnano.10.176 Abstract Cell surface engineering, as a

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• Barbara Pem Igor M. Pongrac Lea Ulm Ivan Pavicic Valerije Vrcek Darija Domazet Jurasin Marija Ljubojevic Adela Krivohlavek Ivana Vinkovic Vrcek Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia University of Zagreb, School of Medicine, Croatian

Growth dynamics and light scattering of gold nanoparticles in situ synthesized at high concentration in thin polymer films

• Corentin Guyot,
• Philippe Vandestrick,
• Ingrid Marenne,
• Olivier Deparis and
• Michel Voué

Beilstein J. Nanotechnol. 2019, 10, 1768–1777, doi:10.3762/bjnano.10.172

• can be used for constructing passively Q-switched or mode-locked lasers [13][14][15]. This type of lasers has numerous applications in telecommunications, medicine, material processing and optical fiber sensing [16][17]. Moreover, AuNPs are good candidates for preparing passive Q-switch films because

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

• Carol López de Dicastillo,
• Cristian Patiño,
• María José Galotto,
• Yesseny Vásquez-Martínez,
• Claudia Torrent,
• Daniela Alburquenque,
• Alejandro Pereira and
• Juan Escrig

Beilstein J. Nanotechnol. 2019, 10, 1716–1725, doi:10.3762/bjnano.10.167

• (USACH), Obispo Umaña 050, 9170201 Santiago, Chile Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170124 Santiago, Chile Program Center for Applied Biomedical Research, School of Medicine, Faculty of Medical Sciences, University of Santiago de Chile, 9170022 Santiago, Chile

Kelvin probe force microscopy work function characterization of transition metal oxide crystals under ongoing reduction and oxidation

• Dominik Wrana,
• Karol Cieślik,
• Wojciech Belza,
• Christian Rodenbücher,
• Krzysztof Szot and
• Franciszek Krok

Beilstein J. Nanotechnol. 2019, 10, 1596–1607, doi:10.3762/bjnano.10.155

• to the formation of d2 electrons. Hence, TiO is a d-band conductor with a room temperature conductivity of 3500 Ω−1 cm−1, which slowly decreases with temperature [18]. There is a growing interest in such metallic oxides, not only as oxide electrodes but also in medicine, since reduced TiO