Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• nanoparticles [34]. The resulting gold–alendronate nanoplatform combines antitumor activity through drug delivery and photothermal therapy, as illustrated in vitro on the inhibition of prostate cancer cells. In the field of hybrid coordination networks, new lanthanide-based networks synthesized by a solvo

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

• Mohammad J. Akbar,
• Pâmela C. Lukasewicz Ferreira,
• Melania Giorgetti,
• Leanne Stokes and
• Christopher J. Morris

Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246

• new therapeutic approaches for targeted drug delivery to SCLC are desperately needed. SCLC belongs to a class known as neuroendocrine tumours in which malignant cells secrete hormones and growth factors – a trait inherited from the neuroendocrine cells of the bronchial epithelium that are transformed

Frontiers in pharmaceutical nanotechnology

• Matthias G. Wacker

Beilstein J. Nanotechnol. 2019, 10, 2538–2540, doi:10.3762/bjnano.10.244

• Matthias G. Wacker National University of Singapore, Faculty of Science, Department of Pharmacy, 6 Science Drive 2, 117546 Singapore 10.3762/bjnano.10.244 Keywords: drug delivery; nanocarriers; nanomedicines; nanotheranostics; pharmaceutical nanotechnology; Today, pharmaceutical nanotechnology

• is a very dynamic and evolving research area that integrates a wide variety of disciplines such as chemical, biological and biomedical science. At the frontier of knowledge, nanoparticles, exosomes and even more advanced drug delivery systems [1] blur the line between drug discovery and formulation

• active transport of nanoparticles into the central nervous system using the low-density lipoprotein receptor family [3][4][5][6], provided an entry route for the cytostatic drug doxorubicin into the brain. The drug delivery system has been tested in a phase II clinical trial and hopefully will make its

pH-Controlled fluorescence switching in water-dispersed polymer brushes grafted to modified boron nitride nanotubes for cellular imaging

• Saban Kalay,
• Yurij Stetsyshyn,
• Volodymyr Donchak,
• Khrystyna Harhay,
• Ostap Lishchynskyi,
• Halyna Ohar,
• Yuriy Panchenko,
• Stanislav Voronov and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2019, 10, 2428–2439, doi:10.3762/bjnano.10.233

• fluorescent probes for a number of bio-responsive applications, ranging from drug delivery to genomics [29][30][31]. Similar to other nanotubes, the pristine BNNTs were not fluorescent, and a fluorophore (e.g., organic molecule or quantum dot) is added via surface modification to make them fluorescent [29][30

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• biocompatibility, improved mechanical characteristics tailored for the specific application, in addition to new release mechanisms and improved permeability [9][12][13][14]. The delivery through the mucosa via buccal administration has shown several advantages as a drug delivery target site. The ease of

• to different types of stimulation, during mastication, speech and swallowing, could hinder the development of drug delivery systems for this route [15][16]. In order to avoid these drawbacks, nanostructured systems with mucoadhesive polymers, such as acrylic-acid derivatives, have been investigated

• with the mechanical and rheological characteristics observed. One of the replicate images is showed in Figure 9B. In vitro drug release profile During the development of drug delivery systems for buccal application, in vitro drug release is highly important and is considered a prerequisite for

Dynamics of superparamagnetic nanoparticles in viscous liquids in rotating magnetic fields

• Nikolai A. Usov,
• Ruslan A. Rytov and
• Vasiliy A. Bautin

Beilstein J. Nanotechnol. 2019, 10, 2294–2303, doi:10.3762/bjnano.10.221

• ; viscous liquid; Introduction Magnetic nanoparticles are promising materials in various areas of biomedicine [1][2][3][4], such as magnetic resonance imaging [5][6][7], targeted drug delivery [8][9][10], and magnetic hyperthermia [11][12][13][14][15][16][17][18][19][20]. Iron oxide nanoparticles are most

Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

• Nashrawan Lababidi,
• Valentin Sigal,
• Aljoscha Koenneke,
• Konrad Schwarzkopf,
• Andreas Manz and
• Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

• is more than 50% for Pluronic F68 and Pluronic 10500. A considerable increase in size and size distribution would hamper the ability of the particles to serve as efficient drug delivery systems. Thus, all stabilizers that do not prohibit agglomeration are not suitable for our application. To

• microfluidics in combination with a specific muco-inert surface chemistry led to a promising drug delivery system with enhanced mucus penetration. Moreover, a high absolute curcumin encapsulation efficiency of ≈67.15% was obtained using microfluidics. Furthermore, the encapsulation was clearly improved in

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• tumor imaging guide and drug delivery system. Keywords: anticancer; cisplatin; copper ferrite; drug delivery; multifunctional; nanomedicine; nanotherapeutics; spherical silica; tumour therapy; Introduction Due to the continuous advancements in the field of nanotechnology, the therapeutic prospects

• expected health crisis [1]. However, the single modal drug delivery system is hampered by low bioavailability (about 5–10%), burst release, and lower target efficiency. Multifunctional theranostic nanoparticles that can respond to an external magnetic field for drug release and assist in bioimaging

• /HYPS, CuFe2O4/AlMSU-F and CuFe2O4/silicalite nanoformulations. The cellulose membrane dialysis tubing was activated, and drug delivery was performed by immersing the bag containing 30 mg of drug formulations in 50 mL of phosphate buffered saline (PBS) at pH 5.6. The release was performed under constant

Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials

• Stefania Ordanini,
• Wanda Celentano,
• Anna Bernardi and
• Francesco Cellesi

Beilstein J. Nanotechnol. 2019, 10, 2192–2206, doi:10.3762/bjnano.10.212

• glycopolymers can be potentially utilized as targeted anti-pathogenic nanomaterials and as well as for cell-targeted drug delivery. Experimental General procedures Chemicals were purchased by commercial sources and used without further purification, unless otherwise indicated. Polyethylene glycol methyl ether

Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications

• Alberto Boretti,
• Lorenzo Rosa,
• Jonathan Blackledge and
• Stefania Castelletto

Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207

• applications, is given in [21], which includes details on biosensing, bioimaging and drug delivery as well as biocompatibility. The toxicity of diamond nanostructures is also discussed. Electron spin resonance (ESR) of the NVs themselves is exploited in [22] to achieve single-spin subwavelength resolution in

• whose features are used in many technologies, from magnetic information storage to ferrofluids or nanoscale drug-delivery systems and magneto-assisted hyperthermia cancer treatments [65]. Single SPION detection with 10 nm accuracy was shown by bulk diamond NV center magnetometry combining spin

Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• signal for energy deposition, as is required for sonothrombolysis or ablation surgery. MBs incorporating iron oxide nanoparticles (IONPs) are sought after as dual contrast agents for ultrasound and magnetic resonance imaging [18][19][20] and drug delivery [21][22]. The shells of the presently available

• also been reported for enhanced gene and drug delivery [24]. These lipospheres consist of gas-filled spheres coated by a film of soybean oil that encases the cargo of nanoparticles and is itself contained within a film of phospholipids [24]. Both polymer-shelled MBs and lipospheres have some advantages

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• . However, the therapeutic window is small, and anticancer therapies are typically associated with severe side-effects [2][3]. One strategy to develop more effective cancer therapies is to use nano-sized drug delivery systems that mediate a more specific tumour accumulation of transported drugs. Tumour

Porous silver-coated pNIPAM-co-AAc hydrogel nanocapsules

• William W. Bryan,
• Riddhiman Medhi,
• Maria D. Marquez,
• Supparesk Rittikulsittichai,
• Michael Tran and
• T. Randall Lee

Beilstein J. Nanotechnol. 2019, 10, 1973–1982, doi:10.3762/bjnano.10.194

• particle composition, core size, and/or shell size to absorb/scatter wavelengths in the NIR region, which is largely transparent to human tissue [49][50][51]. Thermo-responsive hydrogel polymers have been extensively studied and have been utilized in various technological applications such as drug delivery

• various core materials [21][22][23][24]. Recent studies involving spherical capsules have introduced a variety of materials into the core such as DNA, antibiotics, fluorescent dyes, and metal nanoparticles [25][26][27][28][29][30]. These types of particles show great promise for applications such as drug

• delivery, biosensing, chemical separation, nanoscale reactors, and catalysis [31][32][33][34][35][36][37][38][39][40]. While these examples represent a vast array of potential applications using nanocapsules, one particularly interesting application involves the use of NIR-responsive metal nanoparticles to

Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents

• Natalia E. Gervits,
• Andrey A. Gippius,
• Alexey V. Tkachev,
• Evgeniy I. Demikhov,
• Sergey S. Starchikov,
• Igor S. Lyubutin,
• Alexander L. Vasiliev,
• Vladimir P. Chekhonin,
• Maxim A. Abakumov,
• Alevtina S. Semkina and
• Alexander G. Mazhuga

Beilstein J. Nanotechnol. 2019, 10, 1964–1972, doi:10.3762/bjnano.10.193

• genomic and proteomic analysis [5], for drug delivery [6], as magnetic resonance imaging (MRI) contrast agents [7], and for magnetic hyperthermia [8]. This wide variety of applications is due to the unique combination of magnetic, optical and chemical properties that are characteristic of MNPs. However

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• targeted drug delivery to tumors. These nanoparticles can passively accumulate in tumors via enhanced permeability and retention (EPR) effect, thus decreasing the toxicity of nonselective bio-distribution [27]. Considering the advantages of liposomes as a drug delivery system for chemotherapeutic drugs and

• [30]. Phytosomes have been used as drug delivery systems of several insoluble natural drugs in recent years. Sinigrin [31] and epigallocatechin-3-O-gallate [32] loaded in phytosomes showed stronger antiproliferative activity than free drugs against melanoma cells and breast cancer cells. In this work

• between cells treated with free drugs and their corresponding phytosomes. The results indicated that phytosomes could be an ideal drug delivery system for Di and its derivatives to obtain sustained release without affecting drug activity. In vitro anticancer mechanisms of P2P Cell cycle and cell apoptosis

High-tolerance crystalline hydrogels formed from self-assembling cyclic dipeptide

• Yongcai You,
• Ruirui Xing,
• Qianli Zou,
• Feng Shi and
• Xuehai Yan

Beilstein J. Nanotechnol. 2019, 10, 1894–1901, doi:10.3762/bjnano.10.184

• for a wide range of biomedical and nanotechnological applications, such as tissue engineering, drug delivery, and electronic and photonic energy storage. In this work, a cyclic dipeptide (CDP) cyclo-(Trp-Tyr) (C-WY), which has exceptional structural rigidity and high stability, is selected as a

• their high water content and highly tunable mechanical properties, hydrogels as soft nanoarchitectonics and soft matter are well-suited in extensive applications, such as tissue engineering, drug delivery, and electronic and photonic energy storage [1][2][3][4][5][6][7][8][9][10]. Self-assembled peptide

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• Xianping Liu Chengjuan Du Haichun Li Ting Jiang Zimiao Luo Zhiqing Pang Daoying Geng Jun Zhang Department of Radiology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of

• radical surgery [36]. In addition, Mao and co-workers have reported the multitargeted drug delivery system by a d-peptide ligand (d-AE) based EGFRvIII targeting strategy, which provides a promising path for glioma therapy [37]. Through the conjugation of Cy7.5 to PEPHC1-modified PEGylated SPIONs, a

• PEPHC1 peptide conjugation greatly enhanced PNP accumulation in U87MG-EGFRvIII tumors (Figure 7a and 7b). For the biodistribution study, similar to other drug delivery systems based on tumor-targeting nanoparticles [45][46][47], both PNP and NP nanoprobes were found distributed in other major organs

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

• Mohammad A. Obeid,
• Ibrahim Khadra,
• Abdullah Albaloushi,
• Margaret Mullin,
• Hanin Alyamani and
• Valerie A. Ferro

Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177

• capability. These results demonstrate that niosomes prepared by microfluidic mixing to encapsulate curcumin are a promising delivery system to reach target cells. Keywords: curcumin; drug delivery; microfluidic mixing; niosomes nanoparticle; Introduction Curcumin is a natural product that is derived from

• [6]. The use of nanoparticles as drug delivery systems is currently a corner stone in the field of drug delivery in order to improve the pharmacokinetics and pharmacodynamics of many drugs that have limitations in bioavailability [7]. Therefore, to improve the curcumin characteristics, nanoparticles

• nanoparticles components to be used as a drug delivery system for curcumin and for other therapeutic agents. TEM images of (A) SP80 niosomes prepared at 1:1 FRR, (B) SP80 niosomes prepared at 3:1 FRR, (C) T85 niosomes prepared at 1:1 FRR, (D) T85 niosomes prepared at 3:1 FRR. Curcumin standard curve measured by

Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints

• Elvira Rozhina,
• Ilnur Ishmukhametov,
• Svetlana Batasheva,
• Farida Akhatova and
• Rawil Fakhrullin

Beilstein J. Nanotechnol. 2019, 10, 1818–1825, doi:10.3762/bjnano.10.176

• fillers, drug-delivery vehicles and tissue engineering scaffolds [27]. Halloysite nanotubes derived from various geological deposits differ in their mesoscopic structures [28], allowing to choose the clay nanotubes most suitable for a desired application. The positively charged nanotube lumen can be

Toxicity and safety study of silver and gold nanoparticles functionalized with cysteine and glutathione

• Barbara Pem,
• Igor M. Pongrac,
• Lea Ulm,
• Ivan Pavičić,
• Valerije Vrček,
• Darija Domazet Jurašin,
• Marija Ljubojević,
• Adela Krivohlavek and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2019, 10, 1802–1817, doi:10.3762/bjnano.10.175

• nanoparticles (AuNPs) range from molecular imaging, targeted drug delivery, gene therapy, cancer treatment or radio-sensitization and theranostics [1][4][6]. Moreover, AgNPs and AuNPs are among the most investigated engineered nanomaterials for medical use. A search performed in the Web of Science (WoS

Biocatalytic oligomerization-induced self-assembly of crystalline cellulose oligomers into nanoribbon networks assisted by organic solvents

• Yuuki Hata,
• Yuka Fukaya,
• Toshiki Sawada,
• Masahito Nishiura and
• Takeshi Serizawa

Beilstein J. Nanotechnol. 2019, 10, 1778–1788, doi:10.3762/bjnano.10.173

• nanoarchitectonics [1][4][11]. Achievements include nanopatterning [12], drug delivery [13], molecular sensing [14], nanodevices [15][16], and cell architectures [17][18]. On the other hand, crystalline poly- and oligosaccharides, such as cellulose and chitin, lag behind in nanoarchitectonics despite the superiority

Layered double hydroxide/sepiolite hybrid nanoarchitectures for the controlled release of herbicides

• Ediana Paula Rebitski,
• Margarita Darder and
• Pilar Aranda

Beilstein J. Nanotechnol. 2019, 10, 1679–1690, doi:10.3762/bjnano.10.163

• components in diverse electrochemical devices (such as supercapacitors, sensors, and biosensors), in drug delivery and controlled-release formulations, or in non-viral gene transfection [21][22][23][24][25][26]. The fact that the stability of LDH varies with the pH value has proved advantageous in some of

• nanometric LDH particles for controlled drug delivery and other applications. Experimental Starting reagents and materials 4-Chloro-2-methylphenoxyacetic acid (MCPA) was purchased from Sigma-Aldrich (MW 200.62 g·mol−1, 97% purity). Sepiolite from Vallecas-Vicálvaro (Spain) was provided by TOLSA S.A. as

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

Highly ordered mesoporous silica film nanocomposites containing gold nanoparticles for the catalytic reduction of 4-nitrophenol

• Mohamad Azani Jalani,
• Leny Yuliati,
• Siew Ling Lee and
• Hendrik O. Lintang

Beilstein J. Nanotechnol. 2019, 10, 1368–1379, doi:10.3762/bjnano.10.135

• ; Introduction Mesoporous silica nanomaterials with pore size between 2 to 50 nm [1] have been recently applied to the development of biomedical adsorbents [2][3][4], drug delivery systems [5][6][7], catalysts [8][9][10], as well as supports for metal nanoparticles [11][12][13] due to their large surface area

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

• Hajar Jalili,
• Bagher Aslibeiki,
• Ali Ghotbi Varzaneh and
• Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

• magnetocrystalline anisotropy at room temperature [10]. The anisotropy constant of CoFe2O4 (K = 2 × 105 J·m−3) is nearly one order of magnitude larger than that of Fe3O4 [11][12][13]. Fe3O4 NPs have been studied extensively for bio-medical applications, such as drug delivery [14], magnetic resonance imaging (MRI