Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints

• Elvira Rozhina,
• Ilnur Ishmukhametov,
• Svetlana Batasheva,
• Farida Akhatova and
• Rawil Fakhrullin

Beilstein J. Nanotechnol. 2019, 10, 1818–1825, doi:10.3762/bjnano.10.176

• that methodology reported here will find applications in biomedical and clinical research. Keywords: cell surface engineering; cell-recognising imprints; halloysite nanotubes; nanoarchtectonics; Introduction Nanoarchitectonics has recently emerged as a “post-nanotechnology era” paradigm in the

• such as boron nitride or imogolite nanotubes, which are also considered as safe materials for living organisms [33]. Recently, water-dispersed thermo-responsive boron nitride nanotubes were obtained by their functionalisation with poly(N-isopropylacrylamide), which can widen their biomedical

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• . Keywords: biocompatibility; cysteine; ecotoxicity; glutathione; nano–bio interactions; nanosafety; nanotoxicity; Introduction Metallic nanoparticles (NPs) such as silver and gold have been employed in a wide range of products and applications in the biomedical field owing to their remarkable physico

• -chemical properties. Silver nanoparticles (AgNPs) are extensively used in antimicrobial coatings for medical devices, wound dressing, cosmetic products and food packaging due to their antimicrobial, antiangiogenic and anti-inflammatory properties [1][2][3][4][5]. Biomedical applications of gold

• biomedical aspects of NPs (Figure S1 in Supporting Information File 1). In addition to the increase of papers reporting on the development of NPs for biomedical uses, the WoS search showed that there are ample in vitro and in vivo studies on the toxicity effects of AgNPs and AuNPs. There are a number of

Lipid nanostructures for antioxidant delivery: a comparative preformulation study

• Elisabetta Esposito,
• Maddalena Sguizzato,
• Markus Drechsler,
• Paolo Mariani,
• Federica Carducci,
• Claudio Nastruzzi,
• Giuseppe Valacchi and
• Rita Cortesi

Beilstein J. Nanotechnol. 2019, 10, 1789–1801, doi:10.3762/bjnano.10.174

• " University of Bayreuth, Germany Dipartmento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, I-60131 Ancona, Italy NC State University, Plants for Human Health Institute, Animal Science Dept. NC Research Campus, Kannapolis, NC 28081, USA Department of Biomedical and Specialist

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

• Carol López de Dicastillo,
• Cristian Patiño,
• María José Galotto,
• Yesseny Vásquez-Martínez,
• Claudia Torrent,
• Daniela Alburquenque,
• Alejandro Pereira and
• Juan Escrig

Beilstein J. Nanotechnol. 2019, 10, 1716–1725, doi:10.3762/bjnano.10.167

• (USACH), Obispo Umaña 050, 9170201 Santiago, Chile Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170124 Santiago, Chile Program Center for Applied Biomedical Research, School of Medicine, Faculty of Medical Sciences, University of Santiago de Chile, 9170022 Santiago, Chile

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

• ][28][29][30][31], and biotechnological and biomedical developments [32][33][34][35][36][37] have been explored to achieve these objectives. One of the common key concepts for all these developments is regulating functional molecular systems with high spatial precision, which can often induce the

• ], environmental protection [118][119], catalysts [120][121], biology [122][123][124], and biomedical applications [125][126]. For example, the following recent research works on low-dimensional materials have been carried out using the nanoarchitectonics concept: Hasegawa and co-workers used atom-manipulation

• , C60) molecules as assembling components are both technically and scientifically attractive [235]. In addition to the technical importance of fullerene in many applications including physical devices and biomedical usages, assembly processes from completely symmetrical zero-dimensional objects with

Highly ordered mesoporous silica film nanocomposites containing gold nanoparticles for the catalytic reduction of 4-nitrophenol

• Mohamad Azani Jalani,
• Leny Yuliati,
• Siew Ling Lee and
• Hendrik O. Lintang

Beilstein J. Nanotechnol. 2019, 10, 1368–1379, doi:10.3762/bjnano.10.135

• ; Introduction Mesoporous silica nanomaterials with pore size between 2 to 50 nm [1] have been recently applied to the development of biomedical adsorbents [2][3][4], drug delivery systems [5][6][7], catalysts [8][9][10], as well as supports for metal nanoparticles [11][12][13] due to their large surface area

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

• Hajar Jalili,
• Bagher Aslibeiki,
• Ali Ghotbi Varzaneh and
• Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

• demagnetized) [5][6]. Magnetic interactions (e.g., exchange and dipolar interactions) have a strong effect on the magnetic behavior of a NP system (e.g., coercivity and blocking temperature) [7][8] and its potential for different applications. For example, there may be unfavorable effects in biomedical

On the relaxation time of interacting superparamagnetic nanoparticles and implications for magnetic fluid hyperthermia

• Andrei Kuncser,
• Nicusor Iacob and
• Victor E. Kuncser

Beilstein J. Nanotechnol. 2019, 10, 1280–1289, doi:10.3762/bjnano.10.127

• implications in various fields of nanotechnology such as biomedicine, magnetic data storage and sensors [1][2][3][4][5][6]. Concerning the biomedical applications, the magnetic relaxation of nanoparticles is of key interest in magnetic resonance imaging (through the influence of the relaxation time of the

• should be taken into account in hyperthermia biomedical applications, which has also been reported in other previous studies [34][35]. Theoretical investigation of the relaxation time by micromagnetic simulations The dynamic magnetic behavior of parallelepiped nanoparticles with specific configurations

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• . In conclusion, the high cellular uptake and the antioxidant properties associated with the phenolic moieties in the modified particles allow for a potential application in biomedical areas. Keywords: antioxidants; chitosan; maghemite nanoparticles; oxidative stress; phenolic compound; Introduction

• [12]. Due to its biocompatibility, it has been investigated in several biomedical applications, e.g., tissue engineering, ophthalmology, and drug delivery. Chitosan modification with phenolic compounds leads to the enhancement of already existing antioxidant properties [13]. The antioxidant properties

• assays indicated the necessity of using additional methods for the examination of the antioxidant properties. γ-Fe2O3 nanoparticles The advantages of iron oxides in biomedical applications include biocompatibility, excellent magnetic properties, and the possibility to modify the surface with reactive

Tailoring the stability/aggregation of one-dimensional TiO₂(B)/titanate nanowires using surfactants

• Atiđa Selmani,
• Johannes Lützenkirchen,
• Kristina Kučanda,
• Dario Dabić,
• Engelbert Redel,
• Ida Delač Marion,
• Damir Kralj,
• Darija Domazet Jurašin and
• Maja Dutour Sikirić

Beilstein J. Nanotechnol. 2019, 10, 1024–1037, doi:10.3762/bjnano.10.103

• . Considering that the size of nano- and microaggregates greatly influences their degree of toxicity, and consequently their impact on human health and the environment, the conditions under which aggregation occurs are of interest for environmental but also for biomedical applications [13][14]. The stability of

• biomedical. On the other hand, quaternary ammonium surfactants are the most commonly encountered cationic surfactants due to their high surface activity, good antibacterial properties as well as availability due to the ease of synthesis. In addition, comparing the effects of monomeric and corresponding

Correlation of surface-enhanced Raman scattering (SERS) with the surface density of gold nanoparticles: evaluation of the critical number of SERS tags for a detectable signal

• Vincenzo Amendola

Beilstein J. Nanotechnol. 2019, 10, 1016–1023, doi:10.3762/bjnano.10.102

• suitability of plasmonic SERS labels for ultrasensitive analytical and biomedical applications is evident. Keywords: discrete dipole approximation (DDA); gold nanoparticles (AuNPs); nanotags; surface-enhanced Raman scattering (SERS); surface plasmon resonance (SPR); Introduction In surface-enhanced Raman

• , which can be obtained more easily with low-magnification optics when the surface density of the SERS tags is as low as a few units per micrometer square. These results contribute to the optimization of the experimental conditions for the use of SERS tags in analytical and biomedical analysis with high

• noted that a density of few SERS tags per micrometer square is much lower than that typically pursued in practical cases for both analytical and biomedical purposes [13][16][17][18][19][20][21][22]. The good performance of AuNTs is confirmed by the fact that no Raman signal was detected from the pure

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• the need to carefully evaluate the data acquired so far from in vitro studies in order to develop safe biomedical applications. Conclusion We investigated the importance of selecting a proper physiological medium used for in vitro protein corona analysis. Therefore, we employed several analytical

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• restricts its use for biomedical applications. Scientists have overcome this challenge through the oxidation of graphene by an improved Hummer’s method [3]. Graphene oxide (GO), due to its hydrophilic nature, can host a large number of biocompatible polymers, such as chitosan [4], polyethylene glycol (PEG

• principles for biomedical research. In vivo assays Lipid peroxidation The amount of lipid peroxides (LOPs) in the collected organs of mice was estimated by TBA assay as described by Dubovskiy and co-workers [53]. Briefly, 1 mL of 0.6% thiobarbituric acid (TBA) was mixed with 0.25 mL of 20% trichloroacetic

Co-doped MnFe₂O₄ nanoparticles: magnetic anisotropy and interparticle interactions

• Bagher Aslibeiki,
• Parviz Kameli,
• Hadi Salamati,
• Giorgio Concas,
• Maria Salvador Fernandez,
• Alessandro Talone,
• Giuseppe Muscas and
• Davide Peddis

Beilstein J. Nanotechnol. 2019, 10, 856–865, doi:10.3762/bjnano.10.86

• implemented for large-scale nanoparticle applications, such as for permanent magnets and biomedical applications. Given their good particle size distribution (≈10 nm diameter) and almost the same saturation magnetization per particle, these samples represent a good model system to study the systematic effect

• different magnetic anisotropy opens interesting perspectives for applications in biomedical fields (e.g., MRI, drug delivery, hyperthermia) [20][21] and energy harvesting. Experimental Synthesis Several samples consisting of manganese ferrite nanoparticles with different cobalt doping, i.e., Mn1−xCoxFe2O4

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• effect, other ligands on the cerium ion can be replaced by different polymers and linkers. The resulting nanocomposites can be used for biomedical applications, such as gene silencing [52], magnetic imaging, and drug delivery. Here we present a new and simple-to-fabricate WS2-NT-CAN-mag (WS2-NT-CM

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• taken together give the opportunity to use AuNR/PDA composites as promising agents for theranostics. The published examples of fabrication and biomedical applications of PDA-coated nanorods include the following nanoconstructs: (1) AuNR-PDA-Ab for targeted PPT of cells in vitro [28]; AuNR-CuPDA for non

Self-assembly and wetting properties of gold nanorod–CTAB molecules on HOPG

• Imtiaz Ahmad,
• Floor Derkink,
• Tim Boulogne,
• Pantelis Bampoulis,
• Harold J. W. Zandvliet,
• Hidayat Ullah Khan,
• Rahim Jan and
• E. Stefan Kooij

Beilstein J. Nanotechnol. 2019, 10, 696–705, doi:10.3762/bjnano.10.69

• , the process of self-assembly at the liquid–solid interface has proved to be an attractive self-assembly route [4][8][9]. The self-assembled structures can play an important role in magnetic [10][11][12][13], electronic [14][15][16], photovoltaic [17][18][19], biomedical [20][21][22], sensing [23][24

Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores

• Kartheek Katta,
• Dmitry Busko,
• Yuri Avlasevich,
• Katharina Landfester,
• Stanislav Baluschev and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53

• free-radical scavengers in biomedical applications as a potent therapeutic option for the treatment of disorders generated by reactive oxygen species, such as neurodegenerative disorders, retinal disorders and cancer [43][44][45]. In this work, we report the process of armoring anionically

Heating ability of magnetic nanoparticles with cubic and combined anisotropy

• Nikolai A. Usov,
• Mikhail S. Nesmeyanov,
• Elizaveta M. Gubanova and
• Natalia B. Epshtein

Beilstein J. Nanotechnol. 2019, 10, 305–314, doi:10.3762/bjnano.10.29

• anisotropy. The magnetite nanoparticles are widely used in biomedical research [3][4][5][6][7][8][9][10][11][12][13][14]. However, when analyzing experimental data, it is implicitly assumed that they have a uniaxial type of magnetic anisotropy, though a single crystal of magnetite possesses cubic type

Mechanism of silica–lysozyme composite formation unravelled by in situ fast SAXS

• Tomasz M. Stawski,
• Daniela B. van den Heuvel,
• Rogier Besselink,
• Dominique J. Tobler and
• Liane G. Benning

Beilstein J. Nanotechnol. 2019, 10, 182–197, doi:10.3762/bjnano.10.17

• of protein-sensitized biomedical devices and sensors [1][2][3][4][5][6]. In a broader perspective, many processes involving the assembly of nanoparticles to higher-level hierarchical structures are known to be directed by small organic molecules and macromolecules [7][8][9][10]. Such fundamental

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• Siyi Hu Yu Ren Yue Wang Jinhua Li Junle Qu Liwei Liu Hanbin Ma Yuguo Tang CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China School of Science, Changchun University of Science and

Characterization and influence of hydroxyapatite nanopowders on living cells

• Przemyslaw Oberbek,
• Tomasz Bolek,
• Adrian Chlanda,
• Seishiro Hirano,
• Sylwia Kusnieruk,
• Julia Rogowska-Tylman,
• Ganna Nechyporenko,
• Viktor Zinchenko,
• Wojciech Swieszkowski and
• Tomasz Puzyn

Beilstein J. Nanotechnol. 2018, 9, 3079–3094, doi:10.3762/bjnano.9.286

• 100 nm can exhibit properties (including toxicological) different from those of non-nanoscale (bulk) materials [4]. Interest in the use of nanomaterials for biomedical applications is constantly growing due to their unique physical, chemical, biological and mechanical properties [5][6]. However

• regenerative medicine. The use of nanosized hydroxyapatites in biomedical applications is constantly growing due to their good mechanical properties and enhanced efficiency of gene transfection in drug delivery. Calcium phosphates are sensitive to the preparation conditions [11][12][13][14][15]. They can be

Magnetic and luminescent coordination networks based on imidazolium salts and lanthanides for sensitive ratiometric thermometry

• Pierre Farger,
• Cédric Leuvrey,
• Mathieu Gallart,
• Pierre Gilliot,
• Guillaume Rogez,
• João Rocha,
• Duarte Ananias,
• Pierre Rabu and
• Emilie Delahaye

Beilstein J. Nanotechnol. 2018, 9, 2775–2787, doi:10.3762/bjnano.9.259

• elaboration of light-emitting devices or for biomedical applications [15]. Moreover, due to the narrowness and the hypersensitivity of their transitions, lanthanide-based networks can also find utility for the sensing of gases, vapors or small molecules [9][16]. In the case of mixed lanthanide coordination

Low cost tips for tip-enhanced Raman spectroscopy fabricated by two-step electrochemical etching of 125 µm diameter gold wires

• Antonino Foti,
• Francesco Barreca,
• Enza Fazio,
• Cristiano D’Andrea,
• Paolo Matteini,
• Onofrio Maria Maragò and
• Pietro Giuseppe Gucciardi

Beilstein J. Nanotechnol. 2018, 9, 2718–2729, doi:10.3762/bjnano.9.254

• Line 1.1- Action 1.1.2) and the European Community within the EuroNanoMed3 ERANET cofund (H2020) project “Surface-enhanced Raman scattering with nanophotonic and biomedical amplifying systems for an early diagnosis of Alzheimer’s disease pathology SPEEDY” (ID 221).

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• a minimally invasive method that increases the exposure of affected tissues to drug-loaded magnetic nanoparticles [5]. Colloidal stability, high drug-loading capacity, and relatively long circulation time are of primary importance for diverse biomedical applications of magnetic nanoparticles ranging

• , biocompatibility, absence of toxicity, minimal immunogenicity, and enhanced permeability and retention to cancer cells [18]. Moreover, PHPMA, which has a long history of biomedical applications as a drug-delivery vehicle, enables the control of biodistribution and accumulation via molecular weight limitations [19

• kDa according to HPLC) were obtained, which was unacceptable from the point of in vivo biomedical applications. Therefore, RAFT copolymerization was selected, which enables the preparation of well-defined telechelic P(HPMA-MMAA) molecules of medium or low molecular weight [21]. With this technique the